Time Limit Research Articles

A general method for the estimation of moments of substitution number in molecular evolution

The random variable ‘substitution number’ N t , i.e.the number of mutations that have accumulated in a sequence under neutral evolution during a time t, is a cornerstone of the field of molecular evolution. We show here that a complete solution of the moments of this random variable can be obtained explicitly by recurrence, using a simple matrix shift method. This result leads to simple expressions for both the short and long time limits of the moments that can be computed directly from the substitution matrix used to model the neutral evolution. The method developed here is also used to compute the moments of the complementary variable, T n , the time it takes to accumulate n mutations. The method we develop here necessitates only elementary operations on the substitution matrix and does not involve spectral decomposition.

Reducing blood product wastage through the inter-hospital redistribution of near-outdate inventory.

Hospital transfusion services order blood products to satisfy orders and maintain inventory levels during unexpected periods of increased blood demand. Surplus inventory may outdate before being allocated to a recipient. Blood product outdating is the largest contributor to blood wastage. A province-wide redistribution program was designed and implemented to redistribute near-outdate plasma protein and related blood products from low-usage to high-usage hospitals. Program operations and details are described in this paper. Two transport container configurations were designed and validated for transport of all blood products. A cost-analysis was performed to determine the effectiveness of this redistribution program. A total of 130 hospital transfusion services contributed at least one near-outdate blood product for redistribution between January 2012 and March 2020. These services redistributed 15,499 products through 3412 shipments, preventing the outdating of $17,570,700 CAD worth of product. Program costs were $14,900 for shipping and $30,000 for staffing. Failed time limits or non-compliance with packing configurations resulted in $388,200 worth of blood products (97 shipments containing 816 products) being discarded. Courier transport delays was the most common reason (42/97; 43%) for transport failure. Redistributing near-outdate blood products between hospitals is a feasible solution to minimize outdating. Despite heterogeneity of Canadian blood product inventory, all products (each with unique storage and transport requirements) were successfully redistributed in one of two validated and simple containers. Total operation costs of this program were small in comparison to the $17.6 million in savings associated with preventing the discard of outdated products.

Methodology of Organizing and Conducting Distance Olympiads in Korean as a Second Foreign Language in the Process of Professional Training of Future Foreign Language Teachers

In this article, the author presents the methodology of organizing and conducting distance Olympiads in Korean as a second foreign language in the process of professional training of foreign language teachers.The purpose of the study is to examine specifics of second foreign language distance Olympiads organization in the context of professional training, main objectives of the Korean language Olympiad (increasing motivation, interest in learning Korean, exposure to Korean culture, etc.), and to analyze the main requirements for distance Olympiad tasks of the first round (tests), and tasks of the second round, which are aimed to identify the level of communication abilities. Interview, testing and observation are used as the main methods of research.Results. The methodology proposed by the author was tested in groups of 3–4 year students of Sarsen Amanzholov East Kazakhstan University (educational program 6B01703 foreign language: two foreign languages). The article presents analysis of the distance Olympiad’s results, examples of tasks for each round and the main criteria for evaluating the tasks. The requirements to the second foreign language Olympiad tasks implied: possibility of mass coverage of students with Olympiad tasks; compliance of the tasks with the curriculum; time limit; relying on the students’ experience, including their native language skills and abilities; increasing tasks complexity; variety of tasks forms and content, the tasks contents and novelty; problem nature tasks to stimulate students thinking, language guess; using authentic material for the Olympiad tasks; the use of local history and extralinguistic material. The general complexity of the tasks, and difficulties associated with the nature of the linguistic material were also taken into account.Conclusion. According to the results of the experimental work, the author comes to the following conclusion: the leading principle of organizing distance Olympiads assumes that the university faculty will be focused on the timely identification of the future teachers’ interest to the Korean language, their involvement in preparation for the Olympiad, thus forming their interest in Korean culture and language. Olympiad assignments should be creative so that students learn to find their own ways of solving problems and develop self-education skills. Participation in the Olympiad increases students’ learning motivation, broadens their horizons, and develops their ability to express their opinions. The variety of requirements to the work of participants makes the assessment of each member of the jury quite subjective, but the collective nature of the evaluation procedure ensures correctness and objectivity of the final decision, allows participants to familiarize with the results of their work and consider appeals after each round of the Olympiad participants.

