Tertiary Care Hospital In Kolkata Research Articles

Clinico-bacteriological profile of lower respiratory tract infections in a tertiary care hospital in Kolkata – A cross-sectional and observational study

Clinico-bacteriological profile of lower respiratory tract infections in a tertiary care hospital in Kolkata – A cross-sectional and observational study

Drug-resistant Pantoea agglomerans Causing Bacteremia at a Tertiary Care Hospital in Kolkata, India: First Report of Carbapenem Resistance Mediated by OXA-181.

The spread of antibiotic resistance (ABR) in uncommon human pathogens endangers global public health, escalating morbidity, death, and healthcare expenditures. Pantoea agglomerans, a member of the Erwiniaceae family that rarely infects humans, is emerging as a drug-resistant nosocomial pathogen. Seven P. agglomerans isolates were recovered from bacteremia patients at a tertiary care hospital in Kolkata, West Bengal, between March 2022 and October 2022. The isolates were evaluated for phenotypic resistance, β-lactamase and plasmid-mediated quinolone resistance (PMQR) genes, plasmid profiling, and clonality assessment. All isolates were resistant to fluoroquinolones and third-generation cephalosporins, with four resistant to carbapenems. The following β-lactamases and PMQR genes were identified: blaOXA-1 (n = 1), blaTEM (n = 1), blaCTX-M-1 (n = 2), blaNDM (n = 5), blaOXA-181 (n = 1), qnrB (n = 2), and qnrS (n = 4). Six isolates carried up to seven plasmids ranging in size from 2kb to > 212kb. IncFI, FII, HI, and X3 plasmid types were detected in three isolates, while the rest remained untypable. Four different genetic patterns were noted. Four isolates were clonally related, with three being clonal. The swap of environmental isolates to human pathogens exacerbates the ABR dilemma, periling patient care and outcomes. This is the first report in India of a carbapenem-resistant P. agglomerans blood isolate carrying blaOXA-181. In-depth genomic research of drug-resistant microbes adapted to the environment-human interfaces might underpin the source-route-containment of ABR.

Blood Culture Contamination in a Busy Emergency Ward of a Tertiary Care Hospital in Kolkata

Blood Culture Contamination in a Busy Emergency Ward of a Tertiary Care Hospital in Kolkata

Mental health problems raise the odds of cognitive impairment in COVID-19 survivors.

COVID-19 survivors around the globe are suffering from mental health issues. While mental health problems can be an early warning sign of dementia, they may also increase the chances of developing the disease. In this study, we examined the mental health of COVID-19 survivors and mapped its associations with cognitive and demographic variables. COVID-19 survivors listed in the databases of three tertiary care hospitals in Kolkata were contacted sequentially. 376 willing patients were interviewed over the telephone. 99 COVID-19 patients and 31 matched controls participated in the in-person interviews that were arranged for a more detailed investigation. The participants were administered standardized tests that are widely used for the assessment of cognitive functioning and mental health status. 64.89% of COVID-19 survivors reported a deterioration in physical functioning. 44.95% reported a decline in mental health, whereas 41.49% reported a drop in cognitive performance. Detailed investigations revealed that they had an increased risk of having depression, anxiety, and poor sleep quality by 91%, 68%, and 140%, respectively. 6.1% of the patients had mild cognitive impairment, and 4% had dementia. COVID-19 patients who had depression and anxiety were 8.6 and 19.4 times more likely to have cognitive decline, respectively. Compared to the matched controls, COVID-19 patients had greater depression (p<.001), anxiety (p<.001), stress (p =.003), and insomnia (p <.001). They also scored significantly lower on Addenbrooke's Cognitive Examination-III (p =.009) and Picture Naming Test (p =.005) and took significantly longer to complete Trail Making Test-A (p =.002). COVID-19 survivors in this study had major mental health issues even one year after contracting the virus. They had significant cognitive deficits that might progress into dementia. Strict monitoring and systematic treatment plans should be implemented as soon as possible.

