Theme Trends Research Articles

Mapping knowledge structures and theme trends in sport diplomacy: a bibliometric analysis

This study aims to analyse knowledge structures and thematic trends in sport diplomacy, an increasingly prominent field. Using bibliometric analysis of 331 studies from the Web of Science (WoS) database, this study identified several key themes, including the role of sport in promoting peace and diplomacy, the use of sport as a tool for soft power, and the challenges and opportunities of hosting sport mega-events. The study also identified several knowledge structures, including the relationship between sport and (international) politics, globalization, and the role of sport in cultural diplomacy. These findings provide insights for researchers, policymakers, and practitioners, guiding theory development, interdisciplinary collaboration, and practical applications. In summary, this study contributes to understanding the evolution and current state of sport diplomacy scholarship, fostering continued progress in this dynamic field.

Knowledge structure and theme trends on mHealth apps for COVID-19: bibliometric analysis

Knowledge structure and theme trends on mHealth apps for COVID-19: bibliometric analysis

Bibliometric analysis of phosphoglycerate kinase 1 expression in breast cancer and its distinct upregulation in triple-negative breast cancer.

Phosphoglycerate kinase 1 (PGK1) has been identified as a possible biomarker for breast cancer (BC) and may play a role in the development and advancement of triple-negative BC (TNBC). To explore the PGK1 and BC research status and PGK1 expression and mechanism differences among TNBC, non-TNBC, and normal breast tissue. PGK1 and BC related literature was downloaded from Web of Science Core Collection Core Collection. Publication counts, key-word frequency, cooperation networks, and theme trends were analyzed. Normal breast, TNBC, and non-TNBC mRNA data were gathered, and differentially expressed genes obtained. Area under the summary receiver operating characteristic curves, sensitivity and specificity of PGK1 expression were determined. Kaplan Meier revealed PGK1's prognostic implication. PGK1 co-expressed genes were explored, and Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Disease Ontology applied. Protein-protein interaction networks were constructed. Hub genes identified. PGK1 and BC related publications have surged since 2020, with China leading the way. The most frequent keyword was "Expression". Collaborative networks were found among co-citations, countries, institutions, and authors. PGK1 expression and BC progression were research hotspots, and PGK1 expression and BC survival were research frontiers. In 16 TNBC vs non-cancerous breast and 15 TNBC vs non-TNBC datasets, PGK1 mRNA levels were higher in 1159 TNBC than 1205 non-cancerous breast cases [standardized mean differences (SMD): 0.85, 95% confidence interval (95%CI): 0.54-1.16, I² = 86%, P < 0.001]. PGK1 expression was higher in 1520 TNBC than 7072 non-TNBC cases (SMD: 0.25, 95%CI: 0.03-0.47, I² = 91%, P = 0.02). Recurrence free survival was lower in PGK1-high-expression than PGK1-low-expression group (hazard ratio: 1.282, P = 0.023). PGK1 co-expressed genes were concentrated in ATP metabolic process, HIF-1 signaling, and glycolysis/gluconeogenesis pathways. PGK1 expression is a research hotspot and frontier direction in the BC field. PGK1 may play a strong role in promoting cancer in TNBC by mediating metabolism and HIF-1 signaling pathways.

Bibliometric and scientometric analysis of PSMA-targeted radiotheranostics: knowledge mapping and global standing.

