Tamsulosin In Treatment Research Articles

The efficacy of vardenafil and tamsulosin in treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: A randomised clinical trial

Objectives: This randomised controlled trial (RCT) aimed to evaluate the efficacy of vardenafil monotherapy, tamsulosin monotherapy, and combination therapy of vardenafil and tamsulosin in treating lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). Methods: This RCT involved 75 patients presenting with LUTS secondary to BPH. Patients were randomly allocated into three groups, receiving either vardenafil monotherapy, tamsulosin monotherapy, or a combination of both drugs. Assessments and follow-ups were conducted 1, 3, and 6 months after treatment initiation, focusing on improvements in LUTS, uroflowmetry measurements, and patients’ sexual performance. Data analysis was performed using Microsoft Office Excel 2007 and IBM SPSS statistics software version 22.0. Results: This study included 75 participants divided into three groups. No significant differences were found in terms of patients’ age (p = 0.504) or treatment duration (p = 0.680) between the groups. The combination of vardenafil/tamsulosin consistently showed the lowest International Prostate Symptom Score (IPSS) scores and grades, followed by the tamsulosin group (p < 0.001). Regarding Q-max and post-void residual urine (PVRU), significant differences were observed between the vardenafil group and the other two groups (p > 0.001), but no significant differences were found between the tamsulosin and vardenafil/tamsulosin groups. Conclusion: The combination therapy with vardenafil and tamsulosin is more effective in improving LUTS secondary to BPH than monotherapy. Tamsulosin monotherapy also appears to be more effective than vardenafil monotherapy. Combination therapy provides a viable treatment option for patients who do not respond adequately to monotherapy or experience adverse effects from either drug. Level of Evidence: Moderate

Therapeutic efficacy of the combination of two surgical procedures with tamsulosin in treatment of benign prostatic hyperplasia complicated with bladder stones

Purpose: To compare the efficacies of two surgical methods combined with tamsulosin in treating benign prostatic hyperplasia (BPH) complicated with bladder stones.
 Methods: A total of 86 patients with BPH complicated with bladder stones and admitted to The People’s Hospital of Dingzhou, Hebei, from October 2021 to October 2022 were selected as subjects. The patients were equally divided into groups A and B (n = 43). Patients in group A were treated with transurethral vaporization and electro-resection of the prostate (TURP) + percutaneous nephroscopic lithotripsy (PCNL), while patients in group B were treated with TURP + holmium laser lithotripsy (HLL). Baseline clinical information, curative effect, surgery-related indicators, clinical symptoms, and recurrence were compared between the two groups of patients.
 Results: At 4 weeks post-surgery, Qmax was significantly higher in group B than in group A, while IPSS score, RUV, and prostate volume were significantly lower in group B than in group A (p ˂ 0.05). The levels of physiological state, psychological state, social functionality and level of subjective judgment were higher in group B than in group A (p ˂ 0.05). The incidence of complications in group A was 11.63 %, with a recurrence rate of 6.98 %, while the corresponding values for group B were 13.95 and 4.65 %, respectively (p > 0.05).
 Conclusion: The effect of TURP + HLL surgery on patients with BPH complicated with bladder stones is significantly better than that of TURP + PCNL surgery. The former also reduces clinical symptoms while improving the quality of life of patients.

Efficacy of cystone versus tamsulosin in treatment of stent-related lower urinary tract symptoms

Objective: Double-J stent is a common tool used in urological procedures that is inserted for 2–6 weeks, but it may induce abdominal and flank pain, incontinence and irritative urinary symptoms. Alleviation of such symptoms would be useful to improve the patients’ quality of life. Accordingly, in this study, the efficacy of cystone versus tamsulosin in the treatment of double-J stent-related lower urinary tract symptoms was determined. Materials and methods: In this randomised clinical trial, 128 patients who required double-J stent insertion after transureteral lithotripsy during 2018–2019 were enrolled. They were randomly assigned to receive either cystone, tamsulosin, both, or placebo. The international prostate symptom score and visual analogue score data were recorded at baseline, after 2 and 4 weeks across the groups. Results: The international prostate symptom score and visual analogue score factors were statistically different across the case groups receiving cystone, tamsulosin and both drugs versus placebo ( P=0.001). Two weeks after drug administration, the visual analogue score and international prostate symptom score were not statistically different in the tamsulosin, cystone and dual therapy groups; however, after 4 weeks the cystone group had the lowest symptoms. Conclusion: Both tamsulosin and cystone are efficient drugs which would relieve stent-related lower urinary tract symptoms. The administration of cystone with or without tamsulosin for 4 weeks may have the best result in reducing the visual analogue score and international prostate symptom score. Level of evidence: Level I, 1b, therapeutic study, randomised controlled trial

