The article discusses some issues of the genetic connection between mud volcanic activity in Azerbaijan and seismicity, the results of monitoring studies of mud volcanoes characterized by active gryphon-salsa activity between eruptions located in tectonic structures of different ages. For the first time, an anomalous change in Br and J, mainly associated with Paleogene-Miocene deposits, was established in the chemical composition of the studied waters based on hydrogeochemical indicators of volcanic activation. The established differences in the studied waters are associated with the location of mud volcanoes within different oil and gas bearing regions of Azerbaijan and the lithofacies features of terrigenous-carbonate rocks in mud volcanic breccia. The above measurements of the temperature of waters carried by mud volcanoes to the earth’s surface confirmed the previously obtained results: during quiet activity of volcanoes, fluids are carried out from Pliocene deposits, and when their gryphon-salsa activity is activated, they are diluted with fluids coming from the depths of the Paleogene-Miocene age. Analyzing various intervals of “rest” between eruptions of mud volcanoes, tracing changes occurring in small crater fields (cracks, subsidence, etc.), the seismogeological material we have accumulated allows us to make an estimated forecast (as a long-term one) of the eruption of a mud volcano within one year.