Candidiasis in Pregnancy: Relevant Aspects of the Pathology for the Mother and the Fetus and Therapeutic Strategies

Vulvovaginal candidiasis (VVC) is a common condition that can lead to significant discomfort, affecting approximately 70–75% of women at least once in their lives. During pregnancy, the prevalence of VVC is estimated to be around 20%, peaking at about 30% in the third trimester, with a number of specific risk factors predisposing to yeast infection being identified and needing elucidation. This review aims to provide updated knowledge on candidiasis during pregnancy, addressing risk factors and maternal and neonatal outcomes, as well as discussing optimal therapeutic strategies to safeguard mothers and newborns. The bibliographic search involved two biomedical databases, PubMed and Embase, without imposing time limits. Among all Candida spp., Candida albicans remains the most frequent causative species. The hyperestrogenic environment of the vaginal mucosa and reduced immune defenses, physiological effects of pregnancy, create conditions favorable for Candida spp. vaginal colonization and hence VVC. Recent evidence shows an association between VVC and adverse obstetric outcomes, including premature membrane rupture (PROM), chorioamnionitis, preterm birth, and puerperal infections. Prompt and effective management of this condition is therefore crucial to prevent adverse obstetric outcomes, maternal–fetal transmission, and neonatal disease. Additional studies are required to confirm the benefits of systemic treatment for maternal candida infection or colonization in preventing premature birth or neonatal systemic candidiasis.

Application of Natural Language Processing in Electronic Health Record Data Extraction for Navigating Prostate Cancer Care: A Narrative Review.

Introduction: Natural language processing (NLP)-based data extraction from electronic health records (EHRs) holds significant potential to simplify clinical management and aid research. This review aims to evaluate the current landscape of NLP-based data extraction in prostate cancer (PCa) management. Materials and Methods: We conducted a literature search of PubMed and Google Scholar databases using the keywords: "Natural Language Processing," "Prostate Cancer," "data extraction," and "EHR" with variations of each. No language or time limits were imposed. All results were collected in a standardized manner, including country of origin, sample size, algorithm, objective of outcome, and model performance. The precision, recall, and the F1 score of studies were collected as a metric of model performance. Results: Of the 14 studies included in the review, 2 articles focused on documenting digital rectal examinations, 1 on identifying and quantifying pain secondary to PCa, 8 on extracting staging/grading information from clinical reports, with an emphasis on TNM-classification, risk stratification, and identifying metastasis, 2 articles focused on patient-centered post-treatment outcomes such as incontinence, erectile, and bowel dysfunction, and 1 on loneliness/social isolation following PCa diagnosis. All models showed moderate to high data annotation/extraction accuracy compared with the gold standard method of manual data extraction by chart review. Despite their potential, NLPs face challenges in handling ambiguous, institution-specific language and context nuances, leading to occasional inaccuracies in clinical data interpretation. Conclusion: NLP-based data extraction has effectively extracted various outcomes from PCa patients' EHRs. It holds the potential for automating outcome monitoring and data collection, resulting in time and labor savings.

The Right to Request Flexible Working: Evidence from Employment Tribunal Judgments

Abstract This study examines five years of Employment Tribunal judgments on flexible working requests and uses a thematic analysis to identify the issues that have been litigated and to assess how employment tribunals, employees and employers have navigated the Act’s provisions. Whilst the right to request flexible working has been much critiqued because of its limited nature, there is little evidence and discussion of whether it provides a useable and effective process for employees and employers on its own terms. This article identifies three problems with the current legislation: employees can find it difficult to comply with the requirements for a valid statutory request, the difficulty of establishing and complying with the time limits in the legislation and finally the difficulty for tribunals in defining and applying core concepts relating to its power of review over employers’ decisions. These issues will not be resolved through the new Employment Relations (Flexible Working) Act 2023 and in some ways will be made more difficult.

The Risk Of Waiting Up To One Year For Cardiac Surgery.

