Testing Main Effects Research Articles

The effect of playing Onigokko on children’s executive function and cardiovascular endurance in the early elementary school grades

This study investigated whether continuously playing Onigokko, a game similar to tag, could enhance children’s cognitive flexibility, a component of executive function, and improve cardiovascular endurance. The intervention group comprised 34 students enrolled in the second-grade A class of H elementary school in Y prefecture. The control group comprised 34 students enrolled in the second-grade B class at the same school. Cognitive flexibility was assessed using the Trail Making Test Task B (TMT-B), while cardiovascular endurance was measured using a 20-meter shuttle run. These measurements were taken for both groups before and after four weeks playing Onigokko with the intervention group. A two-way ANOVA was applied for each measurement item, considering the group (intervention and control groups) and measurement period (pre and post). A significant interaction was found between cognitive flexibility (TMT-B response time) and cardiovascular endurance (20-meter shuttle run count and maximal oxygen consumption [VO2Max]); thereafter, a simple main effect test (Bonferroni method) was conducted. The results revealed that the intervention group’s cognitive flexibility (TMT-B response time) and cardiovascular endurance (20-meter shuttle run count and VO2Max) significantly improved post-intervention compared to the control group. These findings suggest that continuously playing Onigokko can significantly enhance both cognitive flexibility and cardiovascular endurance among early elementary school students.

The Association between Emotional Intelligence and Prosocial Behaviors in Children and Adolescents: A Systematic Review and Meta-Analysis.

Emotional intelligence and prosocial behavior both play an important role in the development of children and adolescents. However, the strength of the association between emotional intelligence and prosocial behavior in children and adolescents is controversial. Hence, this study aimed to conduct a meta-analysis to evaluate the exact association between emotional intelligence and prosocial behavior in children and adolescents. Through a literature search, a total of 40 studies and 40 effect sizes were included in this meta-analysis (n = 20621). In this study, the main effect test shows that there is a significant positive correlation between emotional intelligence and prosocial behavior in children and adolescents (r = 0.43). Moreover, the present study found a significant moderating effect of age. More specifically, the association between early childhood (0-6 years) emotional intelligence and prosocial behavior is stronger than in middle childhood (7-12 years) and adolescence (13-18 years), and the correlation between emotional intelligence and prosocial behavior is stronger in boys than in girls. The culture was also found to be an important moderator, the association was found to be weaker for Western culture than for Eastern culture. Finally, a stronger correlation between the two variables was found when the emotional intelligence measurement tool was LZ (Emotional intelligence questionnaire compiled by Liu Yan and Zou Hong). These results indicated that improving children's and adolescents' emotional intelligence could be an important strategy to enhance children's prosocial behavior.

The association between social support and prosocial behavior: A three-level meta-analysis.

Numerous studies have examined the relationship between social support and prosocial behavior and have concluded that social support is an important factor in generating prosocial behavior. However, different studies have produced different conclusions, and the moderating effect on the relationship is not entirely clear. The current study uses a three-level meta-analysis method to clarify the relationship between social support and prosocial behavior, and explores the moderating variables that affect the relationship between the two variables. Through a systematic literature search, a total of 92 studies, 418 effect sizes, and 74,378 participants were obtained. The main effects test found a significant positive correlation between social support and prosocial behavior. Tests of the moderating effects indicated that the relationship between social support and prosocial behavior was moderated by year of publication, source of social support, measurement of social support and measurement of prosocial behavior. In summary, social support plays an important role in prosocial behavior, and exploring their relationship is beneficial to families, schools and society in guiding individuals' prosocial behavior.

Gender differences in mathematics anxiety: A meta-analysis of Chinese children

Mathematics anxiety (MA) is a widespread phenomenon that affects an individual's learning of mathematics. MA between different genders has been of great interest to researchers. Meta–analysis was used to examine the relationship between MA and gender in Chinese children, along with the influencing factors. After literature search and screening, 83 papers and 91 independent samples met the inclusion criteria. The results of the main effect test of the random effect model revealed a correlation of significant levels between MA and gender, r = −0.131, 95%CI [−0.158, −0.105], Z = –9.508, and p < 0.001. Girls had higher MA than boys. The outcomes of the moderating effect test indicated that the moderating effect of age, economic region and measurement instrument in the relationship between MA and gender was significant. But the moderating effect of period was not significant. Specifically, gender differences in MA were greater at the middle school compared to the elementary school. And the greatest correlation between children's MA and gender was in the western region. The gender difference of MA measured by different instruments varied.

