Thursday July Research Articles

Interview With Dr. William Dale Blair

Interviewed by Peter Willett, Thursday July 14, 2022, at his home in Dallas, GA, USA, and after a great Southern dinner prepared by Kathleen Thompson and him. This is an edited version. The full video of the interview is available at the URL below. https://ieee-aess.org/presentation/aess-historical-interview-dale-blair-peter-willett.

Formation of Sections CAO 19th Biennial Congress Regina, Saskatchewan Thursday July 4, Regina Inn

Formation of Sections CAO 19th Biennial Congress Regina, Saskatchewan Thursday July 4, Regina Inn

Closing Remar ks from the new IUHPE President, Michael Sparks, at the IUHPE 20TH World Conference on Health Promoti on Thursday July 15, 2010, in Geneva, Switzerland

Closing Remar ks from the new IUHPE President, Michael Sparks, at the IUHPE 20TH World Conference on Health Promoti on Thursday July 15, 2010, in Geneva, Switzerland

Computational Neuroscience (CNS*2008)

The international Neuroscience meeting (CNS) has been a premier forum for presenting experimental and theoretical results exploring the biology of computation in the nervous system for the last 17 years. The meeting is organized by the Organization for Neurosciences, a non-profit organization governed by an international executive committee and board of directors. A separate program committee is responsible for the scientific program of the meeting. Participants at the meeting are from academia and industry. The meeting not only provides a venue for research presentation and discussion by senior scientists but actively offers a forum for promoting and supporting young scientists and students from around the world. The papers in this supplemental volume were presented at the 17th annual Neuroscience Meeting (CNS*2008) held in Portland, Oregon, USA from Saturday July 19 to Thursday July 24, 2008. The meeting consisted of a welcome reception, three days of oral and poster sessions, a banquet, and two days of workshops. The main meeting was held at the Benson Hotel in downtown Portland and workshops were held at the Oregon Health and Sciences University. This year the meeting included several invited talks linking systems biology and computational neuroscience. These talks focused on the use of computational models to examine the role of sub-cellular processes in memory and synaptic plasticity. In addition Erik De Schutter discussed the relationship between computational neuroscience and systems biology and the future of computational neuroscience in a special lecture Computational Neuroscience and Systems Biology: the Past, the Now and the Future. Abstracts for the meeting were submitted in early February. Those authors wanting an oral presentation also submitted an extended summary of their work. The abstracts were reviewed by the Program Committee and each extended summary was additionally reviewed and scored by three independent reviewers. In the end 173 papers were accepted for the meeting. The review comments and scores for the extended summaries were used by the Program Committee to construct the final oral and poster programs. Abstracts for invited talks are given first, followed by abstracts of oral presentations in order of presentation at the meeting and abstracts for posters. Abstracts for poster presentations are grouped by topic according to keywords chosen by the authors in their initial submissions. Clearly some papers could fit under multiple topics, so this classification is by no means precise. Nevertheless, these abstracts represent a sampling of some of the exciting work being done today, often by young researchers, in the field of Neuroscience. CNS*2008 Program Committee Bill Holmes, Chair (Ohio University), Don Johnson, Incoming Chair (Rice University), Victoria Booth (University of Michigan), Sharon Crook (Arizona State University), Markus Diesmann (RIKEN), Alex Dimitrov (Montana State University), Jeanette Hellgren-Kotaleski (Karolinska Institute), Tay Netoff (University of Minnesota), Hiroshi Okamoto (RIKEN, Japan), Astrid Prinz (Emory University), Harel Shouval (University of Texas Medical Center), Volker Steuber (University of Hertfordshire) CNS*2008 Reviewers Pablo Achard, Kurt Ahrens, James Bednar, Upinder Bhalla, Avrama Blackwell, Victoria Booth, Alla Borisyuk, Amitabha Bose, Vladimir Brezina, Sharon Crook, Gennady Cymbalyuk, Peter Dayan, Michael Denker, Markus Diesmann, Alex Dimitrov, Ramana Dodla, Roberto Fernandez-Galan, Nicolas Fourcaud-Trocme, Erik Fransen, Marc-Oliver Gewaltig, Bruce Graham, Sonja Gruen, Cengiz Gunay, Michael Hasselmo, Christian Hauptmann, Jeanette Hellgren-Kotaleski, J. Michael Herrmann, Voicu Horatiu, Mikael Huss, Kazuhisa Ichikawa, Vladimir Itskov, Dieter Jaeger, Szabolcs Kali, Maciej Lazarewicz, Tim Lewis, Hualou Liang, Niklas Ludtke, William Lytton, Paul Miller, Samat Moldakarimov, Abigail Morrison, Tay Netoff, Ernst Niebur, Hiroshi Okamoto, Eckehard Olbrich, Sorinel Oprisan, Astrid Prinz, David Redish, Patrick Roberts, Horacio Rotstein, Yasser Roudi, Jonathan Rubin, Yukata Sakai, Emilio Salinas, Chang-Woo Shin, Harel Shouval, Asya Shpiro, Karen Sigvardt, Volker Steuber, David Sterratt, Benjamin Torben-Nielsen, Arjen vanOoyen, Yuguo Yu. CNS*2008 Local Organizer Patrick Roberts (Oregon Health & Sciences University) CNS*2008 Workshop Chair Dieter Jaeger (Emory University) Government Liaisons Dennis Glanzman (NIMH), Yuan Liu (NINDS), Kenneth Whang (NSF) CNS – Organization for Neuroscience http://www.cnsorg.org Ranu Jung (Arizona State University), President Dieter Jaeger (Emory University), Vice-President Alain Destexhe (CNRS), Vice-President Frances Skinner (Toronto Western Research Institute), Treasurer Tim Lewis (University of California-Davis), Travel Grants Christiane Linster (Cornell University) Communications Chair Jean Marc-Fellous (University of Arizona), Sponsorship Linda Larson-Prior (Washington University), past Treasurer, ex-officio CNS Board of Directors James Bednar (University of Edinburgh), Ingo Bojak (Swinburne University), Frances Chance (University of California, Irvine), Sophie Deneve (Ecole Normale Superieure, College de France), Udo Ernst (University of Bremen), Jean-Marc Fellous (University of Arizona), Leslie Kay (University of Chicago), Tim Lewis (University of California, Davis), Christiane Linster (Cornell University), Klaus Obermayer (Technische Universitat Berlin), David Redish (University of Minnesota), Patrick Roberts (Oregon Health and Science University), Emilio Salinas (Wake Forest University), Steven Schiff (Penn State University), Todd Troyer (University of Texas, San Antonio), Susan Wearne (Mt. Sinai School of Medicine), Christina Weaver (Mt. Sinai School of Medicine) For more information about the organization, please see http://www.cnsorg.org

