ObjectiveIn radiofrequency therapy for gastroesophageal reflux disease (GERD), radiofrequency treatment electrodes are inserted into the lower esophageal sphincter and cardiac muscle under the guidance of a gastroscope and heat is administered to burn the gastroesophageal junction in multiple layers and at multiple points, thereby increasing the pressure of the gastroesophageal junction, reducing tissue compliance, and possibly reducing the oversensitivity of the esophagus to prevent reflux and alleviate symptoms. Radiofrequency therapy is a less invasive treatment with a high effective rate and a low incidence of adverse reactions. Radiofrequency therapy is being increasingly applied, but there is no consensus on the indications, contraindications, or preoperative and postoperative evaluation. To improve the accuracy of patient selection and the technical implementation of radiofrequency therapy, it is necessary to summarize and standardize the clinical application of radiofrequency therapy in China to improve the safety and effectiveness of radiofrequency therapy. MethodsFrom December 2022 to April 2024, a total of 25 endoscopists who have performed more than 50 radiotherapy procedures in China conducted 6 rounds of consensus discussion, at which time the surgical indications and contraindications, preoperative evaluation parameters and multidisciplinary follow-up approach as well as the technical operation, postoperative follow-up process, training requirements, and other issues were discussed. The experts voted on each item. A ≥80% agreement was defined as a consensus. ResultsThe expert group consisted of 25 experts from 22 institutions, and the average number of radiofrequency treatment procedures performed was more than 50. The selected experts discussed a total of 8 items including surgical indications, surgical contraindications, basic working conditions and preparation, preoperative preparation, surgical process and technical skills, postoperative management, therapeutic effects, complications, and prevention and reached a consensus on all items. ConclusionRadiofrequency therapy can be used to treat chronic or refractory symptoms caused by gastroesophageal reflux. Before treatment, a detailed examination should be conducted to determine the reflux load and the relationship between reflux and symptoms and to rule out obvious hiatal hernia and other conditions that are not suitable for radiofrequency therapy. The technical requirements and key points of radiofrequency therapy are accurate and uniform distribution of radiofrequency treatment points to the lower esophagus and cardiac area centered on the dentate line, and short-term postoperative acid suppression therapy, complication observation and management, and curative effect observation and evaluation are also crucial. Most of the screened GERD patients had good outcomes and were treated with drugs or surgery. This consensus can be used as a reference guide for endoscopists performing radiofrequency therapy.