Clinical characteristics and analysis of treatment outcome at one year of rhino-orbito-cerebral mucormycosis cases during the second wave of the Covid-19 pandemic (2&lt;sup&gt;nd&lt;/sup&gt; wave); experiences from a tertiary care hospital in Kolkata, India

Clinical characteristics and analysis of treatment outcome at one year of rhino-orbito-cerebral mucormycosis cases during the second wave of the Covid-19 pandemic (2&lt;sup&gt;nd&lt;/sup&gt; wave); experiences from a tertiary care hospital in Kolkata, India

Immunofluorescence Patterns of Antinuclear Antibodies in the Indian Population

Autoimmune diseases are chronic hypersensitive diseases that occur due to an inability of the immune system to recognize self-antigens as part of its system. Antinuclear autoantibodies (ANA) are antibodies that target the proteins located in the nucleus, mitotic spindle, nuclear membrane, and cytoplasmic substructures. Detection of ANA is done using either the ANA-IIF or by ELISA method; the latter might be slightly more sensitive as compared to the ANA-IIF but the specificity is however low. ANA patterns such as nuclear, cytoplasmic, and mitotic can be important to clinical practice because they suggest the significance, as well as the nature of autoimmune Connective Tissue Disorder (CTDs). ANA is a predictor of autoimmune diseases, and the risk is greater in female individuals. The specific objective of this study was to assess the prevalence of ANA and the detection of demographic correlations with them; thereby it would help in the identification of the various autoantibody subclasses in the Indian people. The present cross-sectional descriptive study included 351 patient records from a tertiary care hospital in Kolkata, India expounds on the association of multiple ANA patterns with certain autoantibodies, and demography of the ANA-positive patients. Knowledge of such regional variations of autoimmune diseases would be useful to formulate a strategy for proper diagnosis of systemic autoimmune rheumatic diseases (SARDs) in India.

Socio-demographic and Clinical Profile of Cervical Cancer Patients Undergoing Chemotherapy or Radiotherapy Attending the Department of Radiotherapy of a Tertiary Care Hospital in Kolkata

Socio-demographic and Clinical Profile of Cervical Cancer Patients Undergoing Chemotherapy or Radiotherapy Attending the Department of Radiotherapy of a Tertiary Care Hospital in Kolkata

Prevalence of Onychomycosis by Non Dermatophyte Molds in a Tertiary Care Hospital in Kolkata , West Bengal, India

Prevalence of Onychomycosis by Non Dermatophyte Molds in a Tertiary Care Hospital in Kolkata , West Bengal, India

Do Sleep Time and Duration Affect the Development of Prehypertension in Undergraduate Medical Students? An Experience from a Tertiary Care Hospital in Kolkata

Abstract Introduction and Objective Hypertension is an evolving public health challenge at present, and it is preceded by a prehypertensive stage. Irregular sleep duration and pattern have been found to be linked with cardiovascular diseases. Medical students are highly vulnerable to low quality sleep due to pressure regarding the academic curriculum and poor lifestyle. The present study aimed to estimate the prevalence of prehypertension, describe the risk factors and sleep patterns of undergraduate medical students, and determine the association, if any, involving sleep time and duration and prehypertension. Materials and Methods Data was collected from 254 undergraduate medical students via the Pittsburgh Sleep Quality Index (PSQI) questionnaire and a self-structured questionnaire. The frequency of events was established and the Chi-squared and t-tests were applied to determine the association. Finally, regression analysis was performed to determine the correlation. Results Male sex, high body mass index (BMI), poor sleep quality, and night sleep duration shorter than 5 hours were found to be significant risk factors for the development of prehypertensive condition (prevalence of 42.5%). However, there were no statistically significant associations regarding prehypertension and family history, junk food and salt intake, physical activity and daytime napping, bedtime, and wake-up time. Night sleep duration shorter than 5 hours presented an odds ratio of 4.713 (p = 0.010) for the development of prehypertension after adjusting for other risk factors, such as male sex, sleep quality, and high BMI. Discussion and Conclusion A high prevalence of prehypertension (42.5%) was noted among undergraduate medical students. Night sleep duration shorter than 5 hours was a significant risk factor for the development of prehypertension, whereas sleep time was not significantly associated with prehypertension.

