You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy VII1 Apr 2017MP93-15 FEASIBILITY OF A WEIGHT MANAGEMENT PROGRAM TAILORED FOR OVERWEIGHT MEN WITH LOCALIZED PROSTATE CANCER: A PILOT STUDY Meredith Metcalf, Cole Chana, Lauren Hand, Abigail Stanley, Misty Bechtel, Prabhakar Chalise, Tanner Isaacson, Debra K. Sullivan, Jennifer Klemp, Christie Befort, J. Brantley Thrasher, and Jill M. Hamilton-Reeves Meredith MetcalfMeredith Metcalf More articles by this author , Cole ChanaCole Chana More articles by this author , Lauren HandLauren Hand More articles by this author , Abigail StanleyAbigail Stanley More articles by this author , Misty BechtelMisty Bechtel More articles by this author , Prabhakar ChalisePrabhakar Chalise More articles by this author , Tanner IsaacsonTanner Isaacson More articles by this author , Debra K. SullivanDebra K. Sullivan More articles by this author , Jennifer KlempJennifer Klemp More articles by this author , Christie BefortChristie Befort More articles by this author , J. Brantley ThrasherJ. Brantley Thrasher More articles by this author , and Jill M. Hamilton-ReevesJill M. Hamilton-Reeves More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.2897AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Men who are overweight at the time of prostatectomy are more likely to have recurrence and die from prostate cancer than healthy weight men. They also have higher risk for cardiovascular disease, the most common cause of death for prostate cancer survivors. Our study tests the feasibility of weight loss before and maintenance after prostatectomy in overweight men with localized prostate cancer. METHODS Men scheduled for prostatectomy received a weight management program (intervention; n=15) or standard of care (non-intervention; n=5). The intervention included behavior coaching, diet including meal replacements, physical activity, and self-monitoring technology. Body weight, body composition, cardiometabolic markers, and quality of life were measured at baseline, 1 week before surgery, and 12 weeks after surgery. Changes within and differences between groups were analyzed using the two-sample t-test. RESULTS The intervention led to 6 kg of weight loss (95%CI, 3-8 kg; p<0.001) and 4 kg of fat loss (95%CI, 2-6 kg; p<0.001) from baseline to surgery (mean=6.6 weeks). Between group differences in weight change and fat loss were significant (P=0.012; P=0.032, respectively). In the intervention group, blood glucose decreased by 11 mg/dL (95%CI, 0.5-22 mg/dL; P=0.04); insulin decreased by 3.4 µIU/mL (95%CI, 0.1-7 µIU/mL; P=0.03); C-peptide decreased by 0.7 ng/L (95%CI, 0.17-1.3 ng/L; P=0.01); systolic blood pressure decreased by 8 mmHg (95%CI, 1-15 mmHg; P=0.03); and leptin:adiponectin ratio decreased (P=0.008) from baseline to surgery. Changes in lipid profiles were not significant. Twelve weeks after surgery, weight was maintained and physical quality of life was better in the intervention group than the non-intervention group (P=0.03). CONCLUSIONS The intervention led to significant weight loss and improved cardiometabolic markers. A larger, randomized controlled trial is needed to evaluate efficacy and cancer biomarkers. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e1242 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Meredith Metcalf More articles by this author Cole Chana More articles by this author Lauren Hand More articles by this author Abigail Stanley More articles by this author Misty Bechtel More articles by this author Prabhakar Chalise More articles by this author Tanner Isaacson More articles by this author Debra K. Sullivan More articles by this author Jennifer Klemp More articles by this author Christie Befort More articles by this author J. Brantley Thrasher More articles by this author Jill M. Hamilton-Reeves More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...