Tetramethylethylenediamine Research Articles

WORKPLACE SPIRITUALITY: SHAPING THE FUTURE OF THE MODERN ORGANISATIONS

Creating and maintaining a healthy organization has become a significant challenge for leaders in today’s volatile and competitive business landscape. A crucial component of a healthy organization is the mental well-being of employees. In particular, teaching is a highly stressful profession that exposes educators to the risk of burnout. To mitigate this, techniques that engage higher mental functions—such as transcendental meditation and prayer—have been incorporated into stress and burnout prevention programs. Spirituality in education plays a key role in enhancing the quality of teaching and learning, though it is influenced by various personal, social, religious, and cultural factors. This study explores the relationship between workplace spirituality, meditation, and teacher performance. It evaluates the impact of wellness and spirituality on teachers' work performance. Data were collected from 375 teachers in the Hubli-Dharwad region, revealing that spirituality has a positive influence on work performance. A workplace that supports both wellness and spirituality fosters a more conducive environment for effective work.

Hidden Boron Catalysis: A Cautionary Tale on TMEDA Inhibition.

Hidden boron catalysis plagues catalyzed hydroboration reactions, with the "catalyst" acting to mediate the decomposition of HBpin/HBcat to BH3 which is the actual (hidden) catalyst. N,N,N',N'-Tetramethylethylenediamine (TMEDA) has been used to identify hidden boron catalysis through trapping/inhibition. Kinetic analyses showed that TMEDA inhibition is only applicable below 60 °C and that other amine traps are likewise ineffective. Awareness of this temperature limitation reveals widespread hidden catalysis in previous methods and should limit future false negative tests.

Sodium Alkyl(trimethylsilyl)amides: Substituent- and Solvent-dependent Solution Structures and Reactivities.

The preparation of sodium isopropyl(trimethylsilyl)amide (NaPTA), sodium (1-phenylethyl)(trimethylsilyl)amide (NaPETA), sodium tert-butyl(trimethylsilyl)amide (NaBTA), and isotopologues [15N]NaPTA and [15N]NaBTA are described. Solution structural studies using a combination of 29Si NMR spectroscopy, the Method of Continuous Variations, and density functional theory computations provided insights into aggregation and solvation in a range of solvents including toluene, N,N-dimethylethylamine, triethylamine, MTBE, THF, 1,2-dimethoxyethane (DME), diglyme, N,N,N',N'-tetramethylethylenediamine (TMEDA), N,N,N',N'-tetramethylcyclohexanediamine (TMCDA), N,N,N',N″,N″-pentamethyldiethylenetriamine (PMDTA). 12-crown-4, 15-crown-5, and 18-crown-6 revealed solvent- and substituent-dependent dimer-monomer mixtures with affiliated solvation numbers. Complexation of the three crown ethers documented both crown and substituent dependencies. Qualitative studies of reactivity showed a variety of reactions of NaPETA. Aminolysis of methyl benzoate with dialkylamines mediated by NaPTA afforded high yields of benzamides. Quantitative rate studies of aminolysis of methyl benzoate by NaPTA revealed a 47,000-fold range of rates. Detailed rate studies in toluene and THF showed dimer-based mechanisms. The role of primary- and secondary-shell solvation by THF is discussed, including nuances of methods used to separate the two contributions. PMDTA-solvated NaPTA monomer reacts as a monomer whereas bis-diglyme solvated monomer reacts as a dimer. Rate studies exploring the structure-reactivity correlations of the three crown ethers show mono- and bis-crown-based pathways in which 15-crown-5─the crown ether often said to be of choice for sodium─was decidedly inferior as an accelerant.

Optimization of parameters for the preparation of AlN powder/thin films by tris(N,N,N’,N’-tetramethylethylenediamine) al(III) chloride precursor

The single source precursor tris(N,N,N’,N’-tetramethylethylenediamine)Al(III)Cl3 has been synthesized by the reaction of N,N,N’,N’-tetramethylethylenediamine (TMEDA) with AlCl3 in 3:1 molar ratio in ethanol. The precursor is stable for long periods of time and cleanly generated aluminum nitride upon pyrolysis. The pyrolysis process was optimized by varying parameters such as temperature, pressure, and the flow rate of gases (N2 and Ar). Thin films of AlN were prepared by spin coating the precursor onto Si(100) and quartz substrates followed by pyrolysis under optimized CVD conditions obtained from bulk pyrolysis. Pyrolyzed powders and films were characterized with a variety of techniques. X-ray diffraction (XRD) showed 8.5 nm grain size with a dominant 220 orientation. UV-Vis spectroscopy indicated a band gap for the AlN films of ∼5.7 eV, which is close to bulk AlN (6.1 eV). FESEM showed a smooth and homogeneous film surface and EDAX showed a 1.4:1 ratio of Al:N, respectively.