Cardiac disease is associated with a risk of death, both by the cardiac condition and by comorbidities. The waiting time for surgery begins with the onset of symptoms and includes referral, completion of the diagnosis and surgical waiting list (SWL). This study was conducted during the COVID-19 pandemic, which affected surgical capacity and patients' morbidities. The cohort includes 1914 consecutive adult patients (36.6% women, mean age 67 ±11 years), prospectively registered in the official SWL from January 2019 to December 2021. We analyzed waiting times ranging from 4 days to one year to exclude urgencies and outliers. Priority was classified by the national criteria for non-oncologic or oncology surgery. During the study period, 74% of patients underwent surgery, 19.2% were still waiting, and 4.3% dropped out. Most cases were valvular (41.2%) or isolated bypass procedures (34.2%). Patients were classified as non-priority in 29.7%, priority in 61.8%, and high priority in 8.6%, with significantly different SWL mean times between groups (p<0.001). The overall mean waiting time was 167 ± 135 days. Mortality on SWL was 2.5%, or 1.1 deaths per patient/weeks. There were two mortality independent predictors: age (HR 1.05) and the year 2021 versus 2019 (HR 2.07) and a trend toward higher mortality in priority patients versus non-priority (p=0.065). The overall risk increased with time with different slopes for each year. Using the time limits for SWL in oncology, there would have been a significant risk reduction (p=0.011). The increased risk observed in 2021 may be related to the pandemic, either by increasing waiting time or by direct mortality. Since risk stratification is not entirely accurate, waiting time emerges as the most crucial factor influencing mortality, and implementing stricter time limits could have led to lower mortality rates.

Relaxation Time Limits of Subsonic Steady States for Hydrodynamic Model of Semiconductors with Sonic or Nonsonic Boundary

Relaxation Time Limits of Subsonic Steady States for Hydrodynamic Model of Semiconductors with Sonic or Nonsonic Boundary

Does Timed Testing Affect the Interpretation of Efficiency Scores?—A GLMM Analysis of Reading Components

AbstractThe efficiency of cognitive component skills is typically assessed with speeded performance tests. Interpreting only effective ability or effective speed as efficiency may be challenging because of the within‐person dependency between both variables (speed‐ability tradeoff, SAT). The present study measures efficiency as effective ability conditional on speed by controlling speed experimentally. Item‐level time limits control the stimulus presentation time and the time window for responding (timed condition). The overall goal was to examine the construct validity of effective ability scores obtained from untimed and timed condition by comparing the effects of theory‐based item properties on item difficulty. If such effects exist, the scores reflect how well the test‐takers were able to cope with the theory‐based requirements. A German subsample from PISA 2012 completed two reading component skills tasks (i.e., word recognition and semantic integration) with and without item‐level time limits. Overall, the included linguistic item properties showed stronger effects on item difficulty in the timed than the untimed condition. In the semantic integration task, item properties explained the time required in the untimed condition. The results suggest that effective ability scores in the timed condition better reflect how well test‐takers were able to cope with the theoretically relevant task demands.

Microscopic insights on liquid–vapor phase change phenomena of R1336mzz(Z) nanofilm through molecular dynamics simulations

The ever-growing advances in electronics pose a critical cooling challenge. Two-phase heat transfer technology, with effective heat removal and no extra energy consumption, is emerging as a potential solution for sustainable thermal management. However, questions regarding phase change mechanisms are seemingly not addressed yet due to the limitation in time and space scales. In this work, a series of molecular dynamics simulations are performed where the R1336mzz(Z) liquid film rests over a smooth copper substrate. The molecular system starts with a nanofilm thickness of 4–10 nm and then is subjected to non-equilibrium heating (350, 400, 450, and 500 K) to initiate liquid-to-vapor phase change. Depending on the impacts of film thickness and wall temperature, four distinctive phase change scenarios are identified, i.e., diffusive evaporation, pseudo-diffusive evaporation, explosive boiling, and stable explosive boiling. The characteristics of these phase change modes are explicated from the perspectives of molecular motion, vaporization rate, temperature evolution, heat flux, and interfacial resistance. The phase change mode has a strong dependence on two aspects: improving heat transfer to breakup potential barrier and slowing energy dissipation to support formation of bubble embryos. The insight may deliver better understandings of phase change mechanism and applications of liquid refrigerants.

