Test Scores Research Articles

Evaluating the fairness of a high-stakes college entrance exam in Kuwait

The use of college entrance exams for facilitating admission decisions become controversial, and the central argument is around the fairness of test scores. The Kuwait University English Aptitude Test (KUEAT) is a high-stakes test, but very few studies have examined the psychometric quality of the scores for this national-level assessment. This study illustrates how measurement approaches can be used to examine the fairness issues in educational testing. Through a modern view of fairness, we assess the internal and external bias of KUEAT scores using differential item functioning analysis and differential prediction analysis, respectively, and provide a comprehensive fairness argument for KUEAT scores. The analysis for examining the internal evidence of bias was based on 1790 examinees’ KUEAT scores in November 2018. KUEAT scores and first-year college GPAs of 4033 students enrolled in KU were used for assessing the external evidence of bias. Results revealed many items showing differential item functioning across student subpopulation groups (i.e., nationality, gender, high school majors, and high school types). Meanwhile, KUEAT scores also predicted college performance differentially by different student subgroups (i.e., nationality, high school majors, and high school types). Discussion and implications on the fairness issues of college entrance tests in Kuwait are provided.

Acute Effects of Cadence-Controlled Walking on Cognition and Vascular Function in Physically Inactive Older Adults: A Randomized Crossover Study.

Cadence-controlled walking may be a desirable approach for older adults to self-monitor exercise intensity and achieve physical activity guidelines. We examined the acute effects of cadence-controlled walking on cognition and vascular function in physically inactive older adults. In a randomized crossover design, 26 participants (65% females, 67.8 ± 11.3years) underwent 30-min acute exercise (walking at 100steps/min) and control (sitting) conditions. We measured cognition, central blood pressure (BP), and arterial stiffness before, and immediately, after each condition. We observed significant Time × Condition interactions in the Flanker Inhibitory Control and Attention (Flanker) test and Dimensional Change Card Sort (DCCS) test scores, and in central systolic BP, central pulse pressure, and carotid to femoral pulse wave velocity (p < .05). The Flanker and DCCS scores significantly increased after walking (d = 0.4 and 0.5, respectively), but not after sitting. Central systolic BP, central pulse pressure, and carotid to femoral pulse wave velocity significantly increased after sitting but remained unchanged after acute walking (d = 0.4-0.2), with p-values < .05. After walking, significant correlations were observed between DCCS and diastolic BP and central pulse pressure change scores and change scores in central pulse wave velocity,Flanker, and DCCS (rs = -0.45 to -0.52). These findings suggest that a single bout of cadence-controlled walking elicited an immediate improvement in cognition and might have mitigated increases in arterial stiffness and central BP observed in the seated control condition. Further research is needed to examine the association between cognition and vascular function following acute exercise compared to control conditions. Our findings may have practical implications for developing daily physical activity recommendations for improving the cognitive health for successful aging.

Consequences of age and education correction of cognitive screening tests - A simulation study of the MoCA test in Italy.

Cognitive screening tools are widely used in clinical practice to screen for age-related cognitive impairment and dementia. These tools' test scores are known to be influenced by age and education, leading to routine correction of raw scores for these factors. Despite these corrections being common practice, there is evidence suggesting that corrected scores may perform worse in terms of discrimination than raw scores. To address the ongoing debate in the field of dementia research, we assessed the impact of the corrections on discrimination, specificity, and sensitivity of the Montreal Cognitive Assessment test in Italy, both for the overall population and across age and education strata. We created a realistic model of the resident population in Italy in terms of age, education, cognitive impairment and test scores, and performed a simulation study. We confirmed that the discrimination performance was higher for raw scores than for corrected scores in discriminating patients with cognitive impairment from individuals without (areas under the curve of 0.947 and 0.923 respectively). With thresholds determined on the overall population, raw scores showed higher sensitivities for higher-risk age-education groups and higher specificities for lower-risk groups. Conversely, corrected scores showed uniform sensitivity and specificity across demographic strata, and thus better performance for certain age-education groups. Raw and corrected scores show different performances due to the underlying causal relationships between the variables. Each approach has advantages and disadvantages, the optimal choice between raw and corrected scores depends on the aims and preferences of practitioners and policymakers.

