Fluid flow in subsurface tight reservoirs containing pores, microcracks and macrocracks is notably influenced by the characteristics of macro/micro-cracks. A novel hybrid multiscale model is proposed to address the response of macrocracks and pores/microcracks in different spatial scales. Specifically, an equivalent macroscopic model (EMM) deduced from locally periodic representative element volume (REV) is developed using the asymptotic homogenization method to represent the poroelastic behavior of porous medium with microcracks. Simultaneously, the macrocracks are modeled explicitly using the discrete fracture model (DFM), where the hydraulic properties of cracks influenced by fluid pressure gradient is represented by the nonlinear opening/closure behavior. The obtained hybrid model takes into account the heterogeneous nature of fractured rock masses containing pores, micro/macro-cracks, which is fundamental to describe fluid flow behavior in fracture-matrix system. Specialized finite elements, regular meshing technique and adaptive time stepping algorithm are adopted to improve the computational efficiency. The hybrid multiscale model is firstly validated step by step to demonstrate the accuracy and then used to simulate fluid flow in fractured rock reservoir, shedding light on the underlying mechanisms of the enhanced flow capacity resulting from microcrack distribution, connectivity, and macrocrack stimulation.