Measured Time Constants Research Articles

Enhancing interfacial Li+ transport and dielectric properties in poly(ethylene oxide)-based all-solid electrolytes via inactive g-C3N4 nanosheets filler incorporation

The advancement of all-solid-state Li metal batteries (ASSLMBs) faces a major challenge in the growth of lithium dendrites on the anode-electrolyte interface. In this study, we propose a dual-filler approach using poly(ethylene oxide) (PEO)-based solid polymer electrolytes (SPEs) that combine Li1.4Al0.4Ti1.6(PO4)3 (LATP) ion-conductive particles with graphitic carbon nitride (g-C3N4) nanosheets. Analysis through second harmonic resonance enhanced electrostatic force microscopy and critical current density (CCD) tests reveal that the g-C3N4 additives form nano-capacitors at the SPE-lithium interface, effectively reducing sudden changes in current densities. The distribution of relaxation time constant (DRT) measurements confirms that the g-C3N4 filler suppresses uncontrolled Li dendrite growth, effectively mitigating battery aging caused by anode interfacial degradation. Furthermore, X-ray photoelectron spectroscopy (XPS) analysis indicates that the nitrogen-containing organic groups in g-C3N4 are reduced to form a stable interfacial layer with lithium metal. As a result of these enhancements, the electrolyte demonstrates remarkable interfacial stability in Li/Li symmetrical cells at 0.65 mA/cm2 and delivers promising performance in assembled Li-LiFePO4 batteries, achieving a reversible capacity of 121.6 mAh/g at 1 C after 200 cycles. These findings highlight the potential of dual-filler PEO-based SPEs for promoting interfacial lithium-ion transport in all-solid-state Li metal batteries.

Abstract P2078: Vasohibin Inhibition Improves Myocardial Relaxation In A Rodent Model Of Heart Failure With Preserved Ejection Fraction

Heart failure with preserved ejection (HFpEF) is a complex syndrome with few therapies available to patients. Diastolic dysfunction is a common clinical feature among HFpEF patients, and strategies to mitigate impaired relaxation may have a therapeutic benefit. Recognizing that increased stabilization of the microtubule network induced by detyrosination of α-tubulin contributes to increased cardiomyocyte stiffness ex vivo , we explored if inhibition of detyrosination with a small molecule vasohibin inhibitor (VASHi) could improve in vivo diastolic function in obese/hypertensive (ob) ZSF1 rats, compared to lean/hypertensive ZSF1 and non-hypertensive Wistar Kyoto (Wky) rats as controls. Animals received two intravenous injections of VASHi (6.6mg/kg) or vehicle (veh) at 30 weeks old, when ob have a HFpEF phenotype. Echocardiography and invasive hemodynamics were performed after the first and second injection, respectively. Compared to ob veh-treated animals, ob VASHi-treated animals had a significant improvement in invasively measured time constant of early LV relaxation, tau (veh: 14.73ms ± 0.73 vs. VASHi: 11.02ms ± 0.45; P < 0.05) and echo-derived deceleration time of early LV filling, indicative of improved early relaxation (Fig. A, B). VASHi improved early relaxation in cardiomyocytes isolated from non-failing (NF, N=3) and failing (HF, N=4) human hearts (Fig. C), providing the first evidence of small molecule VASHi improving human myocyte function. These studies indicate that excess detyrosination contributes to impaired early myocyte and myocardial relaxation in a clinically relevant HFpEF model and supports a potential therapeutic role for VASHi in HFpEF.

Strength-duration time constant and rheobase measurements: Comparison of the threshold tracking method and a manual procedure

ObjectiveTo compare the strength-duration time constant (SDTC) and rheobase measurements obtained by the threshold tracking method (TT) and by a non-automated method (MM). MethodsThe MM procedure involved measuring, using a routine electrodiagnostic device, the intensity required to evoke a motor response whose amplitude corresponds to 40% of the maximum amplitude for four stimulus duration (1.0, 0.7, 0.5, 0.2 ms), and studying the linear relationship between stimulus charge and stimulus duration (slope = rheobase, intercept on the x-axis = SDTC). Using TT and MM, 30 successive healthy subjects (mean age = 38 years old) underwent a prospective evaluation of SDTC and rheobase of the median nerve motor axons at the wrist. Nerve stimulation and bipolar recording of evoked motor responses were performed with disposable self-adhesive surface electrodes. ResultsThe Spearman correlations between the two methods were 0.78 (p < 0.0001) for SDTC and 0.96 (p < 0.0001) for the rheobase. The Bland-Altman analysis did not reveal any systematic bias of MM compared to TT. ConclusionsThe MM procedure was reliable for strength-duration relationship analysis. SignificanceWe encourage neurophysiologists, who do not have dedicated threshold tracking equipment, not to hesitate to use these simple tools to assess peripheral nerve excitability.