Bibliometric and scientometric analyses provide a structured approach to large amounts of data, enabling the prediction of research theme trends over time, the detection of shifts in the boundaries of disciplines, and the identification of the most productive countries, institutions and scholars. In the context of prostate-specific membrane antigen (PSMA)-targeted radiotheranostics, no bibliometric or scientometric analysis has been published thus far. Therefore, this study was conducted to identify key contributors to the literature, assess the global scientific production of related research, and possibly predict future development patterns. Scientometrics and bibliometrics were utilized to analyze the current body of knowledge while tracking its evolution to support scientific decision-making comprehensively and systematically. Science mapping techniques were employed to visualize research activities. Two different tools, Tableau and VOSviewer, were utilized, with VOSviewer being deemed the most suitable for the research objectives. The Web of Science (WoS) was used as the principal database for the searches. Through the search process over a period of 30 years (January 1993-January 2023), 694 original studies in the English language were subjected to comprehensive analysis. By employing bibliometric and scientometric methods, multiple networks were created that mapped various concepts, such as publication trends, leading countries, cocitations, coauthorship among researchers and scientists, as well as coauthorship among organizations and funding agencies. This study revealed the evolutionary patterns, trends, outliers, and key players in the PSMA field, which enabled a more nuanced understanding of the research landscape. This research contributes to the enrichment of knowledge on PSMA-targeted radiotheranostics through detailed global bibliometric and scientometric analyses. It stresses the necessity for the development of communication platforms, the establishment of supportive infrastructures, and the implementation of proactive solutions to address emerging challenges. This study offers a significant resource for delineating effective strategies and identifying prominent funding bodies essential for continuous advancements in the field of PSMA-based diagnosis and therapy for prostate cancer. It is vital to sustain this momentum to ensure further progress in this pioneering area.

Innovation at the Board Level: Bibliometric Analysis over Three Decades

Abstract This study aims to investigate the evolutionary path of the relationship between innovation and board research knowledge over the past thirty years. Its objective is to understand the scientific activity and influence of current research in this field. Furthermore, it aims to outline current theme trends and provide suggestions for future study in this field. This research is a quantitative exploration that involves analyzing an intellectual framework within the field. Using a bibliometric methodology, we carefully chose 184 papers from the Scopus database that are specifically focused on innovation at the board level. These studies were then subjected to thorough examination. The utilization of VOSviewer software enabled the clear and concise representation of the outcomes. The bibliometric study involved identifying research themes, current and future directions, co-occurrences, co-citations, impact, and collaboration tendencies. The methodological framework has four consecutive stages: data acquisition, data examination, data representation, and data interpretation. The data demonstrate a noticeable increase in scholarly interest, especially in the past three years, suggesting a growing field of study. Four main areas of research were identified: the relationship between board diversity and its effect on the innovation process; the interaction between board culture and the effectiveness of innovation; the impact of board structure on innovation; and the growing emphasis on green innovation influenced by boards of directors. The methodology of this study recognizes the complex relationships between innovation and the overall setting of the board of directors, providing useful insights for both academic research and practical decision-making in the field of company performance.

Global Scientific Trends in Continuous Renal Replacement Therapy from 2000 to 2023: A Bibliometric and Visual Analysis

Introduction: Continuous renal replacement therapy (CRRT) is one of the most widely used blood purification and organ support methods in the ICU. However, the development process, the current status, hotspots, and future trends of CRRT remain unclear. Method: The WoSCC database was used to analyze CRRT research evolution and theme trends. VOSviewer was used to construct coauthorship, co-occurrence, co-citation, and network visualizations. CiteSpace is used to detect bursts for co-occurrence items. Several important subtopics were reviewed and discussed in more detail. Results: Global publications increased from 56 in 2000 to 398 in 2023, a 710.71% increase. Blood Purification published the most manuscripts, followed by the International Journal of Artificial Organs. The USA, the San Bortolo Hospital, and Bellomo were the most productive and impactful institution, country, and author, respectively. Based on co-occurrence cluster analysis, five clusters emerged: (1) clinical applications and management of CRRT; (2) sepsis and CRRT; (3) CRRT anticoagulant management; (4) CRRT and antibiotic pharmacokinetics and pharmacodynamics; and (5) comparison of CRRT and intermittent hemodialysis. COVID-19, initiation, ECOMO, cefepime, guidelines, cardiogenic shock, biomarker, and outcome were the latest high-frequency keywords or strongest bursts, indicating the emerging frontiers of CRRT. Conclusions: There has been widespread publication and citation of CRRT research in the past 2 decades. We provide an overview of current trends, global collaboration patterns, basic knowledge, research hotspots, and emerging frontiers.

Knowledge Mapping of Primary Dysmenorrhea: Hotspots, Knowledge Structure, and Theme Trends.

