The aim of current paper is to explore the dynamics of Tangent hyperbolic hybrid nanofluid flow and heat transfer over a stretchy surface, combined effect of thermal radiation and Cattaneo-Christov heat flux effects also incorporated in the energy equation. Hybrid nanofluids are advanced class of nanofluid have several engineering applications due to their enhanced thermal, electrical, and rheological properties. Here we developed a mathematical model for two-dimensional hybrid nanofluid containing particles copper (Cu) and alumina oxide (Al2O3) suspended with base fluid H2O. Variable viscosity and viscous dissipation aspect also amalgamated in the present study. After applying the dimensionless variables, the governing PDE's are converted into ODE's. The numerical computations are performed with the help of MATLAB software. The most important outcomes predefined pertinent parameters like magnetic parameter, Weissenberg number, relaxation time, thermal radiation parameter, prosperity parameter, convective parameter, Prandtl number, heat source parameter, Eckert number, on velocity and temperature profile are thoroughly examined graphically and physically. There occur increment in the temperature profile of hybrid nanofluid than regular nanofluid. Also over current outcomes shows close agreement for a particular cases.