Temporal Synchronization Research Articles

Hybrid grain production in wheat benefits from synchronized flowering and high female flower receptivity.

The performance of plant hybrids relative to line breeding types is generally associated with higher yields, better adaptation, and improved yield stability. In bread wheat (Triticum aestivum L.), however, a broad commercial success for hybrids has not been accomplished until now largely due to the low efficiency of hybrid grain production, which is highly attributable to its self-pollinating nature. To better understand how hybrid wheat grains can be produced more effectively, we investigated the influence of synchronized flowering between female, i.e. male-sterile, lines and their male cross-pollinator lines as well as of the duration of flowering on hybrid grain production. We found that synchronization of flowering in combination with the longest possible temporal overlap had the largest positive effect on hybrid grain production. However, despite sufficient spatial and temporal synchronization of flowering, we also found that some female lines had lower hybrid grain set than others, suggesting genetic differences in female floral receptivity. To better assess female receptivity, we established a new phenotyping scale of male-sterile wheat flowers that provides the floral basics for effective cross-pollination. Applying this scale in our field and greenhouse trials revealed that better performing female lines remained longer in the pollen-receptive phase.

Altered electroencephalography-based source functional connectivity in drug-free patients with major depressive disorder

BackgroundCompared to functional magnetic resonance imaging (fMRI), source localization of a scalp-recorded electroencephalogram (EEG) provides higher temporal resolution and frequency synchronization to better understand the potential neurophysiological origins of disrupted functional connectivity (FC) in major depressive disorder (MDD). The present study aimed to investigate EEG-sourced measures to examine the FC in drug-free patients with MDD. MethodResting-state 32-channel EEG were recorded in 84 drug-free patients with MDD and 143 healthy controls, and the cortical source signals were estimated. Exact low-resolution brain electromagnetic tomography (eLORETA) was used to compute the intracortical activity from regions within the default mode network (DMN) and frontoparietal network (PFN). Lagged phase synchronization was used as a measure of functional connectivity. ResultsCompared with control subjects, the MDD group showed greater within-DMN alpha 1 and 2 bands and within-FPN alpha 1, 2, and beta 3 bands. Furthermore, the MDD group showed hyperconnectivity between the DMN and the FPN in the alpha 1 and 2 bands. Finally, higher levels of anhedonia were associated with higher between-network DMN and FPN connectivity in the alpha-1 band. LimitationsDue to the inherent limitations of eLORETA with predefined seeds, we could not exclude connectivity between regions of interest (ROIs), which may be related to the activity from regions adjacent to the ROIs. ConclusionsThe present findings support the importance of phase-lagged functional dysconnectivity in the neurophysiological mechanisms underlying MDD. Exploring the potential of these patterns as surrogates for treatment responses may advance targeted interventions for depression.

Adapting seasonal beekeeping patterns in western Norway

This paper is about how Western Norway beekeepers synchronise their practices to perceived patterns of seasonal rhythms and adapt their timings and ways of working as they sense shifts in these rhythmic seasonal patterns associated with climatic and environmental (and social) change. It contributes to work on adaptation governance with an emphasis on the time sensitivity of adaptive action in institutions – the importance of taking the right action at the right time – and that this timing is coordinated at the convergence of multiple temporalities across human and more-than-human worlds, within temporal assemblages. The research was conducted in close collaboration with beekeepers over the 2021/2022 seasons and found them to be temporally literate practitioners that are capable of gauging shifts in temporalities, drawing on diverse temporal frameworks (both formal and informal), and recalibrating. Recalibration came both in small incremental micro-manoeuvres to maintain synchrony in a seasonal pattern, or collective efforts to fundamentally adapt or reconfiguring seasonal patterns when patterns fail to ‘hold’. From this perspective, the paper centres and elevates temporal synchronisation in adaption, with attention to the institutionalised capacity of temporally competent practitioners to make use of and recraft the cultural frameworks governing timings.