Tamsulosin in the management of distal ureteric calculi

Introductions: Ureteral stones account for 20% urinary stone. Two third of ureteral stones are seen in lower third of ureter. Medical expulsive therapy is effective for such stones. This study was designed to observe the efficacy of ‘tamsulosin’ a selective alpha-1 adrenoreceptor antagonist in the management of lower ureteric stone.Methods: A cross sectional study of 70 cases of distal ureteral stones of sizes 5 to 10 mm was taken in the Department of Surgery of Shree Birendra Hospital, Nepalese Army Institute of Health Sciences (NAIHS) from January 2011 to 2013. Patients were randomly divided into tamsulosin and analgesic only groups. Stone expulsion at the end of three weeks was confirmed by X-ray or Ultrasonography.Results: Out of 70 patients, stone clearance rate in tamsulosin group was 28 in 35 cases (80%) and 21 in 35 cases (60%) in group II with analgesic only. The mean time of stone expulsion was 8.3 days in group I and 13.5 days in group II.Conclusions: In this study the use of tamsulosin in treatment of lower ureteral stones less than 10 mm was safe and effective.

Efficacy of tamsulosin in treatment of upper ureteral calculi: a meta-analysis

Objective To systematically revise the efficacy and safety of tamsulosin in treatment of proximal ureteral calculi.Methods Electronic search was conducted with PubMed,Cochrane library,EMBASE,Wanfang database,CNKI and VIP to collect randomized controlled trials(RCTs) involving the application of tamsulosin in treatment of upper ureteral calculi.The quality of the included trials was assessed;the data were extracted and analyzed with RevMan 5.0 software.Results Five RCTs involving 480 patients were identified.The results of meta-analysis showed that,compared with the control group,patients in the tamsulosin group had(1) a remarkably higher stone clearance rate(RR=1.25,95%CI:1.12-1.40,P0.000 1),(2) shorter mean time of calculi expulsion(shortened by 2.99 days,95%CI:-3.61——2.37,P0.000 01),and(3) decreased incidence of renal colic episodes and mean visual analogue scale pain score(RR=0.39,95%CI:0.26-0.57,P0.000 01;WMD=-10.94,95%CI:-21.30——0.58,P=0.04).Conclusion Our results show that tamsulosin can improve the stone clearance,shorten the mean time for calculi expulsion,decrease the incidence of renal colic episodes and the mean visual analogue scale pain score in patients with proximal ureteral calculi.

UP-1.51: Tolterodine and tamsulosin for treatment of men with benign prostatic hyperplasia and lower urinary tract symptoms

UP-1.51: Tolterodine and tamsulosin for treatment of men with benign prostatic hyperplasia and lower urinary tract symptoms

Tamsulosin for Treatment of ED Patients with Renal Colic

Tamsulosin, an α-adrenergic antagonist commonly used in the treatment of prostatic hypertrophy, has become a common treatment in the emergency

Observation on the curative effect of combination of Epristeride and Tamsulosin for treatment of benign prostatic hyperplasia and the health education

目的 联合应用新型非竞争性5α还原酶抑制剂(爱普列特)与髙选择性的α1受体阻滞剂坦索罗辛(Tamsulosin,哈乐),探讨对老年良性前列腺增生症(BPH)患者主观症状的缓解与客观指标的改善的影响,旨在为老年BPH患者的健康教育对策提供依据.方法 随机选取230例门诊前列腺增生患者,联合应用爱普列特(5 mg口服2次/d)与坦索罗辛(0.2 mg口服1次/d)治疗6～12个月,国际前列腺症状评分(IPSS)观察治疗前、后的主客观症状的改善情况及并发症.结果 治疗后患者主观症状改善明显,生活质量明显提高.IPSS较治疗前平均降低14.2分,残余尿量较治疗前平均减少18.15 ml,最大尿流率较治疗前平均增加6.09 ml/s,前列腺体积较治疗前减小14.47 ml,P<0.01,均有显著性差异.结论 爱普列特与坦索罗辛联合用药治疗良性前列腺增生症安全有效。