Исследование эффективности теста ATTON в диагностике нарушения внимания у детей 5—7 лет

&lt;p&gt;This article describes the study of attention concentration in children using a new method &amp;mdash; the ATTON test for the first time. The duration of the test, the response rate, the number of errors and correct answers in the main (106 children) and control (108 children) groups were measured. The authors identified differences in the groups in test duration, response rate, number of errors and correctly completed tasks at the significance level &amp;alpha;&amp;lt;0.001. And also presented normative indicators of test duration, response rate, number of erroneous and correct answers for children aged 5, 6 and 7 years. The relationship between the duration of the test, the number of errors and correct answers of the ATTON test with the scores of the proof-reading test "Encryption", as well as with a non-verbal intellectual indicator, was revealed. The retest reliability was determined at the level of r=0.757 at p&amp;lt;0.001. The Cronbach's alpha value for the test was 0.973.&lt;/p&gt;

Dysglycemia, gender, and cognitive performance in older persons living with mild cognitive impairment: findings from a cross-sectional, population-based study

ObjectiveThis study aims to examine the relationship between dysglycemia - also known as pre-diabetes or impaired glucose tolerance- and cognitive abilities in an older population living Mild Cognitive Impairment (MCI) and stratified by gender.Study designThis is a retrospective study with data gathered from a large Italian clinical-based database.Main outcome measuresThe evaluation of cognitive performances by the Mini-Mental State Examination and the Addenbrooke’s Cognitive Examination Revised rating scale as tests of screening and a comprehensive neuropsychological evaluation of several cognitive areas.ResultsThe study comprised 682 subjects (445 F/237 M) with a mean age of 76.08 ± 9.03 (range: 66–93) years. In all population, subjects with dysglycemia 193 (28.3%) had significantly poorer performance in memory (p = 0.006) and logic reasoning (p = 0.007) when compared with subjects without dysglycemia. The linear regression analyses revealed significant differences in the correlates of cognitive domains between gender groups. Independent of multiple covariates, women with dysglycemia showed worse performances in attention and short-term memory domains as compared with men. Even in the absence of dysglycemia women were more likely to show lower score in screening test of general cognition and attention.ConclusionsOur findings suggest that dysglycemia in older individuals with MCI is associated with declines in specific cognitive domains, potentially influenced by gender. Implementing a comprehensive approach involving risk stratification and preventive strategies may be more effective in averting further cognitive decline in this high-risk population.

Causality of genetically determined blood metabolites on inflammatory bowel disease: a two-sample Mendelian randomization study

Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory disease of the gastrointestinal tract, including two subtypes: Crohn’s disease (CD) and ulcerative colitis (UC). Metabolic disorders are important factors in the development of IBD. However, the evidence for the causal relationship between blood metabolites and IBD remains limited. A two-sample MR analysis was applied to evaluate relationships between 486 blood metabolites and IBD. The inverse variance weighted method was chosen as the primary MR analysis method. False discovery rate correction was used to control for false positives in multiple testing. Following complementary and sensitivity analyses were conducted using methods such as weight median, MR-egger, weighted mode, simple mode, Cochran Q test, and MR-PRESSO. Moreover, we performed replication, meta-analysis, Steiger test, and linkage disequilibrium score regression to enhance the robustness of the results. Additionally, we performed metabolic pathway analysis to identify potential metabolic pathways. As a result, we identified four significant causal associations between four blood metabolites and two IBD subtypes. Specifically, one metabolite was identified as being associated with the development of CD (mannose: odds ratio (OR) = 0.19, 95% confidence interval (CI) 0.08–0.43, P = 8.54 × 10–5). Three metabolites were identified as being associated with the development of UC (arachidonate (20:4n6): OR = 0.18, 95% CI 0.11–0.30, P = 2.09 × 10–11; 1, 5-anhydroglucitol: OR = 2.21, 95% CI 1.47–3.34, P = 1.50 × 10–4; 2-stearoylglycerophosphocholine: OR = 2.66, 95% CI 1.53–4.63, P = 5.30 × 10–4). The findings of our study suggested that the identified metabolites and metabolic pathways can be considered as useful circulating metabolic biomarkers for the screening and prevention of IBD in clinical practice, as well as candidate molecules for future mechanism exploration and drug target selection.

Study on the impact of comprehensive geriatric assessment on anxiety and depression in chronic obstructive pulmonary disease patients.

