Depressive Tendencies Research Articles

The effects of subjective family status and subjective school status on depression and suicidal ideation among adolescents: the role of anxiety and psychological resilience.

Depression and suicidal tendencies are notably prevalent among adolescents, yet few studies have revealed the impact of social status on them. This study aimed to explore the mediating and moderating effects of anxiety and psychological resilience on family status, school status, depression, and suicidal ideation. A total of 1,190 secondary school students aged 13 to 17 years (mean age: 13.57 ± 2.02 years) were evaluated depression, anxiety, and suicidal ideation using the PHQ-8 and GAD-7 questionnaires. Subjective family and school status were also assessed. Data analysis was conducted using Mplus, SPSS's Process, and the RSA 3.0 plugin. Subjective family/school status, anxiety, psychological resilience, depression, and suicidal ideation were significantly correlated. Anxiety played a partial mediating role in the influence of subjective family status and subjective school on depression and suicidal ideation, and psychological resilience moderated the impact of anxiety on adolescent depression and suicidal ideation (βdepression = -0.05, p < 0.01; βsuicidal ideation = -0.06, p < 0.05). Subjective family status and school status played important roles in depression and suicidal ideation in adolescents, and anxiety and psychological resilience played mediating and moderating roles.

Multimodal Fusion of EEG and Audio Spectrogram for Major Depressive Disorder Recognition Using Modified DenseNet121.

This study investigates the classification of Major Depressive Disorder (MDD) using electroencephalography (EEG) Short-Time Fourier-Transform (STFT) spectrograms and audio Mel-spectrogram data of 52 subjects. The objective is to develop a multimodal classification model that integrates audio and EEG data to accurately identify depressive tendencies. We utilized the Multimodal open dataset for Mental Disorder Analysis (MODMA) and trained a pre-trained Densenet121 model using transfer learning. Features from both the EEG and audio modalities were extracted and concatenated before being passed through the final classification layer. Additionally, an ablation study was conducted on both datasets separately. The proposed multimodal classification model demonstrated superior performance compared to existing methods, achieving an Accuracy of 97.53%, Precision of 98.20%, F1 Score of 97.76%, and Recall of 97.32%. A confusion matrix was also used to evaluate the model's effectiveness. The paper presents a robust multimodal classification approach that outperforms state-of-the-art methods with potential application in clinical diagnostics for depression assessment.

A review of the surveys on health effect of aircraft noise for Narita International Airport

In this paper, we review two previous projects on health effects of aircraft noise for residents living around Narita International Airport, and introduce a summary of the new project which started since 2019. The airport was equipped with a Runway‐A at the opening, and a Runway‐B was constructed to keep pace with increased demand for air transport in 2002. The Runway‐C will be accomplished at the end of fiscal year 2028. The first project on health effects of aircraft noise was conducted in 1998 when the airport had only Runway‐A. And then, second project on health effects of aircraft noise was conducted in 2014 after beginning of conditional relaxation of curfew. These two projects were based on cross‐sectional study, and implemented using a questionnaire to investigate psychological effects like noise annoyance, night‐time insomnia, mental effects like emotional instability and depressive tendency, and physical effects like high‐blood pressure. Since 2019, third project on health effects have been started because of disestablishment of nighttime flight restrictions for the Runway‐A. In this new project, longitudinal data are also included and we have a plan to investigate using objective method. The progress of this project until 2022 is reported in this paper.

Can Avatar Robots Assist Older People and Care Professionals? Evaluation of an Intervention Study in Eight Nursing Homes in Tokyo

Abstract Background Securing human resources to meet increasing demand for older people's care is challenging, particularly in Japan, where the pace of ageing is accelerating. Central and local government have been seeking partial solutions in assistive technologies such as robotics. Against such a background, the study was conducted in 8 nursing care homes in Tokyo, where avatar robots were tested to examine whether and how these robot interventions can affect the daily life of older people and care professionals. Methods Four different types of avatar robot (ORIHIME, NEWME, Piyokame and BOCCO) were introduced to and used in eight nursing care facilities, in order to create conversational opportunities over 12 weeks. Before–after studies were conducted, and a variety of data was collected (interpersonal communication, self-care and depressive tendencies using the International Classification of Functioning, Disability and Health (ICF) and InterRAI assessments). System usability scores (SUS) were collected from care professionals, who also performed a time-on-task analysis. Results Study participants who consented to taking part were 136 older adults (88.4±6.6 years old, 18 men and 118 women) and 63 care professionals. Participants with a high degree of dependency accounted for 31 percent. In total, 136 avatar robots were used. There was an overall, yet marginal, improvement for older people. While the SUS scores were poor, the majority (90 percent) responded that such devices would prove useful in the future. The time-on-task analysis indicates that more time can be secured for ‘person-to-person’ care. Conclusion Positive impacts of avatar robots (to increase the level of social interaction and communication) were observed. However, the results are inconclusive, and more needs to be done with regard to technology skills, competence enhancement and data collection methods for this type of research. The study was funded in part by the Tokyo Metropolitan Government.

