Metal workpieces are the bedrock of modern industries as aerospace, marine and car manufacturing. As the pursuit for machinery with excellent performance continues to increase, existing metals are unable to fulfill the requirements of machinery, so surface modification technology has emerged. In this paper, a highly efficient and cost-effective surface modification method using laser interference lithography (LIL) is proposed to prepare superhydrophobic surfaces with corrosion resistance over a large area on Ti6Al4V surfaces. Large-area uniform stripe structures were fabricated on the Ti6Al4V surface by controlling the interference process parameters and spot splicing paths, and then modifying FAS to obtain a superhydrophobic surface. The stripe structure provides more air pockets, which lays the foundation for improved superhydrophobicity and friction reduction. Furthermore, the dense recast layer formed by LIL cauterization completely isolates the Ti6Al4V materials from the corrosive medium, further improving corrosion resistance. The experimental results showed that the hardness reached 15.62 Gpa (313.65 % improvement), the coefficient of friction (COF) was reduced to 0.144 (66.5 % reduction), and the corrosion resistance was improved by two orders of magnitude. As a contactless fabrication technology for periodic structures, LIL has great potential in the field of surface modification.