The main motivation behind this numerical analysis is to disclose the salient magneto-thermo characteristic features of two-dimensional viscous incompressible magnetized Soret and Dufour effects on the boundary layer flow of Walter’s-B fluid over a stretching sheet under the influence of viscous dissipation. The novel physical effects such as nonuniform heat source/sink and magnetic Ohmic heating are included in the governing equations. Further, prescribed surface temperature condition is introduced in the boundary conditions to describe the thermal transport features. However, the deployed non-Newtonian Walter’s-B fluid rheology model finds its innumerable applications in numerous areas of science and engineering including electronic cooling, polymer processing, nuclear reactor cooling, extraction of polymer sheet, plastic sheet drawing, chemical engineering, metallurgy, injection molding and many more. Therefore, authors have motivated with these applications and advantageous of considered fluid model. Hence, an effort is made to describe the dynamic characteristic features of non-Newtonian Walter’s-B rheology model about a stretching sheet. However, present physical flow model produces highly nonlinear coupled two-dimensional partial differential equations and which are not acquiescent to available analytical methods. Owing to this, a robust MATLAB-based BVP4C technique is deployed to produce the appropriate numerical solutions through suitable similarity transformations. The graphical representations of velocity, temperature and concentration profiles along with skin-friction coefficient, Nusselt and Sherwood numbers are presented. Magnifying magnetic number decays the velocity profile and enhances the thermal and concentration fields. Rising viscoelastic parameter diminishes the thermal and concentration fields and magnifies the velocity field. Rising the radiation parameter diminish the thermal field. Magnifying Soret number raises the concentration field. Rising the space and temperature dependent heat source/sink coefficient amplifies the thermal diffusion field. Magnifying Dufour and Eckert numbers amplifies the thermal field. Finally, the guarantee and accuracy of the investigated problem is presented through a comparison with previous studies.