Temporal Variations In Amplitude Research Articles

Temporal Contrast Sensitivity Increases despite Photoreceptor Degeneration in a Mouse Model of Retinitis Pigmentosa.

The detection of temporal variations in amplitude of light intensity, or temporal contrast sensitivity (TCS), depends on the kinetics of rod photoresponse recovery. Uncharacteristically fast rod recovery kinetics are facets of both human patients and transgenic animal models with a P23H rhodopsin mutation, a prevalent cause of retinitis pigmentosa (RP). Here, we show that mice with this mutation (RhoP23H/+) exhibit an age-dependent and illumination-dependent enhancement in TCS compared with controls. At retinal illumination levels producing ≥1000 R*/rod/s or more, postnatal day 30 (P30) RhoP23H/+ mice exhibit a 1.2-fold to 2-fold increase in retinal and optomotor TCS relative to controls in response to flicker frequencies of 3, 6, and 12 Hz despite significant photoreceptor degeneration and loss of flash electroretinogram (ERG) b-wave amplitude. Surprisingly, the TCS of RhoP23H/+ mice further increases as degeneration advances. Enhanced TCS is also observed in a second model (rhodopsin heterozygous mice, Rho+/−) with fast rod recovery kinetics and no apparent retinal degeneration. In both mouse models, enhanced TCS is explained quantitatively by a comprehensive model that includes photoresponse recovery kinetics, density and collecting area of degenerating rods. Measurement of TCS may be a non-invasive early diagnostic tool indicative of rod dysfunction in some forms of retinal degenerative disease.

Near‐term fetuses process temporal features of speech

The perception of speech and music requires processing of variations in spectra and amplitude over different time intervals. Near-term fetuses can discriminate acoustic features, such as frequencies and spectra, but whether they can process complex auditory streams, such as speech sequences and more specifically their temporal variations, fast or relatively slow acoustic variations, is unclear. We recorded the cardiac activity of 82 near-term fetuses (38 weeks GA) in quiet sleep during a silent control condition and four 15 s streams presented at 90 dB SPL Leq: two piano melodies with opposite contours, a natural Icelandic sentence and a chimera of the sentence--all its spectral information was replaced with broadband noise, leaving its specific temporal variations in amplitude intact without any phonological information. All stimuli elicited a heart rate deceleration. The response patterns to the melodies were the same and differed significantly from those observed with the Icelandic sentence and its chimera, which did not differ. The melodies elicited a monophasic heart rate deceleration, indicating a stimulus orienting reflex while the Icelandic and its chimera evoked a sustained lower magnitude response, indicating a sustained attentional response or more focused information processing. A conservative interpretation of the data is that near-term fetuses can perceive sound streams and the rapid temporal variations in amplitude that are specific to speech sounds with no spectral variations at all.

Synthesizing Ensembles of Spatially Correlated Accelerograms

A new approach has been proposed for the simulation of ensembles of spatially correlated accelerograms from an equivalent stationary random field model of the design earthquake motion. This is based on the method of stochastic decomposition and the use of a stationary coherency model. Realistic temporal variations in amplitudes and frequency composition have been introduced into the simulated motions by using the phase and duration spectra of recorded earthquake motions. The simulated motions are consistent with the design spectrum in the mean sense. The proposed method has been illustrated by synthesizing accelerograms with widely different characteristics at four stations spaced 100 m apart.

Venus: Density of Upper Atmosphere from Measurements of Drag on Pioneer Orbiter

Measurements of the changes in orbital period of the Pioneer Venus orbiter have yielded estimates of the density of the upper atmosphere of Venus at altitudes in the range from 150 to 200 kilometers. At the lower limit of this range, the density on the dayside of the terminator exhibits a temporal variation of amplitude near 4 x 10(-14) gram per cubic centimeter aboult a mean of approximately 1.4 x 10(-13) gram per cubic centimeter. The variation appears oscillatory, with a 4- to 5-day period, but barely one cycle was observed. The density on the nightside of the terminator, sampled inthe same 150-kilometer altitude range, fluctuates about a smaller mean of approximately 4 x 10(-14) gram per cubic centimeter. The density between the altitudes of 150 and 200 kilometers, sampled only on the dayside of the terminator, imply a scale height of between 15 and 20 kilometers. The interpretation of this estimate is uncertain, however, in view of the measurements at the different altitudes having been made at different times and, hence, at different values of solar phase.

Demodulation of stream-flow series

The temporal variations in amplitude of a specific discharge-oscillation in two rivers are explored using demodulation techniques. It is suggested that, combined with similar investigations for precipitation, future studies might explore the modifying influence of the drainage basin upon the precipitation-amplitude series of given oscillations.