A new perspective to understand public response to the Typhoon Doksuri from coastal and inland regions

Massive amounts of data from social media possess the potential to rapidly identify the primary issues of concern in emergency disaster management. In summer 2023, Super Typhoon Doksuri which was an exceptionally special typhoon disaster that caused severe damage to China's coastal areas and disastrous impacts in inland regions, particularly triggered the most severe rainstorm in Beijing area in over a century. To enhance typhoon hazard reduction in both coastal and interior locations, it is crucial to examine public response to these events. This study uses microblog text data from July 27 to August 3 of 2023 to map the public response to Typhoon Doksuri. The Support Vector Machine (SVM) algorithm was used to classify the microblog text in combination with the typhoon path to analyze the spatial and temporal variations of the emotions of the affected individuals. The relationship between changes in public opinion, the distribution of topics, and the major disasters triggered by the residual circulation of Typhoon Doksuri in the Beijing-Tianjin-Hebei region is discussed. The Mentougou mega-storm in Beijing area that occurred in July 2023 is a typical case. The findings demonstrate that during the typhoon event, the focus of public attention changed with the movement of the typhoon path, and various public opinion topics exhibited temporal synchronization. Public sentiment indicates that the overall supportive sentiment is higher than is fearful sentiment. Based on this, it is crucial to strengthen the Beijing-Tianjin-Hebei cooperative emergency response, and response measures were proposed related to urban flood control and drainage construction, public awareness, backward areas, secondary disasters, resident relocation, and social media technology.

Linked Links—A Research Project: The Multiple Superimposed Soft Networks as Network Profiles

This article, based on network science, aims to contribute to overcoming its geometric and technological phases. The novelty consists in considering links of networks as linked by superimposed networks, termed here multiple superimposed soft networks (MSSN), which is introduced as a research issue. Such links of links (termed here as passive links) concern, for instance, correspondences, incompatibilities, and temporal synchronizations between the occurrences of pairs of active links of effective networks, such as those based on electrical and telecommunication. A possible constitutive mechanism of such passive linkage consists of linkage representations for practices and histories of use expressed by their validating statistical reoccurrences. We consider the possible emergent nature of the passive linkage. The reason for introducing the design and usage of MSSN properties as a research issue involves making new approaches to profile and manage networks available. Correspondence between active linkage and MSSN properties should be a matter for an experiential, machine-learning approach. Research issues relate their possible usage on the active linkage such as for classification, comparations, detection of criticalities, diagnosis, performance evaluation, and regulatory as weak forces. Furthermore, the possible identification of standard corresponding configurations of passive and active linkage is finalized to avoid their establishment or, conversely, in facilitating their establishment and keeping their replication in different contexts (or partially and in combinations) and identifying related standardized approaches (also for classes of configurations having significant levels of equivalence). This research project has methodological generalizing aspects of trans-disciplinarity. We conclude by mentioning related research issues.

An improved variable neighborhood search algorithm embedded temporal and spatial synchronization for vehicle and drone cooperative routing problem with pre-reconnaissance

Drones are increasingly utilized for transportation reconnaissance due to their expansive field of view, cost-effectiveness, and agility. They can pre-reconnaissance the traveling routes of the ground vehicles carrying valuable goods to ensure the safety of vehicles and their goods. This rises a novel routing problem for the Vehicles and their Pre-Reconnaissance Drones, which is an integrated point and arc routing problem with temporal and spatial synchronization. A mixed integer linear programming model is developed to formulate the problem with complex synchronization constraints. The Variable Neighborhood Search algorithm integrated with the Temporal & Spatial synchronization-based Greedy search and simulated annealing strategy is designed to solve the model. A practical case based on real urban data from Beijing, China, and random instances with different sizes are tested and compared with the proposed algorithm. Computational results indicated that the proposed algorithm can solve the problem efficiently and outperform the simulated annealing algorithm and the greedy algorithm.

Rapid liver self-recovery: A challenge for rat models of tissue damage

Animal models, mainly murine, stay as a fundamental resource in diverse research pursuits, notably contributing to significant strides in discovering novel treatments for therapeutic applications. Preclinical assays must consider the existence of self-recovery mechanisms in the murine species to achieve a well-designed control group. This study focuses on unveiling the innate rapid regenerative capacity of rat liver by utilizing the thioacetamide-induced sub-chronic liver injury model. Employing histopathological, biochemical, and molecular liver function tests, we assessed the recovery of liver tissue functionality. Moreover, animals were housed with voluntary running wheels and locomotory activity was recorded and employed as an indirect index of overall animal recuperation. Remarkably, basal locomotory activity reestablished to normal levels only two weeks post-thioacetamide exposure. Our results raise vital considerations about the importance of temporal synchronicity in comparative assays to validate the real action of treatments, emphasizing the role of the rapid rat liver endogenous self-recovery.