The Impact of the Internet on Adolescents’ Mental Health

Studies have found that the age of adolescent first exposure to the Internet is getting younger and younger, and the bad information on the Internet may have a negative impact on their mental health. Communication of Network community in online social media may cause extreme emotions among teenagers, especially under online anonymity, teenagers may show extreme emotions different from those in reality, which may lead to mental health problems such as anxiety and depression. According to the research, the author pointed out that Internet addiction is positively associated with depression in adolescents, and Internet addicts may disperse their depressive emotions through the Internet, but this behavior may aggravate the degree of depression. Moreover, the negative emotional atmosphere and social comparison on the Internet may lead to low self-esteem and anxiety among adolescents. Excessive use of Internet technology for recreational activities may adversely affect the educational development of adolescents, leading to decreased academic performance and depression tendencies. This paper explores in depth the effects of the Internet on adolescent mental health, especially the effects of Internet addiction, online social networking, cyberbullying and online use on sleep. And how to guide teenagers to use the Internet correctly and protect their mental health has become an urgent social problem to be solved.

Altered emotion perception in insomnia, anxiety, depression, mania, psychotic experiences and schizotypal symptoms: a dataset

This data resource provides evidence concerning the prevalence of perceptual alterations of emotional faces amongst individuals experiencing symptoms of insomnia, anxiety, depression, mania, psychotic experiences, and schizotypal tendencies. More specifically, we explored the categorisation accuracy (whether the displayed emotion was correctly identified), misperception (which emotion an incorrect judgment was perceived to be), intensity (extent of the emotion signal strength) and emotional valence (the extent and direction of perceived affect) of six facial expressions of emotion from the Karolinska Directed Emotional Faces database. Complete data from N = 572 respondents are included. The dataset is available to other researchers and is provided on Figshare. Information concerning the data records, usage notes, code availability and technical validation are presented. Finally, we present demographic and correlational data concerning psychiatric symptoms and alterations in the perception of emotional faces.

Characteristics and treatment outcomes of musical tinnitus: a prospective study

PurposeTinnitus, the perception of sound without an external source, affects millions worldwide. Although its origin may be organic or psychological, musical tinnitus (hearing music in the absence of external stimuli) presents a distinct challenge. This study investigated musical tinnitus, focusing on its clinical profile, treatment outcomes, and associated psychiatric symptoms.MethodsThe demographics, auditory perceptions, psychiatric history, and treatment response of 20 patients with musical tinnitus were prospectively evaluated. Sound therapy using hearing aids and tinnitus counselling were administered. Data were collected using the Tinnitus Handicap Inventory (THI), Visual Analogue Scale (VAS) for tinnitus loudness and distress, Self-Rating Depression Scale (SDS), and the State-Trait Anxiety Inventory (STAI).ResultsOf the 20 patients who underwent these tests every year until the 2-year follow-up, 15 were able to follow a sound therapy treatment regimen with hearing aids for > 2 years. The results revealed the prevalence of musical tinnitus in older women with hearing loss, emphasising its association with aging and the female sex. Patients reported varied musical content, predominantly nursery rhymes and melodies originating from the ear or head. No significant psychiatric symptoms were observed; this contrasts with previous reports linking musical hallucinations and psychiatric disorders. Sound therapy using hearing aids and counselling led to significant improvements in THI, VAS, and STAI-state scores at 1-year and 2-year follow-ups, suggesting the efficacy of this approach. However, no significant changes were noted in SDS or STAI-trait scores, indicating a lack of prominent depressive tendencies and stable anxiety traits.ConclusionsMusical tinnitus primarily affects older women with hearing loss and responds favourably to sound therapy. Understanding its clinical characteristics and treatment outcomes is crucial for optimising patient care and enhancing quality of life.