The global incidence of primary dysmenorrhea is continuously increasing, and understanding its research trends is crucial for effective pain management and women's health. Therefore, this study aims to perform a comprehensive bibliometric analysis of primary dysmenorrhea research to identify hotspots, explore emerging trends, and provide valuable insights for future research endeavors. All of the relevant studies on primary dysmenorrhea in the Web of Science™ Core Collection database were searched for bibliometric analysis. Biclustering analysis using gCLUTO software was performed to identify research hotspots. Social network analysis with Ucinet was employed to reveal knowledge structure. Evolutionary analysis using SciMAT was utilized to predict thematic trends. A total of 903 papers were analyzed, indicating a gradual increase in research on primary dysmenorrhea in recent years, with the scope of research expanding and diversifying. We identified seven hotspots, three treatment nodes, and four thematic trends. Research hotspots focused on epidemiological studies, adolescent primary dysmenorrhea, drug and non-drug treatments. Within the realm of treatments, we have identified three treatment nodes: acupuncture, acupressure, and ibuprofen. The evolution of research has witnessed a shift from traditional epidemiological studies toward a more diverse research landscape. Adolescent primary dysmenorrhea is expected to remain a prominent research topic while dietary supplements and lifestyle are predicted to gain more attention. An emerging theme is the study of variation and polymorphism of circadian rhythm genes concerning primary dysmenorrhea. This bibliometric analysis provides valuable insights into the current state of research on primary dysmenorrhea, offering a clearer understanding of the field's landscape. The identified hotspots, knowledge structure, and thematic trends can serve as valuable references for future investigations in this area. The research holds significant scientific importance and innovative value in elucidating the mechanisms of primary dysmenorrhea and finding more effective treatment approaches.

Analyzing Talent Trends of Generation Z Students in College of Agriculture Classrooms

Generation Z, born between 1997 and 2012, has taken over university classrooms. A sample of 592 U.S. Generation Z students enrolled in an agricultural leadership course was examined to determine if talent theme trends exist for the target population and how this information could enhance learning environments and agricultural education. The results indicate that the studied population have the signature talent themes of Achiever, Restorative, Empathy, Strategic, and Futuristic. Additionally, one substantial difference is that the Responsibility and Learner talent themes were sixteenth and eighteenth for the population in this study, respectively. At the same time, they were second and third in the Gallup Organization’s 2014 study. This difference may suggest a shift of Generation Z students in college of agriculture classrooms preferring outcomes in their education that can help them make an impact in the future over the learning process. A ranking of talent themes for the sample was determined, along with rankings based on sex. Significance was found that males were more likely to have one-or-more talents in the Influencing domain and two-or-more in the Strategic Thinking domain.

Nano zero valent iron in the 21st century: A data-driven visualization and analysis of research topics and trends

Nano zero valent iron (nZVI) is an environmental functional material with a core-shell structure, which has been widely used for environmental remediation. The published literatures in the Web of Science Core Collection database from 2000 to 2021 were used to reveal crucial information and guidance on what has been investigated and what the changes in research interests using a bibliometric method, in order to better understand the developments and trends in research on nZVI. The knowledge structure, hot issues, and trend directions in the field of nZVI were analyzed using VOSviewer, Bibliometrix, and Microsoft Charticulator. Keywords copolymerization analysis revealed four main directions of nZVI research, including groundwater remediation, in situ soil remediation, adsorption-related research, modification of nZVI and innovative applications. The heavy metal Cr(VI) is the pollutant that has received the most attention in the field of nZVI. “Electron transfer”, “S-nZVI (Sulfidated nZVI)" and “copper” are the research theme trends. Meanwhile, we summarize the mechanisms of nZVI for decontamination, different typical modification methods, the application disadvantage and make some suggestions for the field of nZVI. This work will provide insights for future research and practical applications related to nZVI.

