Xizang Research Articles

Fasciola hepatica and Fasciola hybrid form co-existence in yak from Tibet of China: application of rDNA internal transcribed spacer.

Fasciolosis is a parasitic disease affecting humans and livestock, caused by digenean trematodes of the genus Fasciola, primarily F. hepatica and F. gigantica. This study investigates the coexistence of these species and their hybrids in yaks from Tibet, China. We analyzed the nuclear rDNA internal transcribed spacer (ITS) regions, including ITS1 and ITS2, through Sanger sequencing and Next-Generation Sequencing (NGS) to assess single-nucleotide polymorphisms (SNPs). Our results reveal that one specimen (NM008B) is identical to pure F. hepatica, while another (NM008A) contains genetic information from both F. hepatica and F. gigantica, indicating potential hybridization or introgression. The morphological analysis reveals that the collected adult F. hepatica specimens exhibit distinct characteristics, while the hybrid specimens display "intermediate" features of F. hepatica and F. gigantica. This study is the first to document the coexistence of F. hepatica and hybrid Fasciola forms in a single yak. The findings underscore the complexities of hybridization dynamics and the necessity for advanced molecular techniques in accurately identifying Fasciola species. Future research should focus on mitochondrial DNA and other nuclear gene analysis to further elucidate the nature of these hybrids and their ecological implications.

Coupling Coordination Relationships Between Ecosystems and Economic Development in Qinghai and Tibet

The coordinated development of ecological protection and socioeconomics in the Tibetan Plateau is of great significance. This study examines the coupling coordination of urban ecosystems and economic development across 15 municipal administrative units in Qinghai Province and the Tibet Autonomous Region, the core areas of the Tibetan Plateau. The findings reveal that a larger proportion of the Qinghai and Tibet ecosystems are classified above the medium vulnerability level, primarily due to inherent natural geographic conditions. Additionally, the area of the two provinces and regions below the medium development level is larger, which is mainly influenced by indicators of economic strength and industrial structure. The degree of coupling coordination between the ecosystem and economic system in Qinghai and Tibet is predominantly driven by economic factors. Given the existing natural environmental conditions, the eastern regions of Qinghai and Tibet still possess certain development potential, while the economic development in the western areas is somewhat constrained by the natural environment. Based on this, further policy recommendations have been proposed to adjust and upgrade the industrial structure, aligning ecological protection with economic development in the Qinghai–Tibet Plateau. These recommendations aim to facilitate the formulation of strategies and policies for sustainable urban construction and social development in such high-ecological-value regions as the Tibetan Plateau.

Seasonal Variations of PM2.5 Pollution in the Chengdu–Chongqing Urban Agglomeration, China

During the development of the Chengdu–Chongqing Urban Agglomeration (CCUA) in China, PM2.5 pollution severely threatened public health, presenting a significant environmental challenge. This study employs a novel spatial interpolation method known as High Accuracy Surface Modeling (HASM), along with the geographical detector method, local and regional contributions calculation model, and the Hybrid Single–Particle Lagrangian Integrated Trajectory model to analyze the seasonal spatial distribution of PM2.5 concentrations and their anthropogenic driving factors from 2014 to 2023. The transport pathway and potential sources of seasonal PM2.5 concentrations were also examined. The results showed the following: (1) HASM was identified as the most suitable interpolation method for monitoring PM2.5 concentrations in the CCUA; (2) The PM2.5 concentrations exhibited a decreasing trend across all seasons, with the highest values in winter and the lowest in summer. Spatially, the concentrations showed a pattern of being higher in the southwest and lower in the southeast; (3) Industrial soot (dust) emissions (ISEs) and industry structure (IS) were the most important anthropogenic driving factors influencing PM2.5 pollution; (4) The border area between the eastern part of the Tibet Autonomous Region and western Sichuan province in China significantly contribute to PM2.5 pollution in the CCUA, especially during winter.

