Than Typically Developing Children Research Articles

Idiosyncratic pupil regulation in autistic children.

Recent neuroimaging and eye-tracking studies have suggested that children with autism exhibit more variable and idiosyncratic brain responses and eye movements than typically developing (TD) children. Here, we extended this research to pupillometry recordings. We successfully acquired pupillometry recordings from 111 children (74 with autism), 4.5-years-old on average, who viewed three 90 s movies, twice. We extracted their pupillary time-course for each movie, capturing their stimulus evoked pupillary responses. We then computed the correlation between the time-course of each child and those of all others in their group as well as between each autistic child and all children in the TD group. This yielded an average inter-subject correlation value per child, representing how similar their pupillary responses were to all others in their group or the comparison group. Children with autism exhibited significantly weaker inter-subject correlations than TD children in all comparisons. These differences were independent of previously reported differences in gaze inter-subject correlations and were largest in responses to a naturalistic movie containing footage of a social interaction between two TD children. The results demonstrate the utility of measuring the idiosyncrasy of pupil regulation, which can be performed with passive viewing of movies even by young children with co-occurring intellectual disability. These findings reveal that a considerable number of children with autism have significantly less stable, idiosyncratic pupil regulation than TD children, indicative of more variable, weakly regulated, underlying neural activity.

NAO robot promoting sensorimotor synchronization in high-functioning autism spectrum disorder children

Objectives Sensorimotor synchronization (SMS) refers to an individual’s motor rhythm is temporally coordinated with a predictable external rhythm. Autism spectrum disorder (ASD) children have weakened SMS performance than typically developing (TD) children, which may affect their relationship with peers and caregivers, and social cognition abilities. Synchronization referent (e.g. an adult or a non-social beat) and the length of inter-stimulus interval (ISI) would influence SMS performance. Methods In this study, we adapted a tapping task to investigate the SMS ability in twenty-one 5–8-year-old high-functioning ASD and twenty-one age-, gender- and IQ-matched TD children. Children were asked to tap on a computer keyboard with videos of a woman or a robot tapping with one finger. We compared the synchronization performance of the two groups when they synchronized with different partners (an adult or an NAO robot) and under different ISIs (800 ms or 1500 ms). The relationships with participants’ autistic traits (Social Responsiveness Scale (SRS-2) and Autism Spectrum Quotient), and cognitive ability (IQ) were also examined. Results We found that ASD children had an overall attenuated synchronizing accuracy and stability than TD children only when ISI was longer than one second. Both groups performed better when synchronized with the NAO robot than the adult partner. The synchronization performance was correlated with the cognitive ability of ASD children when ISI was 1500 ms. Conclusions Results show that tapping with the robot could improve the SMS performance of ASD children since it promoted a higher motivation level. ASD children have an attenuated SMS ability, which may be caused by abnormal temporal perceptions when ISI is longer than one second, while their SMS ability may be intact in sub-second ISIs.

Investigating pausing and gesturing patterns in children with and without developmental language disorder

Abstract This study aims at observing the co-occurrence of filled (FP) and unfilled pauses (UP) and gestures in the narratives of children with and without Developmental Language Disorder (DLD). Although children with DLD are known to be more “disfluent” than typically developing children (TD), little is known about the role of pauses in children’s speech and their interaction with gestures. 22 French-speaking children with DLD and 22 age- and gender-matched controls, between 7 and 10, recounted a cartoon excerpt. We annotated pauses and their position in utterances, and we coded gestures according to their function. Despite a similar pausing rate across groups, results show that TD children produced more utterance-beginning FPs and more mid-utterance UPs, while children with DLD produced more standalone FPs and mid-utterance UPs. Furthermore, multimodal patterns of co-occurrence, specific to pause type, emerged. While both groups had similar gesture rates and produced mostly referential gestures, TD children produced slightly more beat gestures during FPs and more self-adaptors and pragmatic gestures during UPs. Children with DLD produced more referential gestures and object-adaptors during UPs. These differences point to the temporal relationship between gestures and pauses and the multiple ways these two phenomena may interact according to the child’s profile.

