This paper proposes a redesign technique for heat exchanger channels based on a Local Entropy Generation (LEG) analysis and numerical simulations. The approach first divides the computational domain into zones and then identifies the zones responsible for increasing irreversibilities due to viscous and heat transfer effects. By evaluating different geometric features and flow conditions, the wall shape is modified (zone by zone) with the configurations that offer the lowest local entropy generation rates. The redesigned channels demonstrate that sudden changes in geometry along the streamwise direction reduce the size of regions with high thermal entropy generation and promote the creation of vortices, thereby reducing the magnitude of thermal irreversibilities. Smooth wall shape transitions might not be desirable when the goal is to improve heat transfer. The redesign process enhances the thermal performance of the system without significantly increasing power demand. The proposed methodology is evaluated using three wavy channels with a non-uniform amplitude-to-wavelength ratio (β1,β2,andβ3) since they allow for better management of wall geometry. As demonstrated for case β1, the LEG analysis enables the construction of new channels with a thermal performance 3.9 % superior to those with a uniform amplitude-to-wavelength ratio of α = 0.16 (best-case scenario), but with approximately 20 % less pumping power. While this study employs wavy channels as a case study, the methodology is broadly applicable to various heat exchanger configurations, including trapezoidal, triangular, and zigzag channels, making it a versatile tool for improving thermodynamic performance across different designs.