Technology Readiness Level Research Articles

3D printing in surgery: relevance of technology maturity assessment in bioprinting research studies

Biological 3D printing (bioprinting) is an extension of what is defined as additive manufacturing in the American Society for Testing and Materials (ASTM) and International Organization for Standardization (ISO) standards and is based on the automated printing of living cells and biomaterials. Researchers and experts in the field of biomaterial science, tissue engineering and regenerative medicine (TE&RM) are constantly pointing to the potential of biological 3D printing and scientific articles regularly announce the imminent clinical application. We argue in this article that these announcements are often premature and counterproductive as they focus heavily on technological progress but regularly ignore the critical stages that need to be completed in order to successfully translate atechnology into the healthcare market. The technology readiness level (TRL) scale is apotentially useful tool for measuring the relative maturity of atechnology in terms of overcoming aseries of critical milestones. We propose an adaptation of the TRL scale and use it to discuss the current state of research on biological 3D printing. Finally, we provide specific recommendations for optimizing future research projects to pave the way for clinical applications of biological 3D printing and thus achieve adirect positive impact on surgical patient care.

Early Technology Readiness Level (TRL) Development of the Microfluidic Inorganic Conductivity Detector for Europa and the Solenoid-Based Actuator Assembly for Impact Penetrators

This study introduces an innovative in situ lander/impact-penetrator design tailored for Discovery-class missions to Europa, specifically focused on conducting astrobiological analyses. The platform integrates a microfluidic capacitively coupled contactless conductivity detector (C4D), optimized for the detection of low-concentration salts potentially indicative of biological activity. Our microfluidic system allows for automated sample routing and precise conductivity-based detection, making it suitable for the harsh environmental and logistical demands of Europa’s icy surface. This technology provides a robust toolset for exploring extraterrestrial habitability by enabling in situ chemical analyses with minimal operational intervention, paving the way for advanced astrobiological investigations on Europa.

A performance evaluation of commercially available and 3D-printable prosthetic hands: a comparison using the anthropomorphic hand assessment protocol

Despite significant technological progress in prosthetic hands, a device with functionality akin to a biological extremity is far from realization. To better support the development of next-generation technologies, we investigated the grasping capabilities of clinically prescribable and commercially available (CPCA) prosthetic hands against those that are 3D-printed, which offer cost-effective and customizable solutions. Our investigation utilized the Anthropomorphic Hand Assessment Protocol (AHAP) as a benchtop evaluation of the multi-grasp performance of 3D-printed devices against CPCA prosthetic hands. Our comparison sample included three open-source 3D-printed prosthetic hands (HACKberry Hand, HANDi Hand, and BEAR PAW) and three CPCA prosthetic hands (Össur i-Limb Quantum, RSL Steeper BeBionic Hand V3, and Psyonic Ability Hand), along with including previously published AHAP data for four additional 3D-printed hands (Dextrus v2.0, IMMA, InMoov, and Limbitless). Our findings revealed a notable grasping performance disparity, with 3D-printed prostheses generally underperforming compared to their CPCA counterparts, specifically in cylindrical, diagonal volar, extension, and spherical grips. We propose that the observed performance shortfalls are likely attributed to the design or build quality of the 3D-printed prostheses, owing to the fact that 3D-printed hands often have a lower technology readiness level for widespread use. Addressing the limitations highlighted in this work and subsequent research will play a crucial role in refining the design and functionality of both 3D-printed and CPCA prosthetic devices.

Hydrothermal carbonization of primary sewage sludge in a prototype reactor: Sensitivity analysis of key parameters for hydrochar and liquid phase upscaling and reuse