Self-Sacrificed Additive in Preparing PbI2 Film Enables the Oriented Growth of Perovskite Crystals for Improved Solar Cell Performance.

Due to the limitation of the diffusion kinetics of organic amine salts on the PbI2 layer in the two-step method, prepared perovskite particles are small in size, have many defects, and are randomly oriented, and the cell efficiency and stability are difficult to guarantee due to PbI2 residues. Here, we added a volatile additive, N,N,N',N'-tetramethylethylenediamine (TMEDA), to the PbI2 precursor solution and formed preaggregated atomic clusters with PbI2 through TMEDA, which reduced the Gibbs free energy of nucleation to obtain a porous PbI2 layer, and finally obtained a perovskite film with large particles, few defects, ideal crystal plane orientation, and no additive residues. The results show that the photoelectric conversion efficiency of the optimized device is increased by 1.68% (from 21.68% to 23.36%), and the unpackaged optimized device still maintains the maximum efficiency of 77% after being placed in the air for 1200 h. This study provides an effective way to fabricate efficient and stable perovskite solar cells by promoting the nucleation-induced crystallization orientation by volatile additives.

Spirituality and Transcendental meditation practitioners’ experiences in South Africa and Ghana

ABSTRACT Spirituality involves being in harmony with the cosmos or nature and a willingness to engage in good works for the sake of mankind; for instance, love for one another, care for the environment, and the production and protection of the common good for society. Spirituality could also be defined as the connectedness with nature or the cosmos, seeing beyond the circumstances of one’s limitation and the suffering one encounters (transcendence) and understanding one purpose and meaning of one existence. In an African context, spirituality is experienced by many people as being in touch with one’s spirit which is an indication of integration of the body with the spirit and without this spiritual aspect of the essence of oneself, it becomes natural to see and feel problem. When one is permanently established on the platform of the Transcendental Being, life is lived in eternal freedom and enjoyment of blissfulness throughout the day. In this vein, the self silently witnesses daily activity. This is the essence of TM practice where practitioners experience spiritual upliftment. Though much research has been done on TM globally, the spiritual lived experiences of the practitioners have not been adequately explored, especially in South Africa and Ghana. Therefore, the study sought to explore the spiritual lived experiences of TM practitioners in South Africa and Ghana. The study adopted the constructivist paradigm through the lens of phenomenology. In all, 28 participants took part in the study − 14 participants from South Africa and another 14 from Ghana. Open-ended questionnaires and semi-structured interviews were used to collect data for the study. Husserl’s transcendental phenomenological data analysis was used to analyze and synthesize the descriptions of the spiritual lived experiences of the TM practitioners. The results suggest that TM act as a catalyst for the spiritual growth of the participants from both countries and that they experienced spiritual upliftment with the practice of TM. However, two participants both females were of the view that TM has nothing to do with their spirituality. It is the recommendation of this study that people who seek a spiritual path to discover their purpose and meaning in life explore this technique although there are other paths toward spiritual enlightenment. For instance, Christian’s contemplations player and Sufism.

Development of nanocomposite hydrogel using citrate-containing amorphous calcium phosphate and gelatin methacrylate.

Nanocomposite hydrogels are suitable in bone tissue engineering due to their resemblance with the extracellular matrix, ability to match complex geometries, and ability to provide a framework for cell attachment and proliferation. The nanocomposite hydrogel comprises organic and inorganic counterparts. Gelatin methacrylate (GELMA) is an extensively used organic biomaterial in tissue engineering due to its excellent biocompatibility, biodegradability, and bioactivity. The photo-crosslinking of GELMA presents a challenge when aiming to create thicker nanocomposite hydrogels due to opacity induced by fillers, which obstructs the penetration of ultraviolet (UV) light. Therefore, using a chemical crosslinking approach, we have developed nanocomposite GELMA hydrogel in this study by incorporating citrate-containing amorphous calcium phosphate (ACP_CIT). Ammonium persulfate (APS) and Tetramethylethylenediamine (TEMED) were deployed to crosslink the methacrylate group of GELMA. The oscillatory shear tests have confirmed that crosslinking enhances both storage (G') and loss modulus (G″) of GELMA. Subsequently, incorporation of ACP_CIT in GELMA hydrogel shows further enhancement in G' and G″ values. In vitro analysis of the developed hydrogels revealed that chemical crosslinking and incorporation of ACP_CIT do not compromise the cytocompatibility of the GELMA. Hence, for developing nanocomposite GELMA hydrogels employing APS/TEMED crosslinking emerges as a promising alternative to photo-crosslinking.

