THz Medical Imaging Research Articles

Statistical Analysis of Gastric Cancer Cells Response to Broadband Terahertz Radiation with and without Contrast Nanoparticles.

The paper describes the statistical analysis of the response of gastric cancer cells and normal cells to broadband terahertz radiation up to 4 THz, both with and without the use of nanostructured contrast agents. The THz spectroscopy analysis was comparatively performed under the ATR procedure and transmission measurement procedure. The statistical analysis was conducted towards multiple pairwise comparisons, including a support medium (without cells) versus a support medium with nanoparticles, normal cells versus normal cells with nanoparticles, and, respectively, tumor cells versus tumor cells with nanoparticles. When generally comparing the ATR procedure and transmission measurement procedure for a broader frequency domain, the differentiation between normal and tumor cells in the presence of contrast agents is superior when using the ATR procedure. THz contrast enhancement by using contrast agents derived from MRI-related contrast agents leads to only limited benefits and only for narrow THz frequency ranges, a disadvantage for THz medical imaging.

Antenna gain enhancement by using metamaterial radome at THz band with reconfigurable characteristics based on graphene load

The reconfigurable concept of a graphene loaded patch antenna with increasing gain is proposed in this paper. We have developed the patch antenna with inset feed for THz band application for which graphene load is used to obtain the reconfigurable characteristic. It has been shown that by increasing the graphene chemical potential, the antenna resonant frequency shifted and the gain increased drastically up to 4 dBi. Additionally, we have shown that antenna efficiency is improved up to 78% which shows more than 100% of enhancement in comparison to basic antenna by increasing the graphene chemical potential. Finally, considering the antenna gain improvement, we have implemented the metamaterial layer over the antenna. In this case, the gain is increased more than 5–6 dBi. In addition, when we put the metamaterial layer over the antenna, the graphene layer shows more linear characteristics. By using parametric studies, we have defined the best point for metamaterial layer around 0.58λ. The final antenna gain is more than 11 dBi, which is useful for THz communication and THz medical imaging systems.

Wide band yagi antenna for terahertz application with graphene control

Antennas are an important part in the microwave and THz systems for the enhancement of the radiation in various application such as medical imaging. Yagi antenna because of end fire radiation, wide bandwidth and high gain are attractive in THz detector, wireless communications and THz medical imaging. Therefore, in this article we have developed a Yagi antenna for 1THz applications with high gain and in this antenna a graphene loop is added to dipole radiator and with variation in the graphene biasing, reconfigurable characteristic is obtained and the Q-factor is controlled in antenna. The CST microwave studio is used for modeling and simulation with FDTD solution. The antenna’s total size is 0.53λ×0.73λ for 1THz with the 1μm thickness of the Silicon substrate. Finally, a novel model has been suggested for the implementation of graphene layer in PBG layer and by embedding a graphene pin in PBG layer a Fabry-Perot waveguide has been designed that improves the bandwidth and antenna gain simultaneously. Higher Q- factor, higher bandwidth with high gain pattern are the benefits of the novel structure that are important in THz systems.

Independent polarization and multi-band THz absorber base on Jerusalem cross

In this paper, we present the design and simulation of a single and multi-band perfect metamaterial absorber (MA) in the THz region base on Jerusalem cross (JC) and metamaterial load in unit cells. The structures consist of dual metallic layers for allowing near-perfect absorption with absorption peak of more than 99%. In this novel design, four-different shape of Jerusalem cross is presented and by adding L, U and W shape loaded to first structure, we tried to achieve a dual-band absorber. In addition, by good implementation of these loaded, we are able to control the absorption resonance at second resonance at 0.9, 0.7 and 0.85THz respectively. In the other hand, we achieved a semi stable designing at first resonance between 0.53 and 0.58THz. The proposed absorber has broadband polarization angle. The surface current modeled and proved the broadband polarization angle at prototype MA. The LC resonance of the metamaterial for Jerusalem cross and modified structures are extracting from equivalent circuit. As a result, proposed MA is useful for THz medical imaging and communication systems and the dual-band absorber has applications in many scientific and technological areas.

Sb-based semiconductors for low power electronics

Sb-based semiconductors incorporating heterostructures of InP, InAs, AlSb, InSb, GaSb, InGaAs, InGaSb, GaAsSb and InGaAsSb can be used for high speed, low power applications such as wide-bandwidth telecommunications for aircraft, satellites, wireless communication, and global positioning systems, as well as thermophotovoltaic cells, THz medical imaging and remote sensing, IR sensors for space exploration, high resolution biomedical spectroscopy and military systems, including security scanners. Sb-based electronic devices such as heterojunction bipolar transistors (HBTs) offer high speed, low power consumption and good breakdown voltages. High electron mobility InAs/AlSb or InSb/AlSb and high hole mobility InGaSb/AlSb quantum well heterostructure field effect transistors (HFETs) have also been widely pursued for THz amplifiers and high speed complementary logic circuits.

THz Medical Imaging: in vivo Hydration Sensing.

The application of THz to medical imaging is experiencing a surge in both interest and federal funding. A brief overview of the field is provided along with promising and emerging applications and ongoing research. THz imaging phenomenology is discussed and tradeoffs are identified. A THz medical imaging system, operating at ~525 GHz center frequency with ~125 GHz of response normalized bandwidth is introduced and details regarding principles of operation are provided. Two promising medical applications of THz imaging are presented: skin burns and cornea. For burns, images of second degree, partial thickness burns were obtained in rat models in vivo over an 8 hour period. These images clearly show the formation and progression of edema in and around the burn wound area. For cornea, experimental data measuring the hydration of ex vivo porcine cornea under drying is presented demonstrating utility in ophthalmologic applications.

The development of terahertz sources and their applications

The terahertz region of the electromagnetic spectrum spans the frequency range between the mid-infrared and the millimetre/microwave. This region has not been exploited fully to date owing to the limited number of suitable (in particular, coherent) radiation sources and detectors. Recent demonstrations, using pulsed near-infrared femtosecond laser systems, of the viability of THz medical imaging and spectroscopy have sparked international interest; yet much research still needs to be undertaken to optimize both the power and bandwidth in such THz systems. In this paper, we review how femtosecond near-infrared laser pulses can be converted into broad band THz radiation using semiconductor crystals, and discuss in depth the optimization of one specific generation mechanism based on ultra-fast transport of electrons and holes at a semiconductor surface. We also outline a few of the opportunities for a technology that can address a diverse range of challenges spanning the physical and biological sciences, and note the continuing need for the development of solid state, continuous wave, THz sources which operate at room temperature.