Three-layer Tissue Model Research Articles

Characterization of a Thermoacoustic-based Pulsed High Power Microwave Detector Chain.

Detection of microwave-induced thermoacoustic (TA) wave generation was evaluated as a potential technique for detection of high power microwave (HPM) directed energy exposure. Even when HPM is employed for counter-materiel effects, incidental but still potentially harmful personnel exposure is possible. Real-time detection of ongoing exposure with potentially unknown time and frequency domain characteristics is a critical first step in preventing acute health effects by alerting and then enabling the timely use of electromagnetic frequency energy shielding, such as structures and vehicles. Leveraging the TA effect as a field interaction mechanism, a lossy dielectric polymer subjected to pulsed HPM was tested using a planar sample geometry with thin film piezoelectric sensors used to capture the resulting TA output. The piezoelectric signal was analyzed in both the time and frequency domain to determine empirical relationships between incident microwave beam properties and signal components. This analysis was coupled with an empirically-based single term Cole-Cole model approximation fit for the complex permittivity. The results were used to identify appropriate signal conditioning and processing techniques needed to convert the TA response into a useful form for personnel exposure applications. These results also served as a comparison point for multi-physics finite element method computational modeling of the electromagnetic response of a simplified three-layer tissue model.

MAS: Standalone Microwave Resonator to Assess Muscle Quality.

Microwave-based sensing for tissue analysis is recently gaining interest due to advantages such as non-ionizing radiation and non-invasiveness. We have developed a set of transmission sensors for microwave-based real-time sensing to quantify muscle mass and quality. In connection, we verified the sensors by 3D simulations, tested them in a laboratory on a homogeneous three-layer tissue model, and collected pilot clinical data in 20 patients and 25 healthy volunteers. This report focuses on initial sensor designs for the Muscle Analyzer System (MAS), their simulation, laboratory trials and clinical trials followed by developing three new sensors and their performance comparison. In the clinical studies, correlation studies were done to compare MAS performance with other clinical standards, specifically the skeletal muscle index, for muscle mass quantification. The results showed limited signal penetration depth for the Split Ring Resonator (SRR) sensor. New sensors were designed incorporating Substrate Integrated Waveguides (SIW) and a bandstop filter to overcome this problem. The sensors were validated through 3D simulations in which they showed increased penetration depth through tissue when compared to the SRR. The second-generation sensors offer higher penetration depth which will improve clinical data collection and validation. The bandstop filter is fabricated and studied in a group of volunteers, showing more reliable data that warrants further continuation of this development.

Machine learning for direct oxygen saturation and hemoglobin concentration assessment using diffuse reflectance spectroscopy.

.Significance: Diffuse reflectance spectroscopy (DRS) is frequently used to assess oxygen saturation and hemoglobin concentration in living tissue. Methods solving the inverse problem may include time-consuming nonlinear optimization or artificial neural networks (ANN) determining the absorption coefficient one wavelength at a time.Aim: To present an ANN-based method that directly outputs the oxygen saturation and the hemoglobin concentration using the shape of the measured spectra as input.Approach: A probe-based DRS setup with dual source-detector separations in the visible wavelength range was used. ANNs were trained on spectra generated from a three-layer tissue model with oxygen saturation and hemoglobin concentration as target.Results: Modeled evaluation data with realistic measurement noise showed an absolute root-mean-square (RMS) deviation of 5.1% units for oxygen saturation estimation. The relative RMS deviation for hemoglobin concentration was 13%. This accuracy is at least twice as good as our previous nonlinear optimization method. On blood-intralipid phantoms, the RMS deviation from the oxygen saturation derived from partial oxygen pressure measurements was 5.3% and 1.6% in two separate measurement series. Results during brachial occlusion showed expected patterns.Conclusions: The presented method, directly assessing oxygen saturation and hemoglobin concentration, is fast, accurate, and robust to noise.

Evaluation of Specific Absorption Rate in Three-Layered Tissue Model at 13.56 MHz and 40.68 MHz for Inductively Powered Biomedical Implants

This paper presents an optimized 3-coil inductive wireless power transfer (WPT) system at 13.56 MHz and 40.68 MHz to show and compare the specific absorption rate (SAR) effects on human tissue. This work also substantiates the effects of perfect alignment, lateral and/or angular misalignments on the power transfer efficiency (PTE) of the proposed WPT system. Additionally, the impacts of different tissue composition, input power and coil shape on the SAR are analyzed. The distance between the external and implantable coils is 10 mm. The results have been verified through simulations and measurements. The simulated results show that the SAR of the system at 40.68 MHz had crossed the limit designated by the Federal Communications Commission and hence, it is unsafe and causes tissue damage. Measurement results of the system in air medium show that the optimized printed circuit board coils at 13.56 MHz achieved a PTE of 41.7% whereas PTE waned to 18.2% and 15.4% at 10 mm of lateral misalignment and 60° of angular misalignment respectively. The PTE of a combination of 10 mm lateral misalignment and 60° angular misalignment is 21%. To analyze in a real-environment, a boneless pork sample with 10 mm of thickness is placed as a medium between the external and implantable coils. At perfect alignment, the PTE through pork sample is 30.8%. A RF power generator operating at 13.56 MHz provides 1 W input power to the external coil and the power delivered to load through the air and tissue mediums are 347 mW and 266 mW respectively.