Three new species of the genus Oedichirus Erichson, 1839 (Coleoptera: Staphylinidae: Paederinae: Pinophilini) from China

Three new species of Oedichirus Erichson, 1839 are described: Oedichirus haishengensis Duan, Yue & Li sp. nov. from Guangxi Province, O. ovalisis Duan, Yue & Li sp. nov. from Fujian and Hainan Province, and O. tibetanus Duan, Yue & Li sp. nov. from Tibet Autonomous Region. Color plates of the habitus, antenna, abdominal segments VII–IX of the males, as well as the aedeagal structures in different views are provided. In addition, an updated key to the species and a checklist of all known species of the genus Oedichirus from China are included.

Study on the balance and gait characteristics of subjects with generalized joint hypermobility residing in high-altitude using wearable devices: a cross-sectional study

PurposeTo investigate the characteristics of balance and gait functions in Generalized Joint Hypermobility (GJH) subjects residing in high-altitude areas.MethodsThis study included 61 university students (28 with GJH and 33 healthy controls) all from the high-altitude region of Linzhi, Tibet Autonomous Region. The Riablo™ wearable intelligent rehabilitation assessment and training system was used to assess static balance (with eyes open and closed) and gait function (during flat walking) in both groups.ResultsCompared to healthy subjects, GJH subjects exhibited significantly impaired balance, indicated by an increased distance of the center of pressure position from the ideal center of gravity(EO: P = 0.007, EC: P = 0.031) and greater amplitude of center of pressure displacements (EO: P = 0.043, EC: P = 0.032). Gait velocity(P = 0.007), stride length(P = 0.012), and swing stance phase of the gait cycle(P = 0.046) were significantly reduced in GJH subjects compared to healthy subjects. A significant increase in the flat-foot phase of the gait cycle(P = 0.022) was observed in GJH subjects compared to healthy subjects.ConclusionThe current study demonstrated that GJH subjects residing in high-altitude areas exhibit impairments in balance and gait, providing a basis for training and prevention strategies tailored for this population. And this study used the wearable intelligent rehabilitation evaluation and training system in high-altitude areas, providing methodological references for scientific research on balance and gait function under non laboratory conditions.Trial registrationControlled Trials No.102772023RT133, Registered 13 October 2023.

Combined endovascular interventions for pulmonary embolism at high altitude in Tibet.

Managing pulmonary embolism (PE) at extremely high altitudes poses unique challenges due to harsh environmental conditions and limited healthcare resources. This study retrospectively analyzed Tibetan PE patients in the Tibet Autonomous Region of China to evaluate the effectiveness and safety of combined endovascular interventional therapy in high-altitude areas. The average altitude of long-term residence for Tibetan patients was 3,863.4 ± 317.4 m, with an average age of 62.0 ± 16.0 years, and the time from computed tomography pulmonary angiography (CTPA) diagnosis to interventional treatment averaged 2.8 ± 2.2 days. The operation time for these patients was 106.1 ± 22.2 min, and the intraoperative dose of alteplase used was 23.3 ± 5.0 mg. All 9 patients reported profound remission of dyspnea and chest pain after endovascular interventions. The heart rate (p < 0.05) and respiratory rate (p < 0.001) of all enrolled patients were significantly decreased, and the peripheral capillary oxygen saturation (SpO2) was significantly increased (p < 0.05) after interventions. No severe complications, such as bleeding, occurred in any patient. This study demonstrated the potential clinical benefits and feasibility of combined endovascular interventional therapy for treating acute PE in extreme high-altitude regions.

Wildlife Infection of Peste des Petits Ruminants Detected in China, 2024.

In 2013, the second outbreak of peste des petits ruminants occurred in China, leading to a spillover in more than 20 provinces and municipalities over the next few months. Thereafter, the epidemic situation was stable owing to strict prevention and control measures. In February 2024, several bharals and argali with suspected symptoms of PPR were discovered in Rutog country, Tibet Autonomous Region. Samples collected from these animals were delivered to our laboratory for diagnosis; the results of fluorescence quantitative reverse-transcription (RT) PCR indicated that all samples were positive for PPR viral RNA. The N and F gene fragments were amplified successfully via RT-PCR, and these results confirmed that these animals were infected with PPRV. A PPRV strain (subsequently named ChinaTibet2024) was sequenced, and its genome length was 15,954 nucleotides. A phylogenetic tree analysis using N and F genes and viral genomes showed that the ChinaTibet2024 genome was classified into lineage IV of the PRRV genotypes. The genome of the ChinaTibet2024 strain was found to be closely related to PPRVs isolated in China between 2013 and 2014. A base insertion and a base deletion were detected in the M gene 5' untranslated region. Results indicated that the prevalent PPRV strains in China did not show significant changes and that special attention should be paid to the surveillance of wild animals as an important part of PPR prevention and control.