Computational Neuroscience (CNS*2007)

The international Computational Neuroscience meeting (CNS) has been a premier forum for presenting experimental and theoretical results exploring the biology of computation in the nervous system for the last 16 years. The meeting is organized by the Organization for Computational Neurosciences, a non-profit organization governed by an international executive committee and board of directors. A separate program committee is responsible for the scientific program of the meeting. Participants at the meeting are from academia and industry. The meeting not only provides a venue for research presentation and discussion by senior scientists but actively offers a forum for promoting and supporting young scientists and students from around the world. The papers in this supplemental volume were presented at the 16th Annual Computational Neuroscience Meeting (CNS*2007) held in Toronto, Ontario, Canada from Saturday July 7 to Thursday July 12, 2007. The meeting consisted of a welcome reception, three days of oral and poster sessions, an evening harbor cruise and dinner, and two days of workshops. The main meeting was held at 89 Chestnut, a University of Toronto conference facility and the workshops took place at the University of Toronto downtown campus. Abstracts for the meeting were submitted in early February. Those authors wanting an oral presentation also submitted an extended summary of their work. The abstracts were reviewed by the Program Committee and each extended summary was additionally reviewed and scored by two independent reviewers. In the end 230 papers were accepted for the meeting. The review comments and scores for the extended summaries were used by the Program Committee to construct the final oral and poster programs. Abstracts for oral presentations are given first, in order of presentation at the meeting. Abstracts for poster presentations are grouped by topic according to keywords chosen by the authors in their initial submissions. Clearly some papers could fit under multiple topics, so this classification is by no means precise. Nevertheless, these abstracts represent a sampling of some of the exciting work being done today, often by young researchers, in the field of Computational Neuroscience. CNS*2007 Program Committee Bill Holmes, Chair (Ohio University), Steve Bressler (Florida Atlantic University), Frances Chance (University of California, Irvine), Sharon Crook (Arizona State University), Markus Diesmann (RIKEN), Alex Dimitrov (Montana State University), Sonja Gruen (Free University, Berlin), Tay Netoff (University of Minnesota), Hiroshi Okamoto (RIKEN), Mike Paulin (University of Otago), Astrid Prinz (Emory University), Michelle Rudolph (CRNS) CNS*2007 Reviewers Kurt Ahrens, Athena Akrami, Jose Ambros-Ingerson, Peter Andras, Toru Aonishi, Ildiko Aradi, Francesco Battaglia, Maxim Bazhenov, James Bednar, Jan Benda, Upinder Bhalla, Ingo Bojak, Victoria Booth, Amitabha Bose, Steve Bressler, Romain Brette, Robert Butera, Ronald Calabrese, Carmen Canavier, Jeremy Caplan, Hide Cateau, Michela Chippalone, Thomas Cleland, Albert Compte, Felix Creutzig, Patrick Crotty, Gennady Cymbalyuk, Peter Dayan, Gustavo Deco, Paolo DelGiudice, Michael Denker, Alain Destexhe, Alexander Dimitrov, Mingzhou Ding, Ramana Dodla, Brent Doiron, Chris Eliasmith, Udo Ernst, Gabbiani Fabrizio, Adrienne Fairhall, Jean-Marc Fellous, Roberto Fernandez Galan, Nicolas Fourcaud-Trocme, Erik Fransen, Marc-Oliver Gewaltig, Stan Gielen, Bruce Graham, Lyle Graham, Cengiz Gunay, Christian Hauptmann, J. Michael Herrmann, Yutaka Hirata, Kazuhisa Ichikawa, Hide Ikeno, Dieter Jaeger, Don Johnson, Ranu Jung, Szabolcs Kali, Amir Karniel, Gabriel Kreiman, Linda Larson-Prior, Aurel A Lazar, Maciej Lazarewicz, Tim Lewis, Hualou Liang, Benjamin Lindner, Marja-Leena Linne, Andre Longtin, Niklas Ludtke, William Lytton, Paul Miller, Samat Moldakarimov, Abigail Morrison, Tay Netoff, Ernst Niebur, Haruka Nishimura, Klaus Obermayer, Eckehard Olbrich, Sorinel Oprisan, Stefano Panzeri, Gordon Pipa, Panayiota