Despite the numerous contributions assessing the efficiency and effectiveness of Cohesion Policies, their role in stimulating growth and cohesion in different macroeconomic settings and in different business cycle periods remains highly debated. This article aims at contributing to this literature by investigating the link between Cohesion Policy, economic growth and interregional inequalities over periods of crisis and recovery. In particular, the article analyses whether Cohesion Policy is beneficial for the recovery of those regions mostly hit by the crisis and contributes to narrowing interregional gaps enhanced by the crisis. In addition, the paper analyses how the link between Cohesion Policy and interregional inequalities changes by investment axes, as it is the case of Research, Technology Development and Innovation funds, targeted to different goals. Based on an analysis covering all EU27 and UK NUTS2 regions in the period 2008–2019, the article confirms the multifaceted nexus between Cohesion Policy and interregional inequalities. It also raises warnings about the potential conflicts between its overarching goals and its multiple and expanding strategic objectives.