An Observational Study to Find the Association of Viral Load, NS1 Antigen, IgG Antibody, and Other Laboratory Parameters With the Outcome of Dengue Patients in Eastern India.

Background Dengue, the mosquito-borne febrile disease caused by the dengue virus, has become one of the major concerns of public health. It may present with only fever, or there may be a hemorrhagic manifestation or septic shock. As there is no specific treatment for dengue, early detection of the disease, assessment of progression, and prediction of outcome by studying the laboratory markers will help guide the management of cases and lower morbidity and mortality. Methodology This clinico-observational study was conducted at the Department of Microbiology in a tertiary care hospital in Kolkata, India, from February 2020 to August 2022 to determine the outcome of dengue patients in correlation with viral load, NS1 antigen, IgM and IgG antibodies, ferritin level, platelet count, and other laboratory parameters. Results Out of 316 samples from fever patients, 103 (32.5%) were NS1 antigen reactive. We followed up the dengue patients (n = 103) for 15 days and divided them into three groups according to their duration of symptoms (group A suffered for ≤5 days, group B for 5 to 10 days, and group C for >10 days) and per the WHO classification of disease severity, namely dengue without warning signs (DOS), dengue with warning signs (DWS), and severe dengue (SD). Based on severity, 65 (63.1%) patients had DOS, whereas 31 (30.09%) patients had DWS, and seven (6.79%) patients had SD. Secondary infection was present in 83.33% of patients in group C, 71% of DWS cases, and 57% of SD cases, which positively correlates with liver enzymes, viral load (mean value 102195 in secondary infection vs. 1195 copies/10 µl in primary infection), and negatively correlates with platelet counts (mean value 60,213 in secondary infection vs. 1,25,516 in primary infection). Patients in group C had higher liver enzymes, a lower platelet count, and a higher initial viral load than groups A and B. Similarly, SD cases had a higher ferritin level (9215 ug/l), a lower platelet count (mean value 23,250), and a higher initial viral load (mean value 2,74,257 copies/10 µl). An increase in hematocrit value considering the peak value and its baseline value is an important marker for disease severity rather than its absolute value. Conclusion Poor outcome of dengue infection, i.e., an increase in the duration of symptoms and disease severity depends on concurrent associations between high serum ferritin, increased hematocrit level, thrombocytopenia, secondary infection, increasing liver enzymes, and increased initial viral load.

β-lactamase and Plasmid-mediated Quinolone Resistance Determinants Among Proteus spp. Isolates at a Tertiary-care Hospital in Kolkata, India

Background: Emerging antibiotic resistance (ABR) in Proteus spp., especially to third-generation cephalosporins (3GCc), carbapenems, and fluoroquinolones, challenges the treatment outcome and infection prevention. Limited studies pose a knowledge gap between them and ABR. Methods: We investigated the in vitro efficacy of therapeutic options and prevalence of β-lac-tamase and plasmid-mediated quinolone resistance (PMQR) traits in 3GC- and/or fluoroquino-lone-nonsusceptible Proteus (P.) spp. (n=27) in Kolkata, India, during 2021–2022. P. mirabilis was commonly isolated (&gt;80%) from superficial and urine samples. The majority of the isolates (48-78%) remained susceptible to piperacillin-tazobactam, meropenem, amikacin, cefoperazone-sulbactam, and cefepime. Results: All isolates showed &gt;0.2 multiple-antibiotic resistance index, with &gt;65% being multi-drug and &gt;30% being extensively drug-resistant. blaTEM (n=9), blaNDM (n=9), and qnrA (n=6) were commonly noted with the co-production of β-lactamases and PMQR in ten (37%) isolates. More than 50% of the isolates were devoid of the tested acquired genes. Conclusion: The study concludes that superbugs dominate, with limited occurrence of plasmid-borne markers in this geographic location.

