Tandem Substitution Reaction Research Articles

Synthesis of Fused Purine Heterocycles via a One-pot Cascade Reaction of a Trisubstituted Pyrimidine

A rapid and expedient one-pot procedure for the synthesis of fused purine derivatives from a trisubstituted pyrimidine and various amines has been developed. The tandem substitution reaction and copper(I)-catalyzed annulation exhibited high efficiency. The fused heterocyclic products contain the purine scaffold and may be useful in medicinal chemistry and bioscience.

Efficient Synthesis of O-glycosyl-5′-H-Phosphonate Diesters of d4T

A novel and one-pot route for the synthesis ofO-glycosyl-5′-H-phosphonate diesters of d4T has been developed. This analogs were synthesized by controlling tandem substitution reaction on PCl3with 2,6-lutidine as suitable base.

A Novel Synthesis of AZT-5<i>'</i>-Glycosyl-1″-<i>H</i>-Phosphonate Diesters

A novel and efficient method for the preparation ofO-AZT-5′-O-glycosyl-1-H-phosphonate diesters has been developed. TheH-phosphonate diesters were synthesized by tandem substitution reaction on PCl3with 2,6-lutidine as base.