N°43 – Strength-duration time constant and rheobase measurements: Comparison of the threshold tracking method and a non-automated procedure

N°43 – Strength-duration time constant and rheobase measurements: Comparison of the threshold tracking method and a non-automated procedure

Dependence of cortical neuronal strength-duration properties on TMS pulse shape

ObjectiveThe aim of present study was to explore the effects of different combinations of transcranial magnetic stimulation (TMS) pulse width and pulse shape on cortical strength-duration time constant (SDTC) and rheobase measurements. MethodsResting motor thresholds (RMT) at pulse widths (PW) of 30, 45, 60, 90 and 120 µs and M−ratios of 0.2, 0.1 and 0.025 were determined using figure-of-eight coil with initial posterior-to-anterior induced current. The M−ratio indicates the relative phases of the induced current with lower values signifying a more unidirectional stimulus. Strength-duration time constant (SDTC) and rheobase were estimated for each M−ratio and various PW combinations. Simulations of biophysically realistic cortical neuron models assessed underlying neuronal populations and physiological mechanisms mediating pulse shape effects on strength-duration properties. ResultsThe M−ratio exerted significant effect on SDTC (F(2,44) = 4.386, P = 0.021), which was longer for M−ratio of 0.2 (243.4 ± 61.2 µs) compared to 0.025 (186.7 ± 52.5 µs, P = 0.034). Rheobase was significantly smaller when assessed with M−ratio 0.2 compared to 0.025 (P = 0.026). SDTC and rheobase values were most consistent with pulse width sets of 30/45/60/90/120 µs, 30/60/90/120 µs, and 30/60/120 µs. Simulation studies indicated that isolated pyramidal neurons in layers 2/3, 5, and large basket-cells in layer 4 exhibited SDTCs comparable to experimental results. Further, simulation studies indicated that reducing transient Na+ channel conductance increased SDTC with larger increases for higher M−ratios. ConclusionsCortical strength-duration curve properties vary with pulse shape, and the modulating effect of the hyperpolarising pulse phase on cortical axonal transient Na+ conductances could account for these changes, although a shift in the recruited neuronal populations may contribute as well. SignificanceThe dependence of the cortical strength-duration curve properties on the TMS pulse shape and pulse width selection underscores the need for consistent measurement methods across studies and the potential to extract information about pathophysiological processes.

RC-to-Digital Converter Using Single-Slope Integration With Bisection of the Reference Voltage

An <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">RC</i> -to-digital converter (RCDC) for the measurement of the <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">RC</i> time constant of the resistor and capacitor connected in series is presented in this paper. A simple RCDC design insensitive to the parasitic capacitances is based on the single-slope integration. The output voltage of the integrator is linearly changed from half the value of the reference voltage to its final value. The <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">RC</i> time constant is equal to the duration of the single-slope integration, and is independent of any other parameter. The proposed RCDC has been prototyped using discrete off-the-shelf components mounted on a printed circuit board, with a single supply voltage of 2.7 V. Measurements have been performed for 36 different combinations of the resistors and capacitors connected in series, where the measured time constant is in the range 45.77 μs < <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">RC</i> < 2.32 ms, for three different reference voltages. Achieved relative error is smaller than 1.96 % for the largest reference voltage used.