Hydrothermal carbonization (HTC) of untreated sewage sludge with high water content was evaluated as an alternative to usual wastewater treatment. This bold approach allowed bioproducts useful as biofuel and nutrient sources to be obtained directly from raw sludge. HTC experiments were performed in a scalable arrangement (technology readiness level >4) composed of a 10-liter high-pressure reactor. The influence of the experimental conditions, including temperature (180-220°C), reaction time (60-120min), and pH (6.5-12.0), was evaluated on nutrients and heavy metal distribution through the liquid phase by a 23 central composite design with a triple central point. The bioproducts were characterized by a set of six analytical techniques, and the results were refined by statistical procedures (Principal Component Analysis and Response Surface Methodology). pH is a variable that impacts bioproducts’ characteristics, making it a guiding factor for application. Basic pH promotes transfer of components from solid to liquid phase, while natural pH favors the heating value of hydrochars. Liquid phase is a carbon- and nitrogen-rich source that can be useful for plant nutrition, mainly due to the increase of ammonia nitrogen from 20.6 to 51.7wt.% under pH 6.5, and an expressive decrease of chemical oxygen demand from 32 to 6-16 mgO2L-1. The hydrochar can be considered a renewable solid fuel, reaching up to 12.43 MJ kg-1 under pH 6.5; the basic pH favored an increase in the O/C ratio and lower HHV values. HTC of primary sewage sludge can replace steps of a conventional treatment station and promotes treated wastewater reuse.

Technoeconomic analysis of supercritical water gasification of canola straw for hydrogen production

Production of hydrogen from renewable sources is gaining popularity to reduce our dependency on non-renewable fossil fuels to meet growing hydrogen demand. However, despite the great prospect of production of hydrogen from sustainable sources such as lignocellulosic biomass via supercritical water gasification (SCWG), it has not been commercialized at a large industrial scale. This is due to the lack of detailed economic analysis of SCWG of lignocellulosic biomass, owing to the complexity of the SCWG process and the heterogeneous nature of biomass. Therefore, to address this knowledge gap, in this study, a detailed technoeconomic analysis (TEA) of a conceptual SCWG pilot having the capacity to process 200 tons/day of canola straw for the production of green hydrogen was conducted. Mass and energy balance of conceptual pilot was performed using Aspen Plus ® simulation by utilizing experimental data and hydrogen yield of 41.62 mmol/g was obtained at optimized reaction conditions of 500 °C, 23 MPa, and 10 wt%. Economic analysis based on calculated mass and energy balance was performed using SuperPro software. Cash flow analysis for capital expenses (CAPEX) of 81 Million USD showed a high internal rate of return (IRR) of 38.9% and an undiscounted net present value (NPV) of 548 million USD. A minimum selling price (MSP) of 3.38 USD/kg H2 for produced hydrogen was estimated, which is lower than other renewable hydrogen production processes and comparable to non-renewable hydrogen production technologies. A high positive IRR and NPV, while a lower MSP showed that despite having a low technological readiness level (TRL) of 4, SCWG of lignocellulosic biomass is a technically feasible and economically viable process for the production of hydrogen. Furthermore, sensitivity analysis also revealed that capital expenses (CAPEX) and canola straw price had the highest influence on net present value (NPV) and MSP. However, overall NPV and MSP were highly stable to changes in parameters highlighting the robustness of the economic analysis.

TECHNOLOGICAL PROSPECTION OF THE USAGE OF BARU FRUIT (DIPTERYX ALATA VOG.) TO IMPROVE THE LIVING CONDITIONS OF QUILOMBOLAS, EXTRACTIVIST COMMUNITIES IN BRAZIL

Barueiro (Dipteryx alata Vog.) is an arboreal plant species native to Brazil's fertile Cerrado region. holds great promise for cultivation and technological development due to its versatile uses and the complete reuse of its parts. Given its local significance, increased research support is essential, as the species has the potential to generate high-value products and offer a sustainable income source for its producers. This study is a prospective analysis of articles and patents on barueiro (baru fruit), highlighting that most technologies have low technological readiness levels (TRL 3-4) and remain at the bench stage, with most patents filed by universities. Collaboration between extractive communities and academia is crucial for knowledge transfer, cooperative creation, and project development for processing centers, training, and decentralized energy generation, thereby supporting SDGs and circular economy principles by adding value and improving community well-being. Once these cooperatives and processes are established, applying for geographical indication could further enhance the value of baru-based products.

