Innovation and entrepreneurship education an important direction in the construction of vocational teaching systems in higher vocational colleges and universities, the application of e-commerce professional teaching can effectively cultivate the professional quality and innovation ability of students, to make them better adapt to the development of the current education and teaching reform and the demand for social professional talents. Therefore, this paper discusses the reform path of higher vocational e-commerce teaching guided by innovation and entrepreneurship, analyzes the current dilemma faced by e-commerce teaching in higher vocational colleges and universities, and puts forward corresponding reform paths in three aspects: innovation of teaching content, innovation of teaching methods and construction of teachers, and aims to cultivate e-commerce talents with innovation consciousness and entrepreneurial ability by updating the curricula, adopting the project-driven teaching methods and strengthening the training of teachers. entrepreneurial ability of e-commerce talents to meet the needs of industrial development.