Testing for Level–Degree Interaction Effects in Two-Factor Fixed-Effects ANOVA When the Levels of Only One Factor Are Ordered

In testing for main effects, the use of orthogonal contrasts for balanced designs with the factor levels not ordered is well known. Here, we consider two-factor fixed-effects ANOVA with the levels of one factor ordered and one not ordered. The objective is to extend the idea of decomposing the main effect to decomposing the interaction. This is achieved by defining level–degree coefficients and testing if they are zero using permutation testing. These tests give clear insights into what may be causing a significant interaction, even for the unbalanced model.

Efficacy of acupuncture for a cough-related symptom cluster in patients with lung cancer: A randomized controlled trial

PurposeThis study was designed to evaluate the effect of acupuncture on cough, expectoration, and shortness of breath in lung cancer patients. MethodsBetween December 2021 and June 2022, a total of 130 lung cancer patients were recruited, and they were split into control and intervention groups at random. Routine nursing was provided to the control group, whereas routine nursing with acupuncture using LU7 (Lie Que), LU9 (Tai Yuan), BL13 (Fei Shu), and BL20 (Pi Shu) was administered to the intervention group for 7 days. The severity of cough, expectoration, and shortness of breath was assessed 1 day before and after the interventions using the lung cancer-specific module of the MDASI. A two-way ANOVA was performed for group comparisons. ResultsCompared with the control group, the symptoms of cough in the intervention group were significantly improved (F = 5.095, MD = −0.32, 95% CI, −0.59 to 0.04, P = 0.025), while expectoration (F = 0.626, MD = −0.11, 95% CI, −0.38 to 0.16, P = 0.430) and shortness of breath (F = 0.165, MD = −0.05, 95% CI, −0.27 to 0.18, P = 0.685) had no significant change. Cough also identified an obvious interaction effect (P = 0.014), and the post-intervention simple main effect test demonstrated a tangible difference between the two groups (MD = −0.66, 95% CI, −0.99 to 0.33, P < 0.001) post-intervention. ConclusionsAcupuncture using LU7, LU9, BL13, and BL20 can relieve the cough of lung cancer patients, but not relieve expectoration and shortness of breath.

Effects of Task Interference on Kinematics and Dual-Task Cost of Running in Early Childhood.

Children aged 3-8 are in a critical period for motor development and postural control. Running is a basic motor skill that children need to master in early childhood. While running, children are prone to dangerous events such as falls. This study investigates the kinematic characteristics of running by children associated with different interference tasks, i.e., normalized running, cognitive dual-tasks, and obstacle crossing tasks, and provides a theoretical foundation for the interference mechanism of children's dynamic postural control and for screening of motor disorders. Two hundred children aged 3-8 were recruited. The BTS Bioengineering infrared motion capture system was used to collect spatiotemporal and kinematic running data under three tasks. Repeated measures of variance analysis were used to compare the effects of different interference tasks and ages on children's running signs. The main and interaction effect tests were compared by the Bonferroni method. The results and conclusions are as follows: (1) Running characteristics of early childhood are influenced by interference tasks and age. With interference tasks, the overall characteristics of running by children aged 3-8 showed an increasing trend in running cycle time and a decreasing trend in stride length, step length, cadence, and speed. (2) Both cognitive and obstacle crossing tasks had costs, and cognitive task costs were greater than obstacle crossing costs. Children adopted a "task first" running strategy with different interference tasks. When facing cognitive tasks, their overall joint motion decreased, and they reduced joint motions to promote task completion. When facing obstacle crossing tasks, because of the characteristics of the task itself, children increased joint motions to cope with interference. (3) In terms of age, the running characteristics showed a nonlinear development trend in various indicators, with a degree of recurrence and high variability in adjacent age groups. (4) The dual-task interference paradigm of "postural-cognition" can be used as a motor intervention tool to promote the development of basic motor skills in early childhood.