Mental Health and Meditation in a Post-Pandemic Perú: A Normative Study of Upper Primary School Children

In a post-pandemic Perú, problems associated with the mental health of children have been highlighted and effective methods of intervention have been discussed. This study sought to examine: 1) current levels of depression, anxiety, and stress in Perúvian school children; 2) how these levels compare to other children in Latin America and elsewhere; 3) whether these levels are different when covaried for school, age, gender, and grade level; and 4) whether there are any indications that depression, anxiety, or stress are lower when Perúvian school children practice Transcendental Meditation. For a group of 809 children from two schools using the DASS-21, findings indicate depression M = 6.79, anxiety M = 6.31, and stress M = 7.37. These data indicate somewhat elevated levels when compared to other pre-pandemic adolescents in Australia, Chile, China, and Malaysia, but were lower when compared to a group of similar-aged children at another school in China. Preliminary results also suggest lower levels of depression, anxiety, and stress can be observed in children who practice Transcendental Meditation as part of the school curriculum. School, age, gender, and grade level did not predict these differences, although girls had higher levels than boys, a finding consistent with other research.

Visible‐Light‐Promoted Cascade Radical Cyclization for Difluorochroman‐4‐ones via Electron Donor‐Acceptor Complexes

The research of electron donor‐acceptor complex has developed fast in the field of photochemistry. Herein, the green and efficient metal‐free visible‐light‐promoted synthesis of difluorochroman‐4‐ones has been achieved with 2‐(allyloxy)arylaldehyde and bromodifluoroacetamide, which is driven by noncovalent interactions between 2‐(allyloxy)arylaldehyde/N,N,N',N'‐tetramethylethylene diamine (TMEDA) and bromodifluoroacetamide/TMEDA. By precisely optimizing the electron donor and reaction solvent, a wide range of structurally diverse difluorochroman‐4‐ones, including aryl amide, aliphatic amide and ester groups, were obtained in up to 76% yields. This strategy offers the benefits of simple operation, good yields, high atomic economy and broad applicability, providing an essential complement to traditional approaches for the preparation of chroman‐4‐one skeletons without any transition metals, photocatalysts or oxidants.

Visible-Light-Induced Domino Perfluoroalkylation/Cyclization to Access Perfluoroalkylated Quinazolinones by an EDA Complex.

The electron donor-acceptor (EDA) complexes have been extensively studied, which formed an electronically excited state, obviating the need for an exogenous photocatalyst. Herein, we report a mild and efficient strategy for photoinduced radical domino perfluoroalkylation/cyclization using N,N,N',N'-tetramethylethane-1,2-diamine (TMEDA) as an electron donor. This protocol could be well expanded to access various polycyclic quinazolinones containing perfluoroalkyl groups, exhibiting photocatalyst-free, good functional group tolerance, and environmentally friendly features.

Dual Photoreactive Ternary Ruthenium(II) Terpyridyl Complexes: A Comparative Study on Visible-Light-Induced Single-Step Dissociation of Bidentate Ligands and Generation of Singlet Oxygen.

