Introduction: Analysis of African Adventist theology of mission in the 21st century highlights theological African Adventist issues of concern. As an Adventist researcher, one is challenged by the growing anticipations and expectations that arise or are questioned in certain areas and sectors, including doctrinal issues in some grey areas. This research article probes those challenges that may be tabled by higher organizations or are just difficult to handle. Problem: Analysis of African Adventist Theology of Mission in the 21st Century presents problematic, unresolved doctrinal issues and teachings upheld by the mother body, the General Conference of the Seventh-day Adventists. These issues are still debated in other circles and regions. Purpose: To analyze the Seventh-day Adventists’ beliefs as a lifestyle for the African Adventists in the 21st century and highlight some downsides that may hinder the mission’s progress among Africans. Old and New Testament Scriptures guide, teach, and instruct a person to the esteemed life of Christ-like character. However, some scholars still argue that Christians and Adventists teach Creation Week. To an African, the belief in a creator God who shares space with His people has brought doubts to the very God who created everything in one week. Discussions: An African Adventist Theology of Ministry for the 21st Century article presented communication, ways of ministry in diverse settings, the Biblical foundation for mission and ministry, and God’s purpose for ministry. The Seventh-day Adventist Church is a family of Christian believers united in mission, purpose, and belief. Adventists seek to follow Biblical principles of Christ-like living, communicating, disciplining, teaching, healing, and serving communities regardless of where they are. Since God is the creator and owner of the mission, He has a purpose for His ministry and creation, which includes human beings. The purpose of God for his church is being revealed amongst His people through the publishing of literature, public evangelism, the gospel ministry, and medical missionary. As the mission owner (Missio Dei), God chooses how to direct the mission using His created world. All the people of different cultures and traditions are part of God’s mission. There are diverse ways of ministry, including reaching people in their homes, welfare ministry, friendship evangelism, Adventism, and God’s mission. When spreading the gospel, theologians need to recognize different types of communication: secular, Christian, and Adventist approaches. Findings: An analysis of African Adventist theology of mission in the 21st century found that God’s purpose for the ministry is to involve all means and people, regardless of creed, race, or ethnicity. God would employ any method to spread the gospel all over the world. Finally, communication plays a significant role in God’s mission.