Can human-machine feedback in a smart learning environment enhance learners' learning performance? A meta-analysis.

The human-machine feedback in a smart learning environment can influences learners' learning styles, ability enhancement, and affective interactions. However, whether it has stability in improving learning performance and learning processes, the findings of many empirical studies are controversial. This study aimed to analyze the effect of human-machine feedback on learning performance and the potential boundary conditions that produce the effect in a smart learning environment. Web of Science, EBSCO, PsycINFO, and Science Direct were searched for publications from 2010 to 2022. We included randomized controlled trials with learning performance as outcome. The random effects model was used in the meta-analysis. The main effect tests and the heterogeneity tests were used to evaluate the effect of human-machine feedback mechanism on learning performance, and the boundary conditions of the effect were tested by moderating effects. Moreover, the validity of the meta-analysis was proved by publication bias test. Out of 35 articles identified, 2,222 participants were included in this study. Human-machine interaction feedback had significant effects on learners' learning process (d = 0.594, k = 26) and learning outcomes (d = 0.407, k = 42). Also, the positive effects of human-machine interaction feedback were regulated by the direction of feedback, the form of feedback, and the type of feedback technique. To enhance learning performance through human-machine interactive feedback, we should focus on using two-way and multi-subject feedback. The technology that can provide emotional feedback and feedback loops should be used as a priority. Also, pay attention to the feedback process and mechanism, avoid increasing students' dependence on machines, and strengthen learners' subjectivity from feedback mechanism.

The Interaction between Dramatic Writing and the Construction of National Identity in the Southern National Society Period

Abstract Starting from the background of the development of Chinese and Western cultures, this paper analyzes the textual themes and interprets the ideas of the dramas created during the period of the Nanguosha. Taking into account the specificity of the era and the national perception of Nanguosha’s theatrical works, the concept of theatrical cultural interaction is put forward to analyze the basis of cultural interaction in the cultural acceptance behavior of drama. Audience interaction behavior and audience emotional intelligence are chosen as intermediary and moderating variables respectively, and a four-variable research model is constructed for the creation of Nanguosha’s dramas, the construction of national identity, audience interaction behavior and audience emotional intelligence. Introduce the causal mediation effect model based on Nanguosha theater culture, explain the symbolic variables, and discuss the estimation method for the causal mediation effect. Combine the empirical data with the descriptive analysis and correlation analysis of the variables, and carry out the main effect test, mediation effect test, moderating effect test, and moderated mediation effect test of the research hypotheses in order to verify the interaction of the variables. After introducing the mediator variable of audience interaction behavior, the regression coefficient of Nanguosha’s drama creation on national identity construction is β =0.198, P&lt;0.01, which confirms that there is a relationship of positive influence of Nanguosha’s drama creation on national identity construction, and that the audience interaction behavior plays a partly mediating role in the process of Nanguosha’s drama creation’s role in national identity construction.

Impairments of social interaction in a valproic acid model in mice.

