Thick Lips Research Articles

Further delineation of the facial 13q14 deletion syndrome in 13 retinoblastoma patients

Thirteen years ago, Motegi and colleagues (J Med Genet 1987;24:696–697) summarized the specific facial phenotype of six Japanese retinoblastoma patients with interstitial 13q14 deletions. Among a series of 228 propositi with retinoblastoma referred to the Lausanne Retinoblastoma Clinic for treatment and genetic counseling between 1986 and 1997, 13 (5.7%) were diagnosed with a cytogenetic de-novo 13q14 deletion. We confirm the presence of the reported facial phenotype in our population of Caucasian patients and describe additional clinical traits, thus extending the facial phenotype associated with the 13q14 deletion. Del(13q14) comprises, among others, cranial anomalies, frontal bossing, deeply grooved and long philtrum, depressed and broad nasal bridge, bulbous tip of the nose, thick lower lip, thin upper lip, broad cheeks, and large ears and lobules. Recognition of this particular facial appearance was instrumental in the genetic diagnosis of 13q deletions and in the presymptomatic diagnosis of retinoblastoma in a significant number of our cases. Identification of this phenotype in a retinoblastoma patient allows for efficient diagnosis of recurrence in his progeny and/or sibship, while its ignorance will compromise genetic counseling due to the possible difficulties in detecting large deletions by standard molecular mutation analysis. Recognition of this syndrome in newborns without known familial risk for retinoblastoma is even more important as it is a clear warning sign that indicates immediate ophthalmic examination.

Victims or Villains: Jewish Images in Classic English Detective Fiction (review)

Victims or Villains: Jewish Images in Classic English Detective Fiction, by Malcolm J. Turnbull. Bowling Green, OH: The Popular Press, 1999. 200 pp. $22.00. At the turn of the twentieth century literature changed. Hitherto chiefly the province of the upper-middle class, the introduction of universal education along with the invention of the rotary press, linotype, half-tone engraving, advertising, incandescent illumination, and the vacation combined to make reading a form of entertainment for the first time. Beginning with Doyle's Scandal in Bohemia (1891), the detective story became the most prominent form of popular fiction in England. Conventionally viewed, the history of the detective story proceeds from Doyle, through a number of turn-of-thecentury imitators, to its Golden Age: the period between the wars when all of the big names - Christie, Sayers, Marsh, Cox, Allingham, et al. - began to write. And Malcolm Turnbull has read them all. He has read them, moreover, with an eye toward the ways in which detective stories from about the turn of the century through about the end of World War II treat Jewish characters. They mostly treat them badly. Scarcely a surprise. Turnbull chronologically pursues the ways in the English detective writers use and describe Jewish characters. His chapters cover the periods of 1887 to 1918, 1919 to 1939, 1939 to 1945, and 1945 to the present. In the middle of the book he also takes a look at the ways in which three writers - Christie, Sayers, and Cox - treat Jews. In this survey Turnbull follows the rise and fall of stereotypes imposed on Jewish characters. These begin with the image of influential wealthholder and cunning immigrant pauper inherited from older English fiction and proceed after World War I to the Jew as parvenu, as revolutionary, and as war-profiteer. Throughout each of the periods persists the stereotype of the Jew as alien, as someone whose appearance (swarthy complexion, hooked nose, thick lips, dark hair), dress (rags or exhibitionistic clothes), speech (lisping), morals (sexually aggressive), and mannerisms differ from those of the other characters in the world of the fiction. Turnbull touches on events which coincide with the creation and adoption of antisemitic images from the Dreyfus case, to the emigration of Russian Jews in the 1 890s, to the publication of The Protocols of the Elders ofZion, to the role of two Jewish M.P.s in the Marconi and Indian Silver Scandals, as well as the association of several Jewish activists with the causes of communism and the Russian Revolution. Turnbull, however, shows both that in each period some detective story writers express philosemitic attitudes and that after 1933 antisemitism largely disappears from British detective fiction. In 1 899, for instance, while E. M. Hornung presented Reuben Rosenthall in The Amateur Cracksman as the most astonishing brute to look at, well over six feet, with a chest like a barrel and a great hook-nose, and the reddest hair and whiskers you ever saw. ... He boasted of his race, he bragged of his riches, and he blackguarded society for taking him up for his money and dropping him out of sheer pique and jealousy because he had so much[,] his brother-in-law, Arthur Conan Doyle, can and should be seen as philosemitic in his writing and private life. While Doyle was ready enough to express religious prejudice (consider Mormons in A Study in Scarlet), and generally creates villains who are either foreign or have been tainted by otiier cultures, Turnbull finds no evidence in the Holmes canon of prejudice against Jews and mentions Doyle's campaign to free the wrongly accused Oscar Slater in 1927. …