Development of a non‐invasive measurement system to the thickness of the subcutaneous adipose tissue layer

It is important to measure the thickness of hypodermis, including the subcutaneous fat layer in several fields such as global assessment of nutritional status and monitoring of dietary manipulation. It also provides useful information concerning the amount of peripheral adipose tissue and can be used as an index of obesity. To measure the thickness of the subcutaneous adipose tissue layer, the optical properties of tissue components, several lipids and animal tissue samples in vitro were measured over the wavelength range from 1000 to 1700 nm, using the transmittance measurement system and the diffuse reflectance measurement system. A wavelength range for the thickness measurements was selected from the experimental result. The corresponding signal according to the changes of adipose tissue thickness was measured. Experimental data measured by the non-invasive measurement system were compared with the actual thickness of animal samples, and the results could be explained by the three-layered tissue model. The result showed high correlation to the thickness changes (R2 = 0.9954). The experimental result implies positive possibility for the development of a system to measure the thickness of subcutaneous adipose tissue using near infrared in vivo.

The effect of visual and haptic feedback on computer-assisted needle insertion

Objective: We present a study evaluating the effects of visual and haptic feedback on human performance in a needle insertion task.Materials and Methods: A one-degree-of-freedom needle insertion simulator with a three-layer tissue model (skin, fat and muscle) was used in perceptual experiments. The objective of the 14 subjects was to detect the puncture of each tissue layer using varying haptic and visual cues. Performance was measured by overshoot error—the distance traveled by the virtual needle after puncture.Results: Without force feedback, real-time visual feedback reduced error by at least 87% in comparison to static image overlay. Force feedback, in comparison to no force feedback, reduced puncture overshoot by at least 52% when visual feedback was absent or limited to static image overlay. A combination of force and visual feedback improved performance, especially for tissues with low stiffness, by at least 43% with visual display of the needle position, and by at least 67% with visual display of layer deflection.Conclusion: Real-time image overlay significantly enhances controlled puncture during needle insertion. Force feedback may not be necessary except in circumstances where visual feedback is limited.

Temperature elevations computed for three-layer and four-layer obstetrical tissue models in nonlinear and linear ultrasonic propagation cases

The authors computed temperature elevations in a three-layer and a four-layer tissue model, assuming the crucial obstetrical case when the ultrasonic pulse propagating through the abdomiinal wall and the fluid-filled bladder penetrates into soft fetal tissues.To consider nonlinear propagation, the authors applied a new theory of nonlinear increase of absorption recently developed by the first author. Computations were carried out for pulses with a carrier frequency of 3 MHz, duration time of 1.33 μs, and pulse repetition frequency of 3.3 kHz. Similar computations were carried out for a four-layer tissue model corresponding to the third trimester of gestation. The ceramic piezoelectric transducer 2 cm in diameter radiated the ultrasonic beam focused at a distance of 6.5 cm. The intensities at the radiating transducer (at the source) were I SAPA= 10 and 5 W/cm 2. Temperature elevations and distributions were determined numerically for various values of low-amplitude absorption coefficients assumed to be the same as attenuation coefficients. It was shown in the three-layer tissue model that the maximum temperature elevation can be about 50% higher for nonlinear than for linear propagation.The maximum fetal temperature elevation in this case was 2.36°C for nonlinear and 1.84°C for linear propagation. The temperature elevation in the abdominal wall was lower than those temperatures when the attenuation of the abdominal wall was assumed to be a low value of 0.05 Np/cm.MHz (0.45 dB/cm.MHz). However, when it was increased to 0.16 Np/cm.MHz (1.4 dB/cm.MHz), the temperature elevation of the abdominal wall reached 3.2°C and the maximum fetal elevation was 1.65°C. In such cases, the abdominal wall became the principal source of heat production. In this case, the difference between fetal temperature elevations for nonlinear and linear propagation was only about 10%. The results obtained in the four-layer tissue model, in which the uterus tissue also was represented, show that temperature elevations in this case are about 3.6 times lower than in the three-layer tissue model, with comparable attenuation of the abdominal wall. Differences between nonlinear and linear propagation in the four-layer tissue model are negligible. The temperature elevations obtained were proportional to the pulse repetition frequency, without changing temperature distributions in the ultrasonic beam. In this manner, fetal temperature elevations can be reduced by reducing the repetition frequency.

Analysis of the power coupling from a waveguide hyperthermia applicator into a three-layered tissue model

The power deposition from a rectangular-aperture flanged waveguide into a three-layered stratified tissue medium is analyzed theoretically. The fields inside the tissue layers are expressed in terms of Fourier integrals satisfying the corresponding wave equations, while the fields inside the waveguide are expanded in terms of the guided and evanescent normal modes. An integral equation is derived on the aperture plane of the flanged waveguide by applying the continuity of the tangential electric and magnetic fields. This integral equation is solved by expressing the unknown electric field in terms of the waveguide mode fields and by applying a Galerkin procedure. The electromagnetic fields inside the tissue medium are then determined and patterns of the deposited power at frequencies of 432 MHz and 144 MHz for apertures of 5.6*2.8 cm/sup 2/ and 16.5*8.3 cm/sup 2/, respectively, are computed and presented. >