The enthalpies of protonation of 12-(2′-hydroxy-5′-bormo-benzyl)-1,4,7,10-tetraazacyclotridecane-11,13-dione(HBTADO) have been determined in aqueous solution at 25.0±0.1°C and ionic strength 0.1 mol dm −3 KNO 3 by means of model RD-1 automatic conduction calorimeter. The enthalpies of coordination of the binary complex compounds of this ligand with copper(II) and the ternary complex compounds of this ligand copper(II)-5-substituted 1,10-phenathrolines have also been determined under identical conditions of the ternary complex compounds of the type Cu(II)-α-aminoacids-HBTADO have been evaluated through “overall calculation”. Linear enthalpiesrelationships, linear enthalphy-entropy relationships have been found to exist between the enthalpies of formation of ternary complex compounds Cu(II)-R′Phen-HRTADO and the enthalpies, entropies of protonation of ligands HRTADO. In addition, linear enthalpy relationships have been found to exist between the enthalpies of formation of ternary complex compounds Cu(II)-α-aminoacids-HRTADO and the enthalpies of formation of binary complex compounds Cu(II)H −1A and linear entropy relationships have been found to exist between the entropies of formation of ternary complex compounds Cu(II)-α-aminoacids-HRTADO and the entropies of formation of binary complex compounds Cu(II)H −1A.