In this paper, the averages annual radon concentrations in buildings placed in a karst area are analyzed in order to understand which factors may affect the occurrence of high levels of radon indoor. Statistical analysis on the radon dataset is performed using analytical factors described by two or three levels according to the characteristic of the measured buildings. The factors that determine higher radon levels in terms of arithmetic mean (AM) at ground floor (GF) are mainly the presence of sedimentary calcareous rock (SCR) in walls and the direct attack or crawl space as type of foundation. At first floors (FF), the presence of walls of only SCR showed radon levels higher (in terms of AM) than the one found for walls of mixed typology. These outcomes suggest that in karstic area buildings with SCR as the main construction material and direct attack or crawl space as the type of foundation, can be considered as radon-prone buildings. Moreover, this study confirms the need to measure radon levels not only at below ground floor and at GF, but also at FF and above for buildings in karst areas with construction materials including SCR blocks.