Near‐Field Thermal Profiling and 3D Anisotropic Thermal Analysis of Quantum Cascade Lasers

The development of a scanning near‐field optical microscopy (SNOM) method with high temperature and spatial resolution to probe the thermal behavior of quantum cascade lasers (QCLs) is reported. Specifically, thermal profiling of InGaAs/InAlAs/InP buried heterostructure (BH) mounted epi‐layer side down QCLs is performed. The findings are verified by 3D anisotropic thermal analysis of QCLs with anisotropic thermal conductivities in the superlattice active region. Good agreement is observed between the simulated and the measured time constants. Within this design, various realistic device configurations, such as overhanging the laser chip on the submount and placing different dielectric coatings on the front facet, are considered. Analytical studies of the steady‐state thermal performance of QCL arrays compared to an isolated QCL are demonstrated for high‐power requirements with minimal thermal damage and future application in spectroscopic devices.

Measurements of Coupling Time Constants and Geometry Factors of Coupling Losses in Spiral Copper-Plated Multifilament Coated Conductors

Spiral geometry is effective to reduce coupling time constants of copper-plated multifilament coated conductors. We wound copper-plated multifilament coated conductors with various specifications spirally on round cores, and measured their magnetization losses in a wide range of frequency to determine their coupling time constants as well as the geometry factors of coupling losses. The core diameter was decreased down to 2.5 mm in order to show the feasibility of such conductors with reasonably high overall current density. The influence of various conductor parameters such as copper thickness, conductor width, and number of striations (filament width) as well as core diameter on coupling time constants and geometry factors were studied. By using the obtained coupling time constants and geometry factors, we calculated coupling losses of various conductors, whereas we calculated their hysteresis losses by using Brandt and Indenbom's formulae. These calculated hysteresis losses and coupling losses were compared with measured magnetization losses for various conductors.

An Inquiry Approach to Effective Use of Instrumentation: An Example from RC Circuits

In this article, we present an intriguing experimental exercise that does not fall foul of improper use of instrumentation. The activity is designed as an electronics exercise where the role of the instruments in the measurement of the RC time constant is considered. Essentially, we study the accuracy and precision of a measurement of the RC time constant in a series circuit with an oscilloscope as a function of the value of the resistor, against the predicted linear model of τ = RC. As the value of the resistor approaches the value of the impedance of the oscilloscope, the time constant deviates from the linear model. We show how to adapt the model to account for this and create a mathematical model that agrees with the measurements. It is hoped that such an exercise will solidify a rule of effective use of oscilloscopes—that the resistance of the circuit should be much lower than the impedance of the scope—in the mind of the student.

Programmed Multi-Level Ventilation: A Strategy for Ventilating Non-Homogenous Lungs.

Mechanical ventilation (MV) has been an integral method used in ICU care for decades. MV is typically viewed as a life-supporting intervention. However, it can also contribute to lung injury through stress and strain, as evidenced by ventilator-induced lung injury (VILI), even in previously healthy lungs. The negative impact may be worsened when significant lung non-homogeneity is present, eg. ALI and ARDS. Protective lung strategies to minimize VILI are to use low tidal volumes (Vt 4–6 mL/kg/PBW), plateau pressures (Pplat) <30 cmH2O and relatively high positive end-expiratory pressures (PEEP). Yet, use of constantly high PEEP levels is well recognized to result in hemodynamic compromise of the right ventricle, increased stress and strain through high mechanical energy impact on the lung and overdistension of relatively healthy lung tissue. Taking these issues into consideration, a different approach to mechanical ventilation was developed specifically for patients with non-homogeneity. This review focuses on a feature called programmed multi-level ventilation (PMLV). It is not a ventilation mode per se, but rather a form of extension that adjusts and modifies any ventilation mode (eg PCV,PSV, VCV, SIMV, etc.). PMLV is based on measured time constants (Tau) of the whole respiratory system, including artificial airways, breathing circuits, humidification devices and mechanical ventilator. Using a physiology-based approach presents a method to ventilate non-homogenous lungs through cyclic changes of different PEEP levels; recruitment takes place in lung areas with long time constants but protects relatively healthy lung areas from overdistension thus minimizing excessive mechanical power to the lung tissue.

Monitoring of Dynamic Plantar Foot Temperatures in Diabetes with Personalised 3D-Printed Wearables.