The versatile and tunable ligand-exchange dynamics in ruthenium(II)-polypyridyl complexes imposed by the modulation of the steric and electronic effects of the coordinated ligands provide an unlimited scope for developing phototherapeutic agents. The photorelease of a bidentate ligand from the Ru-center is better suited for potent Ru(II)-based photocytotoxic agents with two available labile sites for cross-linking with biological targets augmented with possible phototriggered 1O2 generation. Herein, we introduced a phenyl-terpyridine (ptpy) ligand in the octahedral Ru(II) core of [Ru(ptpy)(L-L)Cl]+ to induce structural distortion for the possible photorelease of electronically distinct bidentate ligands (L-L). For a systematic study, we designed four Ru(II) polypyridyl complexes: [Ru(ptpy)(L-L)Cl](PF6), ([1]-[4]), where L-L = 1,2-bis(phenylthio)ethane (SPH) [1], N,N,N',N'-tetramethylethylenediamine (TMEN) [2], N1,N2-diphenylethane-1,2-diimine (BPEDI) [3], and bis[2-(diphenylphosphino)phenyl]ether (DPE-Phos) [4]. The detailed photochemical studies suggest a single-step dissociation of L-L from the bis-thioether (SPH) complex [1] and diamine (TMEN) complex [2], while no photosubstitution was observed for [3] and [4]. Complex [1] and [2] demonstrated a dual role, involving both photosubstitution and 1O2 generation, while [3] and [4] solely exhibited poor to moderate 1O2 production. The interplay of excited states leading to these behaviors was rationalized from the lifetimes of the 3MLCT excited states by using transient absorption spectroscopy, suggesting intricate relaxation dynamics and 1O2 generation upon excitation. Therefore, the photolabile complexes [1] and [2] could potentially act as dual photoreactive agents via the phototriggered release of L-L (PACT) and/or 1O2-mediated PDT mechanisms, while [4] primarily can be utilized as a PDT agent.

Transcendental Meditation Enriches Nurses' Authentic Presence Through Caring for Self and Others.

Purpose of Study: Given the enormity of the most recent challenges to clinician well-being, intensified by the pandemic, we decided to explore the influence of Transcendental Meditation® (TM)® on the well-being of clinical nurses. The purpose of our study was to use qualitative analysis to enhance our understanding of the experiences of clinical nurses who practiced TM, as viewed through the lens of our conceptual model and Watson's holistic unitary caring science theory. Design and Method: This qualitative study involved a thematic analysis of clinical nurses' written descriptions following the completion of the TM program during the COVID-19 pandemic. Findings: The nurse participants shared their experiences with the practice of TM as creating present moment focus, leading to enhanced self-care, and development of authentic presence with others. The overall theme uncovered in the analysis is that authentic presence is veritas (truth) in knowing, being, doing, and becoming. Conclusions: The findings were congruent with Watson's unitary caring science theory and provided illumination of the holistic value of TM as a self-care strategy for supporting nurses' well-being with the goal of retaining nurses in practice. When nurses care for themselves, they are more likely and able to care for others, thus helping them to enjoy their nursing careers.

Understanding the synergistic effect in green propellants 2-azido-N,N-dimethylethanamine and tetramethylethylenediamine: From drop test to gas-phase autoignition

2-Azido-N,N-Dimethylethanamine (DMAZ) and tetramethylethylenediamine (TMEDA) are promising green propellants for hypergolic applications, and blending DMAZ with TMEDA can achieve short ignition delay time (IDT) and comparable specific impulse to hydrazine-based fuels simultaneously. There are reports of a synergistic effect between DMAZ and TMEDA, but its mechanism is not well understood. In this work, drop tests and gas-phase autoignition experiments were combined to provide insights of this synergistic effect from different aspects. The drop tests of DMAZ/TMEDA blends with white-fuming nitric acid were conducted in a confined transparent chamber with controlled O2 concentration. Results show that the hypergolic ignition is much faster for blends with 20–40 wt% DMAZ under all O2 concentration conditions, and higher concentration of O2 in the environment significantly promotes the hypergolic ignition process. To further investigate the chemistry between DMAZ/TMEDA with O2, gas-phase IDTs were measured using a rapid compression machine and a shock tube in a wide temperature range of 500–1100 K and at pressure of 10 bar. TMEDA shows a higher reactivity at lower temperatures (<690 K), while the autoignition of DMAZ is much faster at higher temperatures (>690 K). A synergistic effect between DMAZ and TMEDA was also observed in the gas-phase autoignition, i.e., fuel blend with 30 % DMAZ showed equal or even lower IDTs than pure TMEDA at lower temperatures. The newly measured IDTs of DMAZ/TMEDA were further adopted to validate a previously developed chemical kinetic model for pure TMEDA and DMAZ, which exhibits good predictions for the blending effects nonetheless. Kinetic analyses reveal that the low-temperature reactivity contributed from the TMEDA can be enhanced by the heat release from DMAZ decomposition, causing the synergistic effect in gas-phase autoignition of DMAZ/TMEDA blends.