Theme trends and knowledge‐relationship in frail older adults and quality of life research: A bibliometric analysis

AbstractBackgroundFrailty is a multidimensional construct that represents an age‐related reduction in physiologic reserve and resistance to stressors. Health‐related quality of life was found to be significantly low for the frail older adults.MethodVOS viewer is a program that graphically represents them through bibliometric analysis. Using the Web of Science data and VOS viewer program, we analyzed frail older adults and quality of life. We identified and incorporated 194 publications. We searched all years the data from 2012 to 2021 using the keywords: TITLE ((frail OR frailty OR feeble) AND (qol OR “quality of life” OR “life satisfaction” OR satisfaction OR “well‐being” OR “subjective life”)) AND DOCTYPE (ar) AND PUBYEAR 2012‐2021 LANGUAGE (English).ResultLooking at the trend of changes in the number of published documents from 2012 to 2021, it showed an increase of 337.5% (Figure 1). The most research was included 74 and 27 cases in Geriatrics Gerontology (Figure 2). A total of 188 papers on the QoL for the frail older adults were published in 110 journals (Table 1). Australia and the United States published the largest number of papers with 29 (15.10%) (Figure 3). Studies on the quality of life of the frail older adults were conducted by researchers belonging to 434 institutions. Maastricht University, University Groningen, and Erasmus University published the largest number of papers with 6 each (Figure 4). A total of 909 keywords were searched in 188 papers, and the top 100 keywords were selected based on the frequency. There were 6 clusters and Based on the TLS and the top 5 keywords were health (49 times), mobility (41 times), disability (37 times), prevalence (37 times), and adults (33 times) (Figure 5).ConclusionResearch on the QoL and the frail older adults is increasing. For preventive treatment for the frail older adults, which determines the quality of life, it is necessary to focus on research topics on this.

A bibliometric analysis of the theme trends and knowledge structures of pulmonary embolism from 2017 to 2021.

Pulmonary embolism (PE) is a popular area of research in the field of respiratory medicine. We performed a bibliometric analysis based on PubMed database to characterize the distribution pattern of literature and knowledge structures related to PE. Literature pertaining to PE from January 1, 2017, to December 31, 2021, was retrieved from the PubMed database. Bibliographic information was generated using the Bibliographic Item Co-Occurrence Matrix Builder (BICOMB). The visualization matrix was established using gCLUTO software. Strategic diagram analysis was performed using GraphPad Prism 9 software. Social network analysis (SNA) was generated using Ucinet6.0 and NetDraw 2.084 software. Out of all the retrieved MeSH terms and subheadings, 52 MeSH terms/MeSH subheadings with a high frequency were found, and hot subjects were sorted into 6 clusters. The strategy diagram showed that the epidemiology, etiology, and drug therapy of PE were well advanced. In contrast, studies on diagnostic imaging, pathology, and complications of PE were still immature and offered potential research space. Social network analysis showed that marginal topics such as surgical treatment of pulmonary hypertension, prevention and control of postoperative complications, and metabolism and analysis of fibrin/fibrinogen degradation products were emerging research hotspots. Objective analysis of the research developments in the field of PE can provide intuitive knowledge structure for researchers and clinicians. Analysis of the research hotspots related to PE is helpful for researchers and clinicians by highlighting future research directions.

Identifying Hot Information Security Topics Using LDA and Multivariate Mann-Kendall Test

Discovering promising research themes in a scientific domain by evaluating semantic information extracted from bibliometric databases represents a challenging task for Natural Language Processing (NLP). While existing NLP methods generally characterize the research topics using unique key terms, we take a step further by more accurately modeling the research themes as finite sets of key terms. The proposed approach involves two stages: identifying the research themes from paper metadata using LDA topic modeling; and, evaluation of research theme trends by employing a version of the Mann-Kendall test that is able to cope with multivariate time series of term occurrences. The results obtained by applying this general methodology to Information Security domain confirm its viability.

Virtual reality for neurorehabilitation: A bibliometric analysis of knowledge structure and theme trends.

As an emerging technology, virtual reality (VR) has been broadly applied in the medical field, especially in neurorehabilitation. The growing application of VR therapy promotes an increasing amount of clinical studies. In this paper, we present a bibliometric analysis of the existing studies to reveal the current research hotspots and guide future research directions. Articles and reviews on the related topic were retrieved from the Science Citation Index Expanded of Web of Science Core Collection database. VOSviewer and Citespace software were applied to systematically analyze information about publications, countries, institutions, authors, journals, citations, and keywords from the included studies. A total of 1,556 papers published between 1995 and 2021 were identified. The annual number of papers increased gradually over the past three decades, with a peak publication year in 2021 (n = 276). Countries and institutions from North America and Western European were playing leading roles in publications and total citations. Current hotspots were focused on the effectiveness of VR therapy in cognitive and upper limb motor rehabilitation. The clusters of keywords contained the four targeted neurological diseases of VR, while the burst keywords represented that the latest studies were directed toward more defined types of VR therapy and greater study design. Our study offers information regarding to the current hotspots and emerging trends in the VR for rehabilitation field. It could guide future research and application of VR therapy in neurorehabilitation.

