Thyroid Profile Levels Research Articles

Thyroid Dysfunction in Patient with Cirrhotic Liver Disease and its Relation to the Severity of Cirrhosis

Background: Liver carries its vital significance due to ability to control over excretion, metabolism and transportation of the thyroid hormone. Peripheral change of T4 to T3 occurs in the live leading to initiation of action and breakdown of the hormones. Any morbidity in the liver can result in the decrease in TSH level and leading to thyroid dysfunction. So it is necessary to determine this impact in cases with liver cirrhosis. Methodology: 115 cases of chronic liver disease who were not on the any therapy were involved in this research. The age of >18 years and both genders were selected. Data was collected from Department of Medicine, Lahore General Hospital, and Lahore in a duration of one year. All the demographics and baseline information mandatory for the selection of the appropriate sample was recorded. The participants were informed about the purpose of the research and after their consent they were selected for this study. Finally, the collected data was analyzed using SPSS 23.inc. Practical implication: Thyroid dysfunction in patients with cirrhotic liver disease has practical implications for their management and outcomes. Regular screening and early intervention are important to detect and treat thyroid dysfunction promptly. Managing both cirrhosis and thyroid dysfunction requires a multidisciplinary approach involving hepatologists and endocrinologists. Patient education and support are crucial for raising awareness and ensuring adherence to treatment plans. Further research is needed to understand the relationship between thyroid dysfunction and cirrhosis severity and to explore potential therapeutic targets. Integrating thyroid evaluation into the overall management of cirrhosis can improve patient outcomes and quality of life. Results: Mean age of 51(9.81) years were involved in this research. The male cases were higher in number 81(70.4%). The body mass index value was 27.5(3.65). Child Pugh A class was noted in 37(32.2%), B in 32(27.8%) & C in 46(40%). Serum T3 level was 2.05, serum T4 level was 8.69, serum FT3 level was 3.06, serum FT4 was 1.24 and TSH level was having a mean value 3.15. A significant inverse relationship noted in the severity of cirrhosis and thyroid profile levels. Conclusion: Thyroid function depends on the smooth functioning of the liver through its hormones. As the liver compromise some disease, this normal function disturbs and thyroid dysfunction occurs which increase with the harshness of liver disease. Keywords: Liver Disease, Thyroid Dysfunction, HCV, TSH

Circulating Leptin, Insulin and Thyroid Profile Levels in Different Age Groups of Women Population of Manipur, India

Background: Age is linked to a number of hormonal disorders. This study was designed to look for changes in leptin, insulin, and thyroid profile concentrations in women of various ages.
 Materials and Methods: This study was carried out in the Department of Physiology, Regional Insititute of Medical Sciences, Imphal. Female subjects (350 participants) between the ages of 20 and 65 were recruited. Subjects were grouped as pre-menopause (< 40 age), menopause (≥ 40 to < 50 age) and post-menopause (≥ 50 age). Blood samples were separated serum and estimated levels of leptin, insulin and thyroid profile levels. Statistical calculation was done using SPSS software version 26, at P < 0.05 as significant.
 Results: Body mass index (BMI) had significant changes in different age groups (P < 0.05), but the levels were not in the higher range of BMI. Serum levels of leptin, insulin, T4 (thyroxine) and TSH (thyroid stimulating hormone) were found no significant differences among the different age groups.
 Conclusion: Study demonstrates that age has no effect on the levels of leptin, insulin, T4, and TSH in this Manipuri women's group.

Thyroid Profile in Drug Naive Cases of Depression

Background: Depression is a major public health problem, in terms of its prevalence and suffering, dysfunction, morbidity, and economic burden. Thyroid dysfunction is often seen in the patient with depression. Thyroid Function Test’s (TFT) can be considered as an integral part of the evaluation of newly depressed patients. Therefore, it will be beneficial for the psychiatrists to be cautious during the management of treatment resistant depression cases. Aim: 1) To assess the thyroid profile in newly diagnosed drug naive depression cases and healthy control and 2) To find out the clinical correlation between the thyroid profile and severity of depression. Materials and Methods: It is a case control study where - Study group is newly diagnosed drug naive case of depression and control group is the equal number of same age and sex matched people selected from the normal healthy population. Thyroid profile level is evaluated in both this group and levels are compared. Results and Discussion: This study shows that the number of moderate and severe depression cases is more than the mild depression of cases and thyroid profile levels (T3, T4, and TSH) are increased with increasing severity of depression. A Maximum number of cases in study group show normal thyroid level (76%), only 2% of cases have hypothyroidism and 14% and 8% of cases have subclinical hypothyroidism and hyperthyroidism. Conclusion: Many a time it has been seen that cases of depression show resistance to treatment and thyroid dysfunction are one the causes of such resistant cases. Therefore thyroid screening test is necessary for depression. Future prospective studies are needed, to clarify the significance of thyroid dysfunction in depression and help us to understand the etio-pathology and management of depression.