Auditory rhythm facilitates perception and action in children at risk for developmental coordination disorder

Developmental Coordination Disorder (DCD) is a common neurodevelopmental disorder featuring deficits in motor coordination and motor timing among children. Deficits in rhythmic tracking, including perceptually tracking and synchronizing action with auditory rhythms, have been studied in a wide range of motor disorders, providing a foundation for developing rehabilitation programs incorporating auditory rhythms. We tested whether DCD also features these auditory-motor deficits among 7–10 year-old children. In a speech recognition task with no overt motor component, modulating the speech rhythm interfered more with the performance of children at risk for DCD than typically developing (TD) children. A set of auditory-motor tapping tasks further showed that, although children at risk for DCD performed worse than TD children in general, the presence of an auditory rhythmic cue (isochronous metronome or music) facilitated the temporal consistency of tapping. Finally, accuracy in the recognition of rhythmically modulated speech and tapping consistency correlated with performance on the standardized motor assessment. Together, the results show auditory rhythmic regularity benefits auditory perception and auditory-motor coordination in children at risk for DCD. This provides a foundation for future clinical studies to develop evidence-based interventions involving auditory-motor rhythmic coordination for children with DCD.

Modulation of attentional blink with sound in children with attention deficit hyperactivity disorder (ADHD)

Although it has been found that children with attention deficit hyperactivity disorder (ADHD) with impaired ability of inhibition control often showed greater attentional blink (AB), there is minimal information in regards to attention deficit in the interaction of AB enhancement with sound induction. A rapid serial visual presentation (RSVP) task was used by presenting an audiology pure tone evaluation simultaneously with T2 to investigate how auditory-driven visual perception enhances AB in children with ADHD. The results showed that children with ADHD had greater AB, and they performed worse than typically developing children (TD) in AB amplitude and recovery time. In addtion, the sound enhanced AB in TD children but interfered in children with ADHD. These results indicate that children with ADHD with faulty attentional allocation have fewer resources available for targets in the cross-modality AB, thus leading to a severe interference effect and a larger AB. It demonstrates that sound can only enhance AB when attentional resources are previously invested and the ability to suppress interference are still sufficient after dividing attention in cross-modality.

Neural responses to syllable-induced P1m and social impairment in children with autism spectrum disorder and typically developing Peers.

In previous magnetoencephalography (MEG) studies, children with autism spectrum disorder (ASD) have been shown to respond differently to speech stimuli than typically developing (TD) children. Quantitative evaluation of this difference in responsiveness may support early diagnosis and intervention for ASD. The objective of this research is to investigate the relationship between syllable-induced P1m and social impairment in children with ASD and TD children. We analyzed 49 children with ASD aged 40-92 months and age-matched 26 TD children. We evaluated their social impairment by means of the Social Responsiveness Scale (SRS) and their intelligence ability using the Kaufman Assessment Battery for Children (K-ABC). Multiple regression analysis with SRS score as the dependent variable and syllable-induced P1m latency or intensity and intelligence ability as explanatory variables revealed that SRS score was associated with syllable-induced P1m latency in the left hemisphere only in the TD group and not in the ASD group. A second finding was that increased leftward-lateralization of intensity was correlated with higher SRS scores only in the ASD group. These results provide valuable insights but also highlight the intricate nature of neural mechanisms and their relationship with autistic traits.

Altered Cytokine and BDNF Levels in Individuals with Autism Spectrum Disorders

Previous studies have shown that immunological factors are involved in the pathogenesis of autism spectrum disorders (ASDs). The present study examined whether immunological abnormalities are associated with cognitive and behavioral deficits in children with ASD and whether children with ASD show different immunological biomarkers and brain-derived neurotrophic factor BDNF levels than typically developing (TD) children. Sixteen children with TD and 18 children with ASD, aged 6–18 years, voluntarily participated in the study. Participants’ executive functions were measured using neuropsychological tests, and behavioral measures were measured using parent ratings. Immunological measures were assessed by measuring the participants’ blood serum levels of chemokine ligand 2 (CCL2) and chemokine ligand 5 (CCL5). Children with ASD showed greater deficits in cognitive functions as well as altered levels of immunological measures when compared to TD children, and their cognitive functions and behavioral deficits were significantly associated with increased CCL5 levels and decreased BDNF levels. These results provide evidence to support the notion that altered immune functions and neurotrophin deficiency are involved in the pathogenesis of ASD.

Associations of Motor Performance and Executive Functions: Comparing Children with Down Syndrome to Chronological and Mental Age-Matched Controls.

