<p>Proper understanding of LULC changes is considered an indispensable element for modeling. It is also central for planning and management activities as well as understanding the earth as a system. This study examined LULC changes in the region of the proposed Pwalugu hydropower project using remote sensing (RS) and geographic information systems (GIS) techniques. Data from the United States Geological Survey's Landsat satellite, specifically the Landsat Thematic Mapper (TM), the Enhanced Thematic Mapper (ETM), and the Operational Land Imager (OLI), were used. The Landsat 5 thematic mapper (TM) sensor data was processed for the year 1990; the Landsat 7 SLC data was processed for the year 2000; and the 2020 data was collected from Operation Land Image (OLI). Landsat images were extracted based on the years 1990, 2000, and 2020, which were used to develop three land cover maps. The region of the proposed Pwalugu hydropower project was divided into the following five primary LULC classes: settlements and barren lands; croplands; water bodies; grassland; and other areas. Within the three periods (1990–2000, 2000–2020, and 1990–2020), grassland has increased from 9%, 20%, and 40%, respectively. On the other hand, the change in the remaining four (4) classes varied. The findings suggest that population growth, changes in climate, and deforestation during this thirty-year period have been responsible for the variations in the LULC classes. The variations in the LULC changes could have a significant influence on the hydrological processes in the form of evapotranspiration, interception, and infiltration. This study will therefore assist in establishing patterns and will enable Ghana's resource managers to forecast realistic change scenarios that would be helpful for the management of the proposed Pwalugu hydropower project.</p>