Identification of multiple novel viruses in bar-headed goose feces from Tibet of China.

The bar-headed goose is a typical high-altitude bird that primarily inhabits alpine lakes and wetlands in Central Asia, with a remarkable ability to adapt to high elevations. Previous studies have shown that they can be infected with parasites such as Cryptosporidium spp. At present, there were few reports on its infection with the virus. In this study, we utilized viral metagenomics to conduct a detailed analysis of the viral components in the fecal samples of bar-headed geese (Anser indicus) from the Tibet region of China. Multiple novel viruses were identified including four novel astroviruses, four novel caliciviruses, ten novel circoviruses, and nineteen novel parvoviruses. Among them, four astroviruses shared the highest amino acid sequence identities of 63.45-99.47% with different avastrovirus strains. Four caliciviruses and ten circoviruses were identified as unclassified caliciviruses and unclassified circoviruses, separately. Nineteen parvoviruses clustering into four groups maybe four different novel species of the genus Chaphamaparvovirus. These newly discovered viruses have potential implications for the health of avian species, particularly bar-headed geese. This study not only helps us understand the health status of bar-headed geese, but also offers crucial genomic information for future disease prevention and treatment strategies.

New insights into the geographical distribution of brown bears Ursus arctos in Nepal

Abstract In the current IUCN Red List assessment, the south-western distribution range of the brown bear Ursus arctos in Nepal ends in Upper Mustang, in the central Himalaya, and extends northwards into the Tibetan Autonomous Region of China. Although brown bears have been recorded further west of Upper Mustang, details of these findings have not been published previously. Using camera traps, we present new evidence of brown bears in Limi Valley, Upper Humla, north-western Nepal. Covering a study area of 336 km2, we deployed 61 camera traps for 3,145 trap-nights during July–October 2021 and 10,748 trap-nights during June 2022–October 2023. In 2021 we recorded a single independent image of a brown bear, followed by 23 independent images during 2022–2023. The images were captured during spring and autumn but not in summer and winter. These new records increase the distribution range of the brown bear in Nepal, extending its global range south-westwards. Our results indicate the significance of Limi Valley as a stronghold for brown bears in Nepal and underscore the importance of formally protecting the currently unprotected wildlife habitats in Limi Valley. Our study emphasizes the need for further research into the ecology and population status of brown bears in Nepal.

Phylogeography of the Sinica Group of Macaques in the Himalayas: Taxonomic and Evolutionary Implications.

Owing to the taxonomic incongruence between the morphological features and genetic relationships of the sinica group of macaques (genus Macaca), the taxonomy of this macaque group has remained inconclusive. We aimed to resolve the taxonomic quandary and improve our understanding of the historical biogeography of the group by including macaque DNA samples from previously unsampled areas in the Himalayas. We sequenced and analyzed three mitochondrial DNA loci [cytochrome b (CYTB), cytochrome oxidase subunit 1 (COI) and D-loop; 2898 bp] for sequence polymorphism, phylogenetics, species delimitation, and ancestral area reconstruction. We confirmed the occurrence of Arunachal macaque (Macaca munzala) on the southern slopes of the Eastern Himalayas in the Xizang Zizhiqu (Tibet Autonomous Region) of China. The results revealed that the sinica group of macaques is a parapatric species group composed of seven distinct species. Phylogenetic and species delimitation analyses revealed that the two previously considered subspecies of Assamese macaques (the eastern subspecies M. assamensis assamensis and the western subspecies M. a. pelops) are two distinct species. The eastern Assamese macaque is a sister species to the Tibetan macaque, whereas the western Assamese macaque and Arunachal macaque are the closest genetic sister species. The sinica group of macaques underwent five vicariance and seven dispersal radiations in the past, which mainly coincided with the Quaternary climatic oscillations between the late Pliocene and the late Pleistocene. By integrating our phylogenetic and ancestral area reconstruction results with findings from previous paleontological and molecular studies, we propose a robust hypothesis about the phylogeography of the sinica group of macaques.