Photocatalytic Pyridine Synthesis with Enaminones and TMEDA under Metal-Free Conditions.

Reported herein is a new photocatalytic annulation for the synthesis of 2,3,4,6-tetrasubstituted pyridines with enaminones and N,N,N',N'-tetramethyl ethylenediamine (TMEDA). The photocatalytic reactions take place without requiring a transition metal reagent and provide products with broad scope. The methyl in TMEDA acts as the carbon source in pyridine ring construction, and BrCF2CO2Et plays the role of the terminal oxidant for free radical quenching.

Test de Autoevaluación de Meditación Transcendental: a psychometric study of Peruvian school children and adolescents

The specific, as well as holistic, effects of practicing the Transcendental Meditation technique have been thoroughly documented. Findings associated with the practice have included a range of physiological, psychological and sociological benefits, but have also encompassed measures of general health, well-being and human development. However, few if any indigenous test instruments have been used to gather these data. In Perú, a test instrument called Test de Autoevaluación de Meditación Transcendental (i.e., Self-Assessment Test of Transcendental Meditation) designed to measure benefits of Transcendental Meditation in school children and adolescents has been deployed with some degree of success. The test was designed about 25 years ago to measure physical health, cognitive health, emotional health, and school performance, and has been completed by about 50,000 primary and secondary school students since its introduction. Recently published studies have documented the results. But the test has never been psychometrically evaluated. The purpose of the present study therefore was to rigorously assess the reliability and construct validity of the instrument using exploratory factor analysis and confirmatory factor analysis. Results of these analyses revealed a five latent factors—more alertness and energy, improved physical and mental health, enhanced cognitive performance, enhanced emotional and behavioural self-regulation, and more fulfilling interpersonal relationships—which reliably predicted an overall scale of health in students. Application of a revised Test de Autoevaluación de Meditación Transcendental is now ready for further use in Perú and, with translation, other school settings.

Characterization of the hypergolic ignition of green fuels with hydrogen peroxide by drop test and jet impingement

This work presents an experimental study on the hypergolic behavior of variants of N,N,N’,N’-tetramethylethylenediamine (TMEDA)/N,N-dimethylethanolamine (DMEA) system, named PAHyp 0, with 93 wt% hydrogen peroxide. Two different copper-based catalyst and one cobalt-based catalytic agent were dissolved in the fuels to trigger the pre-ignition reactions. When employing copper chloride dihydrate, the resultant fuel requires methanol (ternary system) as a stabilizing agent, whereas both carboxylic salts of copper and cobalt dissolved in TMEDA/DMEA deliver a stable formulation (binary system) without the need for any organic solvent. Shadowgraph high-speed imaging was used to capture the ignition process and pressure wave development of over 30 fuel samples in a modified drop test. An ignition/stability envelope was proposed to map the safe and unstable formulations. It was demonstrated that the concentration of TMEDA should be no more than 50% in the binary system, while the amount of methanol should fall within a concentration window of 33 to 50% in the ternary system. Lower loadings of catalyst, ranging from 0.5 to 1.0 wt%, are required to deliver stable fast-igniting fuels. Three promising formulations catalyzed with 1 wt% copper salts were selected to perform impinging jet fire experiments. Impinging jets yielded significantly lower ignition delay times than drop tests due to the better mixing conditions. However, it was verified that ignition may fail for low values of jet velocities, below 0.8 m/s, and for high jet velocities, exceeding 14 m/s. An attempt to explain the ignition and non-ignition events was made by using the fundamentals of explosion limits of the hydrogen/oxygen system and oxidation reactions at low temperature. Remarkably, ultra-fast ignitions of about 10 ms were measured by the impinging jet setup within near-optimal operational conditions. Therefore, TMEDA/DMEA-based fuels with reduced catalyst loadings (0.5–1.0 wt%) offer new opportunities in aerospace propulsion and should be further studied.

