For injured and after-stroke patients who temporarily lose their hand’s grasping abilities, assisting them in regaining their index finger mobility is very important in the rehabilitation process. In this paper, a finger rehabilitation device based on one degree-of-freedom (DOF) linkage mechanism is designed, aiming to lead the index finger through the flexion–extension trajectory during grasping tasks. Two types of one-DOF mechanisms, a four-bar linkage and a Watt-I six-bar linkage, are synthesized for the task trajectory. Various algorithms such as PSO, GA, and GA–BFGS are adopted and compared for the synthesis of these two types of mechanisms, among which the Watt-I six-bar linkage obtained with GA–BFGS shows the optimal performance in accuracy. Clinical biomechanical data are utilized to perform static analyses of the mechanisms, and the feasibility of the Watt-I six-bar linkage models is tested, compared, and demonstrated. Finally, the prototype of the six-bar linkage as well as a wearable exoskeleton finger rehabilitation device are designed to show how they are applied in the finger rehabilitation scenario.
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