Diabetic foot ulcers (DFUs) are a life-changing complication of diabetes that can lead to amputation. There is increasing evidence that long-term management with wearables can reduce incidence and recurrence of this condition. Temperature asymmetry measurements can alert to DFU development, but measurements of dynamic information, such as rate of temperature change, are under investigated. We present a new wearable device for temperature monitoring at the foot that is personalised to account for anatomical variations at the foot. We validate this device on 13 participants with diabetes (no neuropathy) (group name D) and 12 control participants (group name C), during sitting and standing. We extract dynamic temperature parameters from four sites on each foot to compare the rate of temperature change. During sitting the time constant of temperature rise after shoe donning was significantly (p < 0.05) faster at the hallux (p = 0.032, 370.4 s (C), 279.1 s (D)) and 5th metatarsal head (p = 0.011, 481.9 s (C), 356.6 s (D)) in participants with diabetes compared to controls. No significant differences at the other sites or during standing were identified. These results suggest that temperature rise time is faster at parts of the foot in those who have developed diabetes. Elevated temperatures are known to be a risk factor of DFUs and measurement of time constants may provide information on their development. This work suggests that temperature rise time measured at the plantar surface may be an indicative biomarker for differences in soft tissue biomechanics and vascularisation during diabetes onset and progression.

Broadband adiabatic inversion experiments for the measurement of longitudinal relaxation time constants.

Accurate measurements of longitudinal relaxation time constants (T1) in solid-state nuclear magnetic resonance (SSNMR) experiments are important for the study of molecular-level structure and dynamics. Such measurements are often made under magic-angle spinning conditions; however, there are numerous instances where they must be made on stationary samples, which often give rise to broad powder patterns arising from large anisotropic NMR interactions. In this work, we explore the use of wideband uniform-rate smooth-truncation pulses for the measurement of T1 constants. Two experiments are introduced: (i) BRAIN-CPT1, a modification of the BRAIN-CP (BRoadband Adiabatic-INversion-Cross Polarization) sequence, for broadband CP-based T1 measurements and (ii) WCPMG-IR, a modification of the WURST-CPMG sequence, for direct-excitation (DE) inversion-recovery experiments. A series of T1 constants are measured for spin-1/2 and quadrupolar nuclei with broad powder patterns, such as 119Sn (I = 1/2), 35Cl (I = 3/2), 2H (I = 1), and 195Pt (I = 1/2). High signal-to-noise spectra with uniform patterns can be obtained due to signal enhancements from T2 eff-weighted echo trains, and in favorable cases, BRAIN-CPT1 allows for the rapid measurement of T1 in comparison to DE experiments. Protocols for spectral acquisition, processing, and analysis of relaxation data are discussed. In most cases, relaxation behavior can be modeled with either monoexponential or biexponential functions based upon measurements of integrated powder pattern intensity; however, it is also demonstrated that one must interpret such T1 values with caution, as demonstrated by measurements of T1 anisotropy in 119Sn, 2H, and 195Pt NMR spectra.

The reliability of VO2 kinetics during a 6-minute walking test is influenced by walk speed.

[Purpose] This study aimed to investigate the reliability of time constant measurements of oxygen intake at fast and comfortable speeds during a 6-min waling test. [Participants and Methods] The study included 10 healthy young males who walked at 4.5 km/h and 6.0 km/h twice for 6 min each in speed treadmill. Breath-by-breath gas exchange data were continuously measured and used to calculate the time constant of oxygen uptake. The reproducibility and variability of the variables were verified using the limit of agreement, inter-class correlation coefficient, coefficient of variation, and standard error of measurement. [Results] The limit of agreement was −8.5 to 2.3 s and −3.9 to 2.1 s for speeds 4.5 km/h and 6.0 km/h, respectively. The inter-class correlation coefficient, coefficient of variation, and standard error of measurement of the time constant for both speeds were 0.52 and 0.83, 11.2% and 6.4%, and 5.3 s and 1.8 s, respectively. [Conclusion] The results of this study suggested that the cardiopulmonary response, in terms of oxygen uptake, was more consistent during fast walking than during comfortable walking in a 6-min walking test with constant speed.