Effects of Jet Temperature and Nozzle-Lip Thickness on Screech Tones

Imperfectly expanded supersonic jets, invariably, generate discrete frequency sound known as screech tones. In the low supersonic jet Mach-number range of 1.0-1.25, the screech phenomenon is axisymmetric. In this investigation the effects of jet temperature and nozzle-lip thickness on the axisymmetric jet screech modes are studied by numerical simulation. At the present time there is no known way to predict the intensities of screech tones, even empirically, except by numerical simulation. Numerical results of screech frequencies and directivities of heated jets will be reported. The computed screech frequencies are found to agree well with experimental measurements. Computed tone intensities indicate a gradual decrease in the screech amplitude with an increase in jet temperature. Screech tones are known to be sensitive to the presence of acoustic reflection surfaces. Sound reflected off such surfaces could sometimes affect the feedback loop that drives the screech tones. The nozzle lip is a good reflection surface. As a part of this work, the effect of nozzle-lip thickness on screech tone frequency and intensity is investigated. There are good agreements between the computed tone frequencies, intensities, and experiments at several nozzle-lip thickness to jet diameter ratios. Thick lip nozzles, as expected, are found to generate the loudest tones. But the change in sound-pressure level between a thin and a thick lip nozzle is found to be quite modest.

Systematics of Macrhybopsis tetranema (Cypriniformes: Cyprinidae)

Morphometry, meristic features, pigmentation, and tuberculation were examined from 632 specimens of the Macrhybopsis aestivalis complex from the Arkansas River basin. Patterns of morphological variation support the recognition of two species in the basin: M. hyostoma in the middle and lower portions of the basin in Arkansas, Kansas, and Oklahoma; and M. tetranema in the middle and upper portions of the basin in Colorado, Kansas, New Mexico, Oklahoma, and Texas. Macrhybopsis tetranema is redescribed and compared to M. hyostoma, from which it can be distinguished by longer barbels, smaller eyes, smaller scales, reduced belly squamation, thicker lips, more conical head, and biserial pectoral fin tuberculation. These species are sympatric and maintain their identities in the Cimarron, Salt Fork of Arkansas, and Arkansas Rivers. Morphological intermediacy of M. tetranema in some areas of sympatry may reflect convergent adaptation to local conditions or hybridization with M. hyostoma. THE rivers of the western half of the Arkansas River Basin support cyprinids adapted

Malcolm's Conk and Danto's Colors; or, Four Logical Petitions Concerning Race, Beauty, and Aesthetics

I have opened with this passage from Toni Morrison for a number of reasons. The passage reflects the long-standing preoccupation that African-American activists have had with standards of physical beauty, a preoccupation that I will soon call antiracist aestheticism. The passage also captures in singularly effective language the existential, social, and psychological conditions that motivate this preoccupation, and contributes the language of logical petitions that I will use to frame my discussion of aestheticism. Morrison's ugly little black girl, a character named Pecola, makes a request that would be ludicrous were it not for the nature of her circumstances. In this essay I want to consider how Pecola's circumstances motivate her petition and two others, after which I will offer my own petition concerning the practice of aesthetics. First, a few words about the social and intellectual conditions that make Pecola's petition "logical." One of the cornerstones of the modern West has been the hierarchical valuation of human types along racial lines. (Unless I say otherwise, I will be concerned throughout with the modern West, particularly with England and its former possessions in the Americas.) The most prominent type of racialized ranking represents blackness as a condition to be despised, and most tokens of this type extend this attitude to cover the physical features that are central to the ascription of black identity. So a central assumption has been that black folks-with our kinky hair, flat noses, thick lips, dark skin, prognathism, and steatopygia-are ugly. (I call to your attention the evaluative overtones of this standard descriptive language: imagine the difference if I had said broad noses, full lips, curly hair, and so on.) The Journal of Aesthetics and Art Criticism

Malcolm's Conk and Danto's Colors; Or, Four Logical Petitions concerning Race, Beauty, and Aesthetics