Research Trends in Crop-Livestock Systems: A Bibliometric Review.

Agricultural straw waste and livestock manure are often misplaced resources. The separation of planting and breeding has induced significant pressure on the environment. Thus, there is a growing need for a system that can integrate crop and livestock farming to improve resource efficiency. To clarify the current state of crop–livestock systems in China and elsewhere, a bibliometric analysis was conducted for a total of 18,628 published English and 3460 published Chinese research articles and dissertations on circular agriculture. The published research papers were taken from the ISI Web of Science and CNKI database to explore research hotpots, research methods, theme trends, and mainstream technical models of crop–livestock systems from 1981 to 2021. Recent progress in crop–livestock systems was analyzed from ecological, economic, social benefits, and stakeholder perspectives. The research results showed that compared with traditional agricultural models, crop–livestock systems had far more ecologic and social benefits, including gaining higher net income and input-output ratio, improving soil quality, and mitigating global warming. The drivers of crop–livestock systems’ development were also analyzed from stakeholders’ perspectives. The study provides insights into the development of circular agriculture by reducing the pollution risks of agricultural waste and improving both ecological and economic benefits of the system.

Global Research Status and Trends of Femoral Neck Fracture Over the Past 27 Years: A Historical Review and Bibliometric Analysis.

BackgroundFemoral neck fracture (FNF) is a commonly encountered injury in orthopedic practice, and many studies have been conducted in this field. However, no bibliometric studies regarding the global research trend concerning FNF have been performed. This study aims to analyze the knowledge framework, research hotspots, and theme trends in the field of FNF research.MethodsThe scientific outputs related to FNF from 1994 to 2021 were retrieved from the Web of Science Core Collection. Three bibliometric tools were used for this study. The main analyses include publication and citation counts, contributions of countries, institutions, authors, funding agencies and journals, and clustering of keywords.ResultsIn total, 3,553 articles were identified. The annual publication counts of FNF showed an ascending tendency as a whole. The United States has the most prominent contributions, with the most number of publications and the highest H-index. Karolinska Institutet devoted the most in this domain. Professors Bhandari M, Schemitsch EH, Frihagen F, Parker MJ, and Rogmark C were the core authors in this field. The most productive journal was Injury International Journal of the Care of the Injured. Keywords were divided into four clusters: epidemiology and mortality, fracture prevention, internal-fixation and risk factors, and hip replacement. A trend of balanced and diversified development existed in these clusters. Keywords with the ongoing bursts, including “outcome,” “reoperation,” “complication,” “revision,” “displaced intracapsular,” “fracture,” and “adult,” are considered as the research hotspots in the future and deserve more attention.ConclusionsThe management of FNF in young patients is drawing more attention from orthopedic surgeons, and it is expected that these research topics may continue to be the research hotspots and focus in the near future.

A Bibliometric Analysis on Motivation Between 2016 and 2020 of Physical Education in Scopus Database

PurposeIn the field of physical education (PE), which encompasses a wide range of variables, the question of motivation has become increasingly important. The bibliometric methods can help researchers and educators understand the related research of motivation. The purpose of this study was to explore the bibliometric characteristics of motivation in the field of PE from 2016 to 2020 that try to discover the related research context and topics.MethodsBy using the keywords “motivation” and “physical education,” the bibliographic records and references have been retrieved from the Scopus databases (date of search: September 7, 2021). The Vosviewer software tool and Bibliometrix R package were used for information analysis and visualization. The themes include the annual publication, countries/regions, journals, authors, co-occurrences, and theme trends. Finally, it is presented with the characteristics of the big picture of bibliometrics.ResultsFrom the analysis of the above theme, this study showed that there were 623 studies published over the 5 years, with the number gradually increasing in 2017 and peaking in 2020. The number of citations was the highest in 2016. In terms of total publications, Spain, the United States, and Australia are the top three countries/regions. Most of the articles were published in sport pedagogy and public health relevant journals. The four main research directions were identified: Education, activity, health, and self-determination theory.ConclusionThis study helped us to comprehend the consistent publishing and rapid development of motivation in PE research. Via the bibliometric analysis, we can also incorporate previous research and predicted trends. All these works can help us to understand the basic psychological needs, leadership styles, and teacher support of PE teachers, and the intrinsic and extrinsic motivations of students at different ages. It is suggested that the in-depth study could be conducted on a single variable or emerging issues for future investigation. Researchers can keep tracking and reviewing motivation-related models.

