To investigate the consequence of thermophoresis and Brownian diffusion on convective boundary layer micropolar fluid flow over a stretching wedge-shaped surface. The effects of non-dimensional parameters namely coupling constant parameter (0.01 ≤ B1 ≤ 0.05), magnetic parameter (1.0 ≤ M ≤ 15.0), Grashof number (0.3 ≤ Gr ≤ 0.9), modified Grashof number (0.3 ≤ Gm ≤ 0.8), micropolar parameter (2.0 ≤ G2 ≤ 7.5), vortex viscosity constraint (0.02 ≤ G1 ≤ 0.2), Prandtl number (7.0 ≤ Pr ≤ 15.0), thermal radiation parameter (0.25 ≤ R ≤ 0.50), Brownian motion parameter (0.2 ≤ Nb ≤ 0.62), thermophoresis parameter (0.04 ≤ Nt ≤ 0.10), heat generation parameter (0.1 ≤ Q ≤ 0.5), Biot number (0.65 ≤ Bi ≤ 1.0), stretching parameter (0.2 ≤ A ≤ 0.5), Lewis number (3.0 ≤ Le ≤ 7.0), and chemical reaction parameter (0.2 ≤ K ≤ 0.7) on the steady MHD heat and mass transfer is investigated in the present study. The coupled non-linear partial differential equations are reduced into a set of non-linear ordinary differential equations employing similarity transformation. Furthermore, by using the Runge-Kutta method followed by the shooting technique, the transformed equations are solved. The main goal of this study is to investigate the numerical analysis of nanofluid flow within the boundary layer region with the effects of the microrotation parameter and velocity ratio parameter. The novelty of this paper is to propose a numerical method for solving third-order ordinary differential equations that include both linear and nonlinear terms. To understand the physical significance of this work, numerical analyses and tabular displays of the skin friction coefficient, Nusselt number, and Sherwood number are shown. The new approach of the present study contributes significantly to the understanding of numerical solutions to non-linear differential equations in fluid mechanics and micropolar fluid flow. Micropolar fluids are becoming even more of a focus due to the desire for engineering applications in various fields of medical, mechanical engineering, and chemical processing.