Micronutrient shortage is rapidly becoming apparent have drawn more attention in the cultivation of crops. The main causes of this deficit are the introduction of high-yielding varieties, an intensified cropping strategy, and advanced irrigation systems etc. A further aspect contributing to this issue is the increased use of high analysis chemical fertilizers instead of organic plant nutrition (composts, farmyard manure, etc.). Most countries have acute shortages of micronutrients due to the significant depletion of soil reserves caused by current agricultural production technologies. In order to increase both the quantity and quality of crops, micronutrients are crucial. Through the integration of agronomic, breeding and transgenic techniques, researchers seek to strengthen the zinc concentration in field crops, so improving their nutritional value and mitigating the risk of zinc deficiency in human diets. The availability and absorption of micronutrients in crops are improved by agronomic techniques such as foliar spraying, and soil fertilizer treatment including organic amendments. Meanwhile, biofortification of vegetable and fruit crops has also been achieved by transgenic and breeding strategies. In other hand, Rhizobacteria-based biofortification, Chelated Zn biofortification, nutri-priming are also important techniques in Zinc fortification programs to ensure food security and nutritional quality, bio-fortification of micronutrients in crops is vital. In addition, bio-fortification improved quality and crop output, reducing hidden hunger and demonstrating that it was a viable and economical approach. The present review addresses several aspects of zinc insufficiency in human populations, including public health and socioeconomic issues, bio-fortification and ferti-fortification studies, and future efforts to mitigate zinc deficiency in soil and the population at large.