Mapping the research hotspots and theme trends of simulation in nursing education: A bibliometric analysis from 2005 to 2019

BackgroundSimulation-based nursing training has been used incorporated into nursing education for decades, however, there is limited information related to simulation research hotspots and theme trends over time. ObjectivesTo investigate the research hotspots and theme trends of simulation in nursing education through bibliometric analysis. MethodsRelevant articles on simulation in nursing education published between 2005 and 2019 were retrieved from PubMed. The Bibliographic Item Co-occurrence Matrix Builder (BICOMB) was used to extract and quantitatively analyze the Medical Subject Headings (MeSH) terms and subheadings. The biclustering analysis was conducted using gCluto1.0 to identify the research hotspots. A strategic diagram was employed to reveal the development trend of the theme. ResultsA total of 4102 publications were retrieved from PubMed showing an overall increasing trend. Based on the results, the United States was the most productive country (2868,55.7 %), the journal Nurse Education Today journal was the top journal concerning this field, and Cooper SJ and Holtschneider ME were authors with the highest number of publications on this topic. Quantitative and co-word biclustering analyses were used in this study. The research hotspots in recent 5 years were focused on: (1) interprofessional simulation in patient-care teams; (2) patient simulation in psychiatric nursing education; (3) virtual reality simulation (VRS) in midwifery and nursing education; (4) simulation in critical care nurses' continuing education/training, and (5) simulation in pediatric resuscitation education. The strategic diagram showed that the VRS in midwifery and nursing education might have a significant potential to become an emerging hotspot soon. ConclusionThe research literature production of simulation in nursing education was increasing over the past 15 years. Through co-word biclustering analysis, five research hotspots were identified. Among them, simulation in psychiatric education and critical care continuing education had a central priority that researchers should pay further attention to, and VRS could be the major trend for future study. Furthermore, this study described the overall range of research interests and provided ideas for innovative and efficient research projects.

Mapping theme trends and knowledge structure of Sjögren's syndrome (SS), a bibliometric analysis from 2010 to 2021.

Sjögren's syndrome is an autoimmune disease with a complicated pathophysiology, and treatment strategies are in desperate need of improvement. In this research, we provide the literature topic trends and knowledge structure connected to Sjögren's syndrome from the perspective of bibliometrics for further research. We acquired 3753 publications from the PubMed database and 3880 catalogs from the Web of Science Core Collection, with a time limit of 2010 to 2021 and the search term as "Sjögren's syndrome." Using the VOSviewer and bibliographic item co-occurrence matrix generator, we conducted cocited analysis, extracted major MeSH terms, generated matrices and performed biclustering analysis, visual matrix, drawn strategy diagram, and social network analysis. Through the clustering of the major MeSH terms, a total of five categories and 10 research topics were identified. Cocitation analysis suggests that diagnosis and clinical manifestations have been the main basis over the past 12 years and also are the mature content in the first quadrant of the strategy map. Ultrasonography, immunosuppressive agents and therapy, mechanism and therapeutic targets, and diagnostic autoantibodies are examples of the third quadrant, which wields great potential to progress. Genetic predisposition and psychology, in the fourth quadrant, need to be developed additionally. The subject keywords near the network's edge, such as "Salivary Glands, Minor/pathology," "Immunosuppressive Agents/therapeutic use," and "Autoantibodies/blood," are all growing research hotspots with much space, according to social network analysis. Through bibliometric analysis of the literature related to Sjögren's syndrome in the past 12 years, we obtained the knowledge basis, undeveloped topics, and emerging hotspots, which can suggest recommendations for future research. Key Points • We disclosed the topic trends and knowledge structure of Sjögren's syndrome literature over the past 12 years. • Clinical manifestations and diagnosis of Sjögren syndrome are included in mature and comprehensive studies, whereas ultrasonography, immunosuppressants and treatments, mechanisms and therapeutic targets, and diagnostic autoantibodies are studies with high potential for advancement. Additional research in genetics and psychology is needed. • We identified potential future research hotspots, including "Salivary Glands, Minor/pathology," "Immunosuppressive Agents/therapeutic use," and "Autoantibodies/blood."