What Is Rural Well‐Being and How Is It Measured? An Attempt to Order Chaos*

AbstractWhile a substantial body of literature has been built on rural well‐being, due to the great heterogeneity of rural territories, the literature is highly fragmented, even contradictory. Moreover, no systematic review of the entire domain exists to guide rural decision‐makers. Debated conceptualization, contradicting results, and pressing policy requirements make it timely to deliver a systematized state‐of‐the‐art on rural well‐being to anchor public policies in the rural development domain. By systematically reviewing the scholarly literature on rural well‐being and all documents developed by government and private entities that academia highlighted as relevant to this subject, the study provides a bibliometric and thematic analysis of the domain without a time limit. Thirty‐three rural well‐being dimensions and over 9,000 indicators within these dimensions have been identified, their interconnections established and their relevance to international development goals highlighted. The study presents the structure and content of this indicator database and provides suggestions for rural researchers and policymakers on how to use it to build their own well‐being framework. It also provides an overview of each rural well‐being dimension by discussing the key theories, the main inconsistencies, the most relevant studies and authors, the fundamental measurement frameworks, and the indicators used.

Optimization of Reduction Time for Chemically Synthesized rGO

Introduction: This article presents structural and morphological analysis for graphene oxide (GO) synthesized via Hummers' method and for reduced Graphene Oxide (rGO) prepared by chemical reduction. Graphene Oxide is synthesized from graphite powder at room temperature. Hydrazine hydrate is used as a reducing agent to reduce the accumulated GO. Method: To understand the impact of reduction time on structural parameters of produced rGO, three different time limits, i.e. 4, 5, and 6 hrs at 800 °C are used. FTIR spectra show the presence of all functional groups to confirm the authenticity of rGO samples. The XRD peaks are utilized to calculate different structural parameters for all the samples to identify the effect of reduction time. A change in the band gap energy may be noticed from UV-Vis absorption spectra. Result: It indicates that with the increase in reduction time, the absorption edge shifts to a lower wavelength value. FESEM micrographs reveal a flake-like random growth of rGO with prominent wrinkled structures, which is a signature of graphene-like 2D material. Conclusion: Hence, from the structural and absorption studies, it can be concluded that an increase in reduction time will produce smaller rGO flakes in the Hummers synthesis method.

Amputated Digit Replantations: Critical Digit Ischemia Timing, Temperature, and Other Predictors of Survival.

A common consideration for replantation success is the ischemia time following injury and the preservation temperature. A classic principle within the hand surgery community describes 12 hours of warm ischemia and 24 hours of cold ischemia as the upper limits for digit replantation; however, these limits are largely anecdotal and based on older studies. We aimed to compare survival data from the large body of literature to aid surgeons and all those involved in the replantation process in hopes of optimizing success rates. The PubMed database was queried on April 4th, 2023, for articles that included data on digit replantation survival in terms of temperature of preservation and ischemia time. All primary outcomes were analyzed with the Mantel-Haenszel method within a random effects model. Secondary outcomes were pooled and analyzed using the chi-square statistic. Statistical analysis and forest plot generation were completed with RevMan 5.4 software with odds ratios calculated within a 95% confidence interval. Our meta-analysis identified that digits preserved in cold ischemia for over 12 hours had significantly higher odds of replantation success than the amputated digits replanted with 0-12 hours of warm ischemia time (P ≤ 0.05). The odds of survival in the early (0-6 hours) replantation group were around 40% greater than the later (6-12 hours) replantation group (P ≤ 0.05). Secondary outcomes that were associated with higher survival rates included a clean-cut amputation, increased venous and arterial anastomosis, a repair that did not require a vein graft, and replants performed in nonsmokers (P ≤ 0.05). Overall, these findings suggest that when predicting digit replantation success, time is of the essence when the digit has yet to be preserved in a cold environment. This benefit, however, is almost completely diminished when the amputated digit is appropriately maintained in a cold environment soon after injury. In conclusion, our results suggest that there is potential for broadening the ischemia time limits for digit replant survival outlined in the literature, particularly for digits that have been stored correctly in cold ischemia.

On the relevance of weak measurements in dissipative quantum systems

We investigate the impact of dissipation, including energy relaxation and decoherence, on weak measurements. While weak measurements have been successful in signal amplification, dissipation can compromise their usefulness. More precisely, we show that in systems with a unique steady state, weak values always converge to an expectation value of the measured observable as dissipation time tends to infinity, in contrast to systems with multiple steady states, where the weak values can remain anomalous, i.e. outside the range of eigenvalues of the observable, even in the limit of an infinite dissipation time. In addition, we propose a method for extracting information about the dissipative dynamics of a system using weak values at short dissipation times. Specifically, we explore the amplification of the dissipation rate in a two-level system and the use of weak values to differentiate between Markovian and non-Markovian dissipative dynamics. We also find that weak measurements operating around a weak atom-cavity coupling can probe the atom dissipation through the weak value of non-Hermitian operators within the rotating-wave approximation of the weak interaction.