Identification of College Students' Depressive Tendency Through Text Big Data Analysis

Identification of College Students' Depressive Tendency Through Text Big Data Analysis

Serum molecules of the folate-driven one-carbon cycle as indicators of depressive tendencies in the elderly

AimsThe folate-driven one-carbon (1C) cycle plays a significant role in the occurrence and development of depression. This study aimed to examine the potential of important molecules of the folate-driven 1C cycle as biomarkers for depressive tendency. MethodsNinety-five serum samples from older adults (age >60 years) were collected for this study. We quantified the concentrations of key metabolites and coenzymes of the folate-driven 1C cycle using Ultra-Performance Liquid Chromatography coupled with Tandem Mass Spectrometry (UPLC-MS/MS) and familiar clinical liver and kidney indicators in serum. Based on the differences in Hamilton Depression Rating Scale (HAMD)-17 scores, we compared the concentrations of measured molecules between elderly individuals with low and high levels of depression defined as HAMD-17 scores of 0–7 and 8–24, respectively. We also analyzed the concentration ranges of these molecules reflecting the level of depressive tendencies in the cohort. ResultsOur results showed significant variations in serum folate concentrations, SAM (S-adenosylmethionine), TBA (total bile acid), and SAM/SAH (S-enosylhomocysteine) ratios in elderly individuals with different HAMD-17 scores. Serum folate concentrations below 15.5 nmol/L and SAM/SAH ratios below 13.0 exhibited elevated levels of depressive tendency experienced among the participants. ConclusionsThe concentrations of serum folate, SAM, TBA, and SAM/SAH ratios might be used as indicators of depressive tendencies in the elderly population. A serum folate concentration of 15.5 nmol/L and a SAM/SAH ratio of 13.0 might be critical thresholds for indicating depressive tendencies in the Chinese elderly population.

Psychological resilience is positively correlated with Habenula volume

BackgroundPsychological resilience is defined as the process and outcome of individuals' successful adaptation to challenging life experiences. The Habenula (Hb) is known to be involved in the stress response; however, the relationship between Hb volume and resilience in humans remains unclear. This study investigated the correlation among resilience, Hb volume, and depressive tendencies in adults. MethodsHb volumes were assessed using deep learning techniques applied to 110 healthy participants. Resilience and depression were evaluated using the Connor-Davidson Resilience Scale and Beck Depression Inventory-II, respectively. We examined the relationship between Hb volume and resilience and assessed the mediating effects of resilience on the relationship between Hb volume and depressive tendencies. ResultsCorrelation analysis revealed a positive correlation between resilience and Hb volume (partial r = 0.176, p = 0.001), which was more pronounced in women (partial r = 0.353, p = 0.003). Hb volumes on the left and right sides exhibited significant lateralization (LI = 0.031, 95 % CI = [0.016, 0.046]). Despite Hb asymmetry, lateralization was not significantly associated with resilience. The mediation analysis shows significant indirect effect of resilience on the relationship between Hb volume and depressive tendencies (β = −0.093, 95%CI = [−0.189, −0.019]). ConclusionThis study found that populations with lower resilience have smaller Hb volume. Previous research has shown that Hb volume decreased with the increasing severity of depression symptoms in patients. Our findings support this view and extend it to a population that has not been clinically diagnosed with depression. Additionally, we found that psychological resilience can be predicted by Hb volume and may serve as a mediating factor indirectly affecting depressive tendencies, even in healthy individuals. LimitationsDue to its cross-sectional design, this study was unable to analyze dynamic changes in Hb volume during the process of resilience adaptation.

Empowerment of Posyandu Lansia cadres in overcoming depression and violence among elderly women after the Covid-19 pandemic in Dukuh Panggungan

Introduction: The COVID-19 pandemic has significantly impacted the mental health and safety of the elderly, particularly affecting elderly women. Research indicates a rise in anxiety and depression among older adults, with pre-existing elevated depressive symptoms exacerbating their resilience during this period. Increased isolation, financial strain, and restricted access to support services have led to a surge in elder abuse cases, disproportionately affecting women. Effective strategies, such as raising awareness and ensuring timely provision of resources, are crucial to safeguarding the mental well-being of the elderly. Indonesia's commitment to sustainable development and health equity, exemplified through initiatives like the Sustainable Development Goals, must address the specific challenges faced by elderly women in communities like Panggungan Village. The demographic shift towards an aging population, coupled with the pandemic's effects, further magnifies vulnerabilities. Empowering community-based resources can provide holistic support to elderly women, contributing to sustainable health development and social equity. Methods: The approach targets 15 Posyandu Lansia cadres and 20 elderly women in Panggungan Village through an offline community service program adhering to health protocols. Tools used in this study were the Mental Health Improvement Module, Geriatric Depression Scale questionnaire, and knowledge/skills assessment for Posyandu Lansia cadres. A combined quantitative and qualitative analysis was applied. Results: Results showed that 55% prevalence of verbal violence, 45% neglect, and 35% exploitation violence among elderly women. Post-training, these figures improved to 25% for verbal violence, 10% for exploitation violence, and 15% for neglect violence. Depression tendencies witnessed a 25% shift. Cadres’ knowledge increased from 58.2 to 82.1, and skills improved from 63.5 to 79.2. Conclusion: Elevated violence and depression tendencies that were quite high, negatively impact elderly women's mental health in Panggungan Village. Cadre’s training significantly enhances residents' well-being and mental health, offering a meaningful solution.