ARISGAN: Extreme super-resolution of arctic surface imagery using generative adversarial networks

Introduction: This research explores the application of generative artificial intelligence, specifically the novel ARISGAN framework, for generating high-resolution synthetic satellite imagery in the challenging arctic environment. Realistic and high-resolution surface imagery in the Arctic is crucial for applications ranging from satellite retrieval systems to the wellbeing and safety of Inuit populations relying on detailed surface observations.Methods: The ARISGAN framework was designed by combining dense block, multireceptive field, and Pix2Pix architecture. This innovative combination aims to address the need for high-quality imagery and improve upon existing state-of-the-art models. Various tasks and metrics were employed to evaluate the performance of ARISGAN, with particular attention to land-based and sea ice-based imagery.Results: The results demonstrate that the ARISGAN framework surpasses existing state-of-the-art models across diverse tasks and metrics. Specifically, land-based imagery super-resolution exhibits superior metrics compared to sea ice-based imagery when evaluated across multiple models. These findings confirm the ARISGAN framework’s effectiveness in generating perceptually valid high-resolution arctic surface imagery.Discussion: This study contributes to the advancement of Earth Observation in polar regions by introducing a framework that combines advanced image processing techniques with a well-designed architecture. The ARISGAN framework’s ability to outperform existing models underscores its potential. Identified limitations include challenges in temporal synchronicity, multi-spectral image analysis, preprocessing, and quality metrics. The discussion also highlights potential avenues for future research, encouraging further refinement of the ARISGAN framework to enhance the quality and availability of high-resolution satellite imagery in the Arctic.

Research on a Distributed Cooperative Guidance Law for Obstacle Avoidance and Synchronized Arrival in UAV Swarms

In response to the issue where the original synchronization time becomes inapplicable for UAV swarms after temporal consistency convergence due to obstacle avoidance, a new distributed consultative temporal consistency guidance law that takes into account threat avoidance has been proposed. Firstly, a six-degree-of-freedom dynamic model and a guidance control model for unmanned aerial vehicles (UAVs) are established, and the guidance commands are decomposed into control signals for the pitch and yaw planes. Secondly, based on the theory of dynamic inversion control, a temporal consistency guidance law for a single UAV is constructed. On the other hand, an improved artificial potential field theory is used and integrated with a predictive correction network to generate guidance commands for threat avoidance. A threshold smoothing method is employed to integrate the two guidance systems, and a cluster consultation mechanism is introduced to design a two-layer temporal synchronization architecture, which negotiates to change the synchronization time of the swarm to achieve the convergence of consistency once again. Finally, in typical application scenarios, simulation verification demonstrates the effectiveness of the control method proposed in this paper. The proposed control method achieves the guidance of UAV formations to synchronize their arrival at the target location under complex threat conditions.

Subwavelength and broadband on-chip mode splitting with shifted junctions

We design and fabricate a sub-wavelength on-chip mode splitter based on the implementation of a shifted junction between a single-mode waveguide and a multimode waveguide. A proper choice of the device parameters enables to split the input beam into a combination of different guided modes of the multimode waveguide, minimizing radiation and reflection losses that amount to ∼ 0.4 dB in our experiments. Because the splitting mechanism does not rely on phase-matching, we achieve broadband operation that could exceed 200 nm bandwidth (<0.5 dB splitting variation). This approach ensures temporal and phase synchronization among the output modes, with applications spanning from the emergent multimode photonics platform to traditional single-mode photonics operations.

The uncertainty of waiting: the liminality of the Western Balkans in the process of EU enlargement

ABSTRACT This article deals with the concepts of time and temporality in the context of EU enlargement. It offers a critique of the prevailing understanding of time as linear, objective and abstract, unilinear flow of time and based on the exclusivity of its use as a universal measure. Accordingly, the article examines the EU construction of time as linear, objective, neutral and universal and in relation to progress and modernity. It argues that the EU’s understanding of time in terms of the temporal singularity of linear time creates temporal borders in the enlargement process by situating the EU and the candidate countries in different temporalities, thus demanding temporal synchronisation as a practice of shaping time. This article focuses on the Western Balkans as a region aspiring to EU membership. It examines how the EU shapes the time of the Western Balkans in the EU enlargement process by establishing temporal borders for the Western Balkans that define where progress occurs and consequently, how waiting is introduced as a means of temporal synchronisation.