Psychological factors such as anxiety and depression will not only aggravate the symptoms of chronic obstructive pulmonary disease (COPD) patients and reduce the quality of life of patients, but also affect the treatment effect and long-term prognosis. Therefore, it is of great significance to explore the clinical application of senile comprehensive assessment in the treatment of COPD and its influence on psychological factors such as anxiety and depression. To explore the clinical application of comprehensive geriatric assessment in COPD care and its impact on anxiety and depression in elderly patents. In this retrospective study, 60 patients with COPD who were hospitalized in our hospital from 2019 to 2020 were randomly divided into two groups with 30 patients in each group. The control group was given routine nursing, and the observation group was given comprehensive assessment. Clinical symptoms, quality of life [COPD assessment test (CAT) score], anxiety and depression Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD) were compared between the two groups. CAT scores in the observation group decreased from an average of 24.5 points at admission to an average of 18.3 points at discharge, and in the control group from an average of 24.7 points at admission to an average of 18.3 points at discharge. The average score was 22.1 (P < 0.05). In the observation group, HAMA scores decreased from 14.2 points at admission to 8.6 points at discharge, and HAMD scores decreased from 13.8 points at admission to 7.4 points at discharge. The mean HAMD scores in the control group decreased from an average of 14.5 at admission to an average of 12.3 at discharge, and from an average of 14.1 at admission to an average of 11.8 at discharge. The application of comprehensive geriatric assessment in COPD care has a significant effect on improving patients' clinical symptoms and quality of life, and can effectively reduce patients' anxiety and depression.

Approach to the Game Take the Ball to Practice Swimming Skills for Beginners in Physical Education

This study aims to explore the effectiveness of the grab the ball game approach as an alternative method of teaching swimming skills to beginners in physical education. Teaching swimming skills to beginners in physical education is often challenged by the need to create an engaging and effective learning environment for students. This research method uses an experimental approach one group pretest postest with the need for 8 sessions. Swimming skills were assessed before and after the intervention. The research sample was 15 students at Bina Darma University with the category of not able to swim or beginners. Data were collected by measuring test of swimming 50 meters freestyle. Data analysis using paired test between pre-test and post-test with SPSS version 21. Empirical findings show that students who were taught the grab-the-ball approach experienced significant improvements in swimming skills. The resulting t-statistics (23.858 for the pre-test and 19.192 for the post-test) indicate that these differences are very statistically significant, with p-values (Sig.) that are extremely low (p&amp;lt;0.0001). This means that the observed difference between the sample group average and the expected test score is very unlikely to have occurred by chance. Conclusion The results of this study indicate that the grab-the-ball approach can be an effective alternative in teaching swimming skills to beginners in physical education. The implications of these findings highlight the importance of using engaging and playful methods to improve student learning outcomes in swimming skills. Suggestions for future research include extending the research by including a larger sample, which may provide greater statistical power to support research findings in the area of swimming 50 meters freestyle.

Effect of serial night shifts on the cognitive, psychomotor, and moral performance of residents in the department of Emergency Medicine.

The objective was to study the effect of serial night shifts on the cognitive, psychomotor, and moral performance of emergency medicine residents of an academic Emergency Medicine Department. This prospective case-crossover study compared emergency medicine residents' sleep time, subjective sleepiness, cognitive function, moral judgment, and psychomotor skills after 5 consecutive days versus night shifts using sleep diaries, activity monitors, and multiple performance tests. Paired t-tests and Wilcoxon signed-rank tests were used to analyze data based on normality. Correlation analysis was done using Spearman's correlation test. Subgroup analysis was also performed to find any difference based on gender and year of residency. Twenty-seven emergency medicine residents participated (13 males, 48.1%). The distribution across residency years was as follows: 44.4% in their first year, 25.9% in their second year, and 29.6% in their third year. Following five consecutive night shifts, total sleep duration decreased significantly from 338.1 ± 67.8 to 307.4 ± 71.0 min (p < 0.001), while subjective sleepiness scores increased from 9.6 ± 3.3 to 13.6 ± 4.6. Psychomotor performance and reaction times did not significantly differ between night and day shifts. However, working memory declined, assessed by self-paced three-back test scores (median [IQR] 517.1 [471.9-546.7] vs. 457.6 [334.4-508.8]; p = 0.034) and interference test scores (445.5 ± 59.9 vs. 407.2 ± 56.8; p < 0.001), along with moral judgment (median [IQR] 19 [18-28] vs. 15 [11-21]; p = 0.010) after serial night shifts. No correlations existed between performance measures nor differences based on gender or residency year. Residents sleep less following night versus day shifts, reporting the highest sleepiness levels after 5 consecutive nights. Despite this, psychomotor performance and reaction times did not significantly differ. However, considerable reductions occurred in moral judgment, working memory, and interference test performance after serial night shifts.

