Flooding is becoming more frequent along U.S. coastlines due to the rising impacts of fluvial and coastal flood sources, as well as their compound effects. However, we have a limited understanding of mechanisms whereby sea level rise (SLR) changes flood drivers and contributes to flood compounding. Additionally, flood mitigation studies for fluvial floodplains near tidal water bodies often overlook the potential future contribution of coastal water levels. This study investigates the role of SLR in inducing high-tide flooding (HTF) and compound flooding in a neighborhood that lies on a fluvial floodplain. Eastwick, Philadelphia, is a flood-prone neighborhood that lies on the confluence of two flashy, small tributaries of the tidal Delaware River. We develop a combined 1D-2D HEC-RAS fluvial-coastal flood model and demonstrate the model’s accuracy for low-discharge tidal conditions and the extreme discharge conditions of tropical Cyclone (TC) Isaias (2020) (e.g., Root Mean Square Error 0.08 and 0.13 m, respectively). Simulations show that Eastwick may experience SLR-induced HTF as soon as the 2060s, and the flood extent (34.4%) could become as bad as present-day extreme event flooding (30.7% during TC Isaias) as soon as the 2080s (based on 95th percentile SLR projections). Simulations of Isaias flooding with SLR also indicate a trend toward compounding of extreme fluvial flooding. In both cases the coastal flood water enters Eastwick through a different pathway, over a land area not presently included in some fluvial flood models. Our results show that SLR will become an important contributor to future flooding even in fluvial floodplains near tidal water bodies and may require development of compound flood models that can capture new flood pathways.