Tolterodine and Tamsulosin for Treatment of Men With Lower Urinary Tract Symptoms and Overactive Bladder: A Randomized Controlled Trial

Tolterodine and Tamsulosin for Treatment of Men With Lower Urinary Tract Symptoms and Overactive Bladder: A Randomized Controlled Trial

The use of tamsulosin in the medical treatment of ureteral calculi: where do we stand?

It has recently been demonstrated that specific adrenoceptors subtypes (alpha(1A)/alpha(1D)) are prevalent in the distal part of the ureter, a finding supporting the interesting results obtained by different groups with the use of tamsulosin in the treatment of distal ureteral calculi. We performed a prospective randomized study to evaluate the effects of the addition of tamsulosin on our standard pharmacological therapy for the treatment of selected ureteral stones. A total of 64 patients referred to our department for the management of symptomatic ureteral calculi were considered. Patients were randomly divided into two treatment groups: group A (n=32) who received diclofenac (100 mg/daily) plus aescin (80 mg/daily) and group B (n=32) who received the same therapy plus tamsulosin (0.4 mg/daily) for a maximum of 2 weeks. No significant differences were found between the groups for age, gender distribution and mean stone size measured in the single largest dimension at presentation. The stone expulsion rate was 60% (19/32 patients) for group A and 88% for (28/32) for group B with a mean expulsion time of 7.4+/-2.2 (range 3.5-12) and 4.8+/-2.7 days (range 1.8-10.5), respectively. Group B showed a significant advantage in terms of both expulsion rate (P=0.01) and expulsion time (P=0.005). Different analgesics from those used in the standard treatment regimen were required in ten patients in group A (31%) but only three patients in group B (9%). This difference was significant (P=0.003). Hospitalization for recurrent colic was needed in 21% of patients in group A (7/32) and in 9% in group B (3/32) (P=0.01). Only two patients in each group (6%) experienced minor side effects associated with the expulsive therapy. Our data confirm the efficacy of tamsulosin in the treatment of distal ureteral stones up to 1 cm. This selective alpha-blocker should therefore be included in the pharmacological regimen of patients when a conservative approach is considered in the treatment of ureteral lithiasis.

Role of tamsulosin in treatment of patients with steinstrasse developing after extracorporeal shock wave lithotripsy

Objectives To evaluate whether tamsulosin, as an alpha 1-blocker, was effective for the treatment of steinstrasse in the lower ureter after shock wave lithotripsy. Methods A total of 67 patients (43 men and 24 women) with steinstrasse in the lower portion of the ureters were randomly divided into two groups. Only hydration and tenoxicam (20 mg orally once daily) was given to group 1 (35 patients). Group 2 (32 patients), was also given tamsulosin (0.4 mg daily). All patients were reevaluated and questioned about the number of episodes and severity of ureteral colic and the rates of spontaneous resolution of steinstrasse 6 weeks after beginning treatment. They were asked to score the severity of pain according to a visual analog scale. Results In 23 (65.7%) of 35 patients in group 1 and in 24 (75%) of 32 patients in group 2, steinstrasse resolved during the first 6 weeks. The resolution rates were not significantly different ( P >0.05) between groups 1 and 2. Group 1 had more ureteral colic episodes than did group 2 while passing their stones. This difference was statistically significant ( P <0.01). Group 1 patients reported significantly greater ( P <0.001) visual analog scale scores than did group 2 patients. Conclusions The addition of tamsulosin to conservative treatment seemed to be beneficial in terms of the reduced number of ureteral colic episodes and the severity of pain in the patients who developed steinstrasse after shock wave lithotripsy.

Tamsulosin for treatment of symptomatic benign prostatic obstruction: a systematic review of efficacy and adverse effects

Tamsulosin for treatment of symptomatic benign prostatic obstruction: a systematic review of efficacy and adverse effects