We aimed to evaluate the short-term functional and radiological outcomes of the minimally invasive fixation of three-part proximal humerus fractures without using calcar screws. Twenty patients were treated with the minimally invasive approach using locking plate-screws. The relationship between the cephalo-diaphyseal angles and the functional outcomes were evaluated. The mean follow-up time were 22.7 months. The mean Constant-Murley score of the patients was 83.7. The modified Constant-Murley score was excellent in 16 and good in four patients. A statistically significant difference was detected between cephalo-diaphyseal angles. Osteosynthesis with minimally invasive plate-screw and deltoid splitting application is encouraging with its satisfactory results in three-part fractures of the humerus; however, the total complication rate of 35% should not be ignored. In addition, in order to prevent a significant varus collapse and angular loss, the fracture subgroups should be studied in detail and additional measures should be taken based on the fracture type.