Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) were determined in sediment samples collected from 34 locations in Lake Qarun, Egypt to elucidate their concentrations, distribution, possible sources and potential ecological risk. A total of 25 OCPs and 29 PCBs were identified and quantified. OCPs and PCBs were found to be ubiquitous pollutants in the aquatic environment of Lake Qarun, particular near urban areas reflecting the local usage and input of these pollutants. Total concentrations of OCPs and PCBs in sediments ranged from 1.01 to 164.8nggâ1 and 1.48 to 137.2nggâ1, respectively. Among OCPs, Îł-HCH, heptachlor, aldrin, endrin, p,pâČ-DDE, oxy-chlordane and endosulfan I and II were the most abundant compounds. The composition of PCB congeners was dominated by the tri-, tetra-, penta- and hexa-chlorinated biphenyls. The ratios of certain metabolites (isomers) to their parent compounds (mixtures) indicated there are still new inputs of lindane, endrin, heptachlor and technical endosulfan to Qarun Lake, while the ratios of (p,pâČ-DDE+p,pâČ-DDD)/âp,pâČ-DDTs indicate earlier usage of DDT. Contamination levels of PCBs and HCHs can be categorized as moderate to high compared to other urbanized regions worldwide. According to established sediment quality guidelines, Îł-HCH, endrin and chlordanes would be more concerned OCP species for the ecotoxicological risk in Lake Qarun.