Towards an Acoustically Accessible Campus: A Case Study of the Acoustic Conditions of an Australian University

AbstractUniversity is an important stage of learning for students, so it is vital that higher education spaces are acoustically accessible to all and are places that promote equity and inclusion. The aim of this study was to measure the unoccupied noise levels and reverberation times of all of the classrooms in a typical Australian university to assess acoustic accessibility with a view to planning for a more accessible campus. A total of 166 classrooms were measured and categorised into good, ok, and poor classrooms according to the Macquarie University (MQU) Design Guidelines Review Performance Standards. Regarding unoccupied noise levels, 52% of classrooms were within the recommended &lt; 35 dBA limit. Regarding reverberation times, 65% of classrooms were within the recommended 0.4–0.6 s limit. Finally, 40% of classrooms met both the noise level and reverberation time limit. The plans at the university to incorporate these findings to make the campus more acoustically accessible are discussed, as well as future research avenues so that all students and teachers can flourish.

The impact of time between surgery and adjuvant chemoradiotherapy in advanced oral cavity squamous cell carcinoma

ObjectiveIn advanced oral squamous cell carcinoma (OSCC), adjuvant therapy (AT) is an important part of the treatment to ensure extended locoregional control after primary surgical resection. The impact of the time interval between surgery and AT on the oncological prognosis remains unclear, particularly in high-risk constellations. The aim of this study is to categorize treatment delays and to determine their impact on the oncological prognosis within the context of the histopathological risk parameters of patients with advanced OSCC.MethodsIn this single-institutional retrospective cohort study, all patients treated for OSCC between 2016 and 2021 and who received postoperative chemoradiation (POCRT) were included. Patients were divided into two groups: Group I: ≤ 6 weeks between surgery and POCRT; and Group II: &amp;gt; 6 weeks between surgery and POCRT.ResultsOverall, 202 patients were included (Group I: 156 (77.2%) vs. Group II: 46 (22.8%)). There were no statistically significant differences in epidemiological aspects and histopathological risk factors between the two groups. The maximum time to initiation of POCRT was 11 weeks. Delayed POCRT initiation had no statistically significant influence on the 5-year OS (61.6% vs. 57.3%, p = 0.89), locoregional control rate (38.6% vs. 43.3%, p = 0.57), and RFS (32.3% vs. 30.4%, p = 0.21). On multivariate analysis, extracapsular spread (HR: 2.21, 95% CI: 1.21 – 4.04, p = 0.01) and incomplete surgical resection (HR: 2.01, 95% CI: 1.10 – 3.69, p = 0.02) were significantly correlated with OS. For RFS, ECS (HR: 1.82, 95% CI: 1.15 – 2.86, p = 0.01), incomplete resection (HR: 1.67, 95% CI: 1.04 – 2.71, p = 0.04), and vascular infiltration of the tumor (V-stage; HR: 2.15, 95% CI: 1.08 – 4.27, p = 0.03) were significant risk predictors.ConclusionDelays in POCRT initiation up to 11 weeks after surgical resection for advanced OSCC were not statistically significantly associated with impaired survival. In cases of prolonged surgical treatment due to management of complications, a small delay in AT beyond the recommended time limit may be justified and AT should still be pursued.

An enhanced exact algorithm for the multi-trip vehicle routing problem with time windows and capacitated unloading station

