The last several decades have seen significant development of new technologies in dentistry. Certainly, one of the most important of them is the development of CAD/CAM systems. While a few systems were available in the 1980s, currently this number has reached about fifteen. Many benefits associated with CAD/CAM-generated dental restorations include: easier, faster, more compatible, more accurate restorations. Furthermore, data or information about treatment has been stored in digital media for many years. CAD/CAM systems are usually used in prosthodontic, restorative dentistry and oral surgery in dentistry. Especially, compliance of maxillofacial prosthesis increases with the development of CAD/CAM systems. All these developments have revealed higher-quality prosthesis and increased aesthetics and quality of life of patients. In this article, we review the history, systems, materials, and use in dentistry of CAD/CAM.