Background. Children with Down syndrome (DS) exhibit lower motor and cognitive performance than typically developing children (TD). Although there is a relationship between these two developmental domains, only a few studies have addressed this association in children with DS compared to groups of the same chronological age (CA) or mental age (MA) within one study. This study aimed to fill this research gap. Method and Procedures. The Movement Assessment Battery for Children-2 and the Trail-Making Test was used to assess motor and cognitive performances in 12 children (M = 10.5 ± 10.08) with DS, 12 CA-matched, and 12 MA-matched controls. Results. There are significant group differences in the motor dimension (total test score; p < 0.001, η2p = 0.734), for processing speed (p < 0.001, η2p = 0.396), and cognitive flexibility (p < 0.001, η2p = 0.498). Between TD-CA and both other groups, the differences in the magnitude of correlations for the motor dimension balance are also significant (compared to DS: z = −2.489; p = 0.006, and to TD-MA: z = −3.12; p < 0.001). Conclusions. Our results suggest that the relationships depend on the studied cognitive and motor skills. It seems crucial to select a wide range of tasks for both domains that are as isolated as possible for future studies, to better understand the relationships between cognitive and motor skills in children with DS.

Adverse childhood experiences predict neurite density differences in young children with and without attention deficit hyperactivity disorder.

Adverse childhood experiences (ACEs) put millions of children at risk for later health problems. As childhood represents a critical developmental period, it is important to understand how ACEs impact brain development in young children. In addition, children with attention-deficit/hyperactivity disorder (ADHD) are more likely than typically developing (TD) peers to experience ACEs. Therefore, the current study examined the impact of ACEs on early brain development, using a cumulative risk approach, in a large sample of children with and without ADHD. We examined 198 young children (Mage =5.45, 82.3% Hispanic/Latino; 52.5% ADHD) across measures of brain volume, cortical thickness, neurite density index (NDI), and orientation dispersion index (ODI). For the NDI measure, there was a significant interaction between group and cumulative risk (ß=.18, p=.048), such that for children with ADHD, but not TD children, greater cumulate risk was associated with increased NDI in corpus callosum. No other interactions were detected. Additionally, when examining across groups, greater cumulative risk was associated with reduced ODI and volume in the cerebellum, although these findings did not survive a correction for multiple comparisons. Our results highlight the role early cumulative ACEs play in brain development across TD and children with ADHD.

Children's Behavior and Maternal Parenting Stress in Young Children With Sex Chromosome Trisomies.

Children and adolescents with sex chromosome trisomies (SCTs) usually show a higher frequency of behavioral problems than typically developing (TD) children. However, little is known about the presence of behavioral issues in toddlers with SCT. This study aimed at investigating their behavioral profile in the second year of life and its impact on maternal stress. Participants were 87 children ranging in age from 18 to 26 months: 63 children with SCTs (all diagnosed prenatally) and 24 TD children. Their psychomotor and language development and their behavioral profile were assessed. In addition, the level of maternal parenting stress was evaluated. Both psychomotor and language development were significantly lower in children with SCTs than in TD children. Conversely, no significantly greater behavioral problems emerged in children with SCTs. However, a significantly higher level of parenting stress related to a dysfunctional interaction with the child emerged in the mothers of children with SCTs. In this population, maternal stress seemed positively related to their children's emotional problems and pervasive disorders and negatively related to their children's psychomotor and linguistic competence. Although no significant behavioral issues emerged in the second year of life, the relationships found between children's behavioral profiles and maternal parenting stress highlight the importance of prenatal counseling and support groups for parents of children with SCTs. This might help them recognize the first signs of behavioral problems and become aware of their influence on parenting stress.

Children with Poor Motor Skills Have Lower Health-Related Fitness Compared to Typically Developing Children.

Most of the current empirical evidence regarding the relationship between health-related fitness and level of motor performance is based on children from high-income countries. Yet, children from low-resource areas may have fewer opportunities to develop their fitness skills. The aim of the study was to determine if South African children from both low- and middle-income areas scoring below the 16th percentile on the Movement Assessment Battery for Children-2 (probable-Developmental Coordination Disorder (p-DCD)) have lower health-related fitness levels than typically developing (TD) children. We hypothesized that children with p-DCD would have lower overall health-related fitness than TD children. A sample of 146 participants aged 10 to 11 (10.05 years (SD = 0.41)) was collected from schools in the North West Province of South Africa, on the basis of their poverty classification. Children were tested for anaerobic capacity and strength using the Bruininks–Oseretsky test of motor proficiency second edition (BOT-2) and aerobic capacity using the Progressive Aerobic Cardiovascular Endurance Run (PACER). Body composition was evaluated using body mass index corrected for age and sex (BMI-z), body fat (BF), and waist circumference. The data was analyzed using Spearman correlations and chi-squared tests. Statistically significant differences (p < 0.05) were found between groups for running and agility, strength, and aerobic capacity. No significant differences were found between p-DCD and TD groups in terms of body mass (36.1 kg vs. 33.3 kg), waist circumference (62.2 cm vs. 59.8 cm), BMI-z (19.7 vs. 17.6), and fat percentage (20.2 vs. 18.1%). Overweight and obesity prevalence was 15% in those with low socio-economic status (SES) and 27% in high SES. In conclusion, children with p-DCD had lower muscular strength, aerobic capacity, and endurance than TD children. Although it has been reported that children with p-DCD have a higher risk for overweight/obesity than TD children, this is not (yet) the case in 10–11-year-old children living in rural areas in South Africa (North West Province).