Examining spatial and socioeconomic disparities in internet resilience during extreme weather events: a case study of Hurricane Harvey and Winter Storm Uri

The resilience of internet service is crucial for ensuring consistent communication, situational awareness, facilitating emergency response in our digitally-dependent society. However, due to empirical data constraints, there has been limited research on internet service disruptions during extreme weather events. To bridge this gap, this study utilizes observational datasets on internet performance to quantitatively assess the extent of internet disruption during two recent extreme weather events. Taking Harris County in the United States as the study region, we jointly analyzed the hazard severity and the associated internet disruptions in the context of two extreme weather events. The results show that the hazard events significantly impacted regional internet connectivity. There exists a pronounced temporal synchronicity between the magnitude of disruption and hazard severity: as the severity of hazards intensifies, internet disruptions correspondingly escalate, and eventually return to baseline levels post-event. The spatial analyses show that internet service disruptions can happen even in areas that are not directly impacted by hazards, demonstrating that the repercussions of hazards extend beyond the immediate area of impact. This interplay of temporal synchronization and spatial variance underscores the complex relationships between hazard severity and Internet disruption. Furthermore, the socio-demographic analysis suggests that vulnerable communities, already grappling with myriad challenges, face exacerbated service disruptions during these hazard events, emphasizing the need for prioritized disaster mitigation strategies and interventions for improving the resilience of internet services. To the best of our knowledge, this research is among the first studies to examine the Internet disruptions during hazardous events using a quantitative observational dataset. The insights obtained hold significant implications for city administrators, guiding them towards more resilient and equitable infrastructure planning.

Exploiting holographically encoded variance to transmit labelled images through a multimode optical fiber.

Artificial intelligence has emerged as promising tool to decode an image transmitted through a multimode fiber (MMF) by applying deep learning techniques. By transmitting thousands of images through the MMF, deep neural networks (DNNs) are able to decipher the seemingly random output speckle patterns and unveil the intrinsic input-output relationship. High fidelity reconstruction is obtained for datasets with a large degree of homogeneity, which underutilizes the capacity of the combined MMF-DNN system. Here, we show that holographic modulation can encode an additional layer of variance on the output speckle pattern, improving the overall transmissive capabilities of the system. Operatively, we have implemented this by adding a holographic label to the original dataset and injecting the resulting phase image into the fiber facet through a Fourier transform lens. The resulting speckle pattern dataset can be clustered primarily by holographic label, and can be reconstructed without loss of fidelity. As an application, we describe how color images may be segmented into RGB components and each color component may then be labelled by distinct hologram. A ResUNet architecture was then used to decode each class of speckle patterns and reconstruct the color image without the need for temporal synchronization between sender and receiver.

Walk with me? Part 2: Dogs synchronize with an unfamiliar person who first synchronized with their owner

Dogs exhibit sensitivity to human behaviours directed towards them (see Part 1), but dogs’ sensitivity to human third-party interactions, i.e. eavesdropping or indirect sensitivity, remains unclear. This study aimed to investigate dogs' indirect sensitivity in an ecological context devoid of food incentives. We thus explored dogs’ responsiveness to interactions between their owner and an unfamiliar person during a synchronous walk in an outdoor environment. To do so, we delineated two experimental groups of pet dogs: an unfamiliar experimenter either walked and talked with the owner for 15 minutes, maintaining a 1-metre proximity and aligning speed (n = 16 dogs) or stayed away from the owner for 15 minutes (n = 16 dogs) in the dog’s presence. We then compared the dogs’ locomotor synchronization with the experimenter and the dogs’ gaze behaviour during a straight-line walk. Dogs for which the experimenter had interacted with the owner displayed enhanced location, temporal and activity synchronization with the experimenter during the straight-line walk compared to dogs for which the experimenter had not interacted with the owner. Specifically, these dogs were closer to the experimenter, had a smaller speed difference compared to the experimenter’s speed at the beginning of the straight-line walk, and more dogs from this group adjusted their speed directly after the experimenter’s change of speed. Regarding dogs’ gaze behaviour, we did not find significant differences between the two experimental groups. Finally, we found that dogs from both experimental groups were attracted to their owner during the straight-line walk. Our results demonstrate, for the first time, that dogs’ behavioural synchronization with an unfamiliar person occurs subsequently to the dogs’ perception of intraspecific behavioural synchronization between their owner and the unfamiliar person. This third-party sensitivity may result from an automatic process of reproducing perceived behaviours, suggesting interspecific motor contagion when dogs perceive synchronous behaviour of two human agents; and/or from a transitivity of familiarity, the unfamiliar person becoming indirectly familiar to the dogs through their interaction with the dogs’ owners. These findings bear practical significance, as encounters between unfamiliar people and dog-owner dyads can be enhanced if those people first synchronize and talk with dogs’ owners before interacting with dogs.