Prominent early adulthood hyperferritinemia in scrub typhus

Background: Scrub typhus is an acute infectious disease, caused by Orientia tsutsugamushi. It is endemic to a geographically distinct region of Japan, Taiwan, China, and South Korea, known as the tsutsugamushi triangle, as well as in Nepal, Pakistan, and Papua New Guinea. In India, the incidence of this disease varies from 4-46% with high morbidity and mortality. Methods: In this cross-sectional study at a tertiary care hospital in Kolkata, India we analysed ferritin blood levels along with different demographic and laboratory test parameters of 60 suspected scrub typhus patients who were also scrub typhus IgM antibody positive during a one-year study period. Results: It was found that serum ferritin levels were unusually high in 21-40 years age group patients along with mildly increased urea and creatinine levels. Other important findings were below 40 years of age males were mostly affected, but above 40 years of age, females were generally affected. Haemoglobin and platelet levels were normal in all age groups. Although WBC count and neutrophils were normal in the 21-40 years age group, in other age groups increased levels were observed. CRP, SGPT, and SGOT levels were uniformly high above 20 years of age. Electrolytes were mildly decreased. Conclusions: It appears that oxidative stress-induced acute kidney injury may be an important reason for the rising ferritin levels in the 21-40 years age group. These important findings may be helpful to clinicians in management of these patients.

A comparative study of clinical symptoms, demographic characteristics and laboratory parameters among primary and secondary dengue cases in a tertiary care hospital in Kolkata

A comparative study of clinical symptoms, demographic characteristics and laboratory parameters among primary and secondary dengue cases in a tertiary care hospital in Kolkata

IJCM_304A: A Study on Stigma-Discrimination and Sense of Grip on Disease Experienced by the PLHIV Visiting ART Centre of a Tertiary Care Hospital of Kolkata

Background: People Living with HIV face not just a health challenge but also the burden of stigma-discrimination. The impact isn’t just physical; it takes a toll on their mental health. Many internalize this stigma, feeling shame about their condition. It Is crucial to address these issues not only for those directly affected but also to build a society that is compassionate and understanding, supporting individuals with HIV/AIDS rather than marginalizing them. Objective: To determine the level of stigma-discrimination faced by PLHIV visiting the ART center of a tertiary care hospital of Kolkata including the factors associated with it. The second objective is to explore their sense of grip on the disease among them. Methodology: This descriptive method study was conducted in November 2023 among 120 PLHIV (Selected by systematic random sampling) visiting the ART center of the School of Tropical Medicine, Kolkata after getting permission from IEC &amp; NACO. Qualitative data was collected via IDI &amp; KII. Quantitative data were analyzed using MS Excel, SPSS v. 16, employing descriptive and inferential statistics. Manual thematic analysis applied for qualitative data. Results: Among 120 participants 45.8% of the participants faced more stigma &amp; discrimination in comparison to others. There was a statistically significant difference in the level of stigma &amp; discrimination based on their age group (p-value 0.033), type of family (p-value 0.014), Addiction status (p-value 0.037), co-morbidities (p-value 0.011), viral load (p-value 0.033). On exploring sense of grip on disease majority of the participants were shown to have a compliant profile. Conclusion: The levels of stigma- discrimination were associated with their behavioral &amp; disease characteristics. Thus, raising awareness is essential to combat stigma and enhance sense of grip on the disease.

