CO2 booster pump valves are key components in the CO2 oil drive industry, and their reliability is critical to the safe operation of pumping booster systems. Due to the special nature of CO2, heat transfer occurs during valve movement, which can cause damage to the valve body and poppet, and thus in-depth studies on CO2 properties are needed to better predict the locations where the valve is vulnerable to damage. However, relatively few studies have been conducted to analyze the fluid-thermal-solid coupling failure of CO2 booster pump valves. This paper establishes a multi-physics coupled thermodynamic model of CO2 booster pump valves, analyzes the transient simulation of valves at different valve openings, pressures and temperatures, and investigates the thermal properties of four different poppet materials. The results show that: with the increase of valve opening, the maximum deformation of the valve decreases sharply, and then tends to stabilize; in the process of pressure increasing from 4.77 MPa to 10.52 MPa, the turbulent kinetic energy inside the valve increases by about 78 %; it is also found that the thermal deformation of different poppet materials is directly proportional to the coefficients of thermal expansion of the materials, among which the deformation of aluminum alloy poppet is the largest. In addition, the results of thermal deformation and thermal stress distribution indicate that the failure region of the valve is usually concentrated in the poppet and its corresponding body wall. These results provide theoretical references for optimizing the structural design of CO2 booster pump valves and help reduce the risk of failure of CO2 booster pump valves.