I have opened with this passage from Toni Morrison for a number of reasons. The passage reflects the long-standing preoccupation that African-American activists have had with standards of physical beauty, a preoccupation that I will soon call antiracist aestheticism. The passage also captures in singularly effective language the existential, social, and psychological conditions that motivate this preoccupation, and contributes the language of logical petitions that I will use to frame my discussion of aestheticism. Morrison's ugly little black girl, a character named Pecola, makes a request that would be ludicrous were it not for the nature of her circumstances. In this essay I want to consider how Pecola's circumstances motivate her petition and two others, after which I will offer my own petition concerning the practice of aesthetics. First, a few words about the social and intellectual conditions that make Pecola's petition logical. One of the cornerstones of the modern West has been the hierarchical valuation of human types along racial lines. (Unless I say otherwise, I will be concerned throughout with the modern West, particularly with England and its former possessions in the Americas.) The most prominent type of racialized ranking represents blackness as a condition to be despised, and most tokens of this type extend this attitude to cover the physical features that are central to the ascription of black identity. So a central assumption has been that black folks-with our kinky hair, flat noses, thick lips, dark skin, prognathism, and steatopygia-are ugly. (I call to your attention the evaluative overtones of this standard descriptive language: imagine the difference if I had said broad noses, full lips, curly hair, and so on.) The Journal of Aesthetics and Art Criticism

Craniotubular dysplasia with severe postnatal growth retardation, mental retardation, ectodermal dysplasia, and loose skin: Lenz-Majewski-Like syndrome

The heterogeneous group of craniotubular dysplasias is characterized by modeling errors of the craniofacial and tubular bones. Some conditions in this category cause not only skeletal abnormalities but also a variety of mesoectodermal dysplasias, as exemplified in Lenz-Majewski syndrome (MIM 151050), which comprises craniodiaphyseal dysplasia, failure to thrive, mental retardation, proximal symphalangism, enamel hypoplasia, and loose skin. We report on a boy with a hitherto unknown multisystem disorder, including skeletal changes that were regarded as a form of craniotubular dysplasia. The patient had a large head, exophthalmos, a broad nasal root, anteverted nostrils, large auricles, thick lips, micrognathia, severe postnatal growth retardation with emaciation, severe mental retardation, sparse hair growth, enamel hypoplasia, and thin, loose skin with hyperlaxity. Skeletal changes consisted of thickened calvaria, sclerosis of the skull base and facial bones, thick ribs, and metaphyseal undermodeling of the tubular bones. In addition, generalized osteopenia was evident. The present disorder overlaps phenotypically with Lenz-Majewski syndrome; nevertheless, the absence of diaphyseal hyperostosis and proximal symphalangism in the present patient was not consistent with Lenz-Majewski syndrome.

Craniotubular dysplasia with severe postnatal growth retardation, mental retardation, ectodermal dysplasia, and loose skin: Lenz‐Majewski‐Like syndrome

The heterogeneous group of craniotubular dysplasias is characterized by modeling errors of the craniofacial and tubular bones. Some conditions in this category cause not only skeletal abnormalities but also a variety of mesoectodermal dysplasias, as exemplified in Lenz-Majewski syndrome (MIM 151050), which comprises craniodiaphyseal dysplasia, failure to thrive, mental retardation, proximal symphalangism, enamel hypoplasia, and loose skin. We report on a boy with a hitherto unknown multisystem disorder, including skeletal changes that were regarded as a form of craniotubular dysplasia. The patient had a large head, exophthalmos, a broad nasal root, anteverted nostrils, large auricles, thick lips, micrognathia, severe postnatal growth retardation with emaciation, severe mental retardation, sparse hair growth, enamel hypoplasia, and thin, loose skin with hyperlaxity. Skeletal changes consisted of thickened calvaria, sclerosis of the skull base and facial bones, thick ribs, and metaphyseal undermodeling of the tubular bones. In addition, generalized osteopenia was evident. The present disorder overlaps phenotypically with Lenz-Majewski syndrome; nevertheless, the absence of diaphyseal hyperostosis and proximal symphalangism in the present patient was not consistent with Lenz-Majewski syndrome. Am. J. Med. Genet. 71:87–92, 1997. © 1997 Wiley-Liss, Inc.