Lessons Learned for Developing an Effective High-Speed Research Compressor Facility

Few universities in the world conduct experimental research on high-speed, high-power turbomachinery. The Purdue High-Speed Compressor Research Laboratory has a longstanding tradition of partnering with industry sponsors to perform high-TRL (technology readiness level) experiments on axial and radial compressors for aerospace applications. Early work in the laboratory with Professor Sanford Fleeter and Professor Patrick Lawless involved aeromechanics and the addition of a multistage axial compressor facility to support compressor performance studies. This work continues today under the guidance of Professor Nicole Key. While other universities may operate a single-stage transonic compressor or a low-speed multistage compressor, the Purdue 3-Stage (P3S) Axial Compressor Research Facility provides a unique environment to understand multistage effects at speeds where compressibility is important. Over the last two decades, several areas of important research within the gas-turbine engine industry have been explored: vane clocking, stall/surge inception, tip-leakage/stator-leakage (cavity leakage) flow characterization, and forced response, to name a few. This paper addresses the different configurations of the facility chronologically so that existing datasets can be matched with correct boundary conditions and provides an overview of the different upgrades in the facility as it has developed in preparation for the next generation of small-core compressor research.

Identification of Cause–Effect Relationships between Process Parameters and the Film Formation in the Semidry Electrode Production for Lithium‐Ion Batteries

Conventional electrode production for lithium‐ion batteries has high energy and plant space demand, due to the high solvent content of the slurry to be processed by slot die or doctor blade coating. By using the semidry electrode production, the solvent content is reduced by more than 50% compared to the conventional electrode production, decreasing energy demand and drying length. Regarding technology readiness level, the semidry electrode production is on the pilot scale, as the basic principles have been shown. However, many unknown cause–effect correlations exist between the process parameters and the product properties. This study aims to analyze process parameter variations and their influence on the geometric, electrochemical, and mechanical properties of the electrode. An experimental design is utilized to obtain statistically relevant conclusions. It is found that the first calender gap and the roller speed influence the mass loading and the porosity of the electrode. The roller speed significantly influences the ionic resistance within the electrode, which may be attributed to the used release foil.

Systematic Review on Additive Friction Stir Deposition: Materials, Processes, Monitoring and Modelling

Emerging solid-state additive manufacturing (AM) technologies have recently garnered significant interest because they can prevent the defects that other metal AM processes may have due to sintering or melting. Additive friction stir deposition (AFSD), also known as MELD, is a solid-state AM technology that utilises bar feedstocks as the input material and frictional–deformational heat as the energy source. AFSD offers high deposition rates and is a promising technique for achieving defect-free material properties like wrought aluminium, magnesium, steel, and titanium alloys. While it offers benefits in terms of productivity and material properties, its low technology readiness level prevents widespread adoption. Academics and engineers are conducting research across various subfields to better understand the process parameters, material properties, process monitoring, and modelling of the AFSD technology. Yet, it is also crucial to compile and compare the research findings from past studies on this new technology to gain a comprehensive understanding and pinpoint future research paths. This paper aims to present a comprehensive review of AFSD focusing on process parameters, material properties, monitoring, and modelling. In addition to examining data from existing studies, this paper identifies areas where research is lacking and suggests paths for future research efforts.

A Comprehensive Review of Approaches in Carbon Capture, and Utilization to Reduce Greenhouse Gases

Addressing atmospheric CO2 levels is crucial for mitigating global warming and promoting sustainable fossil fuel use. This review explores various CO2 capture strategies, including pre-combustion, post-combustion, oxy-fuel combustion, direct air capture, chemical looping, and polymeric membranes. Each strategy is critically evaluated in terms of its advantages, limitations, and overall effectiveness. Additionally, this study discusses advanced separation techniques for captured CO2, emphasizing recent innovations in membrane technology integrated with cryogenic processes. This integration has the potential to economically extract CO2 from diverse industrial processes, offering significant benefits in terms of operational cost reduction and increased efficiency. A detailed market analysis is also presented to explore feasible CO2 utilization options, highlighting potential incentives and motivations for capturing CO2. Furthermore, the technological readiness level of various capture and separation techniques is assessed, offering insights into their development and progress over time. This comprehensive analysis aims to support the advancement of effective and economically viable CO2 management solutions, contributing to a more sustainable and climate-resilient future.