Poirazi, Bernd Porr, Jennifer Read, Patrick Roberts, Horacio Rotstein, Yasser Roudi, Alex Roxin, Michelle Rudolph, Ko Sakai, Yukata Sakai, Emilio Salinas, Steven Schiff, Shihab Shamma, Harel Shouval, Asya Shpiro, Karen Sigvardt, Leslie Smith, Martin Stemmler, David Sterratt, Benjamin Torben-Nielsen, Horatiu Voicu, Christina Weaver. CNS*2007 Local Organizer and Workshop Chair Frances Skinner (Toronto Western Research Institute and University of Toronto) Government Liaisons Dennis Glanzman (NIMH), Yuan Liu (NINDS), Kenneth Whang (NSF) Supporting Agencies National Institute of Mental Health CNS – Organization for Computational Neuroscience http://www.cnsorg.org Ranu Jung (Arizona State University), President Dieter Jaeger (Emory University), Vice-President Alain Destexhe (CNRS), Vice-President Linda Larson-Prior (Washington University), Treasurer Phillip Ulinski (University of Chicago) Grants Chair Tim Lewis (University of California-Davis), Travel Grants Christiane Linster (Cornell University) Past-President and Communications Chair Jean Marc-Fellous (University of Arizona), Sponsorship Chair CNS Board of Directors James Bednar (University of Edinburgh), Ingo Bojak (Swinburne University), Erik DeSchutter (University of Antwerp), Udo Ernst (University of Bremen), Jean-Marc Fellous (University of Arizona), Mark Goldman (Wellesley College), Leslie Kay (University of Chicago), Tim Lewis (UC Davis), David Redish (University of Minnesota), Patrick Roberts (Oregon Health and Science University), Steven Schiff (Penn State University), Todd Troyer (University of Maryland), Susan Wearne (Mt. Sinai School of Medicine), Christina Weaver (Mt. Sinai School of Medicine) For more information about the organization, please see http://www.cnsorg.org

Thursday July 6, 2006 11:30-13:30 Hall 3A Discussion Group Session Further understanding of the pathophysiological mechanisms involved in Landau-Kleffener and related syndromes

Abstract 1 P. Van Bogaert ( 1 Université Libre de Bruxelles, Hôpital Erasme, Belgium ) The pathophysiological mechanisms underlying the EEG phenomenon of continuous spike-waves during sleep (CSWS) and related cognitive and behavioral deficits remain poorly understood. It is now admitted that diffusion of the epileptiform discharges during NREM sleep is related to a mechanism of secondary bilateral synchrony from a focal cortical onset. It is probable that thalamic nuclei play an important role in this phenomenon, presumably through a development of the physiological slow-sleep oscillation into diffuse slow waves because of the lack of inhibitory constraint. This hypothesis is supported by experimental CSWS-like pattern obtained in cats following unilateral thalamic ablation. The role of the thalamus in the generation of the CSWS phenomenon was recently emphasized by reports of patients showing thalamic clastic lesions on MRI. Studies performed using PET with 18F-fluorodeoxyglucose (FDG) by our group and by others in children with CSWS and normal MRI have failed to show consistent thalamic abnormalities, but data analysis is complicated by the fact that physiological metabolic changes occur in the thalamus during brain development. Indeed, the metabolic activity of the thalamus adjusted for global metabolism increases significantly during childhood. On the other hand, numerous studies have shown that cortical metabolic abnormalities are frequently found in epileptic children with CSWS. The latter consist in either focal hypermetabolism or focal hypometabolism. The analysis of our FDG-PET data led to the following conclusions: (1) The hypermetabolic zone is the ictal onset zone; (2) Hypermetabolic areas are usually associated with distinct cortical hypometabolic areas, probably as a result of either loss of functional connectivity or inhibition mechanism; (3) Both hypermetabolic and hypometabolic areas tend to decrease or even disappear at the recovery phase of CSWS; and (4) Similar types of metabolic patterns and evolution may be seen in children with CSWS associated with polymicrogyric-like lesions.