A rodent autism spectrum disorder (ASD) model based on prenatal exposure to valproic acid (VPA) is widely recognized as a prominent model. Social behavior in rodent ASD models has primarily been evaluated through a three-chamber approach test. However, in this study, we focused on social attention in the VPA model of ASD. In male C57BL/6 J mice, attentional behaviors toward conspecifics were examined through reaching tasks around 9-11 weeks of age. On embryonic day 12.5, pregnant mice underwent a subcutaneous injection of 600 mg/kg VPA sodium salt dissolved in 0.9% saline solution (VPA group) or saline solution alone (Sal group) into their neck fat. Thirty-six mice-nine each in the VPA and saline groups, and 18 partners-underwent training in reaching behavior. Subsequently, we examined whether the VPA or Sal group demonstrated focused attention toward their partners during reaching tasks. A two-way analysis of variance (ANOVA) (condition [VPA/Sal] × situation [face-to-face (attention)/not paying attention (not attention)]) was conducted on the average success rate of the situation. Additionally, we measured the duration of sniffing behavior between pairs of mice in an open field twice in total at 4 and 8 weeks of age before reaching task. The pairs were constructed by pairing a VPA or Sal group mouse with its partner, with the objective of facilitating initial encounters between the mice. A one-way ANOVA was conducted on the average duration of sniffing behavior data from 4 weeks and a second one-way ANOVA on data from 8 weeks. The analysis revealed a significant interaction between condition and situation in the reaching task [F (1, 28) = 6.75, p = 0.015, ηp 2 = 0.19]. The simple main effect test exhibited that the "not paying attention" rate was significantly higher than that of the "face-to-face" in the VPA group (p < 0.01). The results revealed a not significant difference in the average duration of sniffing behavior at 4 weeks [F (3, 32) = 2.71, p = 0.06, n.s., ηp 2 = 0.20], but significant difference at 8 weeks [F (3, 32) = 4.12, p < 0.05, ηp 2 = 0.28]. Multiple comparisons using the Bonferroni method revealed significant differences in the sniffing duration at 8 weeks between from the partner toward the VPA mouse and from the partner toward the Sal mouse (p < 0.05). The VPA rodent model of ASD exhibited differences in social attention compared to the saline group. By focusing on social attention and exploring various ASD models, insights can be gained from the neural mechanisms underlying gaze abnormalities during social interaction in individuals with ASD.

Guideline evaluation and implementation mechanisms in school health services (GuideMe): protocol for a hybrid randomized factorial trial

BackgroundNorwegian school health services received a national best-practice guideline in 2017. To promote healthy life skills and identify adolescents needing support, the guideline includes strong recommendations for individual consultations with all 8th graders and increased collaboration with schools. To help implement the recommendations, a blended implementation strategy (SchoolHealth) was co-created with school nurses, students, and stakeholders. SchoolHealth consists of three implementation elements: Digital dialog and administration tool (audit and feedback +), Dialog support (external consultation), and Collaboration materials (targeted dissemination). This hybrid study will test the main and combined effects of the elements on guideline fidelity and effectiveness.MethodsThe GuideMe study is a factorial cluster randomized controlled trial examining SchoolHealth's effectiveness on guideline fidelity and guideline effectiveness goals. Forty Norwegian secondary schools will be randomized to eight different combinations of the elements in SchoolHealth. Participants will include school nurses and school personnel from these schools, and 8th grade students (n = 1200). Primary outcomes are school nurses' fidelity to the guidelines and student's ability to cope with their life (i.e., health literacy, positive health behaviors and self-efficacy). Quantitative methods will be used to test effects and mechanisms, while mixed- and qualitative methods will be used to explore mechanisms, experiences, and other phenomena in depth. Participants will complete digital questionnaires at the start and end of the schoolyear, and after the consultation during the schoolyear. The study will run in two waves, each lasting for one school year. The multifactorial design allows testing of interactions and main effects due to equal distribution of all factors within each main effect. Sustainment and scale-up of optimized SchoolHealth elements using national infrastructure are simultaneously prepared.DiscussionThe study will investigate possible effects of the implementation elements in isolation and in combination, and hypothesized implementation mechanisms. In-depth study of user experiences will inform improvements to elements in SchoolHealth. The results will yield causal knowledge about implementation strategies and the mechanisms through which they assert effects. Mixed-methods will provide insights into how and when the elements work. Optimizing guideline implementation elements can support adolescents in a crucial life phase.Trail registrationISRCTN24173836. Registration date 8 August 2022.

Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.

Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment interactions in up to 226,315 individuals from five population groups. We considered two educational attainment variables: "Some College" (yes/no, for any education beyond high school) and "Graduated College" (yes/no, for completing a 4-year college degree). Genome-wide significant (p < 5 × 10-8) and suggestive (p < 1 × 10-6) variants were identified in Stage 1 (in up to 108,784 individuals) through genome-wide analysis, and those variants were followed up in Stage 2 studies (in up to 117,531 individuals). Results: In combined analysis of Stages 1 and 2, we identified 18 novel lipid loci (nine for LDL, seven for HDL, and two for TG) by two degree-of-freedom (2 DF) joint tests of main and interaction effects. Four loci showed significant interaction with educational attainment. Two loci were significant only in cross-population analyses. Several loci include genes with known or suggested roles in adipose (FOXP1, MBOAT4, SKP2, STIM1, STX4), brain (BRI3, FILIP1, FOXP1, LINC00290, LMTK2, MBOAT4, MYO6, SENP6, SRGAP3, STIM1, TMEM167A, TMEM30A), and liver (BRI3, FOXP1) biology, highlighting the potential importance of brain-adipose-liver communication in the regulation of lipid metabolism. An investigation of the potential druggability of genes in identified loci resulted in five gene targets shown to interact with drugs approved by the Food and Drug Administration, including genes with roles in adipose and brain tissue. Discussion: Genome-wide interaction analysis of educational attainment identified novel lipid loci not previously detected by analyses limited to main genetic effects.

Phase transformation and mechanical properties of heat-treated nickel-titanium rotary endodontic instruments at room and body temperatures

BackgroundThe aim of this study was to evaluate the phase composition, phase transformation temperatures, bending property, and cyclic fatigue resistance of different heat-treated nickel-titanium (NiTi) rotary instruments with the same tip diameter and taper at room (RT; 25 ± 1 °C) and body (BT; 37 ± 1 °C) temperatures.MethodsFive heat-treated NiTi rotary instruments, HyFlex EDM (EDM), HyFlex CM (CM), Vortex Blue (VB), RE file CT (RE) and JIZAI, and a non-heat-treated NiTi rotary instrument (Mtwo) with a size 40, 0.04 taper were investigated. Temperature-dependent phase transformation was examined with differential scanning calorimetry (DSC). The bending loads of the instruments at RT and BT were evaluated using a cantilever-bending test. Cyclic fatigue resistance at RT and BT was measured using a dynamic test, during which the instruments were rotated in combination with a 2-mm back-and-forth motion in an artificial curved canal, and the number of cycles to failure (NCF) was determined. The results were analyzed using two-way repeated measures analysis of variance, a simple main effect test, and the Bonferroni test (α = 0.05).ResultsDSC results indicated that EDM and Mtwo were primarily composed of martensite/R-phase and austenite, respectively, while the other heat-treated instruments were composed of a mix of martensite/R-phase and austenite at the tested temperatures. Regardless of the temperature setting, the bending loads of heat-treated instruments were significantly lower than those of Mtwo (p < 0.05). EDM showed the lowest bending loads and highest NCF at both temperatures (p < 0.05). CM, VB, and JIZAI showed significantly higher bending loads at BT than at RT (p < 0.05). The NCF of all the heat-treated instruments, except VB, was lower at BT than at RT (p < 0.05). At BT, the NCF of CM, VB, RE, and JIZAI were not significantly higher than that of Mtwo (p > 0.05).ConclusionsHeat-treated NiTi instruments exhibited lower bending loads and higher NCF values than Mtwo. However, this tendency was less pronounced at BT than at RT, especially in the NCF values of instruments with a mixture of martensite/R-phase and austenite phases at the tested temperatures.

Optimization of controlled-release urea application based on the winter wheat yield