IJCM_210A: Assessment of Outdoor Patients Waiting Time and Consultation Time in a Tertiary Care Hospital of Kolkata

Background: Waiting and consultation times affect patient satisfaction and the managerial capacity of the health system. Whereas waiting time is mainly attributed to organizational processes, consultation time is characterized by health demands, concerns, and protocols followed by service providers, which vary between individuals. Therefore, periodic evaluation of the entire process is necessary to achieve continuing health service improvement. Objectives: 1. To measure the waiting time and consultation time for each participant 2. To find out the variation of waiting and consultation time according to the departments visited. Methodology: A descriptive, cross-sectional study was carried out at a tertiary care medical college hospital in Kolkata, between May-June 2023. A systematic sampling design was followed. Data collection was conducted for two weeks for the entire OPD duration (9 AM-3 PM). Waiting Time was defined as the time taken from registration to chamber entry. Consultation Time was defined for the study as the time taken from chamber entry to exit. Timing record was maintained by giving a time-indicated note to the patient at the time of registration. Exit interviews were conducted after completing consultations. Results: Total number of participants was 432, with 74.8% female and mean age of 28.7 years. There were 22% participants who had 10 or more years of schooling and 80.1% resided in rural areas. Mean waiting time was 98.6 minutes (SD 45.4) and the consultation time was 6.5 (SD 13.7) minutes. Waiting time was maximum for general medicine OPD (mean-122 min) and minimum for pediatric medicine OPD (mean 43 min), while consultation time was maximum for surgery OPD (mean 6.8 min). Conclusion: The study shows an imbalance between waiting time and consultation time. Walk-in patients for minor illnesses and unnecessary referrals should be reduced to prevent overcrowding of tertiary institutes and compromising quality of care.

Out-of-pocket Expenditure and its Impact on the Quality of Life among Patients Attending the Anti-retroviral Therapy Centre of a Tertiary Care Hospital in Kolkata

Introduction: Out-of-pocket expenditure (OOPE) has a negative impact on Quality of life (QoL) of People Living with HIV (PLHIV)which can increase the risk of slipping into poverty. Objectives: Primary Objective of this study was to estimate the burden of OOPE in seeking health care among HIV patients attending the Anti-retroviral therapy (ART) centre of a tertiary care hospital; and secondary objectives were to assess their QoL, to identify the association of socio-demographic characteristics with the OOPE &amp; QoL and to find out the correlation between OOPE and QoL. Method: A cross-sectional study was conducted among 232 patients attending ART centre of a tertiary care hospital in Kolkata using a pre-designed, pre-tested, structured schedule. Multivariable binary logistic regression was done to identify the association of their socio-demographic characteristics and clinical profile with the OOPE and QoL. Results: About 41.4% of the study population rated their QoL as neither poor nor good, 18.9% as ‘good’. All the participants reported OOPE; 20.7% in the form of direct health expenditure. Participants belonging to the age group 18-39 years, residing in a joint family, had family member infected with HIV and had associated co-morbidity were statistically significant covariates of direct health expenditure; whereas participants belonging to the age group ≥40 years, living in a joint family, involved in an unskilled occupation, and belonging to middle and lower middle were statistically significant covariates of poor QoL. Conclusion: OOPE was experienced by all participants. As per the study findings Qol was neither poor nor good among participants. With increase in OOPE, the QoL worsened.

A hospital-based cross-sectional study on parental self‑medication among children in a tertiary care hospital in Kolkata

Introduction: Self-medication/self-prescription, the practice of using measures to treat and handle diseases, without consulting appropriate authority, has been significantly inculcated in modern society. Parental self-medication is today a significant paediatric public health problem contributing to global rise of antimicrobial resistance.Objectives: To assess the magnitude and determinants of parental self-medication among children attending a tertiary care hospital in Kolkata. Method: This cross-sectional study was conducted on parents of 105 children attending the paediatric clinic of a tertiary care hospital in Kolkata. Universal sampling was employed. Parents were surveyed by face-to-face interview using a pre-tested semi-structured interview schedule validated by subject experts. Information on pattern, reasons, and perception of parental self-medication were elicited from the schedule. Microsoft Excel and STATA MP16 were used for statistical analysis. Results: Mean ages of the parents and their children were 31.79±5.6 years, and 5.3±2.9 years respectively. Prevalence of parental self-medication was 78.1% (95% CI: 69-85%). Analgesic-antipyretics were the most common type of medicine used during self-medication (77.1%), whereas prior experience in dealing with similar illness was the most common reason (42%) for practising self-medication. Higher educational levelof respondent parent and increased age of child (&gt;3 years) were significantly associated with the practice of self-medication in bivariate analysis.Conclusions: Prevalence of parental self-medication was 78.1%. Analgesic-antipyretics were used during self-medication in 77.1% cases. Prior experience in dealing with similar illness was the reason for practising self-medication in 42% cases. Higher educational level of the respondent parent and increased age of child (&gt;3 years) were significantly associated with the practice of self-medication.