The Impact of Research Pressure on Depression Tendency among Chinese Doctoral Students: The Mediating Effect of Familial Financial Support.

This study aims to explore the impact of research pressure on depression tendency among Chinese doctoral students and analyze the mediating effect of familial financial support in this relationship. Based on the ecological systems theory, this study employs a mediating effect model and OLS regression model for empirical analysis. Through an online questionnaire, 2815 valid data from Chinese doctoral students were successfully collected. The study finds that research pressure has a significant positive impact on depression tendency among doctoral students (t = 18.347, p < 0.01). Married doctoral students show relatively lower depression tendency, indicating a negative impact of marital status on depression tendency (t = 12.579, p < 0.01). In terms of gender, female doctoral students are more prone to depression compared to their male counterparts (t = -2.921, p < 0.01). Additionally, as the doctoral year progresses, depression tendency also tends to increase (t = 3.690, p < 0.01). Importantly, familial financial support is proven to be a significant mediator between research pressure and depression tendency, explaining 32.116% of the relationship. This study not only provides a multi-dimensional perspective for understanding the mental health issues of doctoral students but also offers a scientific basis for universities and related educational departments to formulate more precise mental health intervention strategies.

A review of the impact of sensory processing sensitivity on mental health in university students.

The concept of sensory processing sensitivity (SPS) was first introduced by Aron and Aron (1996) as an innate trait characterized by heightened processing of sensory, emotional, and physical stimuli. Since the concept's introduction in 1996, high SPS has been shown to be associated with poor physical and mental health. It is possible that this is especially true in university students, who are frequently faced with numerous stressors, such as intense workloads and test anxiety. This article is a systematic literature review conducted through EBSCOHost using the following databases: Academic Search Complete, APA PsycArticles, APA PsycInfo, Education Research Complete, ERIC, MEDLINE Complete, and SocINDEX. Search terms included terms regarding high sensory processing sensitivity, university or professional students, and mental health. A total of 6 studies were included. University students with high SPS experienced heightened reactions to sensory, emotional, and physical stimuli. The studies demonstrate correlations of high SPS with outcomes such as depressive tendencies and difficulty adjusting to college. These findings highlight that SPS is associated with poor mental health outcomes. The results underscore the importance of developing support methods for students with high SPS. Future studies should further explore SPS in university students to develop targeted support methods and programs.

Evaluate a comprehensive geriatric assessment service framework targeting frail older people who had high risk of requiring long-term care services in Japan: a community-based pilot study

BackgroundFrailty has become a key concern in an aging population. A comprehensive geriatric assessment (CGA) service framework was developed and evaluated aiming to target and connect frail older adults who are at high risk of requiring long-term care services.MethodsA community-based pilot study was conducted in fiscal year 2016 and 2017 in Kure city, Hiroshima, Japan. Participants aged 65 and over living in Kure city, and 393 persons were extracted from the Kihon Check List (KCL) responses. Among the eligible individuals, 101 consented to participate and received CGA and referred to services based on individual health needs. The efficacy was evaluated by referral rate of services, continuity of the service usage, evaluation of participant’s health condition and the quality of life (QoL) after the 6-month follow-up.ResultsNinety-nine (98.0%) participants needed support for the instrumental activity of daily living, 97 (96.0%) were categorized as locomotive syndrome, and 64 (63.4%) had a depressive tendency. Afterward, 60 participants (59.4%) subsequently accepted the referral services, however, 34 (33.7%) used the services and the remaining 26 (25.7%) did not use the services. The health condition improvements in the service-uses group were statistically significant (p < 0.001), however, QoL score did not change between the baseline and 6th -month.ConclusionKCL extracted high-risks older people, and CGA revealed related diseases and health conditions. However, the high refusal rate of referral services indicates a necessity to modify the service framework such as by collaborating with community general support centers, which could increase the efficacy of service framework.