This paper introduces a vehicle routing problem that simultaneously considers multiple trips, time windows, and a capacitated unloading station. This problem is a generalization of the multi-trip vehicle routing problem with time windows, which determines a set of least-cost vehicle routes to fulfill all customer demands while respecting the constraints of vehicle capacity and time windows. Due to restricted resources (e.g., equipment and labor force) at the depot, vehicles may need to wait in a queue for being unloaded when they arrive. This unloading capacity constraint significantly complicates the problem, as it causes a trip to involve three stages—traveling, waiting, and unloading. We formulate this problem as an arc flow model and a trip-based set partitioning model, where the latter is solved by a branch-price-and-cut (BPC) algorithm. To improve the computational aspect of the BPC framework, a two-phase column generation (CG) algorithm is designed. First, a bidirectional labeling algorithm is tailored to solve the pricing problem, where two accelerating strategies are employed to speed up the resolution process. Meanwhile, k-path inequalities and limited-memory subset row inequalities are utilized to tighten the linear relaxation of the master problem. Computational results based on the instances adapted from the well-known Solomon’s benchmark show that the developed BPC algorithm can solve most instances within 50 customers to optimality in a short time frame and some instances of 100 customers to optimality within a 3-hour time limit. Moreover, our BPC algorithm performs better than exact algorithms in the literature for similar problem variants in both solution quality and computing time.

A bibliometric exploration of infographics as tools for visual literacy in education

The purpose of this paper is to examine how infographics are used in the dynamics of designing or creating in the teaching and learning process. Utilising a bibliometric approach and content analysis, we examined a sample of 760 documents from the Web of Science and Scopus databases with no lower time limit until November 2023. The analyses aimed to identify trends, including main topics, authors, sources, most cited articles, institutional affiliations, and countries in the literature. This bibliometric approach allows for the observation of trends in the educational application of promoting visual literacy through students’ design or creation of infographics in formal and informal learning settings. Initial publications emerged in 2007, gaining momentum from 2014 to the present. The most prolific fields were medical science, chemistry, and computer science. This investigation shows that educational institutions could employ infographics beyond present boundaries to prepare students—particularly Generation Alpha, digital natives—for a data-driven society. Institutions should expand their use of infographics to improve visual literacy and address the changing educational requirements of students in a dynamic learning environment. Overall, this paper provides insights into the readiness of educators and institutions to engage Generation Alpha, the digital natives, through visual literacy and infographics.

The impact of environmental regulation on firms’ markups: evidence from China

ABSTRACT A comprehensive evaluation of the costs and benefits of environmental regulations provides empirical evidence for policymakers to formulate and introduce environmental policies. Firms’ profitability and competitiveness manifest their market power and provide the micro foundation for economic development and social stability. Therefore, this paper focus on investigating the impact of air pollution environmental regulation on manufacturing firms’ market power, measured by markups, with a difference-in-differences (DID) method. Using air pollution control policy, requiring China’s Key Cities for Air Pollution Control (KCAPC) to meet air quality standards within a specified time limit as a natural experiment, our DID estimations show that air pollution regulation significantly leads to an increase in firms’ markup rate by 0.002 in key cities that did not meet air quality standards. Heterogeneous effects show that this impact is larger for polluting firms, private-owned and foreign-owned firms, and firms located in western and central cities and cities with high marketization. Productivity and market share may be two main influencing channels to explain the positive impact of air pollution environmental regulation on firms’ markups. Our findings suggest that strengthening environmental regulation is conducive to improving the competitiveness and market power of manufacturing firms, lending support to the enforcement of environmental regulations.

Short- and Long-Term Outcomes of Suboptimal Medication Adherence in Adolescents with Attention-Deficit/Hyperactivity Disorder: A Systematic Literature Review.

Introduction: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition with severe and life-long consequences. Adolescents and young adults represent a particularly vulnerable subgroup because of the unique demands of their developmental stage. Despite the well-known efficacy of medication treatment for ADHD, there remains a notable concern regarding poor medication adherence in this population. Objectives: This systematic literature review aimed to synthesize the existing empirical evidence on the outcomes and consequences of medication nonadherence among adolescents and young adults with ADHD. Methods: An extensive database search was conducted on September 26, 2022, with no time limits applied. The databases included Scopus, PubMed, CINAHL, Cochrane, and PsycINFO. Results: Six studies met the inclusion criteria. Each study revealed that medication nonadherence was associated with a range of adverse outcomes, including decreased academic performance, heightened familial, and psychological stress, and an increased likelihood of substance use, pregnancy, obesity, and injury. Conversely, adherence led to improvements in at least one ADHD-related outcome. Conclusions: Research exploring the consequences of suboptimal medication adherence in adolescents and young adults with ADHD is currently limited, and effective strategies to address this issue remain scarce. A thorough understanding of such consequences is critical for developing interventions aimed at improving medication adherence and mitigating the risk of adverse outcomes, especially considering the susceptibility of this population.