Bibliometric and visualized analysis of ocular drug delivery from 2001 to 2020.

To perform a bibliometric analysis in the field of ocular drug delivery research to characterize the current international trends and to present visual representations of the past and emerging trends on ocular drug delivery research over the past decade. In this cross-sectional study, a bibliometric analysis of data retrieved and extracted from the Web of Science Core Collection (WoSCC) database was performed to analyze evolution and theme trends on ocular drug delivery research from January 1, 2001, to December 31, 2020. A total of 4334 articles on ocular drug delivery were evaluated for specific characteristics, such as publication year, journals, authors, institutions, countries/regions, references, and keywords. Co-authorship analysis, co-occurrence analysis, co-citation analysis, and network visualization were constructed by VOSviewer. Some important subtopics identified by bibliometric characterization were further discussed and reviewed. From 2001 to 2020, the annual global publications increased by 746.15%, from 52 to 440. International Journal of Pharmaceutics published the most manuscripts (250 publications) and produced the highest citations (9509 citations), followed by Investigative Ophthalmology & Visual Science (202 publications) and Journal of Ocular Pharmacology and Therapeutics (136 publications). The United States (1289 publications, 31,512 citations), the University of Florida (82 publications, 2986 citations), and Chauhan, Anuj (52 publications, 2354 citations) were the most productive and impactful institution, country, and author respectively. The co-occurrence cluster analysis of the top 100 keywords form five clusters: (1) micro/nano ocular drug delivery systems; (2) the treatment of inflammation and posterior diseases; (3) macroscopic ocular drug delivery systems/devices; (4) the characteristics of drug delivery systems; (5) and the ocular drug delivery for glaucoma treatment. Diabetic macular edema, anti-VEGF, ranibizumab, bevacizumab, micelles and latanoprost, were the latest high-frequency keywords, indicating the emerging frontiers of ocular drug delivery. Further discussions into the subtopics were provided to assist researchers to determine the range of research topics and plan research direction. Over the last two decades there has been a progressive increase in the number of publications and citations on research related to ocular drug delivery across many countries, institutions, and authors. The present study sheds light on current trends, global collaboration patterns, basic knowledge, research hotspots, and emerging frontiers of ocular drug delivery. Novel solutions for ocular drug delivery and the treatment of inflammation and posterior diseases were the major themes over the last 20years.

IFRS Adoption Research in Indonesia: A Systematic Literature Review

Research aims: This study aimed to review the development of IFRS research literature in Indonesia from 2011 to 2020.Design/Methodology/Approach: This study was based on the IFRS research articles from nationally accredited journals. The method in this research was a systematic literature review with a bibliometric approach and content analysis.Research findings: The results showed that the publication of the IFRS articles increased in 2014 with the number of authors dominated by two researchers. The research in Indonesia was dominated by the theme of the effect of IFRS convergence on earnings quality. Thus, it is necessary to develop research on the theme of implementation and development of IFRS convergence since the articles related to this theme are still poor. Compared with existing research abroad, there was a common focus of research on the theme of the IFRS convergence effect. However, there were differences in research theme trends, where the most studied theme in Indonesia was related to the effect of IFRS convergence, while abroad, the most studied theme was related to the implementation of IFRS convergence.Theoretical contribution/originality: This research can provide a historical overview of the development of the IFRS research literature in Indonesia.Research limitation/Implication: Further research is expected to expand the data analysis and sources of data. The research is also expected to expand the sub-themes related to the implementation and development of IFRS convergence, where the theme had not been studied much yet from 2011 to 2020.