Rock 'n' Roll, Female Sexuality, and the Cold War Battle over German Identities

Previous articleNext article No AccessRock 'n' Roll, Female Sexuality, and the Cold War Battle over German IdentitiesUta G. PoigerUta G. Poiger Search for more articles by this author PDFPDF PLUS Add to favoritesDownload CitationTrack CitationsPermissionsReprints Share onFacebookTwitterLinkedInRedditEmail SectionsMoreDetailsFiguresReferencesCited by The Journal of Modern History Volume 68, Number 3Sep., 1996 Article DOIhttps://doi.org/10.1086/245343 Views: 56Total views on this site Citations: 6Citations are reported from Crossref Copyright 1996 The University of ChicagoPDF download Crossref reports the following articles citing this article:Michael G. Esch „Wir haben keine Go-Go-Girls mehr“: Der Beat Club als Quelle und Akteur in der Kanonisierung des Rock, (Jun 2018): 213–258.https://doi.org/10.7788/9783412512286.213Franz X. Eder National and Racial Images of the Sexual ‘Other’ in the German-Speaking Countries (1950s–1970s), Sexuality & Culture 21, no.22 (Mar 2016): 362–381.https://doi.org/10.1007/s12119-016-9340-7Toby Thacker Music and Politics in Germany 1933?1955: Approaches and Challenges, History Compass 5, no.44 (Jun 2007): 1338–1358.https://doi.org/10.1111/j.1478-0542.2007.00449.xKonrad Dussel Radio Programming, Ideology and Cultural Change: Fascism, Communism and Liberal Democracy, 1920s–1950s, (Jan 2006): 80–94.https://doi.org/10.1057/9780230800939_5Robert Stephens Drug Use and Youth Consumption in West Germany During the 1960s, Journal for Cultural Research 7, no.22 (Apr 2003): 107–124.https://doi.org/10.1080/14797580305362 Uta G. Poiger A New, "Western" Hero? Reconstructing German Masculinity in the 1950s, Signs: Journal of Women in Culture and Society 24, no.11 (Oct 2015): 147–162.https://doi.org/10.1086/495322

Rigid mask-like face, ear anomalies, deafness, preaxial polydactyly and toe malformations in a patient with normal intelligence

We describe a patient with deafness, normal intellect and a unique phenotype characterized by a rigid mask-like face, narrow, upslanting palpebral fissures, flat malar bones, thick lower lip, malformed auricles, preaxial polydactyly with triphalangeal thumbs, syn-ectrodactyly of toes and first degree hypospadias.

Ctenella aurantia, genre et espèce nouveaux de cténophore tentaculé (Ctenellidae fam.nov.) méditerranéen sans colloblastes et avec ventouses labiales

Ctenella aurantia gen. et sp.nov. is a small Mediterranean tentacled ctenophore. Its ovoid and flattened body is opaque and yellow-orange, with red-pigmented areas. Comb rows are arranged in pairs from the apex to the oral third of the body. The tentacular sheaths situated at the end of the oral third of the body open medially; they terminate in an aboral open groove which can close up around the unramified tentacles. The gastrovascular system is simple and follows the axis of the body; it has no peripheral canals but two long apical canals project into the aboral zone. The mouth forms a sagittal slit bordered by two thick lips, each bearing a sucker on its internal wall. The species also possesses very distinctive cytological features, notably the absence of colloblasts on the tentacles and the consistent presence of exogenic cnidocysts that are embedded in the gastrovascular wall. The muscular cells of the oral zone have no sarcomeres, but have both fine and thick myofilaments that are arranged alternately. The species is very distinctive, both in its cytological characteristics and its general organization. It is tentatively classified in the order Cydippida, and its relationship to some other species is mentioned.

Non-specific X linked mental retardation with aphasia exhibiting genetic linkage to chromosomal region Xp11.

A new type of non-specific X linked mental retardation is described in a three generation family. The three affected males had severe mental retardation (IQ 20 to 30), mutism, growth...

Coffin-Siris syndrome.

In 1970 Coffin and Siris described three unrelated female children with severe mental and developmental retardation, sparse scalp hair, and coarse appearing facies with bushy eyebrows, a wide mouth, and thick lips. There were, in addition, lax joints and brachydactyly of the fifth digits of both hands and feet with absence of the nails and terminal phalanges.' To our knowledge, there have been 31 cases of this condition reported and these are reviewed in the present paper with the addition of two new cases.

Partial monosomy for chromosome 22 in a patient with del(22)(pter----q13.1::q13.33----qter).

An 18 month old girl with partial monosomy for the long arm of chromosome 22 is described. The karyotype was 46,XX,del(22)(pter----q13.1::q13.33----qter). To our knowledge this is the first report of monosomy for this specific segment of chromosome 22. Clinical features include developmental delay in all areas, hypotonia, macrosomia, full cheeks, eyebrows, and eyelids, mild epicanthus, wide nasal bridge, long philtrum, and thick lower lip. Parental chromosome studies were normal.

Paraspinibarbus, a new genus of cyprinid fishes from the Red River basin

Paraspinibarbus, a new and monotypic genus, is erected forSpinibarbus macracanthus Pellegrin et Chevey, 1936, a cyprinid from the Red River basin. It is characterized by a procumbent predorsal spine and a very thick lower lip with a continuous postlabial groove.Balantiocheilus hekouensis Wu, 1977 is a junior subjective synonym ofParaspinibarbus macracanthus. A lectotype is designated forS. macracanthus.