Unassisted N-acetyl-phenylalanine-amide transport across membrane with varying lipid size and composition: kinetic measurements and atomistic molecular dynamics simulation

Biological membranes are essential to preserve structural integrity and regulate functional properties through the permeability of nutrients, pharmaceutical drugs, and neurotransmitters of a living cell. The movement of acetylated and amidated phenylalanine (NAFA) across 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membrane bilayers is investigated to probe physical transport. The rate of transport is measured experimentally applying parallel artificial membrane permeation assay (PAMPA). At the physiological temperature, 310 K, the measured time constants in the neutral pH were ∼6 h in DOPC and ∼3 h in POPC, while in a more acidic condition, at a pH 4.8, the time constants were ∼8 h in both lipids. Computationally, we have expanded our transport study of three aromatic dipeptides across a bilayer composed of DOPC18. In this study, we have examined the effects of lipid composition and bilayer size on the passive transport of NAFA by simulating the dipeptide in three different bilayers, with 50 DOPC lipids, 50 POPC lipids, and 40 POPC molecules. Specifically, atomistic molecular dynamics simulations with umbrella sampling were used to calculate the potential of mean force for the passive permeation of NAFA across the bilayers. Diffusion constants were then calculated by numerically solving the Smoluchowski equation. Permeability coefficients and mean first passage times were then calculated. Structural properties – Ramachandran plots, sidechain torsions, peptide insertion angles, radial distribution functions, and proximal peptide water molecules – were also examined to determine the effect of system size and lipid type. In terms of systems size, we observed a small decrease in the highest barrier of the potential of mean force and fewer sampled sidechain dihedral angle conformations with 40 versus 50 POPC lipids due to weaker membrane deformations within a smaller lipid bilayer. In terms of lipid type, DOPC contains two monounsaturated acyl chains compared to only one such acyl chain in POPC; therefore, DOPC bilayers are less ordered and more easily deformed, as seen by a much broader potential of mean force profile. The NAFA in DOPC lipid also transitioned to an internally hydrogen-bonded backbone conformation at lower membrane depths than in POPC. Similarly, as for other aromatic dipeptides, NAFA tends to insert into the membrane sidechain-first, remains mostly desolvated in the membrane center, and exhibits slow reorientations within the bilayer in both DOPC and POPC. With a joint experimental and computational study we have gained a new insight into the rate of transport and the underlying microscopic mechanism in different lipid bilayer conditions of the simplest hydrophobic aromatic dipeptide. Communicated by Ramaswamy H. Sarma

Study of Temporal Thermal Response of Microfiber Bragg Grating

Fiber Bragg grating has been successfully fabricated in the silica microfiber by the use of femtosecond laser point-by-point inscription. Temporal thermal response of the fabricated silica microfiber Bragg grating has been measured by the use of the CO2 laser thermal excitation method, and the result shows that the time constant of the microfiber Bragg grating is reduced by an order of magnitude compared with the traditional single-mode fiber Bragg grating and the measured time constant is ~ 21ms.

Coupling Time Constant Measurements of Spirally-Twisted Striated Coated Conductors With Finite Transverse Conductance Between Filaments

Striation is effective for AC loss reduction of coated conductors, but it must be associated with twisting. Instead of direct twisting like in low Tc metallic superconductors, we spirally-twisted “striated and copper-plated coated conductor”, in which filaments are electrically connected. The thickness of the plated-copper was varied to examine its influence on filament decoupling. The magnetization losses of these conductors were measured along a transverse magnetic field with a small amplitude, where the coupling loss was dominant. From the frequency dependence of the measured magnetization loss, the coupling time constants of samples with different copper thicknesses, different spiral pitches, and different core diameters were determined. This study demonstrates filament decoupling by spiral twisting the striated and copper-plated coated conductors.

A measurement of the scintillation decay time constant in liquid xenon with the XMASS-I detector

The scintillation decay time constant in liquid xenon was measured using the XMASS-I detector and its calibration setup. The scintillation decay time constants of both electron recoil and nuclear recoil were evaluated by comparing the observed photon detection times with Monte Carlo simulations. Two exponential components, corresponding to the singlet and triplet state of the xenon excited dimer, are needed to reproduce the observed photon detection times. In this paper, we report the measurement of the electron recoil and the nuclear recoil scintillation decay time constants with the XMASS-I detector.