Predicting the geographical potential distribution of species Opisina arenosella Walker in China under different climate scenarios based on the MaxEnt model.

As global warming increases with the frequency of extreme weather, the distribution of species is inevitably affected. Among them, highly damaging invasive species are of particular concern. Being able to effectively predict the geographic distribution of invasive species and future distribution trends is a key entry point for their control. Opisina arenosella Walker is an invasive species, and its ability to live on the backs of foliage and generate canals to hide adds to the difficulty of control. In this paper, the current and future distributions of O. arenosella under three typical emission scenarios in 2050 and 2090 are projected based on the MaxEnt model combining 19 bioclimatic variables. Filter through the variables to find the four key environment variables: BIO 1, BIO 6, BIO 11 and BIO 4. The results show that O. arenosella is distributed only in the eight provinces of Tibet, Yunnan, Fujian, Guangxi, Taiwan, Guangdong, Hong Kong and Hainan in the southeastern region. Its high suitability area is concentrated in Taiwan and Hainan. In the long run, highly suitable areas will continue to increase in size, while moderately suitable areas and poorly suitable areas will decrease to varying degrees. This paper aims to provide theoretical references for the control of O. arenosella.

Current sedation practices for non-invasive procedures in tertiary maternity and children's hospitals in China: a 5-year update.

Sedation techniques can ease anxiety during medical procedures for children. Our previous report on Chinese sedation practices for non-invasive procedures in 2018 is outdated due to the rapid development of sedation services. This study provides an updated report on sedation practices for non-invasive procedures in China. This is a cross-sectional study. Questionnaires were sent to tertiary maternity and children's hospitals nationwide through the WeChat Mini Program. The survey questioned the location and caseloads of hospitals providing sedation services, support facilities, contraindications, fasting practices, sedation regimens, monitoring practices, staff structure, certification requirements for sedation providers and quality control data. Procedural sedation for non-invasive procedures were provided in 88 of 114 hospitals. These hospitals are located across the country except Heilongjiang province and the Tibet Autonomous Region. Compared with previous reports, significant increases were found in the number of hospitals providing sedation services, dedicated sedation rooms and recovery rooms and full-time sedation providers. Most hospitals advocated the 2-4-6 rule for pre-sedation fasting. Dexmedetomidine was the most used first-choice sedative. Anaesthesiologists remain the primary sedation providers, but nurses are also important. The most mentioned qualification requirements for sedation providers were a professional title of attending doctor, ≥5 years of working experience in paediatric anaesthesia and paediatric advanced life support certification. Sedation service records were used in 83 hospitals, but only 42 and 39 recorded success rates and adverse events, respectively. Sedation services for non-invasive procedures are available in most areas of China. More hospitals now provide sedation services and full-time sedation providers. Supporting facilities and sedation regimens have improved. Non-anaesthesiologist sedation providers are important at current stage, developing training programmes for them may be necessary. Attention should be focused on quality control and improvement of sedation services.

Mapping the susceptibility to freeze-thaw deterioration and regionalization of freeze-thaw environments of earthen sites in China: A preliminary study