Wheat is of great significance to ensuring national food security in China. The one-time fertilization for saving labor was common in winter wheat production in the North China Plain, which caused the excessive application of nitrogen (N) fertilizer generally. Controlled-release urea (CRU) has a good application effect in crops with short growth periods such as rice and maize. However, the applications of CRU on winter wheat with a longer growth period are fewer. To investigate the appropriate dosage and blending proportion of CRU and urea in wheat production, the field experiment with 52 treatments was conducted in 2019–2021. This relationship among N application rates, CRU release longevity, CRU proportions and winter wheat yield was systematically studied, and the binary quadratic effect models between yield and CRU factors were established. N application rates, CRU proportion and the interacted effect of CRU proportion and release longevity had the greatest effect on winter wheat yield by the main effects test and correlation analysis. The winter wheat yield could be accurately predicted by CRU proportions and CRU release longevity. The prediction errors of yield models were −9.8%∼4.9% based on the 2018 and 2022 two years winter wheat yield with CRUs application. Reducing N application rates by 20∼30% and mixing with appropriate CRU proportion would increase the yield and NUEs (nitrogen use efficiencies) of winter wheat. In the case of low CRU proportion, the wheat yield could be increased by applying the CRU with long-release longevity; when the CRU proportion was high, the yield increase effect of the CRU with short-release longevity was better. Comprehensive field production survey and Response surface methodology (RSM) partial derivative analysis, CRUs with controlled release longevity of 57d∼150d and CRU proportion of 24∼64% were the best choices for increasing wheat yield and reducing N application rates. It will facilitate the optimization of wheat CRU manufacture and application and promote the ‘Reduction and Efficiency of Chemical Fertilizers’ policies and environmental protection.

Statistical assessment of biomarker replicability using MAJAR method.

In the era of precision medicine, many biomarkers have been discovered to be associated with drug efficacy and safety responses, which can be used for patient stratification and drug response prediction. Due to the small sample size and limited power of randomized clinical studies, meta-analysis is usually conducted to aggregate all available studies to maximize the power for identifying prognostic and predictive biomarkers. However, it is often challenging to find an independent study to replicate the discoveries from the meta-analysis (e.g. meta-analysis of pharmacogenomics genome-wide association studies (PGx GWAS)), which seriously limits the potential impacts of the discovered biomarkers. To overcome this challenge, we develop a novel statistical framework, MAJAR (meta-analysis of joint effect associations for biomarker replicability assessment), to jointly test prognostic and predictive effects and assess the replicability of identified biomarkers by implementing an enhanced expectation-maximization algorithm and calculating their posterior-probability-of-replicabilities and Bayesian false discovery rates (Fdr). Extensive simulation studies were conducted to compare the performance of MAJAR and existing methods in terms of Fdr, power, and computational efficiency. The simulation results showed improved statistical power with well-controlled Fdr of MAJAR over existing methods and robustness to outliers under different data generation processes. We further demonstrated the advantages of MAJAR over existing methods by applying MAJAR to the PGx GWAS summary statistics data from a large cardiovascular randomized clinical trial. Compared to testing main effects only, MAJAR identified 12 novel variants associated with the treatment-related low-density lipoprotein cholesterol reduction from baseline.

The Effects of Mindfulness Meditation on Nursing Students' Stress and Anxiety Levels.

The aim of this study was to evaluate the effects of a virtual mindfulness meditation intervention on stress and anxiety levels of 145 nursing students. Because of the twin demands of classroom and clinical workloads, nursing students experience greater amounts of stress and anxiety than the average college student. Mindfulness meditation is a promising method to alleviate stress and anxiety. A pretest-posttest randomized controlled design was used. Participants received either weekly mindfulness meditation recordings or recordings on nursing information. Participants completed the Perceived Stress Scale and the Generalized Anxiety Disorder-7 Scale. A two-way mixed analysis of variance and follow-up simple main effects tests revealed that participants in the experimental group, who received meditation recordings, experienced significantly lower levels of stress and anxiety on posttest surveys than the control group. Mindfulness meditation can reduce stress and anxiety levels in nursing students. This can improve students' overall mental and physical well-being.

The Interaction of Unmitigated Communion and Gender on Gender System Justification

This study examined the interaction between unmitigated communion (UC) and gender on gender system justification (GSJ). UC is a trait of putting others before oneself. GSJ is a tendency to maintain the status quo, even if it is unequal. Participants included 200 females and 200 males (Mage=20.5). Hierarchical multiple regression analysis was conducted including the interaction terms of UC and GSJ. Since the interaction was significant, a simple main effect test was conducted, a positive association for females, and a negative association for males. The results were interpreted regarding the fit in society for females and a lack of merit for males.