The effect of Transcendental Meditation on self-esteem, self-efficacy, and gratitude, for increasing empowerment of female youth in Uganda

This longitudinal study with female youth in the slums of Kampala, Uganda (n = 130), explored the impact of the Transcendental Meditation® (TM®) technique on self-esteem, the primary outcome measure, and self-efficacy, gratitude, hope, tiredness, and resilience as secondary outcomes. Quality-of-life behaviors were also assessed, including excessive alcohol use. After baseline testing participants learned TM over five consecutive days. Participants practiced TM at home for 20 min twice a day and attended two follow-up sessions. Post-testing occurred at five months. Significant improvements in self-esteem (p < .001), self-efficacy (p < .001), gratitude (p < .001), and tiredness (p = .05) were found. A decrease in excessive alcohol use was also observed (p = .02). At eight months a short answer questionnaire showed improved physical health, decreased stress and anxiety levels, and improved relationships in the family and community. Our findings have important implications for enhancing the well-being and empowerment of these vulnerable female youth.

Testing the Field Nature of Consciousness: A Pilot Test

Researchers are exploring consciousness as a field permeating the world around us, rather than just a feature of human experience. If consciousness is a field, then one should be able to affect others by acting from the field of consciousness. This study used a random-assignment, double-blind design to probe effects of nine students practicing the Transcendental Meditation technique on the subjective experiences and physiological patterns of another student also practicing Transcendental Meditation. For 12 recording sessions, the group (sender) either practiced the Transcendental Meditation technique or read a textbook. When the group was meditating, the individual (receiver) reported more settled meditation experiences, and they exhibited higher alpha EEG power, a correlate of deep meditation experiences. Effect sizes for all measures were large. This was a pilot study to identify markers of field effects of consciousness. Future research could replicate these findings with a larger sample size, modify the distance between the sender and receiver, explore EEG synchrony between the senders and the receiver, called hyperscanning or collective neuroscience, and explore differential effects between friends, family, and strangers to test social influences. This design could meaningful probe the nature of consciousness.

An Aesthetic Exploration of Sound Illusion in David Lynch's Mulholland Drive

Mulholland Drive is the masterpiece of American independent director David Lynch; whose unique sound design constructs an illusory yet real soundscape. Transcendental meditation, polysemous themes, open text, uncontrolled narrative, and disorienting imagery are the keywords to understand the aesthetic characteristics of Lynch's films. However, so far there are few comprehensive and in-depth interpretations of this movie from the perspective of cinematic sound. Therefore, this study analyzes the film from the perspective of sound design and concludes that the unique sound effects in Mulholland Drive can suggest danger and subtly manipulate the audience's emotions. In addition, the human voice in Mulholland Drive has the characteristics of mixing and breaking, and the human voice can establish a new relationship between sound and picture through the audio intervention, and it can also make the character's identity "out of focus" and other artistic effects. Finally, the jazz music in Mulholland Drive can foretell the unknown and create a strong contrast with the narrative of the movie, and other styles of soundtracks in the movie can create a dreamy and perverse ambient space.

Serotonin Transporter (SLC6A4) and FK506-Binding Protein 5 (FKBP5) Genotype and Methylation Relationships with Response to Meditation in Veterans with PTSD.

Meditation-based interventions are novel and effective non-pharmacologic treatments for veterans with PTSD. We examined relationships between treatment response, early life trauma exposure, DNA polymorphisms, and methylation in the serotonin transporter (SLC6A4) and FK506-binding protein 5 (FKBP5) genes. DNA samples and clinical outcomes were examined in 72 veterans with PTSD who received meditation-based therapy in two separate studies of mindfulness-based stress reduction (MBSR) and Transcendental Meditation (TM). The PTSD Checklist was administered to assess symptoms at baseline and after 9weeks of meditation intervention. We examined the SLC6A4 promoter (5HTTLPR_L/S insertion/deletion + rs25531_A/G) polymorphisms according to previously defined gene expression groups, and the FKBP5 variant rs1360780 previously associated with PTSD disease risk. Methylation for CpG sites of SLC6A4 (28 sites) and FKBP5 (45 sites) genes was quantified in DNA samples collected before and after treatment. The 5HTTLPR LALA high expression genotype was associated with greater symptom improvement in participants exposed to early life trauma (p = 0.015). Separately, pre to post-treatment change of DNA methylation in a group of nine FKBP5 CpG sites was associated with greater symptom improvement (OR = 2.8, 95% CI 1.1-7.1, p = 0.027). These findings build on a wealth of existing knowledge regarding epigenetic and genetic relationships with PTSD disease risk to highlight the potential importance of SLC6A4 and FKBP5 for treatment mechanisms and as biomarkers of symptom improvement.