Biomechanical analysis of gait patterns in children with intellectual disabilities

Children with intellectual disabilities (ID) typically master walking skills much later than typically developing (TD) children and have poor postural control ability. This study aimed to explore the gait ability and characteristics of children with ID and whether there is any difference in walking ability between them and TD children. In this study, integrating kinematic-biomechanic-dynamic measurement methods and corresponding analysis methods (video analysis, three-dimensional force analysis and electromyography test analysis) were used to characterise and compare the gait patterns between ID children and TD children. ID children's step length/leg length ratio was lower than TD children. The left-leg single-leg support time and step length of ID children were shorter than TD children. While walking, ID children touched the ground with the whole foot pad and could not powerfully thrust against the ground with their toes. Their left legs had obvious disadvantages compared with their right legs. ID children's lower limb muscle strength was lower than TD children, and their thigh muscles had an obvious compensation function. Correcting ID children's gait should be an important teaching goal for physical education institutors and teachers. Muscle-strength and flexibility training can help ID children reinforce core strength and better coordinate lower limbs.

In vivo operating lengths of the gastrocnemius muscle during gait in children who idiopathically toe-walk.

What is the central question of this study? What are the in vivo operating lengths of the gastrocnemius muscle in children who idiopathically toe-walk? What is the main finding and its importance? Children who idiopathically toe-walk operate at more plantarflexed positions but at longer fascicle lengths than typically developing children during gait. However, these ranges utilised during gait correspond to where children who idiopathically toe-walk are optimally strong. This should be considered when prescribing clinical treatments to restore typical gait. Children who idiopathically toe-walk (ITW) habitually operate at greater plantarflexion angles than typically developing (TD) children, which might result in shorter, sub-optimal gastrocnemius fascicle lengths. However, currently no experimental evidence exists to substantiate this notion. Five children who ITW and 14 TD children completed a gait analysis, whilst gastrocnemius fascicle behaviour was simultaneously quantified using ultrasound. The moment-angle (hip, knee and ankle) and moment-length (gastrocnemius) relationships were determined from isometric maximum voluntary contractions (MVC) on an isokinetic dynamometer combined with ultrasound. During gait, children who ITW operated at more plantarflexed angles (Δ=20°; P=0.013) and longer muscle fascicle lengths (Δ=12mm; P=0.008) than TD children. During MVC, no differences in the peak moment of any joint were found. However, peak plantarflexor moment occurred at significantly more plantarflexed angles (-16 vs. 1°; P=0.010) and at longer muscle fascicle lengths (44 vs. 37mm; P=0.001) in children who ITW than TD children. Observed alterations in the moment-angle and moment-length relationships of children who ITW coincided with the ranges used during gait. Therefore, the gastrocnemius muscle in children who ITW operates close to the peak of the force-length relationship, similarly to TD children. Thus, this study indicates that idiopathic toe-walking is truly an ankle joint pathology, and children who ITW present with substantial alterations in the gastrocnemius muscle functional properties, which appear well adapted to the characteristic demands of equinus gait. These findings should be considered when prescribing clinical treatments to restore typical gait.

Muscle architecture and passive lengthening properties of the gastrocnemius medialis and Achilles tendon in children who idiopathically toe-walk.