Micro-CT analysis of marginal and internal fit of milled and pressed polyetheretherketone single crowns

Statement of problemPolyetheretherketone (PEEK) has been increasingly used as a framework material in prosthetic dentistry. However, data on the marginal and internal fit of PEEK restorations fabricated by using either the computer-aided design and computer-aided manufacturing (CAD-CAM) or heat-pressing technique are sparse. PurposeThe aim of this in vitro study was to assess the marginal and internal fit of milled and pressed PEEK single crowns by using microcomputed tomography (μCT). Material and methodsA custom-made, single stainless-steel die was designed to replicate a maxillary first premolar prepared for a ceramic crown. PEEK copings (N=30) were fabricated and allocated to 3 groups (n=10) according to the fabrication technique: milled from a prefabricated PEEK blank, heat pressed from PEEK pellets, and heat pressed from PEEK granules. All copings were veneered with a composite resin material. The marginal fit was recorded at 4 predetermined points and the internal fit at 8 predetermined points on each crown by using μCT. Two-way ANOVA, pair-wise Tukey honestly significant difference (HSD), and simple main effect tests were used for statistical analysis of the data (α=.05). ResultsConcerning marginal fit, the milled crowns demonstrated the best marginal fit overall (44 ±3 μm), followed by those pressed from pellets (92 ±3 μm), and finally by those pressed from granules (137 ±7 μm) (P<.001). The interaction between the effects of the fabrication technique and the measurement point on the marginal fit was not statistically significant (P=.142). The milled crowns demonstrated the lowest mean gap values overall, followed by those pressed from pellets and those pressed from granules (P<.001). The interaction between the effects of the fabrication technique and the measurement point on the internal fit was statistically significant (P<.001). Except for the distal occlusal gap and mesial occlusal gap, all tested groups showed a statistically significant difference (P<.001). In addition, statistically significant differences were observed among all measurement points in different fabrication techniques (P<.001). ConclusionsThe marginal and internal fit of milled PEEK crowns was significantly better than pressed crowns. However, both CAD-CAM and heat-pressing techniques produced PEEK crowns with a clinically acceptable marginal and internal fit. The mean marginal gap of the PEEK crowns pressed from granules was above the range of clinically acceptable value.

Relation between Unmitigated Communion and Friendship Satisfaction: Gender as a Moderator

This study examined the relationship between unmitigated communion and friendship satisfaction, with gender as a moderator. The participants were 232 females and 132 males (mean age=19.6). Hierarchical multiple regression analysis was conducted with friendship satisfaction as the dependent variable. Gender and unmitigated communion were independent variables. Results showed that the interaction term between gender and unmitigated communion was significant. A simple main effect test indicated a negative association between unmitigated communion and friendship satisfaction only for females. Gender was shown to be a moderator, which was discussed in terms of self-disclosure.

AWOT and CWOT for genotype and genotype by treatment interaction joint analysis in pharmacogenetics GWAS.

Pharmacogenomics (PGx) research holds the promise for detecting association between genetic variants and drug responses in randomized clinical trials, but it is limited by small populations and thus has low power to detect signals. It is critical to increase the power of PGx genome-wide association studies (GWAS) with small sample sizes so that variant-drug-response association discoveries are not limited to common variants with extremely large effect. In this paper, we first discuss the challenges of PGx GWAS studies and then propose the adaptively weighted joint test (AWOT) and Cauchy weighted joint test (CWOT), which are two flexible and robust joint tests of the single nucleotide polymorphism (SNP) main effect and genotype-by-treatment interaction effect for continuous and binary endpoints. Two analytic procedures are proposed to accurately calculate the joint test p-value. We evaluate AWOT and CWOT through extensive simulations under various scenarios. The results show that the proposed AWOT and CWOT control type I error well and outperform existing methods in detecting the most interesting signal patterns in PGx settings (i.e., with strong genotype-by-treatment interaction effects, but weak genotype main effects). We demonstrate the value of AWOT and CWOT by applying them to the PGx GWAS from the Bezlotoxumab Clostridium difficile MODIFY I/II phase 3 trials. The R package COWT is publicly available on CRAN https://cran.r-project.org/web/packages/cwot/index.html. Supplementary data are available at Bioinformatics online.