The Divergence Controversy

T HE HISTORY OF THE STUDY OF the Black English Vernacular (BEV) is essentially a history of controversies.1 Initially, linguists were united in challenging the notion that BEV was the product of physiological differences between blacks and whites (the thick lips and lazy tongues theory) and then the notion that BEV was a deficient dialect, incapable of the sophisticated logical distinctions and categories that characterize higher-level discourse. Later, linguists debated among themselves, often acrimoniously, the relationships between black and white speech and the origins of BEV.2 In spite of the long and bitter polemics that developed during these latter stages, by 1982 William Labov, in the wake of the Ann Arbor decision, was able to assert that a consensus on BEV had emerged. Most linguists, he suggested, agreed that BEV is a subsystem of English which, although incorporating many features of Southern States English, has a distinct set of phonological and syntactic rules. Those rules are now aligned in many ways with the rules of other dialects but still show evidence of derivation from an earlier

Clinical assessment of Zyplast Implant: A year of experience for soft tissue contour correction

The advent of injectable collagen for soft tissue augmentation has opened an entirely new area for the dermatologie cosmetic surgeon and for dermatologists who have a particular interest in the cosmetic aspect of our specialty. Patient demand for correction of soft tissue contour irregularities is high and continues to increase daily. The use of injectable collagen with appropriate technique can provide these patients with significant improvement without great cost or significant side effects. In the year following the introduction of glutaraldehyde cross-linked Zyplast Implant, 188 patients were evaluated for soft tissue augmentation with bovine collagen in my clinical practice. Diagnoses varied from facial elastosis to scars due to acne, pox, trauma, and cancer. Some patients desired changes in facial contour (thicker lips; postrhinoplasty defect). Patient satisfaction was high (83% good or excellent results) and side effects were minimal. In our study we found that 3% of patients demonstrated hypersensitivity to the test implant. Treatment with non—cross-linked Zyderm and Zyplast collagens in the patients with a negative skin test resulted in six hypersensitivity reactions (3%). In these patients reactions were not observed at sites treated only with cross-linked collagen and clinical responses appeared to be directed at the non—cross-linked collagen implant sites. With proper treatment technique and patient consultation, the results obtained with injectable collagen fulfill expectations of treated patients.

Thick Lips, Bumpy Tongue, and Slipped Capital Femoral Epiphysis—A Deadly Combination

Summary: Multiple endocrine neoplasia type 2b (MEN 2b) is a rare genetic disorder. Affected individuals have malignant thyroid tumors, pheochromocytoma, and ganglioneuromatosis. The musculoskeletal manifestations of MEN 2b include a Marfanoid habitus, pes cavus, scoliosis, slipped capital femoral epiphysis, joint laxity, poor muscle development, and delayed maturation. The initial clinical presentation of MEN 2b frequently involves the musculoskeletal system. The characteristic ganglioneuromatosis of the lips and tongue, however, should alert the orthopedic surgeon to the underlying disorder. Effective treatment of the malignant neoplasms hinges on early diagnosis. The risk of perioperative hypertensive crisis is significant; it may be prevented by appropriate treatment of the pheochromocytoma.

Thick Lips, Bumpy Tongue, and Slipped Capital Femoral Epiphysis—A Deadly Combination

Multiple endocrine neoplasia type 2b (MEN 2b) is a rare genetic disorder. Affected individuals have malignant thyroid tumors, pheochromocytoma, and ganglioneuromatosis. The musculoskeletal manifestations of MEN 2b include a Marfanoid habitus, pes cavus, scoliosis, slipped capital femoral epiphysis, joint laxity, poor muscle development, and delayed maturation. The initial clinical presentation of MEN 2b frequently involves the musculoskeletal system. The characteristics ganglioneuromatosis of the lips and tongue, however, should alert the orthopedic surgeon to the underlying disorder. Effective treatment of the malignant neoplasms hinges on early diagnosis. The risk of perioperative hypertensive crisis is significant; it may be prevented by appropriate treatment of the pheochromocytoma.

Sub-Total Loss of Lower Lip

SummaryThe full-thickness loss of lower lip may be due to chemical, electrical burns, cancrum oris, accidental injuries, maxillofacial injuries, gunshot wounds, after surgical excision and rarely due to animal bite. An uncommon cause of the loss of the lower lip due to human bite and its subsequent repair by full thickness lip advancement and check rotation flaps would be presented through this paper.