Multilayer time-variant network edges synchronization method

In this work, we propose a method for measuring synchronization between the edges of a pair of networks with connections that vary over time. The product of this method is an Incidence-Fidelity network, indicating the intensity of edge synchronization during a time interval. Two distinct validations were performed: in the first, we employed time-varying multilayer graphs with random connections to validate the algorithm; and in the second, we used the coupled Rössler oscillator to validate the method. In the algorithm validation, we compared the algebraically predicted results with the results obtained by using random networks. In the method validation, we used the coupled Rössler oscillator to generate time series representing the existence of two edges, one in each layer of the time-varying multilayer graphs. We assessed the relationship between the pre-defined coupling values and the achieved synchronization indices. In the application of our method, we considered time series of 17 years of climate data for the Normalized Difference Vegetation Index (NDVI) and precipitation for all municipalities in the state of Bahia, Brazil. To do so, we first obtained the individual layers of the multilayer network using a motif synchronization method. From the individual layers, we generated the Interlayer Incidence-Fidelity network. The obtained Interlayer Incidence-Fidelity network for the NDVI and precipitation pair reflects a connection pattern that incorporates the configurations of the individual layers. This is because synchronizations are primarily distributed in the more interconnected regions of the individual layers. The Interlayer Incidence-Fidelity networks generated by our method can identify synchronization patterns in the evolution of relationships between networks over time. This method presents a promising tool for evaluating synchronization between networks, generating a weighted network that quantifies the different levels of temporal synchronization for each edge in the networks.

Equilibrium and Stability of the Solar System Rely on a Human-Like Program of Substance and Information Transfer

This study bridges the realms of astronomy and life science, illuminating the intricate interplay between celestial phenomena and terrestrial biology. While humans may perceive the palpable effects of seasons, climate, geographical location, and the movements of the Sun and moon, other phenomena such as changes in Earth's magnetic field and seismic activity are often sensed by animals but elude human perception. However, with disciplined and sustained training, humans possess the potential to harness the rich array of sensors and sensory systems within the body, thereby unlocking the ability to discern and validate the cosmic influences documented by ancient civilizations. In instances where traditional astronomical inquiries, such as the maintenance of galactic equilibrium, present enigmatic puzzles, insights from cutting-edge life science research may offer promising leads. Newly unveiled mechanisms such as the "Function Enhancement Program of Five-Organs through Umbilical Access" and the rhythmic orchestration of the "Rotating Presidency of Twelve-Organs" elucidate the intricate operations of visceral organs within the human body. Indirect evidence suggests a correlation between these biological processes and the transfer of gaseous substances among celestial bodies, including Mercury, Venus, the Sun, and Jupiter, hinting at a temporal synchronicity that may contribute to the equilibrium and stability of the solar system. Confirmation of substance and information transfer processes could unlock new avenues of inquiry in astronomy, shedding light on vexing conundrums such as dark energy and matter, binary pulsars, gravitational waves, inflation fields, and alternative theories to Einstein's General Relativity. Thus, by bridging the disciplines of astronomy and life science, this study offers fresh perspectives and potential breakthroughs in our understanding of the cosmos.

‘Best Known Example of Relativity in Literature’: Personal Supertext of L.N. Tolstoy in V.V. Nabokov’s Novel “Pnin”

This article addresses the issue of interpreting the work and biographical myth of L.N. Tolstoy in V.V. Nabokov’s novel “Pnin.” The aim of the study is to examine how through the reconstruction of Tolstoy’s personal supertext, Nabokov conveys his philosophy of time. This question is relevant in the context of studying Nabokov’s historiosophy and the writer’s reflection on his own literary genealogy. The analysis reveals that in Nabokov’s reception, Tolstoy is a national genius who was able to recreate the effect of natural time flow. Explicit references to Tolstoy and his biography allow for correlating the characters’ reading experience and their perception of time: from frozen time during reading-performance to the reverse flow of time during co-creative reading. The motifs of Tolstoy’s works actualize the key problem of the relativity of time for Nabokov. Although the unreliable narrator emphasizes the power of time and fate over the lonely hero, in reality, Pnin has access to multiple temporal dimensions. Just like in “Anna Karenina,” the technique of temporal synchronization highlights the interconnectedness of characters’ fates. Tolstoy’s personal supertext enables Nabokov to understand the theme of family as a timeless connection between people that defines the characters’ place in the world.