Whole genome sequence-based molecular characterization of blood isolates of carbapenem-resistant Enterobacter cloacae complex from ICU patients in Kolkata, India, during 2017-2022: emergence of phylogenetically heterogeneous Enterobacter hormaechei subsp. xiangfangensis.

Blood-borne infections caused by the carbapenem-resistant Enterobacter cloacae complex (CR-ECC) are major public threats with respect to the challenges encountered during treatment. This study describes the whole genome sequencing-based molecular characteristics of blood isolates (n = 70) of CR-ECC from patients admitted to the intensive care unit of tertiary care hospitals in Kolkata, India, during 2017-2022 with respect to species identification, antimicrobial resistance (AMR) profiling, mechanism of drug resistance, and molecular subtypes. Vitek2 MALDI and species-specific PCR identified Enterobacter hormaechei subsp. xiangfangensis (47.14%) as the emerging CR-ECC subspecies in Kolkata. The predominating carbapenemase and extended-spectrum β-lactamase genes found were blaNDM-1 (51.42%) and blaCTX-M-15 (27%), respectively. Besides, blaNDM-4, blaNDM-5, blaNDM-7, blaCMH-3, blaSFO-1, blaOXA-181, blaOXA-232, blaKPC-3, and blaDHA-7 genes were also detected, which were not previously reported from India. A multitude of Class 1 integrons (including In180, In4874, In4887, and In4888, which were novel) and plasmid replicon types (IncFIB, IncFII, IncX3, IncHI1-HI2, IncC, and IncR) involved in AMR dissemination were identified. Reverse transcription-PCR and western blot revealed that carbapenem resistance in non-carbapenemase-producing CR-ECC isolates was contributed by elevated levels of ampC, overexpression of acrAB, and loss of ompF. A total of 30 distinct sequence types (STs) were ascertained by multi-locus sequence typing; of which, ST2011, ST2018, ST2055, ST2721, and ST2722 were novel STs. Pulsed-field gel electrophoresis analysis showed heterogeneity (69 pulsotypes with a similarity coefficient of 48.40%) among the circulating isolates, suggesting multiple reservoirs of infections in humans. Phylogenetically and genetically diverse CR-ECC with multiple AMR mechanisms mandates close monitoring of nosocomial infections caused by these isolates to forestall the transmission and dissemination of AMR.IMPORTANCEThe emergence and extensive dissemination of the carbapenem-resistant Enterobacter cloacae complex (CR-ECC) have positioned it as a critical nosocomial global pathogen. The dearth of a comprehensive molecular study pertaining to CR-ECC necessitated this study, which is the first of its kind from India. Characterization of blood isolates of CR-ECC over the last 6 years revealed Enterobacter hormaechei subsp. xiangfangensis as the most prevalent subsp., exhibiting resistance to almost all antibiotics currently in use and harboring diverse transmissible carbapenemase genes. Besides the predominating blaNDM-1 and blaCTX-M-15, we document diverse carbapenemase and AmpC genes, such as blaNDM-4, blaNDM-7, blaOXA-181, blaOXA-232, blaKPC-3, blaCMH-3, blaSFO-1, and blaDHA-7, in CR-ECC, which were not previously reported from India. Furthermore, novel integrons and sequence types were identified. Our findings emphasize the need for strengthened vigilance for molecular epidemiological surveillance of CR-ECC due to the presence of epidemic clones with a phylogenetically diverse and wide array of antimicrobial resistance genes in vulnerable populations.