Children who idiopathically toe‐walk (ITW) habitually operate at greater plantarflexion angles and thus, at shorter muscle‐tendon unit (MTU) lengths than typically developing (TD) children. Therefore, it is often assumed that habitual use of the gastrocnemius muscle in this way will cause remodelling of the muscle‐tendon architecture compared to TD children. However, the gastrocnemius muscle architecture of children who ITW has never been measured. It is essential that we gain a better understanding of these muscle‐tendon properties, to ensure that appropriate clinical interventions can be provided for these children. Five children who ITW (age 8 ± 2 years) and 14 TD children (age 10 ± 2 years) participated in this study. Ultrasound was combined with isokinetic dynamometry and surface electromyography, to measure muscle architecture at common positions and passive lengthening properties of the gastrocnemius muscle and tendon across full range of motion. Regardless of which common condition groups were compared under, both the absolute and normalised to MTU muscle belly and fascicle lengths were always longer, and the Achilles tendon length was always shorter in children who ITW than TD children (p < 0.05; large effect sizes). The passive lengthening properties of the muscle and tendon were not different between groups (p > 0.05); however, passive joint stiffness was greater in children who ITW at maximum dorsiflexion (p = 0.001) and at a joint moment common to all participants (p = 0.029). Consequently, the findings of this pilot study indicate a remodelling of the relative MTU that does not support the concept that children who ITW commonly experience muscle shortening. Therefore, greater consideration of the muscle and tendon properties are required when prescribing clinical interventions that aim to lengthen the MTU, and treatments may be better targeted at the Achilles tendon in children who ITW.

Dexterity of the Less Affected Hand in Children With Hemiplegic Cerebral Palsy.

To determine if the "unaffected" hand in children with hemiplegic cerebral palsy (CP) is truly unaffected. We performed a retrospective review of manual dexterity as measured by the Functional Dexterity Test (FDT) in 66 children (39 boys, 27 girls, mean age: 11 years 4 months) with hemiplegic CP. Data were stratified by Manual Ability Classification System (MACS) level, birth weight, and gestational age at birth, and compared with previously published normative values. The FDT speed of the less affected hand is significantly lower than typically developing (TD) children (P < .001). The development of dexterity is significantly lower than TD children (0.009 vs. 0.036 pegs/s/year, P < .001), with a deficit that increases with age. MACS score, birth weight, and age at gestation are not predictors of dexterity. The dexterity of the less affected hand is poorly correlated with that of the more affected hand. Both dexterity and rate of fine motor skill acquisition in the less affected hand of children with hemiplegic CP is significantly less than that of TD children. The less affected hand should be evaluated and included in comprehensive treatment plans for these children.

Children with attention-deficit/hyperactivity disorder spend more time in hyperconnected network states and less time in segregated network states as revealed by dynamic connectivity analysis

Previous studies in children with attention-deficit/hyperactivity disorder (ADHD) have observed functional brain network disruption on a whole-brain level, as well as on a sub-network level, particularly as related to the default mode network, attention-related networks, and cognitive control-related networks. Given behavioral findings that children with ADHD have more difficulty sustaining attention and more extreme moment-to-moment fluctuations in behavior than typically developing (TD) children, recently developed methods to assess changes in connectivity over shorter time periods (i.e., “dynamic functional connectivity”), may provide unique insight into dysfunctional network organization in ADHD. Thus, we performed a dynamic functional connectivity (FC) analysis on resting state fMRI data from 38 children with ADHD and 79 TD children. We used Hidden semi-Markov models (HSMMs) to estimate six network states, as well as the most probable sequence of states for each participant. We quantified the dwell time, sojourn time, and transition probabilities across states. We found that children with ADHD spent less total time in, and switched more quickly out of, anticorrelated states involving the default mode network and task-relevant networks as compared to TD children. Moreover, children with ADHD spent more time in a hyperconnected state as compared to TD children. These results provide novel evidence that underlying dynamics may drive the differences in static FC patterns that have been observed in ADHD and imply that disrupted FC dynamics may be a mechanism underlying the behavioral symptoms and cognitive deficits commonly observed in children with ADHD.

Does physical activity and BMI mediate the association between DCD and internalizing problems in early childhood? A partial test of the Environmental Stress Hypothesis.