Biotechnological Tool for Metal(loid)s as Cd, Cu, Ni, and P Management with Multiple Approaches: Bioremediation, Recovery of Raw Materials, and Food Safety

Contaminated soils are a challenge for implementing biotechnology in bioremediation, the recovery of Critical and Strategic Raw Materials (CRMs and SRMs), and food security. European Union (EU) Governments have established strict limits on As, Pb, Cd, and Hg in foods (Document 32023R0915) and requested the recovery of 34 CRMs within a circular economy (CE) (5th CRMs list). This study proposed a biotechnological tool for the decontamination of soil with heavy metal(loid)s by arbuscular mycorrhizal (AM)-assisted phytoextraction and the subsequent recovery of CRMs or by phytostabilization to prevent their entry into the food chain. It consisted of placing Baccharis salicifolia plants, inoculated or non-inoculated with AM fungi, into bioreactors (BRs) containing mining soil with Cd, Ni, and Cu, according to the Argentinian Patent (AR090183B1). The bioextractive potential (BP) was also estimated at the highest Technological Readiness Level (TRL) using a vegetable depuration module (VDM, TRL 6). Inoculated plants showed significantly higher aerial bioaccumulation coefficients (Cd: 68.62; P: 2.99; Ni: 2.51; Cu: 0.18) in BRs, and the BP values reached 1.16 g, 9.75 g, 2.40 g, and 213.1 g for Ni, Cd, Cu, and P, respectively. Finally, these CRMs and SRMs could be recovered from biomass through hydrometallurgy within a CE framework.

Producing food from CO2 using microorganisms: Lots to do, little to lose!

BackgroundFor the first time, the recently held United Nations Climate Change Conference (COP 28) involved a summit leaders’ declaration to include global food production in their action plan to fight climate change. Reducing meat consumption is the primary way to take this fight seriously, nevertheless the global supply of people with high-quality protein is one of the central challenges of the coming decades. Producing microbial protein from CO2 (aka single cell protein, SCP) offers the unique opportunity to recycle both, CO2 from the atmosphere and food side streams, into consumer-oriented foods - an innovative path to a zero-carbon footprint diet. Scope and approachThe importance of utilizing CO2 as a substrate for microbial food production is underscored by comparative environmental footprint studies of various protein sources. This commentary systematically discusses the opportunities and technical challenges in realizing this vision. Key findings and conclusionsThe herein proposed acetate-based CO2-to-food framework carries the potential to decrease the environmental footprint of food production by several orders of magnitude in terms of greenhouse gas emission, water, and land usage. While all relevant process steps are already advanced to a high technological readiness level, the key engineering challenges encompass their consolidation to a circular process, scale-up and product formulation.

A prospective approach to the optimal deployment of a hydrogen supply chain for sustainable mobility in island territories: Application to Corsica

This study develops a framework for designing hydrogen supply chains (HSC) in island territories using Mixed Integer Linear Programming (MILP) with a multi-period approach. The framework minimizes system costs, greenhouse gas emissions, and a risk-based index. Corsica is used as a case study, with a Geographic Information System (GIS) identifying hydrogen demand regions and potential sites for production, storage, and distribution. The results provide an optimal HSC configuration for 2050, specifying the size, location, and technology while accounting for techno-economic factors. This work integrates the unique geographical characteristics of islands using a GIS-based approach, incorporates technology readiness levels, and utilizes renewable electricity from neighboring regions. The model proposes decentralized configurations that avoid hydrogen transport between grids, achieving a levelized cost of hydrogen (LCOH) of €8.54/kg. This approach offers insight into future options and incentive mechanisms to support the development of hydrogen economies in isolated territories.