Earthen sites in China are widely exposed to freeze-thaw environments. There is a lack of knowledge about the spatial distribution patterns of freeze-thaw deterioration and environments, as well as preventive conservation strategies and subsequent refined research on the freeze-thaw deterioration of earthen sites. In this study, the freeze-thaw deterioration process of earthen sites was divided into two periods. Thirteen relevant factors were selected, and using the GIS-FAHP method, a susceptibility map for freeze-thaw deterioration of earthen sites in China was created. The Jenks Natural Breaks method was then employed to categorize the areas into five susceptibility levels: very low (24.6 %), low (18.2 %), moderate (24.2 %), high (18.2 %) and very high (14.8 %). Based on the susceptibility map, the three-level regionalization scheme for freeze-thaw environments of earthen sites in China was systematically developed, taking into account the differences in freeze-thaw deterioration susceptibility and natural landscape within the geomorphological units, and the environmental codes were assigned to third level small-regions. The freeze-thaw environments of earthen sites in China were finally divided into 5 major-regions, 20 sub-regions and 42 small-regions. The results showed that in the area east of the Heihe-Tengchong line, the susceptibility to freeze-thaw deterioration showed latitudinal correlation, and the susceptibility gradually increased from south to north; in the area west of the Heihe-Tengchong line, the susceptibility to freeze-thaw deterioration exhibited strong zonal characteristics. Among the provincial administrative units, Gansu Province and Xinjiang Uighur Autonomous Region have the most complex freeze-thaw environments, while Qinghai, Tibet, Sichuan and Heilongjiang Provinces have the harshest freeze-thaw environments. This study can support regional management and prevention of freeze-thaw deterioration and deterioration studies of earthen sites in China.

Research on the Markov-Chain State Interval Division Based on Predicted Data Correction

By 2022, the total length of roads in Tibet Autonomous Region reached 121,447 kilometers. Due to the unique geological conditions in Tibet, various natural disasters such as earthquakes, mudslides, landslides, avalanches, and strong winds frequently occur. Along the Sichuan-Tibet Highway alone, over 300 disasters happen each year, significantly impacting the region’s economic development. This study focuses on the complexity and randomness of natural disaster mechanisms and combines Markov chain theory to improve the accuracy of prediction data for mudslides, landslides, and earth subsidence etc. The main method is to modify the state interval of the prediction model parameter-Markov chain based on the distribution of discrete points on the number axis. The following state interval division methods are proposed: (1) If the relative error of the predicted value exceeds 50%, adjust the prediction model. (2) Obtain the lower bound of state E1 by taking the floor value downward. (3) The width of each interval does not need to be uniform. (4) Arrange continuous, dense, and close points on the number line in the same side in batches, and represent a state continuously, dividing it into one suitable interval or batches. Using this method, an improved RMSE of 0.28mm and MAPE of 0.87% were obtained for engineering examples, outperforming other models such as GM(1,1), Verhulst, DGM(2,1) with corresponding RMSE values of 0.86 mm, 0.69 mm, and 1.38 mm, and MAPE values of 2.75%, 2.53%, and 5.99%. The combined prediction results for five sets of data yielded an RMSE of 0.14 mm and MAPE of 0.56%, which are quite close to the results obtained using Markov selection correction with an RMSE of 0.37 mm and MAPE of 1.01%. Furthermore, comparing the four sets of case, the average reduction in RMSE and MAPE is 3.56mm and 1.72%, respectively, demonstrating that this method can further improve the performance of Markov chain prediction.

Correlation Analysis of the Transcriptome and Gut Microbiota in Salmo trutta Resistance to Aeromonas salmonicida

Aeromonas salmonicida is a major pathogenic bacterium that poses a significant threat to salmonid fish. Yadong County, located in the Xizang Autonomous Region, is renowned for its characteristic industry of Salmo trutta aquaculture. In recent years, the outbreak of Bacterial Gill Disease (BGD) has led to substantial economic losses for S. trutta farmers. Our prior research identified A. salmonicida as one of the primary culprits behind BGD. To mitigate the impact of A. salmonicida on S. trutta, we conducted a comprehensive study aimed at identifying genes associated with resistance to A. salmonicida. This involved transcriptome sequencing and 16S rRNA sequencing of intestinal flora, providing valuable insights for the study of disease resistance in S. trutta. In this study, we identified 324 genera with 5171 ASVs in the susceptible group and 293 genera with 5669 ASVs in the resistant group. Notably, Methylobacterium and Sphingomonas were common bacteria present in the salmon’s gut, and their proportions remained relatively stable before and after infection. Shewanella, with its antagonistic relationship with Aeromonas, may play a crucial role in the salmon’s defense against A. salmonicida. Several related genes were identified, including angptl4, cipcb, grasp, ccr9a, sulf1, mtmr11, B3GNT3, mt2, PLXDC1, and ank1b.

