Thiosulphuric Acid Research Articles

ISOLATION OF BIOACTIVE COMPOUNDS FROM DICRANACEAE MOSSES

ABSTRACT Dicranoloma reflexum and Dicranella coarctata are mosses from Dicranaceae family. This study was purposed to identify bioactive compounds contained from both species. Dicranoloma reflexum and Dicranella coarctata collected form Cangar forest, Batu, East Java. Mosses was rinsed, dried and crushed into powder. Extraction was performed using maceration method with n-hexane, acetic acid, and methanol solvent. Compounds obtained then identified using Gass Chromatography Mass Spectra. Result showed that n-hexane, acetic ethyl, and methanol extract of Dicranoloma reflexum contained 61, 16, and 58 compounds respectively. Main component of each extract was 1-octadecene, phenol, and 9-octadecanoic acid. N-hexane, acetic ethyl, and methanol extract of Dicranella coarctata contained 5, 38, and 23 compounds respectively. Main component of each extract was thiosulphuric acid, E-15 heptedecenal, and n-hexadecanoic acid.Key words : Dicranaceae, bioactive compounds

Metabolism by Schistosoma mansoni of a new schistosomicide: 2-[(1-methylpropyl)amino]-1-octanethiosulphuric acid.

In order to investigate the mode of action of a new class of schistosomicides, the N-alkylaminoalkanethiosulphuric acids, the [outer 25S] 2-[(1-methylpropyl)amino]-1-octanethiosulphuric acids was synthesized. Labelling studies of adult Schistosoma mansoni were performed in infected mice and in in vitro incubations. After a single oral dose of the drug to infected mice, 5 metabolites were detected by thin-layer chromatogrpahy in organic extracts of male and female adult schistosomes. In vitro studies showed that the same compounds were present in organic extracts obtained from adult male and female worms. One of these metabolites was identified by mass spectroscopy as being the dimeric disulphide derivative of the parent labelled thiosulphuric acid.

Determination of sulphur by electrolytic hydrogenation

Certain sulphur compounds such as thiosulphuric acid, polythionic acids, thiocyanic acid, thioureas, thioamides and 2-mercapto-acids are readily electrolytically hydrogenated in 1 N sulphuric acid to form hydrogen sulphide which is absorbed in potassium hydroxide solution and titrated with o-hydroxymercuribenzoic acid in the presence of dithizone as indicator. The electrolytic cell consists of a lead anode in 5 N sulphuric acid, a porous ceramic tube as diaphragm, and a cathode made of soft iron. The first-order rate-constants of hydrogenation and the results of determination of sulphur in some sulphur compounds are presented. The limit of determination is 0.1 ppm.

Radiation Protective Agents : Synthesis of Some N'-substituted mercapto alkyl guanidines, lsothiouronium salts and Thiosulphuric acid derivatives I.

Radiation Protective Agents : Synthesis of Some N'-substituted mercapto alkyl guanidines, lsothiouronium salts and Thiosulphuric acid derivatives I.

Hydrolytic reactions of tetrasulphur tetranitride in a homogeneous medium

The hydrolytic reactions of tetrasulphur tetranitride are studied in a homogeneous medium. Alkaline hydrolysis gives sulphite, thiosulphate, sulphate and sulphide whereas the products in acid hydrolysis are mainly sulphur dioxide, elemental sulphur and hydrogen sulphide, with traces of polythionates. Under optimum conditions, tetrasulphur tetranitride reacts with sulphite consuming 2 moles of sulphite per mole of sulphur nitride to give 2 moles of trithionate. The reaction of sulphur nitride with thiosulphuric acid gives pentathionate and tetrathionate.

Hydrolytic reactions of esters and amides of thiosulphurous acid in a homogeneous medium

The hydrolytic reactions of esters and amides of thiosulphurous acid are investigated in a homogeneous medium. The esters are hydrolysed by alkali to give sulphide, sulphite and thiosulphate whereas the amides are resistant towards alkali. Both the esters and amides are hydrolysed by acids giving hydrogen sulphide, sulphur dioxide, polythionates and elemental sulphur. The hydrolysis of these esters and amides in presence of sulphurous acid and thiosulphuric acid gives tetrathionate and hexathionate, respectively.

355. The dissociation constants of thiosulphuric acid

355. The dissociation constants of thiosulphuric acid

Bacterial Reduction of Tetrathionate

THE power of reducing nitrate is widespread among micro-organisms, while the reduction of sulphate is restricted to a few species1. It has long been recognized, however, that many bacteria are able to reduce less highly oxidized inorganic sulphur compounds (tetrathionate, thiosulphate, sulphite, etc.) to hydrogen sulphide2. In the course of attempts to improve selective media for isolating Salmonellas and Bact. typhosum from excreta, we have found that, so far as some organisms are concerned, the tetrathionate is first reduced to thiosulphate. This reaction takes place rapidly and quantitatively, and estimations at different stages show that the molecular concentration of the thiosulphate formed is twice that of the tetrathionate which has disappeared, in agreement with the equation: The subsequent further reduction of thiosulphate to hydrogen sulphide is, in comparison, so slow that the reduction of tetrathionate can be followed accurately by direct iodometric titration of the thiosulphate, provided that the high acidity developing from accumulat on of thiosulphuric acid is controlled by a phosphate buffer.

