The topic of this paper is to couple the passive and active approaches to enhance the heat transfer performance in the inline tube bundle heat exchanger. Firstly, the k-kl-ω turbulence model and Kays turbulent Prandtl number model are validated by liquid metal cross flow tube bundle experiments and rectangular groove pulsating flow experimental results. Then the numerical studies were carried out for pulsating velocity amplitude of 0.5, frequency of 10, and Re of 20,000 with transverse and streamwise pitch-to-diameter ratios of 1.5, 1.65, and 1.8. The introduction of pulsating flow effectively improves the turbulence characteristics between the tube bundles, especially at the first three rows, where the velocity fluctuation is enhanced by about 1.5–2 times. The tube heat transfer performances are all improved. The performance evaluation criterion (PEC) variation ranges from 1.04 to 1.32, which signifies that the introduction of pulsating flow can enhance the comprehensive heat transfer performance. The per unit flow rate thermal entropy generation decreased by about 9.7–33.3 %, in addition, a phase difference between the transient thermal entropy production and pulsating velocity was found. The correlation equations about Nu and f factor within the scope of this paper are presented.