Outcomes of Biophilic Design for Schools

Biophilia is the theory that humans are innately connected to nature. As a basis for forming built space, biophilic design has been proven to reduce stress, improve cognition and enhance mood—it makes us happier. In the last 20 years, research in learning spaces has shown an association between biophilic design and student mood, calmness and improved standardized test scores. In 2019, a group of architects, scientists and educators led an experiment involving 6th-grade Math students at the Green Street Academy, which found that student stress was significantly reduced and learning significantly improved in a classroom enriched with biophilic strategies. The architects applied these strategies to the design of Bethel Hanberry Elementary School, and after a year of occupancy, an independent assessment found positive perceptions of the biophilic design, fewer behavior referrals, better teacher retention, lower absenteeism and improved test scores. In both a controlled research experiment and real-world application, the design of learning space, using biophilic strategies, has a significant impact.

Pengaruh Media Audio Visual Terhadap Hasil Belajar IPA Eksperimen Kelas VII MTs Qotrun Nada Depok

The aim of the research is to determine the effect of implementing Audio Visual Learning Media on science learning outcomes by conducting experiments on class VIII students at MTs Qotrun Nada Depok. The research model used is an experimental method with analysis of the mean difference between two samples. The sample used was 40 students from classes VII.1 and VII.2 as the experimental class and 40 students from classes VII.3 and VII.4 as the control class. Research data to test the hypothesis comes from test scores on Measurement Materials and quantities. The instruments used are validity and reliability. The results of the research are the results of learning science using Audio Visual Learning Media (experimental class), with an average score of 72.30 with a median of 70.59; mode 68.42; variance 177.07; and standard deviation 13.31. It can be concluded that students' science learning outcomes provide good results. The science learning outcomes of students who did not use Audio Visual Learning Media (control class) obtained an average score of 50.85 with a median of 43.75; mode 47.17; variant 190.85; and standard deviation 13.81. This shows that students' science learning outcomes provide quite good results. So it can be concluded that there is an influence of Audio Visual Learning Media on science learning outcomes. From the research results, it was found that tcount = 7.13 was higher than ttable = 1.996 at a significance level of 5%, so H0 was rejected and H1 was accepted. This means that there is a significant difference between students' science learning outcomes taught with Audio Visual Learning Media. Keywords: ,

Clinical efficacy of nusinersen sodium in the treatment of children with spinal muscular atrophy

To investigate the efficacy and safety of nusinersen sodium in the treatment of children with spinal muscular atrophy (SMA). A retrospective analysis was conducted on the clinical data of 50 children with 5q SMA who received nusinersen sodium treatment and multidisciplinary treatment management in Shanxi Children's Hospital from February 2022 to February 2024. Compared with the baseline data, 67% (8/12), 74% (35/47), and 74% (35/47) of the SMA children had a clinically significant improvement in the scores of Philadelphia Infant Test of Neuromuscular Disorders, Hammersmith Functional Motor Scale Expanded, and Revised Upper Limb Module, respectively, and the distance of 6-minute walking test increased from 207.00 (179.00, 281.50) meters to 233.00 (205.25, 287.50) meters (P<0.05) after nusinersen sodium treatment. Of all 50 children with SMA, 24 (48%) showed good tolerability after administration, with no significant or persistent abnormalities observed in 2 034 laboratory test results, and furthermore, there were no serious or immunological adverse events related to the treatment. After treatment, there was a significant change in forced vital capacity as a percentage of the predicted value in 27 children with restrictive ventilatory dysfunction, as well as a significant change in the level of 25-(OH) vitamin D in 15 children with vitamin D deficiency (P<0.05). For children with SMA, treatment with nusinersen sodium can continuously improve the response rates of motor function scales, with good tolerability and safety.