A Note on the Constitution and Isomerism of Thiosulphuric Acid.

A Note on the Constitution and Isomerism of Thiosulphuric Acid.

Isomeric Thiosulphuric Acids

IN continuation of an investigation of thiosulphato-cobalt complexes,1 it has been found possible to isolate two very interesting isomeric modifications of thiosulphato-penta-cyano cobaltic acid H4 [(CN)5.Co.S2O3]; the difference between which lies in the constitution of the thiosulphate radical. The two acids differ in their chemical behaviour and form two corresponding series of crystalline isomeric salts. Both the complex acids hydrolyse in warm water, liberating two different varieties of free thiosulphuric acid. One of the latter decomposes as usual into sulphur dioxide and sulphur, whereas the other gives rise to sulphuretted hydrogen and sulphuric acid. This furnishes a positive and direct evidence of the existence of two isomeric forms of thiosulphuric acid, and has indeed led to their isolation in solution. The two different ways in which the constitution of thiosulphuric acid has been represented in many text-books correspond, therefore, in reality to these two isomeric forms. In fact, Piccard and Thomas2 obtained an indication of the synthesis of thiosulphuric acid from sulphur trioxide and hydrogen sulphide.

Sulphur as a soil fungicide against the potato wart disease organism

(1) Thiosulphuric acid has been shown to exist in a free state.(2) It is relatively stable in dilute solution; an M/200 solution is only half decomposed at the end of 1 day and an M/400 solution at the end of 10 days only.(3) This degree of stability is sufficient to account for the fungicidal action of acidified thiosulphate solutions in terms of the liberated thiosulphuric acid.(4) It can be calculated that it is only necessary to assume 6 per cent. of the minimum quantity of sulphur found effective against Wart Disease in the field to be in the form of thiosulphuric acid over a period of 10 days in order to account for its toxicity.

The influence of charcoal upon the velocity of the reaction between iodide‐iodate and hydrogen ions, the decomposition of thiosulphuric acid and the reaction between phenol and bromine

The influence of charcoal upon the velocity of the reaction between iodide‐iodate and hydrogen ions, the decomposition of thiosulphuric acid and the reaction between phenol and bromine

THE TOXICITY OP CERTAIN SULPHUR COMPOUNDS TO SYNCHYTRIUM ENDOBIOTICUM, THE FUNGUS CAUSING WART DISEASE OF POTATOES

Summary.The toxieities towards the winter sporangia of Synchytrium endobioticum of certain of the simpler sulphur compounds which are at all likely to be formed when sulphur is added to soil were tested and compared with that of sulphuric acid.Sulphuric (H2SO4), sulphurous (H2SO3), dithionic (H2S2O6), trithionic (H2S3O6), tetrathionic (H2S4O6), and pentathionic (H2S5O6) acids were toxic and this toxicity was of the same order in each case at the same hydrogen ion concentration. Their neutral salts were non‐toxic. These facts suggest that the toxicities of these acids are mainly due to their hydrogen ion concentrations.Acidified solutions of sodium thiosulphate Na2S2O3, sodium hydrosulphite Na2S2O4 and sodium formaldehyde sulphoxylate were about ten times as toxic as sulphuric acid.Evidence is brought forward which suggests that the toxicity of these acidified solutions, in excess of that accounted for by the hydrogen ion concentration, is due to the thiosulphuric acid present in each of them. In view of the experimental difficulties due to the instability of some of the compounds and the length of time taken by them to exert their toxic action on the fungus investigated, this conclusion must be regarded as tentative.Of the other compounds tested sodium hydroxide was found to be a little more toxic than sulphuric acid and persulphuric acid about ten times as toxic; hydrogen peroxide, calcium polysulphide and sulphuretted hydrogen were only slightly toxic.

STUDIES ON SULPHUR METABOLISM. I. THE URINARY SULPHUR PARTITION IN VARIOUS DISEASES

I. INTRODUCTION As is well known, the urinary sulphur is made up of the sulphates, both inorganic and ethereal, and certain less highly oxidized compounds, which are called, following Salkowski's 1 suggestion, sulphur. The neutral sulphur compounds are many and include the following: uroferric acid, 2 uroproteic acid, 3 oxyproteic acid, 4 urochrome, 5 thiocyanic acid and its salts, 6 cystin and similar substances, 7 taurin and taurincarbamic acid, 1 methyl mercaptan, 8 ethyl sulphid, 9 thiosulphuric acid 10 and sulphurous acid. 11 Many of the above mentioned substances contain nitrogen in a form which would be included under the term colloidal nitrogen, and on that account one would expect in those cases in which the urine contains an increased amount of colloidal nitrogen, there would also be an increase in the neutral sulphur of the urine. It has been known for some time that the colloidal nitrogen

Societies and Academies.

Societies and Academies.