Gyroid lattice structures, inspired by the natural interconnectivity of human bone, show promise in bone tissue engineering (BTE). This study explores the mechanical properties, and failure mechanisms of selective laser melted (SLM) Gyroid Ti6Al4V lattice structures with varying unit cell rotation angles (RA) of 0∘ (G0), 30∘ (G30), and 60∘ (G60) around the x-axis. The study assesses their mechanical and energy absorption properties through quasi-static compression testing and elastoplastic finite element (FE) analysis. Despite similar relative densities for all designed lattices, the RA variation significantly impacts mechanical performance. G30 exhibits superior load-bearing capacity, with higher modulus of elasticity, yield strength, ultimate strength, and plateau stress. It also has the highest energy absorption capacity, while G60 shows the highest surface area (SA) and surface area-to-volume ratio (SA/VR). These findings highlight the potential of Gyroid lattices for bone replacements due to their tunable mechanical and biological responses.