The iPad as a virtual oscilloscope for measuring time constants in RC and LR circuits

In a university introductory physics laboratory, the measurement of time constants in RC and LR circuits usually employ a conventional oscilloscope. The standard oscilloscope with its many knobs and switches often intimidate first-time users and can cause anxiety especially among non-physics and non-engineering majors. On the other hand, an iPad has a more familiar, less intimidating and friendlier touch-pad interface. We report our experience in using the iPad as a virtual oscilloscope in an introductory algebra-based physics laboratory course. We used a commercial electronic accessory called Oscium iMSO that turns the iPad into a virtual oscilloscope. Using blind surveys and direct observation, we report student responses to this pedagogical tool.

Elastic, inelastic and time constant measurement for M102 (AL–C–O) dispersions-reinforced aluminum alloys

Purpose. To conduct an experimental study on M102 aluminum alloy bulk content characterization under cyclic loadings for precision applications such as balance machines, optical, and laser instruments. M102 (AL-C-O) dispersion-reinforced aluminum alloy was chosen because of its ability to withstand temperatures beyond 200C and has a better strength than precipitation-hardened Al alloys at room temperature. A CNC milling machine is used to manufacture test samples with longitudinal machining directions. A constant time interval is set for the fabric a quarter-hour span, which is based on the investigation of inelastic and plastic deformations in the nanoscale. Methodology. An electromagnetic test instrument applies a tensile stress range of 10 to 145 N/mm2 to samples with particular shape. It should be noted that interferometers and capacitive sensors were used to measure all forms of deformations with and without loading. The experiments are carried out in a temperature-stable environment of 30.5 C; measurements are taken within a residual strain range of 10 microns. Findings. The results obtained show that results for inelastic deformations for samples of longitudinal cuts direction at 30.5 C were measured under 150 N/mm2 stress as 500 nm inelastic deformation and 100 nm plastic deformation were measured, which is much higher than aluminum alloy studied before at room temperature (20 C). Furthermore, it was found that the time constant of the M102 (ALCO) aluminum alloy samples was double times higher than that for other samples, Originality. For the first time, a study has been conducted on inelastic and plastic deformations in the nanoscale for characterization of M102 aluminum alloy bulk content under cyclic loadings for precision applications. Practical value. One of the main factors affecting the using of other materials than steel in precision applications such as balance machines, optical, and laser instruments is measurement and determination of inelastic, plastic and time constant of the process of delamination of materials of different aluminum alloys since they are nonmagnetic, are easily machined and shaped. This will bring new products and opportunities for these materials.

Effects of supplemental oxygen on cardiovascular magnetic resonance water proton relaxation time constant measurements (T1, T2 and T2*)

ObjectiveTo study, the effects of supplemental oxygen on the measurement of native cardiovascular water proton relaxation time constants using commercially available protocols. MethodsT1, T2 and T2* relaxation time constant mapping were performed in twelve volunteers at 1.5 T breathing room air and supplemental oxygen supplied by nasal cannula and a non-rebreather mask. Regions-of-interest were drawn for quantitative measurements in the bloodpool of each ventricle and atria as well as septal myocardium. The effects of supplemental oxygen were investigated statistically using a mixed model analysis of variance. Intra- and inter-observer reproducibility were assessed using the Intraclass Correlation Coefficient and Coefficient of Variation. ResultsBlood T1 relaxation time constants in the left ventricle (T1 change = −241.0 ms) and left atrium (T1 change = −247.0 ms) decreased significantly in every subject after oxygen inhalation with a non-rebreather mask (p < 0.001). No significant changes of T1 in the right side of the heart were detected after oxygen inhalation with the non-rebreather mask (p = 0.345). Oxygen inhalation with nasal cannula did not significantly change blood T1 in the study (p = 0.497). No significant changes in myocardial T1 (p = 0.390), T2 (p = 0.960) or T2* (p = 0.438) were observed with supplemental oxygen supplied by nasal cannula or the non-rebreather mask. Results were similar in mid-short-axis and horizontal long-axis acquisitions. ConclusionSupplemental oxygen does not affect myocardial relaxation time constant measurements with current protocols. On the other hand, blood T1 measurements with the inhalation of supplemental oxygen supplied by a non-rebreather mask change significantly and could affect myocardial tissue characterization if used for the calculation of extracellular volume. Additionally, current relaxation time constant mapping protocols do not reproducibly detect myocardial T1 changes with supplemental oxygen inhalation.