This study analysed Ghana’s demographic patterns as shown by the 2000, 2010, and 2021 censuses and considered how these trends may affect Christian missions. According to the analysis, Ghana’s Muslim population has been steadily increasing over time, and by the year 2096, it may have a Muslim majority. Christian mission organisations working in Ghana must reevaluate their methods and approaches in order to effectively interact with and minister to a shifting religious landscape as a result of this probable demographic upheaval. The study also investigated the probable effects of a Muslim majority in Ghana and discussed the consequences for Christian missionary work, emphasising the need for cultural sensitivity, interfaith communication, and contextualised approaches to engage with the diverse religious beliefs and practices of Ghanaians. This study further examined what this demographic trend suggests and its implication for evangelism and intentional Christlike disciple making if a reversal is to be envisaged. The thesis statement of the paper is that Islam in Ghana unlike Christianity is witnessing steady growth, and the Church is enjoined by her calling to make Christlike disciples for her future survival. This article belongs to the field of missiology. It employed a transdisciplinary approach that incorporated statistical hermeneutics, hermeneutics of comparative theology, history of religion and demography to interpret quantitative results and determine their place and meaning in the religious landscape and their implications for Christian Mission. Keywords: Christian mission, Islamic growth, population census, Disciple-Making.