The characteristics of WM in individuals with depressive tendencies: A functional near-infrared spectroscopy (fNIRS) study

Individuals with depressive tendencies are considered to be at high risk for the onset of depressive disorders. Currently, most research focuses on the impairment of working memory in patients with depression, while there is less attention paid to the WM of individuals with depressive tendencies, and their neural mechanisms underlying it are poorly understood. Therefore, this study focuses on the characteristics and neural mechanisms of WM in individuals with depressive tendencies. This study uses functional near-infrared spectroscopy (fNIRS) to monitor the concentration of Oxy-Hb in the prefrontal cortex and employs the n-back paradigm, designing three levels of load: 0, 1, and 2, to examine the characteristics of WM and its neural mechanisms in individuals with depressive tendencies. Behavioral results show that the accuracy rates of individuals with depressive tendencies is significantly lower than that of healthy individuals, and under the 0-back condition, the reaction time of individuals with depressive tendencies is significantly higher than that of healthy control individuals. Near-infrared results indicate that the activation level in the frontal pole and the dorsal lateral prefrontal cortex of individuals with depressive tendencies is significantly lower than that of healthy control individuals. The β values of channels 2, 7, and 9 are significantly negatively correlated with the Beck Depression Inventory scores of the participants. The results suggest that the reduced activation of the frontal pole and dorsal lateral prefrontal cortex in individuals with depressive tendencies leads to poorer WM performance compared to healthy control individuals. This is a rare brain evidence of the characteristics of WM in individuals with depressive tendencies, which can provide a deeper understanding of the WM characteristics of individuals with depressive tendencies.

Caspase-12 is Expressed in Purkinje Neurons and Prevents Psychiatric-Like Behavior in Mice.

Caspase-12 is a caspase family member for which functions in regulating cell death and inflammation have previously been suggested. In this study, we used caspase-12 lacZ reporter mice to elucidate the expression pattern of caspase-12 in order to obtain an idea about its possible in vivo function. Strikingly, these reporter mice showed that caspase-12 is expressed explicitly in Purkinje neurons of the cerebellum. As this observation suggested a function for caspase-12 in Purkinje neurons, we analyzed the brain and behavior of caspase-12 deficient mice in detail. Extensive histological analyses showed that caspase-12 was not crucial for establishing cerebellum structure or for maintaining Purkinje cell numbers. We then performed behavioral tests to investigate whether caspase-12 deficiency affects memory, motor, and psychiatric functions in mice. Interestingly, while the absence of caspase-12 did not affect memory and motor function, caspase-12 deficient mice showed depression and hyperactivity tendencies, together resembling manic behavior. Next, suggesting a possible molecular mechanistic explanation, we showed that caspase-12 deficient cerebella harbored diminished signaling through the brain-derived neurotrophic factor/tyrosine kinase receptor B/cyclic-AMP response binding protein axis, as well as strongly enhanced expression of the neuronal activity marker c-Fos. Thus, our study establishes caspase-12 expression in mouse Purkinje neurons and opens novel avenues of research to investigate the role of caspase-12 in regulating psychiatric behavior.

The neurobiological mechanism underlying ketamine’s rapid-acting antidepressant effect

Depression is one of the most common disabling mental disorders. However, first-line treatments for depression are typically slow-acting. Ketamine, a glutamatergic modulator with rapid antidepressant effects, has proven effective in treating both refractory depression and suicidal tendencies. The neurobiological mechanisms underlying the effects of antidepressants have become a research hotspot; yet, the exact processes remain unclear. Brain imaging studies have provided important evidence from macroscopic perspectives, such as brain structure and function, while biochemical studies have made significant discoveries from microscopic perspectives, including proteomics and genomics. Previous reviews have summarized a broad range of biomarkers related to the ketamine response, encompassing studies in imaging, electrophysiology, metabolism, immunology, genetics, and neurotrophy. In this review, we systematically summarize a number of potential biomarkers for predicting and modulating the efficacy of ketamine, from both macroperspectives (such as neuroimaging and neuroelectrophysiological markers) and microperspectives (such as neurobiochemical and genetic markers). Although research in this area is still in its infancy, these biomarkers can help clinicians identify whether ketamine intervention is needed for treatment-resistant depression, thereby reducing the burden on patients and society. However, the majority of biomarkers are still in the preclinical exploratory stage, and existing findings are limited. To realize the clinical application of these biomarkers, future studies should combine biomarkers of different types to investigate the relationships and interactions between them. This approach aims to optimize clinical outcomes by enhancing the involvement of biological targets in new models.

