Depression is a kind of mental illness affecting the whole world. Its pathological mechanism is complex, involving neurobiological and psychosocial factors.The depression model rats were randomly divided into control group, warm acupuncture group and drug treatment group. In order to evaluate the local thermal effect of warm acupuncture and moxibustion, real-time temperature changes of rat forebrain were monitored by thermal imaging technology. After the experiment, immunohistochemistry and Western blot were used to detect the expression levels of tPA and BDNF in the forebrain of each group of rats, and the relationship between tPA and BDNF was analyzed. The results of thermal imaging monitoring showed that local forebrain temperature in warm acupuncture group was significantly increased compared with control group (p < 0.05). The ratio of tPA to BDNF was significantly improved in the warm acupuncture and moxibustion group, suggesting that warm acupuncture and moxibustion can effectively regulate the balance of TPA-BDNF. The experimental results based on thermal imaging monitoring suggest that warm acupuncture can improve the balance of TPA-BDNF in the forebrain of depressed rats by promoting the expression of BDNF and tPA in the forebrain, which may provide a new method and mechanism basis for the treatment of depression.
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