Land Change Science (LCS), as a coupled human-environment system, is a multidisciplinary area that explores the dynamics of land use and land cover to understand key theories, problems, methodologies, and model applications. The present review integrated the research that have been conducted in the savanna ecosystem of Sub-Saharan Africa from a geographical perspective. The present study elaborates contemporary issues and thoughts in terms of several key aspects: (1) Impacts of protected areas on the surrounding natural environment, wildlife, and socio-economic activities of humans, (2) with the impact of new developments in remote sensing (RS) technology, observations of land change and the changes in the relationship between ecology and RS, (3) the effects of developments in RS on our environmental perspective and new connection opportunities for interrelated scientific disciplines, (4) the vulnerability of the savanna vegetation due to its multilayered and complex structure. Due to the changing climatic conditions, it is inevitable that ecosystems will encounter various problems in the near future, especially in Sub-Saharan Africa. Understanding the complex savanna ecosystem remains a challenge for researchers. Therefore, it is very essential to observe better and understand the nature and socio-economic cycle of human for a sustainable future of savanna ecosystems.