Methodological approach to assessing the digital infrastructure of the northern regions of the Russian Federation

The northern territories of Russia need high-quality strategic digital changes in the structure of the regional economy. Digitalization and the introduction of digital technologies in the medium term will be able to transform economic relations in the old industrial and raw materials regions of the North, improve the quality of life of local communities. The growth of digital inequality among the regions under study leads to disproportions in their socio-economic development. The purpose of this study is to develop and test a methodology for assessing the level of development of the digital infrastructure of the Russian northern regions, including classification of an indicators system for each level of digital infrastructure, calculation of an integral index and typology of the territories under study. The objects of the study were 13 northern regions of the Russian Federation, the entire territory of which is classified as regions of the Extreme North and equivalent areas. The methodology made it possible to determine the level of technical, technological and personnel readiness of the northern regions for digitalization, to identify regions with the best solutions at each level of digital infrastructure development. The analysis of the results in dynamics helped to assess the effectiveness of regional policy for managing digitalization processes. As a result, the authors came to the conclusion that increasing the competitiveness of northern regions in the era of rapid digitalization is possible through investments in human capital and the creation of a network of scientific and technological clusters. The presented approach to assessing the development of individual levels and elements of digital infrastructure will allow for the diagnosis of priority needs of territories under study in the field of digitalization. The results of the study can form the basis for regional policy in the field of sustainable digital development of Russia.

Wood and Wood-Based Materials in Space Applications—A Literature Review of Use Cases, Challenges and Potential

Current political and sociological efforts to respond to the need for more environmentally friendly technologies have inspired a revival of wood and wood-based material utilization in space systems. The popularity of these materials has faded since their widespread use in the early days of aerospace engineering. This work reviews the literature to provide an overview of use cases, the motivation for using wood and wood-based materials and the challenges involved. A small number of applications were identified in which wood and wood-based materials were preferred over non-renewable raw materials. They are mainly applied for less-stressed disposable components or as a thermal protection material. It can be shown that the applied wooden materials have advantages such as low production costs, easy availability, easy and environment-friendly decomposition and low weight. However, only a limited number of applications have achieved a high level of technological readiness so far. Properties such as anisotropy and a lack of uniformity, defects in wood, the quantity available material and a lack of standards for the certification of wooden materials represent challenges. These are addressed in the current research, which additionally focuses on sustainable growth, enhanced environmental friendliness and advanced lightweight design.

Automating 5G network slice management for industrial applications

The transition to Industry 4.0 introduces new use cases with unique communication requirements, demanding wireless technologies capable of dynamically adjusting their performance to meet various demands. Leveraging network slicing, 5G technology offers the flexibility to support such use cases. However, the usage and deployment of network slices in networks are complex tasks. To increase the adoption of 5G, there is a need for mechanisms that automate the deployment and management of network slices. This paper introduces a design for a network slice manager capable of such mechanisms in 5G networks. This design adheres to related standards, facilitating interoperability with other software, while also considering the capabilities and limitations of the technology. The proposed design can provision custom slices tailored to meet the unique requirements of verticals, offering communication performance across the spectrum of the three primary 5G services (eMBB, URLLC, and mMTC/mIoT). To access the proposed design, a Proof-of-Concept (PoC) prototype was developed and evaluated. The evaluation results demonstrate the flexibility of the proposed solution for deploying slices adjusted to the vertical use cases. Additionally, the slices generated by the PoC maintain a high TRL (Technology Readiness Level) equivalent to that of the commercial-graded network used.

Re-engineering Agricultural Innovation in Southeast Asia (RAISE-Asia)

Feeding the growing global population and reducing poverty require innovative approaches in agriculture and food systems to sustain the planet’s health and food requirements. Sustainable development can be achieved by generating new knowledge and translating them into use through innovation process. A customer-oriented technology readiness level (COTRL) tool is presented to re-engineer agricultural innovation by systematically assessing new agricultural technologies with customer input and ensuring that the early design of the scientific research already has the end-products in mind. The COTRL methodology will integrate research, prototyping, and commercialization efforts and facilitate a disciplined and impactful innovation process. It will guide researchers and scientists, research managers and coordinators, funding agency program managers, policymakers, and other personnel involved in bringing scientific discoveries to market for societal impact. The COTRL framework can be used to strengthen the collaboration among academia, research institutions, networks of excellence, and the private sector in the ASEAN to create an effective ecosystem for manpower and structural capability development, knowledge sharing, and business development within and across member states.