The catalogue of Mycobacterium tuberculosis mutations associated with drug resistance to 12 drugs in China from a nationwide survey: a genomic analysis

WHO issued the first edition catalogue of Mycobacterium tuberculosis complex (MTBC) mutations associated with drug resistance in 2021. However, country-specific issues might lead to arising complex and additional drug-resistant mutations. We aimed to fully reflect the characteristics of drug resistance mutations in China. We analysed MTBC isolates from the nationwide drug-resistant tuberculosis surveillance with 70counties in 31provinces, municipalities, and autonomous regions in China. Three types of MYCOTB plates were used to perform drug susceptibility testing for 12antibiotics (rifampicin, isoniazid, ethambutol, levofloxacin, moxifloxacin, amikacin, kanamycin, ethionamide, clofazimine, linezolid, delamanid, and bedaquiline). Mutations were divided into five groups according to their odds ratios, positive predictive values, false discovery rate-corrected p values, and 95% CIs: (1) associated with resistance; (2) associated with resistance-interim; (3) uncertain significance; (4) not associated with resistance-interim; and (5) not associated with resistance. The Wilcoxon rank-sum and Kruskal-Wallis tests were used to quantify the association between mutations and minimum inhibitory concentrations (MICs). Our dataset was compared with the first edition of the WHO catalogue. We analysed 10 146MTBC isolates, of which 9071 (89·4%) isolates were included in the final analysis. 744(8·2%) isolates were resistant to rifampicin and 1339 (14·8%) to isoniazid. 208 (1·9%) of 11 065mutations were classified as associated with resistance or associated with resistance-interim. 33 (97·1%) of 34mutations in group 1and 92 (52·9%) of 174in group 2also appeared in groups 1or 2of the WHO catalogue. Of 81indel mutations in group 2, 15 (18·5%) were in the WHO catalogue. The newly discovered mutation gyrA_Ala288Asp was associated with levofloxacin resistance. MIC values for rifampicin, isoniazid, moxifloxacin, and levofloxacin corresponding to resistance mutations in group 1were significantly different (p<0·0001), and 12 high-level resistance mutations were detected. 61mutations in group 3occurred as solo in at least five phenotypically susceptible isolates, but with MIC values moderately higher than other susceptible isolates. Among 945phenotypically resistant but genotypically susceptible isolates, 433 (45·8%) were mutated for at least one efflux pump gene. Our analysis reflects the complexity of drug resistance mutations in China and suggests that indel mutations, efflux pump genes, protein structure, and MICs should be fully considered in the WHO catalogue, especially in countries with a high tuberculosis burden. National Key Research and Development Program of China and the Science and Technology Major Project of Tibetan Autonomous Region of China.

A cross-sectional study of the association between physical activity and depressive symptoms among adolescents in southwest China stratified by parental absence: the mediating role of insomnia and the moderating role of resilience

ObjectivesThis study explored the mechanisms by which physical activity was associated with depressive symptoms in multi-ethnic (Han, Yi and Tibetan) adolescents in southwest China. The mediating role of insomnia in...

Impacts of Anthropogenic Emissions and Open Biomass Burning in South Asia and Southeast Asia on Air Quality and Meteorology Over Southern China

AbstractThe emissions from South Asia and Southeast Asia significantly impact air quality and meteorological conditions in China. However, the individual or joint contributions of anthropogenic emissions and/or biomass burning from outside China to surface particulate matter with aerodynamic diameters less than 2.5 μm (PM2.5) and aerosol optical depth (AOD) over southern China have not been fully investigated. Here, five experiments were designed to investigate the impacts of these emissions in January (winter), March (pre‐monsoon), and October (post‐monsoon) for 2017. Aerosols from South Asia and Southeast Asia contributed less to southern China during winter and post‐monsoon seasons, whereas the wind patterns and emission intensity during the pre‐monsoon season were conducive to the transport of aerosols. During pre‐monsoon season, the total emissions contributed approximately 5.0 μg m−3 to surface PM2.5 in Xizang Province. Biomass burning in Southeast Asia increased PM2.5 in Yunnan Province by 37.9 μg m−3, while anthropogenic emissions increased it by 8.9 μg m−3. Transboundary aerosols can be transported to Xizang Province and Yunnan Province, primarily influencing PM2.5 below 2 km height. It mainly affected PM2.5 levels above the planetary boundary layer over southeast China. Aerosols from outside China can account for 79.5% and 54.8% AOD in Yunnan Province and southeast China, respectively. These aerosols reduced surface incident solar radiation by approximately 6%, leading to decreases in air temperature, wind speed, and boundary layer height. The findings are only applicable to the pre‐monsoon season.