Thursday July 6, 2006 11:30-13:30 Hall 3D Discussion Group Session Glutamate and epilepsy: from molecules to molecular imaging

Thursday July 6, 2006 11:30-13:30 Hall 3D Discussion Group Session Glutamate and epilepsy: from molecules to molecular imaging

Thursday July 6, 2006 9:15-11:00 Hall 1 European Epileptology Award Symposium Bridging basic with clinical epileptology

Thursday July 6, 2006 9:15-11:00 Hall 1 European Epileptology Award Symposium Bridging basic with clinical epileptology

Thursday July 6, 2006 11:30-13:30 Hall 1 Discussion Group Session Chronic epilepsy: a development retarding or progressively dementing disease?

Thursday July 6, 2006 11:30-13:30 Hall 1 Discussion Group Session Chronic epilepsy: a development retarding or progressively dementing disease?

Thursday July 6, 2006 11:30-13:30 Hall 5C Discussion Group Session Non-age-related familial focal epilepsies: genotype-phenotype correlations

Thursday July 6, 2006 11:30-13:30 Hall 5C Discussion Group Session Non-age-related familial focal epilepsies: genotype-phenotype correlations

Thursday July 6, 2006 Thursday July 6, 2006 7:30-9:00 Hall 5A Teaching Session Epilepsy surgery in infancy and childhood

Thursday July 6, 2006 Thursday July 6, 2006 7:30-9:00 Hall 5A Teaching Session Epilepsy surgery in infancy and childhood

Thursday July 6, 2006 11:30-13:30 Hall 5B Discussion Group Session Focal drug and gene delivery for refractory epilepsy: fantasy or clinical reality?

Thursday July 6, 2006 11:30-13:30 Hall 5B Discussion Group Session Focal drug and gene delivery for refractory epilepsy: fantasy or clinical reality?

Thursday July 6, 2006 11:30-13:30 Hall 5A Discussion Group Session What future for radiosurgery in epilepsy surgery?

Abstract 1 A. Gil-Nagel ( 1 Hospital Ruber Internacional, Madrid, Spain ) The goal of stereotactic radiosurgery is the precise delivery of a single high dose of radiation to an area of pathological tissue of the brain with minimal effect on normal tissue. Tolerance of normal tissues to radiation depends on total dose, time of exposure, volume radiated, radiation quality, and adjunctive treatments. Mathematical models have been devised to predict a 5% to 50% probability of injury at 5 years (T-D 5/5); according to these models, 50 ± 10 Gy is the T-D 5/5 for the whole brain, and 60 ± 10 Gy is the T-D 5/5 for a limited volume of the brain. The effect of radiation in non-neoplastic brain tissue has been analyzed in the rat frontal lobe model. These studies have demonstrated that radiosurgery produces predictable histological changes: edema within the treatment volume at 14 days, circumscribed cerebral necrosis at 21 days, and complete destruction within the treatment volume later in time. Information on the mechanism of action of radiosurgery in non-neoplastic brain tissue in humans is less abundant. Series on gamma-knife therapy in the treatment of epilepsy have demonstrated some relevant aspects: (1) delayed onset of its effect is probably related to the time mitotic cycles occur in susceptible tissues, such as the endothelium of small vessels and capillaries, and astrocytes; (2) occurrence of an increased frequency of brief simple partial seizures is common at the time of tissue changes seen in brain MRI, and this is probably related to earlier involvement of white matter pathways, those that participate in seizure propagation; (3) differences in individual susceptibility to radiation may explain failure of treatment in some patients, and indicate the existence of a higher risk of radiation necrosis in some individuals. Assays have been devised to quantify individual susceptibility to radiation; however, information on their predictive value is still inconclusive and their use in the analysis of patients with lower sensitivity to radiation has not been explored.

Thursday 8th July 1999

Thursday 8th July 1999