SOFTWARE MATURITY LEVEL AND TRAINING OF QUALIFIED PERSONNEL IN SOFTWARE TECHNOLOGIES AT IFBA

The Brazilian Digital Games Industry has grown significantly over the past few years, resulting in the approval, by the Federal Senate, of Bill PL 2.796/2021, which creates the legal framework for the electronic games industry. Educational programs focused on game development in Brazil are a necessity for training talent and promoting innovation in this segment. Being a high-risk business, digital game development requires metrics that can assess technology development. In this context, the objective of this work was to present a correlation between the level of software technology readiness and the digital game development process, as well as to analyze IFBA courses that increase the supply of qualified personnel in digital game development. For this, bibliographic and documentary research procedures were used. Four technology readiness level (TRL) scales applied to software developed by American and Brazilian government agencies were identified, all adapted from the TRL scales and requiring adjustments for application in the various software technologies. The DG-STRL scale, by Ferreira and Ribeiro, correlates the stages of digital game development with the TRL for software technology, and is an instrument focused on the sector. It was observed that the IFBA offers game development courses at continuing education, undergraduate and specialization levels, contributing to the training of talented developers capable of competing on a global scale.

Nanostructured Magnetite Coated with BiOI Semiconductor: Readiness Level in Advanced Solar Photocatalytic Applications for the Remediation of Phenolic Compounds in Wastewater from the Wine and Pisco Industry

Heterogeneous photocatalysis is an advanced, efficient oxidation process that uses solar energy to be sustainable and low-cost compared to conventional wastewater treatments. This study synthesized BiOI/Fe3O4 using the solvothermal technique, evaluating stoichiometric ratios of Bi/Fe (2:1, 3:1, 5:1, and 7:1) under simulated solar irradiation to optimize the degradation of caffeic acid, a pollutant found in wastewater from the wine and pisco industry. The nanomaterial with a 5:1 ratio (BF-5) was the most effective, achieving a degradation of 77.2% in 180 min. Characterization by X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), Brunauer–Emmett–Teller (BET), Barrett–Joyner–Halenda (BJH), Fourier Transform Infrared Spectroscopy (FTIR), Diffuse Reflectance Spectroscopy (DRS), and Vibrating Sample Magnetometry (VSM) showed that BF-5 has a porous three-dimensional structure with BiOI nanosheets coating the Fe3O4 surface, while retaining the pristine BiOI properties. The magnetite provided magnetic properties that facilitated the recovery of the photocatalyst, reaching 89.4% recovery. These findings highlight the potential of BF-5 as an efficient and recoverable photocatalyst for industrial applications. The technical, economic, and environmental feasibility were also evaluated at the technological readiness level (TRL) to project solar photocatalysis in real applications.

Resilient Sustainability Assessment Framework from a Transdisciplinary System-of-Systems Perspective

The vital role of extensive information exchange among stakeholders across diverse sectors and the interconnection of various scientific fields with nonhomogeneous technology readiness levels has created a new form of a complex engineering problem in the climate change era. Comprehensive sustainability assessment to enable the realization of needs requires transdisciplinary thinking to achieve systematic solutions that bridge the gap between multiple collaborative systems in a portfolio. Although the principal aim of dedicated sustainability regulations is to force companies to move toward sustainability development, general and non-engineered metrics that have not defined clear thresholds for evaluation have encountered severe challenges regarding implementation and economic viability. Therefore, adopting a transdisciplinary systems engineering approach can address multifaceted challenges like sustainability by overcoming collaboration barriers, and traditional disciplinary limits. This paper systematically reviews sustainability-dictated regulations from a transdisciplinary perspective. Different standards are compared, raised opportunities and challenges are discussed, and future remarks are highlighted. The sustainability problem is analyzed from a transdisciplinary systems engineering lens. Finally, a two-level resilient system sustainability assessment framework is proposed to effectively handle and enhance the resilience of companies’ sustainability development roadmaps by enabling decision makers to find robust and highly reliable solutions regarding sustainable system design. The impact of this research is to create a new insight into addressing climate change which not only assesses the current situation but also considers uncertainty sources that affect decision making for the future.