COVID-19 in the Tibet, China, the roof of the world: a comparative analysis of high-altitude residents and newcomers

BackgroundAfter a 920-day hiatus, COVID-19 resurged in the Tibet Autonomous Region of China in August 2022. This study compares the characteristics of COVID-19 between high-altitude residents and newcomers, as well as between newcomers and lowlanders.MethodsThis multi-center cohort study conducted at the Third People’s Hospital of Tibet Autonomous Region and Beijing University Shenzhen Hospital, included 520 high-altitude resident patients, 53 high-altitude newcomer patients, and 265 lowlander patients infected with the Omicron variant. Initially, we documented epidemiological, clinical, and treatment data across varying residency at admission. We compared the severity of COVID-19 and various laboratory indicators, including hemoglobin concentration and SpO2%, over a 14-day period from the date of the first positive nucleic acid test, as well as the differences in treatment methods and disease outcomes between highlanders and high-altitude newcomers. We also compared several characteristics of COVID-19 between high-altitude newcomers and lowlanders. Univariate analysis, multivariable logistic regression, and the generalized linear mixed model were utilized for the analysis.ResultsNo fatalities were observed. The study found no significant differences in COVID-19 severity or in the physiological measures of hemoglobin concentration and SpO2% between high-altitude and lowland residents. Similarly, there were no statistically significant differences in the values or trends of hemoglobin and SpO2% between high-altitude residents and newcomers throughout the 14-day observation period. However, compared to age- and sex-matched lowlander patients (1:5 ratio), high-altitude newcomers exhibited higher heart rates, respiratory rates, and average hemoglobin concentrations, along with lower platelet counts. There were no significant differences in hospital stays between the two groups.ConclusionsHigh-altitude residents and newcomer patients exhibit clinical similarities. However, the clinical characteristics of high-altitude newcomers and lowlander patients differ due to the impact of the high-altitude environment. These results highlight potential considerations for public health strategies in high-altitude regions such as Tibet.

Predicting Polygonum capitatum distribution in China across climate scenarios using MaxEnt modeling

Climate change affects the geographical distribution of species. Predicting the future potential areas suitable for certain species is of great significance for understanding their distribution characteristics and exerting their value. Based on the data of 276 effective distribution points of Polygonum capitatum and 20 ecological factors, the maximum entropy (MaxEnt) model and the ArcGIS software were employed to predict the areas suitable for P. capitatum growth, and the main environmental factors affecting the geographical distribution of this species were explored. Under the current climatic conditions, the areas highly suitable for P. capitatum are mainly distributed in southwestern China, with a small number of sites in coastal areas and most sites in Guizhou Province. Under different climate scenarios, the suitable areas were reduced to varying degrees. The dominant environmental variables affecting the distribution of P. capitatum were precipitation in the driest month, annual precipitation, and elevation, with a cumulative contribution rate of 84.1%. Against the background of a changing climate, the areas suitable for P. capitatum in China will be widely distributed in the southwestern region, with Guizhou Province and Yunnan Province as the main distribution areas; some sites will also be distributed throughout the southwest of Tibet Autonomous Region, the south of Sichuan Province, the north of Guangxi Autonomous Region, and the coastal area of Fujian Province. Optimal conditions for P. capitatum include a dry month precipitation range of 13.4 to 207.3 mm, elevations from 460.3 to 7214.3 m, and annual precipitation between 810 and 1575 mm. Given these insights, we recommend enhanced conservation efforts in current prime habitats and exploring potential cultivation in newly identified suitable regions to ensure the species’ preservation and sustainable use.