Melatonin hormone level in nurses and factors affecting it; Investigation according to shift working pattern

This study aimed to determine the relationship between melatonin hormone levels, sleep, and factors affecting sleep, psychological resilience, and depression in nurses working with a shift work system. Conducted between February 5–12, 2021, at the Training and Research Hospital in Ağrı province, the descriptive study included 41 night shift nurses and 35 day shift nurses, totaling 76 participants. Blood samples for melatonin analysis were collected and data were gathered using the Sociodemographic Information Form, Epworth Sleepiness Scale, Sleep Disorder Scale Short Form, Brief Psychological Resilience Scale, and Beck Depression Scale Short Form. Melatonin analysis was performed using the ELISA method. Statistical significance was set at p < 0.05. Results showed that sleep disorders were present in all nurses with <7 h of daily sleep. Factors such as the use of sleeping pills, marital status, age, and gender affected sleep disorders. Mean scores for melatonin levels were 67.82 ± 40.20 for night shift nurses and 68.08 ± 39.62 for day shift nurses, with no significant difference between shifts. Similarly, no significant differences were found in daytime sleepiness (7.49 ± 4.47 vs. 7.51 ± 4.65), sleep disturbance (24.71 ± 7.33 vs. 25.23 ± 6.64), psychological resilience (18.42 ± 4.19 vs. 17.89 ± 4.74), or depression (3.22 ± 2.60 vs. 3.49 ± 3.35). Nurses exhibited mild sleep disturbances, low depression tendencies, and moderate psychological resilience. Increased daytime sleepiness and sleep disorders correlated with higher depression tendencies and lower psychological resilience. Hospital management and education units are recommended to conduct interventions on sleep quality, depression, and psychological resilience to raise awareness among nurses.

Intestinal microbiota imbalance resulted by anti-Toxoplasma gondii immune responses aggravate gut and brain injury

BackgroundToxoplasma gondii infection affects a significant portion of the global population, leading to severe toxoplasmosis and, in immunocompromised patients, even death. During T. gondii infection, disruption of gut microbiota further exacerbates the damage to intestinal and brain barriers. Therefore, identifying imbalanced probiotics during infection and restoring their equilibrium can regulate the balance of gut microbiota metabolites, thereby alleviating tissue damage.MethodsVimentin gene knockout (vim−/−) mice were employed as an immunocompromised model to evaluate the influence of host immune responses on gut microbiota balance during T. gondii infection. Behavioral experiments were performed to assess changes in cognitive levels and depressive tendencies between chronically infected vim−/− and wild-type (WT) mice. Fecal samples were subjected to 16S ribosomal RNA (rRNA) sequencing, and serum metabolites were analyzed to identify potential gut probiotics and their metabolites for the treatment of T. gondii infection.ResultsCompared to the immunocompetent WT sv129 mice, the immunocompromised mice exhibited lower levels of neuronal apoptosis and fewer neurobehavioral abnormalities during chronic infection. 16S rRNA sequencing revealed a significant decrease in the abundance of probiotics, including several species of Lactobacillus, in WT mice. Restoring this balance through the administration of Lactobacillus murinus and Lactobacillus gasseri significantly suppressed the T. gondii burden in the intestine, liver, and brain. Moreover, transplantation of these two Lactobacillus spp. significantly improved intestinal barrier damage and alleviated inflammation and neuronal apoptosis in the central nervous system. Metabolite detection studies revealed that the levels of various Lactobacillus-related metabolites, including indole-3-lactic acid (ILA) in serum, decreased significantly after T. gondii infection. We confirmed that L. gasseri secreted much more ILA than L. murinus. Notably, ILA can activate the aromatic hydrocarbon receptor signaling pathway in intestinal epithelial cells, promoting the activation of CD8+ T cells and the secretion of interferon-gamma.ConclusionOur study revealed that host immune responses against T. gondii infection severely disrupted the balance of gut microbiota, resulting in intestinal and brain damage. Lactobacillus spp. play a crucial role in immune regulation, and the metabolite ILA is a promising therapeutic compound for efficient and safe treatment of T. gondii infection.Graphical

W143 - Habitual Use of Tobacco and Alcohol on Tendency of Depression and Anxiety Evidence From 27,942 Taiwan Biobank Participants

W143 - Habitual Use of Tobacco and Alcohol on Tendency of Depression and Anxiety Evidence From 27,942 Taiwan Biobank Participants