An integrated temporal and spatial synchronization for two-echelon vehicle routing problem in waste collection system

This paper presents a two-echelon vehicle routing problem (2E-VRP) with vehicle synchronization at meeting points for the reverse logistic network to collect waste in the urban area. Low-capacity vehicles are utilized to perform collection only in the inner part of the city because of restricted access and limited infrastructure to be expanded. While, high-capacity vehicles are used to transform waste from the border of the inner city to the recycling centers located outside of city. Vehicles of the first and second echelons visit each other at meeting points, which do not have storage capacity mainly because of environmental and social consequences of the transshipment of waste. The timing aspect plays a critical role at meeting points to ensure the reasonable sequence of operations. So, temporal synchronization, a critical aspect of 2E-VRP, is considered in this paper, as well as minimization of waiting time of vehicles in meeting points to avoid long dwelling time. Moreover, because the previous study of 2E-VRP has not dealt with space limitation of meeting points, this paper presents a 2E-VRP that incorporates temporal synchronization, waiting time, and temporal capacity simultaneously for the first time to address a more practical model. To solve the mentioned problem a set of capable and latest metaheuristics are proposed as well as the hybrid ones to probe their efficiency and reasonably construct high quality routes. Moreover, the impact of the temporal capacity is investigated compared to temporal synchronization without considering temporal capacity.

When night becomes day: Artificial light at night alters insect behavior under semi-natural conditions

Light is the most important Zeitgeber for temporal synchronization in nature. Artificial light at night (ALAN) disrupts the natural light-dark rhythmicity and thus negatively affects animal behavior. However, to date, ALAN research has been mostly conducted under laboratory conditions in this context. Here, we used the field cricket, Gryllus bimaculatus, to investigate the effect of ALAN on insect behavior under semi-natural conditions, i.e., under shaded natural lighting conditions, natural temperature and soundscape. Male crickets were placed individually in outdoor enclosures and exposed to ALAN conditions ranging from <0.01 to 1500 lx intensity. The crickets' stridulation behavior was recorded for 14 consecutive days and nights and their daily activity patterns were analysed. ALAN impaired the crickets' stridulation rhythm, evoking a change in the crickets' naturally synchronized daily activity period. This was manifested by a light-intensity-dependent increase in the proportion of insects demonstrating an intrinsic circadian rhythm (free-run behavior). This also resulted in a change in the population's median activity cycle period. These ALAN-induced effects occurred despite the crickets' exposure to almost natural conditions. Our findings provide further validity to our previous studies on ALAN conducted under lab conditions and establish the deleterious impacts of ALAN on animal behavioral patterns. TeaserArtificial light at night alters cricket behavior and desynchronizes their stridulation even under near-natural conditions.

A Computational Investigation of the Effects of Temporal Synchronization of Left Ventricular Assist Device Speed Modulation with the Cardiac Cycle on Intraventricular Hemodynamics.

Patients with advanced heart failure are implanted with a left ventricular assist device (LVAD) as a bridge-to-transplantation or destination therapy. Despite advances in pump design, the risk of stroke remains high. LVAD implantation significantly alters intraventricular hemodynamics, where regions of stagnation or elevated shear stresses promote thrombus formation. Third generation pumps incorporate a pulsatility mode that modulates rotational speed of the pump to enhance in-pump washout. We investigated how the timing of the pulsatility mode with the cardiac cycle affects intraventricular hemodynamic factors linked to thrombus formation. Computational fluid dynamics simulations with Lagrangian particle tracking to model platelet behavior in a patient-specific left ventricle captured altered intraventricular hemodynamics due to LVAD implantation. HeartMate 3 incorporates a pulsatility mode that modulates the speed of the pump every two seconds. Four different timings of this pulsatility mode with respect to the cardiac cycle were investigated. A strong jet formed between the mitral valve and inflow cannula. Blood stagnated in the left ventricular outflow tract beneath a closed aortic valve, in the near-wall regions off-axis of the jet, and in a large counterrotating vortex near the anterior wall. Computational results showed good agreement with particle image velocimetry results. Synchronization of the pulsatility mode with peak systole decreased stasis, reflected in the intraventricular washout of virtual contrast and Lagrangian particles over time. Temporal synchronization of HeartMate 3 pulsatility with the cardiac cycle reduces intraventricular stasis and could be beneficial for decreasing thrombogenicity.