A Cross-sectional Study on Awareness and Utilisation of Government Health Insurance Schemes among Patients at a Tertiary Level Hospital in Kolkata, India

Introduction: Despite the presence of multiple Government Health Insurance (GHI) schemes in West Bengal, the National Family Health Survey report (NFHS-5) has indicated that only 29.3% of households are covered by a health scheme. Awareness of health insurance schemes increases their utilisation. The absence of health insurance coverage results in increased out-of-pocket health expenditures, pushing families into debt. Therefore, there is a need to determine whether this lack of awareness among patients contributes to the issue. Aim: To estimate the awareness level, enrollment in GHI schemes, experiences of their utilisation, and to determine the contributory factors of awareness and enrollment among patients attending the Outdoor Patient Departments (OPDs) at a tertiary care hospital in Kolkata. Materials and Methods: An observational cross-sectional study was conducted from April 2023 to June 2023 at Medical College, Kolkata, West Bengal, India. A total of 390 respondents were chosen using a systematic random sampling technique and were interviewed using a predesigned, pretested, and semistructured questionnaire. Data were analysed using R Studio version 4.3.0. A p-value &lt;0.05 was considered statistically significant. Results: Awareness about Swasthya Sathi was found to be present in 318 (81.54%) patients, but only 109 (34.28%) of them were enrolled. Awareness of Sishu Saathi and Rashtriya Bal Swasthya Karyakram (RBSK) was 12 (3.08%) and 10 (2.57%), respectively, and none were enrolled. The major source of information (11.03%) regarding health insurance among respondents was informal sources such as friends, relatives, and neighbours. The age of the respondents, type of family, occupation, and economic status were found to have a significant association with the right awareness (p=0.008, 0.012, 0.0005, and 0.029, respectively). The patient satisfaction level after utilising Swasthya Sathi was found to have a significant positive correlation with the right awareness (Spearman’s ρ=0.322, p-value &lt;0.01). The determinants of enrollment in Swasthya Sathi were female gender, rural residence, and right awareness (p&lt;0.001). The commonest reason for not enrolling in any GHI among the non subscribers was a lack of awareness (82.56%). Conclusion: Correct awareness was found to be a determinant of enrollment in GHI. In order to bridge the gap between awareness and utilisation of GHI, there is a need to focus on Information, Education, and Communication (IEC) activities involving mass media and frontline health workers.

Knowledge, Attitude, and Practice of COVID-19 in Adolescents Attending Covid Vaccination Center in a Tertiary Care Hospital in Kolkata, India: A Cross-sectional Study

Introduction: This study aimed to assess the knowledge, attitudes, and practices related to coronavirus disease 2019 (COVID-19) among adolescents in India, recognizing the vital role this demographic plays in pandemic control. Materials and Methods: Conducted at the Medical College, Kolkata COVID-19 vaccination center from June to August 2022, this web-based prospective cross-sectional study included individuals aged 13–19 years. Data collection involved a structured questionnaire in multiple languages, ensuring broad accessibility. Ethical standards were upheld with online informed consent and rigorous data confidentiality measures. Results: The study revealed balanced gender representation among participants, with most enrolled in the 10th or 12th standard. Parents’ educational backgrounds varied, but a significant proportion had family members employed in the health-care sector (66.7%). Knowledge about COVID-19 in India was surprisingly limited: only 3.7% knew about oxygen saturation and its utility. 18.75% considered depression as a comorbidity of COVID-19. 73.8% of the participants relied on social media for information about COVID-19. A majority (66.25%) of the participants believed 2 doses of the vaccine would protect them from the disease. Twice as many women believed in the protection offered by vaccines. Conclusion: This research, distinct from conventional scoring-based studies, emphasized uncovering misconceptions and knowledge gaps. Importantly, many adolescents lacked awareness of the true COVID-19 situation in India, potentially undermining the pandemic gravity perception and preventive measures. Although participants showed awareness of common COVID-19 symptoms and preventive measures, knowledge about comorbidities’ influence on mortality rates was limited.