Analysis of Indonesian Language Proficiency Test in High School Students' Reading Section

This study aims to identify and evaluate high school students' scores in Sukabumi City on the reading section of the Indonesian Language Proficiency Test. The research method used a descriptive with a qualitative approach. The subjects of this research are students from SMA Muhammadiyah in Sukabumi City, consisting of 5 classes, namely classes X, XI A, XI B, XII IPS, and XII IPA. The instrument used was an Indonesian Language Proficiency Test sheet containing 40 questions. The data analysis technique used was a qualitative descriptive method to describe the results of the students' proficiency data. The results showed that the initial abilities of the five classes in high school in Sukabumi City, namely classes X, XI A, XI B, XII IPS, and XII IPA, obtained an average score of 170, while the abilities in the second test of the five classes in high school in Sukabumi City, namely classes X, XI A, XI B, XII IPS, and XII IPA, obtained an average score of 194. The results of the data from the two test sessions, the scores of the UKBI test in the reading category, showed that from the five classes, the results for test 1 show an average student ability score of 170 with a "Madya" predicate, while test 2 shows an average student ability score of 194 with a "Madya" predicate, indicating an improvement between test 1 and test 2. Although the reading proficiency predicate remains "Madya" between test 1 and test 2.

Effects of nusinersen on motor function in children with spinal muscular atrophy: a retrospective study

BackgroundSpinal muscular atrophy (SMA) is a genetic progressive neuromuscular disease. Nusinersen is the first disease modifying drug approved to treat patients with SMA. Our study aimed to evaluate the efficacy of nusinersen treatment on motor function in children with SMA.MethodsA retrospective analysis was conducted on the data of 52 genetically confirmed SMA patients from November 2020 to September 2023. Motor function was assessed based on standardized scales from baseline to 14 months of follow-up.ResultsOf patients in this study, the majority had SMA type 2 (40/52, 76.9%), 5 (9.6%) and 7 (13.5%) patients had SMA types 1 and 3, respectively. The median disease duration was 11 months (range 0–52), and the median age at initiation of treatment was 44.5 months (range 5–192). Motor function of all the patients with SMA improved from baseline to 14 months of follow-up. Mean increases of 4.6-point (p = 0.173), 4.7-point (p = 0.021) and 2.7-point (p = 0.013) were observed from baseline to 14 months of follow-up for the Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders scores, the Hammersmith Functional Motor Scale Expanded (HFMSE) and the Revised Upper Limb Module (RULM), respectively. Increased disease duration and age of treatment initiation were negatively correlated with the changes in HFMSE scores (r = −0.567, p = 0.043; r = −0.771 and p = 0.002, respectively). Similar results were observed for the RULM scores (r = −0.714, p = 0.014; r = −0.638 and p = 0.035, respectively).ConclusionOur study suggested that 14 months of treatment with nusinersen was effective and improved the motor function of children with SMA types 1, 2, or 3. In addition, disease duration and age at treatment initiation were negatively correlated with treatment outcome in the patients.

The Influence of Asymmetric Hearing Loss on Peripheral and Central Auditory Processing Abilities in Patients With Vestibular Schwannoma.

Asymmetric or unilateral hearing loss (AHL) may cause irreversible changes in the processing of acoustic signals in the auditory system. We aim to provide a comprehensive view of the auditory processing abilities for subjects with acquired AHL, and to examine the influence of AHL on speech perception under difficult conditions, and on auditory temporal and intensity processing. We examined peripheral and central auditory functions for 25 subjects with AHL resulting from vestibular schwannoma, and compared them to those from 24 normal-hearing controls that were matched with the AHL subjects in mean age and hearing thresholds in the healthy ear. Besides the basic hearing threshold assessment, the tests comprised the detection of tones and gaps in a continuous noise, comprehension of speech in babble noise, binaural interactions, difference limen of intensity, and detection of frequency modulation. For the AHL subjects, the selected tests were performed separately for the healthy and diseased ear. We observed that binaural speech comprehension, gap detection, and frequency modulation detection abilities were dominated by the healthy ear and were comparable for both groups. The AHL subjects were less sensitive to interaural delays, however, they exhibited a higher sensitivity to sound level, as indicated by lower difference limen of intensity and a higher sensitivity to interaural intensity difference. Correlations between the individual test scores indicated that speech comprehension by the AHL subjects was associated with different auditory processing mechanisms than for the control subjects. The data suggest that AHL influences both peripheral and central auditory processing abilities and that speech comprehension under difficult conditions relies on different mechanisms for the AHL subjects than for normal-hearing controls.