Young children with Developmental Coordination Disorder (DCD) are more likely to experience internalizing problems, such as depression and anxiety, than typically developing (TD) children. Currently, the underlying mechanisms resulting in increased internalizing problems in DCD remains unknown; however, a previous study based on the Environmental Stress Hypothesis (ESH) indicated that physical inactivity and obesity may mediate the relationship between DCD and internalizing problems. The purpose of this study is to investigate the relationships among DCD, internalizing problems, physical activity, and BMI, and the role of sex in these relationships in preschool children, a population for which we currently have very limited data. Young children between the ages of 4 and 5years enrolled in the Coordination and Activity Tracking in CHildren (CATCH) study comprised the sample (n=589). Of these, 288 (193 boys, 67.0%) were classified as at risk for DCD (rDCD), based on scoring at or below 16th percentile on the Movement Assessment Battery for Children - Second Edition. Physical activity was measured using accelerometers and height and weight were measured by trained research assistants, while parents completed the Child Behavior Checklist to rate internalizing problems. The mediating effects of physical activity and BMI were tested on the relationship between rDCD and internalizing problems. Children with rDCD reported more internalizing problems than TD children. While there was a direct effect of rDCD on internalizing problems, neither physical activity nor BMI were found to mediate this relationship. The findings from this study support co-occurring internalizing problems in preschool children with DCD, and extend these findings to demonstrate that this relationship is not explained by physical activity or BMI in early childhood. Further research should be directed toward other psychosocial factors identified in the ESH to better understand the underlying mechanisms between DCD and co-occurring internalizing problems.

Dyslexia and the magnocellular-parvocellular coactivaton hypothesis

Previous studies showed that the lateral masking of a fast-moving low spatial frequency (SF) target was strong when exerted by static flankers of lower or equal to the target SF and absent when flankers’ SF was higher than the target’s one. These masking and unmasking effects have been interpreted as due to Magnocellular-Magnocellular (M-M) inhibition and Parvocellular-on-Magnocellular (P-M) disinhibitory coactivation, respectively. Based on the hypothesis that the balance between the two systems is perturbed in Developmental Dyslexia (DD), we asked whether dyslexic children (DDs) behaved differently than Typically Developing children (TDs) in conditions of lateral masking. DDs and TDs performed a motion discrimination task, of a .5c/deg Gabor target moving at 16 deg/sec, either isolated or flanked by static Gabors with a SF of .125, .5 or 2 c/deg (Experiment 1). As a control, they also performed a contrast detection task of a static target, either isolated or flanked (Experiment 2). DDs did not perform any different from TDs with either a static target or an isolated moving target of low spatial frequency, thus suggesting efficient feedforward Magnocellular (M) and Parvocellular (P) processing. Also, DDs showed similar contrast thresholds to TDs in the M-M inhibition condition. Conversely, DDs did not recover from lateral masking in the M-P coactivation condition. In addition, their performance in this condition negatively correlated with non-words accuracy, supporting the suggestion that an inefficient Magno-Parvo coactivation may possibly be associated to both higher visual suppression and reduced perceptual stability during reading.

The Production of Pronouns and Verb Inflections by Italian Children with ASD: A New Dataset in a Null Subject Language.

The language of children with autism spectrum disorder (ASD) is often characterized by difficulties with pronouns. The underlying reasons for such difficulties are still unclear. This study is the first to test the abilities of children with ASD who speak Italian, a language in which overt subject pronouns are optional but verbs obligatorily feature person-referencing morphology. We found that Italian children with ASD were less accurate than typically-developing (TD) Italian children in the production of first-, second-, and third-person singular pronouns, avoiding pronouns in favor of nouns or names more often than controls. Moreover, children with ASD produced more overt pronouns than null pronouns in marked contexts, compared to TD children. These phenomena can be accounted for by difficulties with pragmatics.

Out of mind, out of sight? Investigating abnormal face scanning in autism spectrum disorder using gaze-contingent paradigm.

Diminished social motivation is hypothesized to explain abnormal face scanning pattern in individuals with autism spectrum disorder (ASD), especially reduced eye-looking time in ASDs than typically developing (TD) people. Here, we tested an alternative explanation that children with ASD may use a compensatory strategy to avoid direct eye contact by processing the eyes through peripheral vision. We compared the face scanning patterns of children with and without ASD in two conditions: in the clear condition, the face was completely visible; in the blur condition, by using the gaze-contingent paradigm, the whole face was blurred except for a small region being fixated at, thus children could not rely on the peripheral information to process the eyes. We found that children with ASD fixated less on the eyes than TD children in both conditions. Temporal-course analyses further revealed the possible motivation-based guidance of attention to process the eyes in the TD group but not in the ASD group. Additionally, we found that children with ASD scanned faces more randomly and less strategically than TD children. These results have ruled out the alternative hypothesis that the abnormal face scanning pattern in ASDs was due to their compensatory strategy to process eyes through peripheral vision, furthering our understanding of the mechanisms underlying their abnormal face scanning.