The azimuth thruster is mainly installed on a vessel that requires a dynamic positioning (DP) function for special purposes. When the azimuth thruster on a vessel operates for DP, the thrust loss is induced by the thruster-hull interaction. This study examined the influence of boundary conditions in numerical simulations for predicting thrust loss. Wind turbine installation vessels (WTIV) and floating production storage and offloading (FPSO) were chosen as a target vessels. In this study, two types of boundaries were defined. The first consideration is that the boundary condition was assigned with consideration of the azimuth angle of the thruster, whereas it is fixed regardless azimuth angle of the thruster. The predicted thrust loss according to these boundary conditions showed a difference. This observation originated from the current load of the vessel. Therefore, the boundary conditions for which the current load is not induced need to be designated to obtain a realistic thrust loss in a numerical simulation.