The Effect of Drying Methods on The Quality of Dragon Fruit Skin Tea

As a co-product, dragon fruit peels still contain polyphenols that can be used as a tea product alternative, requiring an appropriate drying process. Therefore, it is necessary to find a suitable drying method to obtain high-quality dragon fruit peels as tea product ingredients. The aim of this research is to determine the quality of dragon fruit skin tea with different drying methods. This research used an experimental method by using sun drying against the oven as a drying method in the drying stages of the dragon fruit tea skin making process. The dried fruit peels were then characterized by their tannin, flavonoid, vitamin C, and water contents, as well as their hedonic test scores. The results showed that the qualitative results of tannins and flavonoids in dragon fruit peel tea were positive (+), and the vitamin C content of the peel tea was higher when produced in sun-dried (6.6 mg/100g). On the contrary, the water content of dragon fruit peel tea was higher (7%) by oven drying. Based on hedonic tests, the panelists preferred dragon fruit peel tea produced by the sun drying.

Service development project to pilot a digital technology innovation for video direct observation of therapy in adult patients with asthma

BackgroundAdherence to pharmacotherapy and use of the correct inhaler technique are important basic principles of asthma management. Video- or remote-direct observation of therapy (v-DOT) could be a feasible approach to...

Supplemental Material for The Social Class Test Gap: A Worldwide Investigation of the Role of Academic Anxiety and Income Inequality in Standardized Test Score Disparities

Supplemental Material for The Social Class Test Gap: A Worldwide Investigation of the Role of Academic Anxiety and Income Inequality in Standardized Test Score Disparities

Aquasoya powder from the upcycled soybean cooking water can be a suitable ingredient for plant‐based yoghurt alternatives

SummaryAquasoya, or soybean cooking water, is a novel plant‐based material as an egg substitute due to its functional proteins. However, research on its fermentation is still emergent. To assess its prebiotic potential, we developed a plant‐based yoghurt alternative using aquasoya powder (ASP). After analysing the main components of ASP, six variants of aquasoya yoghurt, employing commercial cultures, underwent physicochemical, rheological properties, lactic acid bacteria viability and sensory attributes. The results showed that all samples were maintained under pH 4.6 and acidity over 0.7 for 20 days of storage and displayed prebiotic potential. Additionally, yoghurt with 8% ASP content and Sacco starter culture exhibited a thinner network phase. Panellists noted yoghurt with culture – Culture For Health – had weaker flavour intensity and yoghurt with 8% ASP received the highest overall liking score in the preliminary consumer acceptance test. This study established aquasoya as a promising food ingredient for incorporation into a novel milk substitute.

Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia

Previous studies that focused on univariate correlations between neuroanatomy and cognition in schizophrenia identified some inconsistent findings. Moreover, antipsychotic medication may impact the brain-behavior profiles in affected individuals. It remains unclear whether unmedicated and medicated individuals with schizophrenia would share common neuroanatomy-cognition associations. Therefore, we aimed to investigate multivariate neuroanatomy-cognition relationships in both groups. A sample of 59 drug-naïve individuals with first-episode schizophrenia (FES) and a sample of 115 antipsychotic-treated individuals with schizophrenia were finally included. Multivariate modeling was conducted in the two patient samples between multiple cognitive domains and neuroanatomic features, such as cortical thickness (CT), cortical surface area (CSA), and subcortical volume (SV). We observed distinct multivariate correlational patterns between the two samples of individuals with schizophrenia. In the FES sample, better performance in token motor, symbol coding, and verbal fluency tests was associated with greater thalamic volumes but lower CT in the prefrontal and anterior cingulate cortices. Two significant multivariate correlations were identified in antipsychotic-treated individuals: 1) worse verbal memory performance was related to smaller volumes for the most subcortical structures and smaller CSA mainly in the temporal regions and inferior parietal lobule; 2) a lower symbol coding test score was correlated with smaller CSA in the right parahippocampal gyrus but greater volume in the right caudate. These multivariate patterns were sample-specific and not confounded by imaging quality, illness duration, antipsychotic dose, or psychopathological symptoms. Our findings may help to understand the neurobiological basis of cognitive impairments and the development of cognition-targeted interventions.