The ITER Test Blanket Modules (TBMs) are installed and operated inside the vacuum vessel (VV) at equatorial ports located within port plugs (PP). The Pipe Forest (PF) is a network of pipes connecting the Ancillary Equipment Unit (AEU) to the TBMs. Depending of the TBM, the Pipe Forest includes various piping system such as Water Coolant (350°, 188 bars), Helium Coolant (500°, 100 bars) Lithium Lead and Tritium Extraction System. During operating states, the Pipe Forest main function is to withstand loads in normal, incidental and accidental situations according to RCC-MRx code criteria (including design rules for mechanical components for fusion installations). It includes severe thermomechanical loadings due to the thermal expansion added to seismic and vertical displacements events. In addition, the PF layout must satisfy constructability in constraint environments and maximize the space available for man access, which constitutes a real challenge for design.Since no existing RCC-MRx post-processing tool exists off the shelves, a specific methodology for pipe stress analysis is being developed by ITER, CEA and ASSYSTEM. This methodology starts with a post-processing calculation tool of stresses and reaction forces for looping back into the structural calculation. Moreover, a specific extraction module from 3D model to processing tool allows the conversion of CAD data to calculation entry files. Finally, a feedback loop is also re-integrated into the core CAD model through an import module, enabling the tracking of displacements and evaluate the impact of incorporating pipe movements into the analysis.This paper describes the pipe stress analysis methodology and its application for Pipe Forest system design life cycle. It covers the historical evolution of the routing including introduction of expansion loops. More recently, it incorporates the integrated calculation of the entire port cell, spanning from the back of the TBM sets, up to the connection pipes of the vertical shaft.